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The map label for this gene is ppiA [H]

Identifier: 119897348

GI number: 119897348

Start: 1136158

End: 1136739

Strand: Reverse

Name: ppiA [H]

Synonym: azo1057

Alternate gene names: 119897348

Gene position: 1136739-1136158 (Counterclockwise)

Preceding gene: 119897349

Following gene: 119897347

Centisome position: 25.98

GC content: 65.98

Gene sequence:

>582_bases
ATGAAACGCCTCATCGCCTTCCTTGCCCTGTCCACCTGGCTCGGGCTCGCCGCCGCCGCCAACCCGCAGGTGCTGTTCAC
CACCAACCAGGGCGAACTCGTCGTCGAGCTGTACCCCGAGAAGGCACCGAAGACGGTCGCCAACTTCCTGCAGTACGTGA
AGGACAAGCACTACGACGGCACGATCTTCCACCGCGTCATCAACGGCTTCATGATCCAGGGCGGTGGCATGGACGCGGCG
ATGAAGGAAAAATCCACCCGCGCCCCGATCGAGAACGAAGCGAAAAACGGCCTGCGCAACGAACCCGGCACGCTGGCGAT
GGCCCGCACCGGCGACCCGCACTCCGCCACCGCGCAGTTCTTCATCAACGTGGCCCCCAACAGCTTCCTCGACTACCCTT
CCCGTGACGGCTGGGGTTACGCGGTGTTCGGCAAGGTGGTGCGCGGCCTCGACGTCGTCGACACCATCGCCCGCGTGCCG
ACGCGCAATGTCGGCTTCCACCAGAATGTCCCGGCCGAGCCGGTCGTCATCCAGTCGGCGCGCGTGATCGAAGCGCAGCC
GGCCGGCCCCGCAGCCCGATAA

Upstream 100 bases:

>100_bases
AGTACTGGGTGCGCGAAGGCGGCGAGTGGAAGATCGTCTACGAAGGCGCCGCCTGAGCCGCCGGCCCCGCCCCACCCTTT
TTCCCCTCCGCGGAGATTCC

Downstream 100 bases:

>100_bases
GCACAAGGAGCACACCATGGCAGTGAACCTGCACACCAACTACGGCGTCATCACCCTCGAACTCGACGCCGAGAAGGCGC
CGGTGACCGTCGAGAACTTC

Product: peptidyl-prolyl cis-trans isomerase A

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MKRLIAFLALSTWLGLAAAANPQVLFTTNQGELVVELYPEKAPKTVANFLQYVKDKHYDGTIFHRVINGFMIQGGGMDAA
MKEKSTRAPIENEAKNGLRNEPGTLAMARTGDPHSATAQFFINVAPNSFLDYPSRDGWGYAVFGKVVRGLDVVDTIARVP
TRNVGFHQNVPAEPVVIQSARVIEAQPAGPAAR

Sequences:

>Translated_193_residues
MKRLIAFLALSTWLGLAAAANPQVLFTTNQGELVVELYPEKAPKTVANFLQYVKDKHYDGTIFHRVINGFMIQGGGMDAA
MKEKSTRAPIENEAKNGLRNEPGTLAMARTGDPHSATAQFFINVAPNSFLDYPSRDGWGYAVFGKVVRGLDVVDTIARVP
TRNVGFHQNVPAEPVVIQSARVIEAQPAGPAAR
>Mature_193_residues
MKRLIAFLALSTWLGLAAAANPQVLFTTNQGELVVELYPEKAPKTVANFLQYVKDKHYDGTIFHRVINGFMIQGGGMDAA
MKEKSTRAPIENEAKNGLRNEPGTLAMARTGDPHSATAQFFINVAPNSFLDYPSRDGWGYAVFGKVVRGLDVVDTIARVP
TRNVGFHQNVPAEPVVIQSARVIEAQPAGPAAR

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=171, Percent_Identity=33.9181286549708, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI24308049, Length=138, Percent_Identity=37.6811594202899, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI5454154, Length=180, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI19557636, Length=140, Percent_Identity=34.2857142857143, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI22547215, Length=139, Percent_Identity=36.6906474820144, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI22547212, Length=141, Percent_Identity=36.1702127659575, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI7657473, Length=141, Percent_Identity=36.1702127659575, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI64276486, Length=166, Percent_Identity=33.1325301204819, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI310110104, Length=154, Percent_Identity=34.4155844155844, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI10863927, Length=154, Percent_Identity=33.7662337662338, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI310129267, Length=154, Percent_Identity=33.1168831168831, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI310120620, Length=154, Percent_Identity=33.1168831168831, Blast_Score=70, Evalue=9e-13,
Organism=Escherichia coli, GI1789763, Length=183, Percent_Identity=56.8306010928962, Blast_Score=202, Evalue=1e-53,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=58.8957055214724, Blast_Score=200, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17539496, Length=145, Percent_Identity=36.551724137931, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=143, Percent_Identity=35.6643356643357, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=143, Percent_Identity=35.6643356643357, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17532641, Length=166, Percent_Identity=33.1325301204819, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=146, Percent_Identity=34.2465753424658, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17552780, Length=195, Percent_Identity=34.3589743589744, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565860, Length=204, Percent_Identity=29.4117647058824, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17559074, Length=145, Percent_Identity=35.1724137931034, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532643, Length=158, Percent_Identity=32.2784810126582, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17552782, Length=163, Percent_Identity=30.6748466257669, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17566266, Length=160, Percent_Identity=33.125, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=177, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6320359, Length=134, Percent_Identity=36.5671641791045, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=161, Percent_Identity=32.9192546583851, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17986117, Length=162, Percent_Identity=33.9506172839506, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19922912, Length=137, Percent_Identity=35.7664233576642, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24586038, Length=181, Percent_Identity=32.5966850828729, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17136360, Length=195, Percent_Identity=30.7692307692308, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19922376, Length=163, Percent_Identity=30.0613496932515, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24652460, Length=141, Percent_Identity=30.4964539007092, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20978; Mature: 20978

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLIAFLALSTWLGLAAAANPQVLFTTNQGELVVELYPEKAPKTVANFLQYVKDKHYDG
CHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCC
TIFHRVINGFMIQGGGMDAAMKEKSTRAPIENEAKNGLRNEPGTLAMARTGDPHSATAQF
HHHHHHHHCEEEECCCCCHHHHHCCCCCCCHHHHHCCCCCCCCCEEEEECCCCCCCEEEE
FINVAPNSFLDYPSRDGWGYAVFGKVVRGLDVVDTIARVPTRNVGFHQNVPAEPVVIQSA
EEEECCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCEEECCC
RVIEAQPAGPAAR
EEEEECCCCCCCC
>Mature Secondary Structure
MKRLIAFLALSTWLGLAAAANPQVLFTTNQGELVVELYPEKAPKTVANFLQYVKDKHYDG
CHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCC
TIFHRVINGFMIQGGGMDAAMKEKSTRAPIENEAKNGLRNEPGTLAMARTGDPHSATAQF
HHHHHHHHCEEEECCCCCHHHHHCCCCCCCHHHHHCCCCCCCCCEEEEECCCCCCCEEEE
FINVAPNSFLDYPSRDGWGYAVFGKVVRGLDVVDTIARVPTRNVGFHQNVPAEPVVIQSA
EEEECCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCEEECCC
RVIEAQPAGPAAR
EEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]