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The map label for this gene is trxA1 [H]

Identifier: 119897321

GI number: 119897321

Start: 1108162

End: 1108488

Strand: Reverse

Name: trxA1 [H]

Synonym: azo1030

Alternate gene names: 119897321

Gene position: 1108488-1108162 (Counterclockwise)

Preceding gene: 119897346

Following gene: 119897320

Centisome position: 25.33

GC content: 55.96

Gene sequence:

>327_bases
ATGAGCGAGCATATCCATTATGTGACCGATGGCAGCTTTGAGGCCGAGGTACTGCAGTCCCAGACGCCCGTCCTGGTCGA
CTACTGGGCTGAATGGTGCGGCCCGTGCAAGATGATTGCGCCGATCCTTGACGAAGTTGCCAAAGACTACGCCGGCAAGC
TCAAGGTCGCCAAGCTCAACATCGACGAAAACCAGGAAACGCCGGCCAAGTACGGCATCCGTGGCATTCCGACCCTGATG
ATCTTCAAGGGCGGCAACATCGAGGCGACCAAGGTTGGCGCCCTGTCCAAATCTCAACTGACTGCTTTCATTGACAGCAA
CATCTAA

Upstream 100 bases:

>100_bases
CTTCGTCGCACCCTGGTCCTTCGGGCCCCGCAGGGCCTCACCGCTCCCGCGACCCAACGCCCCCCGACACACACTACCGT
CACCCCTGATGTGAGGAATC

Downstream 100 bases:

>100_bases
GCCGGAGGCGACTCCGGCCCGTTCTCGCGGTGCTTCGCGGACCCGCCGCAGGGGTGCCCGCAACCGCGACGGTAATTCTC
CCCAAGGCAACACCTCCGAA

Product: thioredoxin-disulfide reductase

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSEHIHYVTDGSFEAEVLQSQTPVLVDYWAEWCGPCKMIAPILDEVAKDYAGKLKVAKLNIDENQETPAKYGIRGIPTLM
IFKGGNIEATKVGALSKSQLTAFIDSNI

Sequences:

>Translated_108_residues
MSEHIHYVTDGSFEAEVLQSQTPVLVDYWAEWCGPCKMIAPILDEVAKDYAGKLKVAKLNIDENQETPAKYGIRGIPTLM
IFKGGNIEATKVGALSKSQLTAFIDSNI
>Mature_107_residues
SEHIHYVTDGSFEAEVLQSQTPVLVDYWAEWCGPCKMIAPILDEVAKDYAGKLKVAKLNIDENQETPAKYGIRGIPTLMI
FKGGNIEATKVGALSKSQLTAFIDSNI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=98, Percent_Identity=36.734693877551, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI5031973, Length=99, Percent_Identity=35.3535353535354, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI21361657, Length=80, Percent_Identity=37.5, Blast_Score=63, Evalue=6e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=64.8148148148148, Blast_Score=155, Evalue=6e-40,
Organism=Escherichia coli, GI1788936, Length=93, Percent_Identity=37.6344086021505, Blast_Score=92, Evalue=5e-21,
Organism=Escherichia coli, GI87081747, Length=85, Percent_Identity=35.2941176470588, Blast_Score=64, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=40.8602150537634, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=43.6619718309859, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17554386, Length=87, Percent_Identity=39.0804597701149, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=104, Percent_Identity=29.8076923076923, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=74, Percent_Identity=37.8378378378378, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115532380, Length=74, Percent_Identity=37.8378378378378, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17544108, Length=72, Percent_Identity=38.8888888888889, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=85, Percent_Identity=38.8235294117647, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323072, Length=89, Percent_Identity=37.0786516853933, Blast_Score=68, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324862, Length=101, Percent_Identity=33.6633663366337, Blast_Score=67, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=42.5, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24664269, Length=74, Percent_Identity=41.8918918918919, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17648013, Length=85, Percent_Identity=34.1176470588235, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24583090, Length=85, Percent_Identity=34.1176470588235, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19921434, Length=83, Percent_Identity=37.3493975903614, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21358065, Length=92, Percent_Identity=33.695652173913, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11874; Mature: 11743

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHIHYVTDGSFEAEVLQSQTPVLVDYWAEWCGPCKMIAPILDEVAKDYAGKLKVAKLN
CCCCEEEEECCCCHHHHHHCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEC
IDENQETPAKYGIRGIPTLMIFKGGNIEATKVGALSKSQLTAFIDSNI
CCCCCCCCCCCCCCCCCEEEEEECCCCCEEEECCCCHHHEEEEECCCC
>Mature Secondary Structure 
SEHIHYVTDGSFEAEVLQSQTPVLVDYWAEWCGPCKMIAPILDEVAKDYAGKLKVAKLN
CCCEEEEECCCCHHHHHHCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEC
IDENQETPAKYGIRGIPTLMIFKGGNIEATKVGALSKSQLTAFIDSNI
CCCCCCCCCCCCCCCCCEEEEEECCCCCEEEECCCCHHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]