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The map label for this gene is hisG [H]

Identifier: 119897108

GI number: 119897108

Start: 872316

End: 872990

Strand: Direct

Name: hisG [H]

Synonym: azo0817

Alternate gene names: 119897108

Gene position: 872316-872990 (Clockwise)

Preceding gene: 119897106

Following gene: 119897109

Centisome position: 19.93

GC content: 66.07

Gene sequence:

>675_bases
ATGACGGCCCGATCCATCAAGGTCCGCTCCGTGTCCAGCATCACCCTTGCCCTTTCCAAGGGCCGAATCTTCGAGGAAAC
CCTGCCGCTGCTGGCGGCGGCCGGCATCACGCCCACCGACAATCCGGAATCGTCGCGCAAGCTGATCATCGGCACGAACC
GCCCCGAGGTTCGGCTGGTCATCGTGCGCGCCACCGATACCCCCACCTACGTGCAGTACGGCGCCGCCGACCTCGGCATC
GCTGGCAAGGACGTGCTGATCGAGCATGGCGGCGCGGGGCTTTACCAGCCGCTCGATCTCAACATCGCGCGCTGCCGCCT
GTGCGTGGCGGTGCGCAAGGGGTTCGACTACGCCGCGGCCACGCGCCCGGGCGGCCGCATCCGCGTCGCCACCAAGTACA
TCAACAGCGCCAAGGCCCATTTCGCGGGCAAGGGCATGCATGTCGACCTGATCAAGCTCTACGGTTCGATGGAGCTTGCG
CCGCTCGTCGGGCTGGCGGACGCGATCGTCGACCTCGTGTCCACCGGCAGCACGCTGCGCGCCAACAACCTCGAAGAGGT
CGAGGACATTGCGCCGATCAGCTCGCGCCTGATCGTCAACCAGGCCTCGCTCAAGCTCAAGCGCGAACTGATCCAGCCGG
TGCTGGACGCTTTTGCAGGAGCGATCAAGCCATGA

Upstream 100 bases:

>100_bases
TCCTGTTCACGTTAAAGGGGCGCACCAAAAGAAAATGGCCGAGCCGCCGGGGCGGTTCAGCCAAGTCTCCGGAGGCTAAC
AGAAGGCGTCGCGGGTTACA

Downstream 100 bases:

>100_bases
GTTTCGCGACCCCGATCCGCCGTCTCGATGCCCGCCAGCCCGATTTCCTCGCGACGCTGGATGCGCTGCTGGCGTTCGAA
AGCGAGGCCGACGAGCGCAT

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MTARSIKVRSVSSITLALSKGRIFEETLPLLAAAGITPTDNPESSRKLIIGTNRPEVRLVIVRATDTPTYVQYGAADLGI
AGKDVLIEHGGAGLYQPLDLNIARCRLCVAVRKGFDYAAATRPGGRIRVATKYINSAKAHFAGKGMHVDLIKLYGSMELA
PLVGLADAIVDLVSTGSTLRANNLEEVEDIAPISSRLIVNQASLKLKRELIQPVLDAFAGAIKP

Sequences:

>Translated_224_residues
MTARSIKVRSVSSITLALSKGRIFEETLPLLAAAGITPTDNPESSRKLIIGTNRPEVRLVIVRATDTPTYVQYGAADLGI
AGKDVLIEHGGAGLYQPLDLNIARCRLCVAVRKGFDYAAATRPGGRIRVATKYINSAKAHFAGKGMHVDLIKLYGSMELA
PLVGLADAIVDLVSTGSTLRANNLEEVEDIAPISSRLIVNQASLKLKRELIQPVLDAFAGAIKP
>Mature_223_residues
TARSIKVRSVSSITLALSKGRIFEETLPLLAAAGITPTDNPESSRKLIIGTNRPEVRLVIVRATDTPTYVQYGAADLGIA
GKDVLIEHGGAGLYQPLDLNIARCRLCVAVRKGFDYAAATRPGGRIRVATKYINSAKAHFAGKGMHVDLIKLYGSMELAP
LVGLADAIVDLVSTGSTLRANNLEEVEDIAPISSRLIVNQASLKLKRELIQPVLDAFAGAIKP

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=222, Percent_Identity=35.1351351351351, Blast_Score=92, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320896, Length=187, Percent_Identity=31.5508021390374, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 23899; Mature: 23768

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARSIKVRSVSSITLALSKGRIFEETLPLLAAAGITPTDNPESSRKLIIGTNRPEVRLV
CCCCCEEEEEECEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCEEEE
IVRATDTPTYVQYGAADLGIAGKDVLIEHGGAGLYQPLDLNIARCRLCVAVRKGFDYAAA
EEEECCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEC
TRPGGRIRVATKYINSAKAHFAGKGMHVDLIKLYGSMELAPLVGLADAIVDLVSTGSTLR
CCCCCEEEEEEEHHHHHHHHHCCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHCCCCEE
ANNLEEVEDIAPISSRLIVNQASLKLKRELIQPVLDAFAGAIKP
CCCHHHHHHHCCCHHHEEEEHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TARSIKVRSVSSITLALSKGRIFEETLPLLAAAGITPTDNPESSRKLIIGTNRPEVRLV
CCCCEEEEEECEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCEEEE
IVRATDTPTYVQYGAADLGIAGKDVLIEHGGAGLYQPLDLNIARCRLCVAVRKGFDYAAA
EEEECCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEC
TRPGGRIRVATKYINSAKAHFAGKGMHVDLIKLYGSMELAPLVGLADAIVDLVSTGSTLR
CCCCCEEEEEEEHHHHHHHHHCCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHCCCCEE
ANNLEEVEDIAPISSRLIVNQASLKLKRELIQPVLDAFAGAIKP
CCCHHHHHHHCCCHHHEEEEHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA