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The map label for this gene is lpxH [H]

Identifier: 119897346

GI number: 119897346

Start: 1134854

End: 1135654

Strand: Reverse

Name: lpxH [H]

Synonym: azo1055

Alternate gene names: 119897346

Gene position: 1135654-1134854 (Counterclockwise)

Preceding gene: 119897347

Following gene: 119897321

Centisome position: 25.95

GC content: 69.41

Gene sequence:

>801_bases
TTGTCTGATCCCCGTACGCAAGCGGCCGCCACCGGCGGCCGTGCCGGCGACGAGCCGGAAGCCGCGTCCGTCGCGCTTCC
GGCTTTCTTCATTTCGGACCTCCACCTGAGCGAGGATCAGCCCGACACGGTTGCCGCCTTCGTGGACTTTCTCGCCGGGC
CCGCGCGCGACGCGGGCAGCCTCTTCATCCTTGGCGACCTGTTCGAATACTGGGCGGGCGATGACGACCTCGAAGCGCCT
TTCAACCAGCGCATCGCGTCCGCATTGCGGGCCCTGGCCGCGAGCGGCACCGCCGTGTATTTCATGGTCGGCAACCGCGA
CCTGCTCGCAGGACACGGACTGGCCGCAGCCACCGGCATGCAGTTGCTGGCGGATCCGGCGCTCGTGCGGCTCGGGCAGC
ACGAAACAGCGCCCCGCGTCCTGCTCAGCCACGGCGACGCCCTGTGCACCGACGACACCGCCTACCAGGCCTATCGGCGG
CAGGTACGCGACCCCGCCTGGCAGGCCGGCTTCCTCTCGCAGCCACTCGCAGCCCGCAAGGCCTTCATCGCCAGCCTGCG
TCAGCAGAGCGAACGCGCGAAGCAGGACAAGGCGATGACAATCATGGACGTCAATCCCGACGCCGTCGCCGCGCTGCTGC
GCGAGTACGGCTACCCCGAACTGATCCATGGCCACACCCATCGACCGGGCCAGCACACCCACCTCGTCGATGGCCGGCAG
TGCGGACGCCACGTGCTGGCGGACTGGCACGGCCGCGCGCGCTGGCTCGCCTACGACGGCACCCGTTTCACCAGCCTGTG
A

Upstream 100 bases:

>100_bases
GGACTGGACGTGGTCGATGCGATCCGCAAGGTCAAGACGGGCTCGAGCGGCTTCCATCAGGATGTGCCGAAGGAAGACGT
GATCATCGAGCGGGCCGAAG

Downstream 100 bases:

>100_bases
CTCCCGCCGCCTGACCAGCGGCGCGCCCCGAACAAAAAAAAAGCGCCGGACCGGCCGGCGCTGTGTGCGGGGCGACGAAT
CTCCGCGGACCTAGGTCGCC

Product: UDP-2,3-diacylglucosamine hydrolase

Products: 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1; UMP [C]

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSDPRTQAAATGGRAGDEPEAASVALPAFFISDLHLSEDQPDTVAAFVDFLAGPARDAGSLFILGDLFEYWAGDDDLEAP
FNQRIASALRALAASGTAVYFMVGNRDLLAGHGLAAATGMQLLADPALVRLGQHETAPRVLLSHGDALCTDDTAYQAYRR
QVRDPAWQAGFLSQPLAARKAFIASLRQQSERAKQDKAMTIMDVNPDAVAALLREYGYPELIHGHTHRPGQHTHLVDGRQ
CGRHVLADWHGRARWLAYDGTRFTSL

Sequences:

>Translated_266_residues
MSDPRTQAAATGGRAGDEPEAASVALPAFFISDLHLSEDQPDTVAAFVDFLAGPARDAGSLFILGDLFEYWAGDDDLEAP
FNQRIASALRALAASGTAVYFMVGNRDLLAGHGLAAATGMQLLADPALVRLGQHETAPRVLLSHGDALCTDDTAYQAYRR
QVRDPAWQAGFLSQPLAARKAFIASLRQQSERAKQDKAMTIMDVNPDAVAALLREYGYPELIHGHTHRPGQHTHLVDGRQ
CGRHVLADWHGRARWLAYDGTRFTSL
>Mature_265_residues
SDPRTQAAATGGRAGDEPEAASVALPAFFISDLHLSEDQPDTVAAFVDFLAGPARDAGSLFILGDLFEYWAGDDDLEAPF
NQRIASALRALAASGTAVYFMVGNRDLLAGHGLAAATGMQLLADPALVRLGQHETAPRVLLSHGDALCTDDTAYQAYRRQ
VRDPAWQAGFLSQPLAARKAFIASLRQQSERAKQDKAMTIMDVNPDAVAALLREYGYPELIHGHTHRPGQHTHLVDGRQC
GRHVLADWHGRARWLAYDGTRFTSL

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP [H]

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family [H]

Homologues:

Organism=Escherichia coli, GI1786735, Length=225, Percent_Identity=44.4444444444444, Blast_Score=194, Evalue=7e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR010138 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 28844; Mature: 28712

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPRTQAAATGGRAGDEPEAASVALPAFFISDLHLSEDQPDTVAAFVDFLAGPARDAGS
CCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCC
LFILGDLFEYWAGDDDLEAPFNQRIASALRALAASGTAVYFMVGNRDLLAGHGLAAATGM
EEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCHHHHHHH
QLLADPALVRLGQHETAPRVLLSHGDALCTDDTAYQAYRRQVRDPAWQAGFLSQPLAARK
HHHHCHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCHHHHH
AFIASLRQQSERAKQDKAMTIMDVNPDAVAALLREYGYPELIHGHTHRPGQHTHLVDGRQ
HHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCHHH
CGRHVLADWHGRARWLAYDGTRFTSL
HHHHHHHCCCCCEEEEEECCCEECCC
>Mature Secondary Structure 
SDPRTQAAATGGRAGDEPEAASVALPAFFISDLHLSEDQPDTVAAFVDFLAGPARDAGS
CCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCC
LFILGDLFEYWAGDDDLEAPFNQRIASALRALAASGTAVYFMVGNRDLLAGHGLAAATGM
EEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCHHHHHHH
QLLADPALVRLGQHETAPRVLLSHGDALCTDDTAYQAYRRQVRDPAWQAGFLSQPLAARK
HHHHCHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCHHHHH
AFIASLRQQSERAKQDKAMTIMDVNPDAVAALLREYGYPELIHGHTHRPGQHTHLVDGRQ
HHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCHHH
CGRHVLADWHGRARWLAYDGTRFTSL
HHHHHHHCCCCCEEEEEECCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; UDP-2,3-bis(3-hydroxymyristoyl)glucosamine [C]

Specific reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1 + UMP [C]

General reaction: Lipid A biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA