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The map label for this gene is hisD [H]

Identifier: 119897109

GI number: 119897109

Start: 872987

End: 874297

Strand: Direct

Name: hisD [H]

Synonym: azo0818

Alternate gene names: 119897109

Gene position: 872987-874297 (Clockwise)

Preceding gene: 119897108

Following gene: 119897112

Centisome position: 19.95

GC content: 68.65

Gene sequence:

>1311_bases
ATGAGTTTCGCGACCCCGATCCGCCGTCTCGATGCCCGCCAGCCCGATTTCCTCGCGACGCTGGATGCGCTGCTGGCGTT
CGAAAGCGAGGCCGACGAGCGCATCGACAGCGCGGTCACCGAGATCCTGCGCGCGGTGCGCAGCACCGGCGACGCCGCGG
TCATGGAATACACCCGCCGCTTCGATCATGTCGAGGCGAAATCGATGGTCGAGCTGGAGCTGCCCAAGGCCGAACTGCAG
GCCGCGCTCGACAGCCTGACCGTGGAGCAGCGCGAGGCATTGCGCATCGCCGCCGACCGCGTGCGCATCTACCACGAGCG
CCAGCGCGCCGAGTCCTGGGACTATGTCGAGGCCGACGGTTCGCGGCTGGGCCAGAAGGTGACGCCGCTCGACCGCGTCG
GCCTCTACGTGCCCGGCGGGCGCGCGTCCTACCCCAGTTCGGTGCTGATGAACGCGATTCCGGCCAAAGTCGCCGGTGTC
GAGGAACTCATCATGGTGGTGCCGACGCCACGCGGCGAGAAGAACCCGCTGGTGCTCGCGGCCGCCGCGATCACCGGCGT
CGACCGGGTGTTCACCATCGGCGGCGCGCAGGCGGTGGCGGCGCTGGCCTACGGCACGCAGACCATTCCGCAGGTCGACA
AGATCGTCGGTCCCGGTAACGCTTTCGTCGCCGAAGCCAAGCGCCGGGTGTTCGGCACGGTGGGCATCGACATGGTGGCC
GGTCCATCCGAGGTGCTGATCATCTCCGACGGTTCCGGCCATGCCGACTGGGTGGCGATGGATCTCTTCGCGCAGGCGGA
GCACGACGAACTGGCGCAGTCCATCCTGCTGTGCACCGATGCCGGTTTTCTCGACGCGGTGCACGCGGCGATCGACCGTC
TGCTGCCCACGATGCCGCGCCGCGAGACCATCGCCAGGTCGCTCGCGAACCGGGGCGCACTGATCCACGTCGGCAGCTTG
GAGCAGGCGTGCGCGATCGCCAACCGCATCGCGCCGGAGCACCTGGAACTGTCGATGGAAGACGCGGAGCGCTGGATCGA
TGCGATCCGCCACGCGGGCGCGATCTTCGTCGGGCACTGGGCGGTGGAGGCGCTGGGTGACTACTGCGCCGGCCCCAACC
ACGTGTTGCCGACCATGCGCAGTGCGCGTTTCTCGTCGCCGCTGGGGGTCTACGATTTCCAGAAGCGGACCAGCATCGTG
CAGATTTCCGAGGCGGGTGCGCAGCATCTGGGCAAGATCGCGTCGGTACTGGCCCACGGCGAGGGCCTGCAGGCGCACGC
CCGCTCGGCGGAGATGCGGCTCAAGGTCTGA

Upstream 100 bases:

>100_bases
CGCCGATCAGCTCGCGCCTGATCGTCAACCAGGCCTCGCTCAAGCTCAAGCGCGAACTGATCCAGCCGGTGCTGGACGCT
TTTGCAGGAGCGATCAAGCC

Downstream 100 bases:

>100_bases
GGGCGGACGCGTGGGCTGAAATGCAAACGGGGCGCCAGGGCGCCCCGTTTCGCTTTACGGCCGCAGCACCGCGGCGATGC
GCTCCGCCGCTTCCAGCAAT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSFATPIRRLDARQPDFLATLDALLAFESEADERIDSAVTEILRAVRSTGDAAVMEYTRRFDHVEAKSMVELELPKAELQ
AALDSLTVEQREALRIAADRVRIYHERQRAESWDYVEADGSRLGQKVTPLDRVGLYVPGGRASYPSSVLMNAIPAKVAGV
EELIMVVPTPRGEKNPLVLAAAAITGVDRVFTIGGAQAVAALAYGTQTIPQVDKIVGPGNAFVAEAKRRVFGTVGIDMVA
GPSEVLIISDGSGHADWVAMDLFAQAEHDELAQSILLCTDAGFLDAVHAAIDRLLPTMPRRETIARSLANRGALIHVGSL
EQACAIANRIAPEHLELSMEDAERWIDAIRHAGAIFVGHWAVEALGDYCAGPNHVLPTMRSARFSSPLGVYDFQKRTSIV
QISEAGAQHLGKIASVLAHGEGLQAHARSAEMRLKV

Sequences:

>Translated_436_residues
MSFATPIRRLDARQPDFLATLDALLAFESEADERIDSAVTEILRAVRSTGDAAVMEYTRRFDHVEAKSMVELELPKAELQ
AALDSLTVEQREALRIAADRVRIYHERQRAESWDYVEADGSRLGQKVTPLDRVGLYVPGGRASYPSSVLMNAIPAKVAGV
EELIMVVPTPRGEKNPLVLAAAAITGVDRVFTIGGAQAVAALAYGTQTIPQVDKIVGPGNAFVAEAKRRVFGTVGIDMVA
GPSEVLIISDGSGHADWVAMDLFAQAEHDELAQSILLCTDAGFLDAVHAAIDRLLPTMPRRETIARSLANRGALIHVGSL
EQACAIANRIAPEHLELSMEDAERWIDAIRHAGAIFVGHWAVEALGDYCAGPNHVLPTMRSARFSSPLGVYDFQKRTSIV
QISEAGAQHLGKIASVLAHGEGLQAHARSAEMRLKV
>Mature_435_residues
SFATPIRRLDARQPDFLATLDALLAFESEADERIDSAVTEILRAVRSTGDAAVMEYTRRFDHVEAKSMVELELPKAELQA
ALDSLTVEQREALRIAADRVRIYHERQRAESWDYVEADGSRLGQKVTPLDRVGLYVPGGRASYPSSVLMNAIPAKVAGVE
ELIMVVPTPRGEKNPLVLAAAAITGVDRVFTIGGAQAVAALAYGTQTIPQVDKIVGPGNAFVAEAKRRVFGTVGIDMVAG
PSEVLIISDGSGHADWVAMDLFAQAEHDELAQSILLCTDAGFLDAVHAAIDRLLPTMPRRETIARSLANRGALIHVGSLE
QACAIANRIAPEHLELSMEDAERWIDAIRHAGAIFVGHWAVEALGDYCAGPNHVLPTMRSARFSSPLGVYDFQKRTSIVQ
ISEAGAQHLGKIASVLAHGEGLQAHARSAEMRLKV

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=408, Percent_Identity=40.9313725490196, Blast_Score=299, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6319819, Length=410, Percent_Identity=37.8048780487805, Blast_Score=253, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47073; Mature: 46942

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFATPIRRLDARQPDFLATLDALLAFESEADERIDSAVTEILRAVRSTGDAAVMEYTRR
CCCCCHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FDHVEAKSMVELELPKAELQAALDSLTVEQREALRIAADRVRIYHERQRAESWDYVEADG
HCCHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCH
SRLGQKVTPLDRVGLYVPGGRASYPSSVLMNAIPAKVAGVEELIMVVPTPRGEKNPLVLA
HHCCCCCCCHHHCCEEECCCCCCCCHHHHHHHHHHHHCCHHHEEEEECCCCCCCCCEEEE
AAAITGVDRVFTIGGAQAVAALAYGTQTIPQVDKIVGPGNAFVAEAKRRVFGTVGIDMVA
EHHHHCCHHHEEECCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEC
GPSEVLIISDGSGHADWVAMDLFAQAEHDELAQSILLCTDAGFLDAVHAAIDRLLPTMPR
CCCEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCC
RETIARSLANRGALIHVGSLEQACAIANRIAPEHLELSMEDAERWIDAIRHAGAIFVGHW
HHHHHHHHHCCCCEEEECCHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHCCEEEEHHH
AVEALGDYCAGPNHVLPTMRSARFSSPLGVYDFQKRTSIVQISEAGAQHLGKIASVLAHG
HHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCHHHCCCEEEEHHHHHHHHHHHHHHHHCC
EGLQAHARSAEMRLKV
CCCHHHHCCCCCEECC
>Mature Secondary Structure 
SFATPIRRLDARQPDFLATLDALLAFESEADERIDSAVTEILRAVRSTGDAAVMEYTRR
CCCCHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FDHVEAKSMVELELPKAELQAALDSLTVEQREALRIAADRVRIYHERQRAESWDYVEADG
HCCHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCH
SRLGQKVTPLDRVGLYVPGGRASYPSSVLMNAIPAKVAGVEELIMVVPTPRGEKNPLVLA
HHCCCCCCCHHHCCEEECCCCCCCCHHHHHHHHHHHHCCHHHEEEEECCCCCCCCCEEEE
AAAITGVDRVFTIGGAQAVAALAYGTQTIPQVDKIVGPGNAFVAEAKRRVFGTVGIDMVA
EHHHHCCHHHEEECCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEC
GPSEVLIISDGSGHADWVAMDLFAQAEHDELAQSILLCTDAGFLDAVHAAIDRLLPTMPR
CCCEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCC
RETIARSLANRGALIHVGSLEQACAIANRIAPEHLELSMEDAERWIDAIRHAGAIFVGHW
HHHHHHHHHCCCCEEEECCHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHCCEEEEHHH
AVEALGDYCAGPNHVLPTMRSARFSSPLGVYDFQKRTSIVQISEAGAQHLGKIASVLAHG
HHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCHHHCCCEEEEHHHHHHHHHHHHHHHHCC
EGLQAHARSAEMRLKV
CCCHHHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA