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The map label for this gene is maeB1 [H]

Identifier: 119897112

GI number: 119897112

Start: 877831

End: 880107

Strand: Direct

Name: maeB1 [H]

Synonym: azo0821

Alternate gene names: 119897112

Gene position: 877831-880107 (Clockwise)

Preceding gene: 119897109

Following gene: 119897113

Centisome position: 20.06

GC content: 66.8

Gene sequence:

>2277_bases
ATGGACGAACTCATTCGCGCTGCGGCGCTCGACTACCACCGCTATCCGCGCCCGGGCAAGATCGCGGTGGCCCCGACCAA
GGTGCTCTCCAACCAGCGCGACCTGTCGCTGGCGTATTCGCCCGGCGTCGCCGCGGCCTGCGACGCCATCGTCGAGGACC
CGGCCGAAGCCGCCAACCTCACCTCGCGCAGCAACCTGATCGGCGTCATCACCAACGGCACCGCGGTGCTCGGCCTGGGC
AACATCGGCGCACTCGCCGCCAAGCCGGTGATGGAAGGCAAGGGCGTGCTGTTCAAGAAGTTCGCCGGCATCGACGTGTT
CGACCTCGAGATCGCCGAGCCCGACCCGGACAAGCTGATCGACATGATCGCCGCGCTCGAACCCACCTTTGGCGGCATCA
ACCTCGAAGACATCAAGGCGCCGGAGTGCTTCTACATCGAGAGCAAGCTGCGCGAGCGGATGAAGATCCCGGTCTTCCAC
GACGACCAGCACGGCACCGCCATCGTGGTCGGCGCGGCCATCCTCAACGGCCTGCAGATGCAGGGCAAGGACCTCAAGCA
GGTCAAGCTCGTCACCTCGGGCGCCGGTGCCGCCGCGCTTGCCTGCCTGGGCCTGCTGGTGAAGCTGGGCGTGCCGGTCG
AGAACATCTGGGTCACCGACCTCGAAGGCGTGGTCTATGAAGGCCGCACCGCGCTGATGGACCCGATCAAGGCGCGCTAT
GCCAAGAAGACCGAAGCGCGCAAGCTCGCCGAAGTCATCGAGGGCGCCGACGTCTTCCTCGGCCTTTCCGCGGGCGGCGT
GCTGAAAGGCGAGATGGTCGCCAAGATGGCCGCCAAGCCGCTGATCCTCGCCCTCGCCAACCCGACTCCGGAGATCCTGC
CGGAAGAGGTCAAGGCGGTGCGCGACGACGCCATCATCGCCACCGGCCGTTCGGACTACCCGAACCAGGTCAACAACGTG
CTGTGCTTCCCCTTCATCTTCCGCGGCGCGCTCGACGTCGGCGCCACCACCATCACCGACGAGATGCAGCTCGCCGCGGT
GCGGGCGATCGCCGAACTGGCGCGCGCCGAGCAGAGCGACATCGTCGCCGCCGCCTACGGCGAGAAGGTCTCCGGTTTCG
GCACCGAGTACATCATCCCGCGCCCGTTCGATCCGCGCCTCATCGTCAAGATCGCCCCGGCGGTGGCCGAGGCCGCGATG
AGTTCCGGCGTCGCCACCCGTCCGATCACCGACTGGGACGCCTACCGTGGTCATCTGAACAACTTCGTGTGGCACTCCGG
GCTGCTGATGAAGCCGGTGTTCGCCGCGGCCAAGAAGGCGCCCAAGCGCATCATCTTCTCCGAAGGCGAGTCCGAGAAAG
TGCTGCGCGCGGTGCAGACAGTGATCGACGAAGGGATGGCGCGGCCCATCCTGATCGGCCGCCCGGACGTCATCGCCAAC
AACATCACCCGCTTCGGCCTGCGCATGGAAGCCGAGCGCGACTTCGAGCTGGTCAATCCGGAATCCGACCCGCGCTTCAA
GGAGTTGTGGACGCACTACCACGCGCTGACCGAGCGCAAGGGCGTGTCGGTCGAATACGCCAAGAAGGAAGTGCGCCGCC
GCACCACGCTGATCGGCTCGCTGCTGCTCAAGTTCGGCTACGGCGATGGCCTCATCTGCGGCACCTACGGCATGCATCGC
CTGCACCTCGACTTCGTCGAGACCGTGCTCGGCCGCCGCGAAGGCGTCAATCACTGCTACACGCTCAACGTGCTGAGCCT
GCCCGAGCGCACGCTGTTCCTCGCCGACACCTACGTCAATTACGACCCCACGCCGGAGCAGGTGGTGGAAATGACGCGGC
TCGCCGCCGAGGAAATGCAGCGCTTCGGCGTCGAACCGCGGGTGGCGCTGCTGTCGCACTCGTCTTTCGGCTCGGCCGAT
TCGCCCACCGCCGAGAAGATGCGCACCGCGCTGCGCCTGCTGCACGAGCGCCATTCGGAACTGCAGGTCGAAGGCGAGAT
GCACGGCGATTCGGCGCTGGACGCAAAGCTGCGCACCCAGATCTTCCCGAATGCGCGCATGCGCGAAGACGCCAACCTGC
TGATCTTCCCGACGCTGGATGCGGCCAACATCGCCTTCAACCTGTTGAAGAGCGCGGCCGGGGAGGGCATGACGGTGGGG
CCGATCCTGCTCGGCGCGGCCAAGCCGGTGCACATCCTCACGCCGTCGGCCACCGTGCGCCGCATCATCAACATGACCGC
GCTGACGGTGGTGGAGGCGGGGCAGCAGGGCGCCTGA

Upstream 100 bases:

>100_bases
CAAGCGGAGTACACTCCCGCCTGCGGCGTTCTCCCCGCCGAGGGCTTTTGTTGCCACCAGCCATCAATAGAACAAGAACA
CACAGAGACGGAAGACAGAC

Downstream 100 bases:

>100_bases
GCCGGCTGCGAGCTTGCCGCGGCTGTGCCATGATCGCTACCCGGAGGGCATTTCATGGCAACGACGGGCGGGTTGGCGGG
GCTGGTGTTGACCGGAGGCG

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 758; Mature: 758

Protein sequence:

>758_residues
MDELIRAAALDYHRYPRPGKIAVAPTKVLSNQRDLSLAYSPGVAAACDAIVEDPAEAANLTSRSNLIGVITNGTAVLGLG
NIGALAAKPVMEGKGVLFKKFAGIDVFDLEIAEPDPDKLIDMIAALEPTFGGINLEDIKAPECFYIESKLRERMKIPVFH
DDQHGTAIVVGAAILNGLQMQGKDLKQVKLVTSGAGAAALACLGLLVKLGVPVENIWVTDLEGVVYEGRTALMDPIKARY
AKKTEARKLAEVIEGADVFLGLSAGGVLKGEMVAKMAAKPLILALANPTPEILPEEVKAVRDDAIIATGRSDYPNQVNNV
LCFPFIFRGALDVGATTITDEMQLAAVRAIAELARAEQSDIVAAAYGEKVSGFGTEYIIPRPFDPRLIVKIAPAVAEAAM
SSGVATRPITDWDAYRGHLNNFVWHSGLLMKPVFAAAKKAPKRIIFSEGESEKVLRAVQTVIDEGMARPILIGRPDVIAN
NITRFGLRMEAERDFELVNPESDPRFKELWTHYHALTERKGVSVEYAKKEVRRRTTLIGSLLLKFGYGDGLICGTYGMHR
LHLDFVETVLGRREGVNHCYTLNVLSLPERTLFLADTYVNYDPTPEQVVEMTRLAAEEMQRFGVEPRVALLSHSSFGSAD
SPTAEKMRTALRLLHERHSELQVEGEMHGDSALDAKLRTQIFPNARMREDANLLIFPTLDAANIAFNLLKSAAGEGMTVG
PILLGAAKPVHILTPSATVRRIINMTALTVVEAGQQGA

Sequences:

>Translated_758_residues
MDELIRAAALDYHRYPRPGKIAVAPTKVLSNQRDLSLAYSPGVAAACDAIVEDPAEAANLTSRSNLIGVITNGTAVLGLG
NIGALAAKPVMEGKGVLFKKFAGIDVFDLEIAEPDPDKLIDMIAALEPTFGGINLEDIKAPECFYIESKLRERMKIPVFH
DDQHGTAIVVGAAILNGLQMQGKDLKQVKLVTSGAGAAALACLGLLVKLGVPVENIWVTDLEGVVYEGRTALMDPIKARY
AKKTEARKLAEVIEGADVFLGLSAGGVLKGEMVAKMAAKPLILALANPTPEILPEEVKAVRDDAIIATGRSDYPNQVNNV
LCFPFIFRGALDVGATTITDEMQLAAVRAIAELARAEQSDIVAAAYGEKVSGFGTEYIIPRPFDPRLIVKIAPAVAEAAM
SSGVATRPITDWDAYRGHLNNFVWHSGLLMKPVFAAAKKAPKRIIFSEGESEKVLRAVQTVIDEGMARPILIGRPDVIAN
NITRFGLRMEAERDFELVNPESDPRFKELWTHYHALTERKGVSVEYAKKEVRRRTTLIGSLLLKFGYGDGLICGTYGMHR
LHLDFVETVLGRREGVNHCYTLNVLSLPERTLFLADTYVNYDPTPEQVVEMTRLAAEEMQRFGVEPRVALLSHSSFGSAD
SPTAEKMRTALRLLHERHSELQVEGEMHGDSALDAKLRTQIFPNARMREDANLLIFPTLDAANIAFNLLKSAAGEGMTVG
PILLGAAKPVHILTPSATVRRIINMTALTVVEAGQQGA
>Mature_758_residues
MDELIRAAALDYHRYPRPGKIAVAPTKVLSNQRDLSLAYSPGVAAACDAIVEDPAEAANLTSRSNLIGVITNGTAVLGLG
NIGALAAKPVMEGKGVLFKKFAGIDVFDLEIAEPDPDKLIDMIAALEPTFGGINLEDIKAPECFYIESKLRERMKIPVFH
DDQHGTAIVVGAAILNGLQMQGKDLKQVKLVTSGAGAAALACLGLLVKLGVPVENIWVTDLEGVVYEGRTALMDPIKARY
AKKTEARKLAEVIEGADVFLGLSAGGVLKGEMVAKMAAKPLILALANPTPEILPEEVKAVRDDAIIATGRSDYPNQVNNV
LCFPFIFRGALDVGATTITDEMQLAAVRAIAELARAEQSDIVAAAYGEKVSGFGTEYIIPRPFDPRLIVKIAPAVAEAAM
SSGVATRPITDWDAYRGHLNNFVWHSGLLMKPVFAAAKKAPKRIIFSEGESEKVLRAVQTVIDEGMARPILIGRPDVIAN
NITRFGLRMEAERDFELVNPESDPRFKELWTHYHALTERKGVSVEYAKKEVRRRTTLIGSLLLKFGYGDGLICGTYGMHR
LHLDFVETVLGRREGVNHCYTLNVLSLPERTLFLADTYVNYDPTPEQVVEMTRLAAEEMQRFGVEPRVALLSHSSFGSAD
SPTAEKMRTALRLLHERHSELQVEGEMHGDSALDAKLRTQIFPNARMREDANLLIFPTLDAANIAFNLLKSAAGEGMTVG
PILLGAAKPVHILTPSATVRRIINMTALTVVEAGQQGA

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=344, Percent_Identity=28.7790697674419, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI62420882, Length=343, Percent_Identity=27.9883381924198, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI62420880, Length=343, Percent_Identity=27.9883381924198, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI239049447, Length=343, Percent_Identity=27.9883381924198, Blast_Score=83, Evalue=9e-16,
Organism=Escherichia coli, GI1788806, Length=757, Percent_Identity=61.0303830911493, Blast_Score=952, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=325, Percent_Identity=30.4615384615385, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1788800, Length=321, Percent_Identity=28.3489096573209, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI87081919, Length=314, Percent_Identity=25.1592356687898, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17537199, Length=456, Percent_Identity=25.6578947368421, Blast_Score=76, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322823, Length=240, Percent_Identity=31.6666666666667, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI281362672, Length=354, Percent_Identity=29.0960451977401, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21356279, Length=354, Percent_Identity=29.0960451977401, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281362674, Length=354, Percent_Identity=29.0960451977401, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24646386, Length=345, Percent_Identity=31.0144927536232, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24646388, Length=345, Percent_Identity=31.0144927536232, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI78707242, Length=349, Percent_Identity=26.647564469914, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI78707238, Length=349, Percent_Identity=26.647564469914, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI78707240, Length=349, Percent_Identity=26.647564469914, Blast_Score=79, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 82220; Mature: 82220

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00976 NMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDELIRAAALDYHRYPRPGKIAVAPTKVLSNQRDLSLAYSPGVAAACDAIVEDPAEAANL
CCHHHHHHHHHHHCCCCCCEEEECHHHHHCCCCCCEEEECCCHHHHHHHHHCCCHHHHCC
TSRSNLIGVITNGTAVLGLGNIGALAAKPVMEGKGVLFKKFAGIDVFDLEIAEPDPDKLI
CCCCCEEEEEECCEEEEEECCCCHHHCCCHHCCCCCEEEHHCCCEEEEEEECCCCHHHHH
DMIAALEPTFGGINLEDIKAPECFYIESKLRERMKIPVFHDDQHGTAIVVGAAILNGLQM
HHHHHHCCCCCCCCHHHCCCCCEEEEHHHHHHHCCCCEEECCCCCCEEEEHHHHHCCHHC
QGKDLKQVKLVTSGAGAAALACLGLLVKLGVPVENIWVTDLEGVVYEGRTALMDPIKARY
CCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCHHHEEEECCCCEEECCCHHHHHHHHHHH
AKKTEARKLAEVIEGADVFLGLSAGGVLKGEMVAKMAAKPLILALANPTPEILPEEVKAV
HHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCHHCCHHHHHHH
RDDAIIATGRSDYPNQVNNVLCFPFIFRGALDVGATTITDEMQLAAVRAIAELARAEQSD
CCCCEEEECCCCCCHHHCCEEEHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCC
IVAAAYGEKVSGFGTEYIIPRPFDPRLIVKIAPAVAEAAMSSGVATRPITDWDAYRGHLN
EEEEECCCCCCCCCCCEECCCCCCCEEEEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHH
NFVWHSGLLMKPVFAAAKKAPKRIIFSEGESEKVLRAVQTVIDEGMARPILIGRPDVIAN
HHHHCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCCEEECCCCHHHH
NITRFGLRMEAERDFELVNPESDPRFKELWTHYHALTERKGVSVEYAKKEVRRRTTLIGS
HHHHHCEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LLLKFGYGDGLICGTYGMHRLHLDFVETVLGRREGVNHCYTLNVLSLPERTLFLADTYVN
HHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEEECC
YDPTPEQVVEMTRLAAEEMQRFGVEPRVALLSHSSFGSADSPTAEKMRTALRLLHERHSE
CCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
LQVEGEMHGDSALDAKLRTQIFPNARMREDANLLIFPTLDAANIAFNLLKSAAGEGMTVG
EEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEC
PILLGAAKPVHILTPSATVRRIINMTALTVVEAGQQGA
HHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDELIRAAALDYHRYPRPGKIAVAPTKVLSNQRDLSLAYSPGVAAACDAIVEDPAEAANL
CCHHHHHHHHHHHCCCCCCEEEECHHHHHCCCCCCEEEECCCHHHHHHHHHCCCHHHHCC
TSRSNLIGVITNGTAVLGLGNIGALAAKPVMEGKGVLFKKFAGIDVFDLEIAEPDPDKLI
CCCCCEEEEEECCEEEEEECCCCHHHCCCHHCCCCCEEEHHCCCEEEEEEECCCCHHHHH
DMIAALEPTFGGINLEDIKAPECFYIESKLRERMKIPVFHDDQHGTAIVVGAAILNGLQM
HHHHHHCCCCCCCCHHHCCCCCEEEEHHHHHHHCCCCEEECCCCCCEEEEHHHHHCCHHC
QGKDLKQVKLVTSGAGAAALACLGLLVKLGVPVENIWVTDLEGVVYEGRTALMDPIKARY
CCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCHHHEEEECCCCEEECCCHHHHHHHHHHH
AKKTEARKLAEVIEGADVFLGLSAGGVLKGEMVAKMAAKPLILALANPTPEILPEEVKAV
HHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCHHCCHHHHHHH
RDDAIIATGRSDYPNQVNNVLCFPFIFRGALDVGATTITDEMQLAAVRAIAELARAEQSD
CCCCEEEECCCCCCHHHCCEEEHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCC
IVAAAYGEKVSGFGTEYIIPRPFDPRLIVKIAPAVAEAAMSSGVATRPITDWDAYRGHLN
EEEEECCCCCCCCCCCEECCCCCCCEEEEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHH
NFVWHSGLLMKPVFAAAKKAPKRIIFSEGESEKVLRAVQTVIDEGMARPILIGRPDVIAN
HHHHCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCCEEECCCCHHHH
NITRFGLRMEAERDFELVNPESDPRFKELWTHYHALTERKGVSVEYAKKEVRRRTTLIGS
HHHHHCEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LLLKFGYGDGLICGTYGMHRLHLDFVETVLGRREGVNHCYTLNVLSLPERTLFLADTYVN
HHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEEECC
YDPTPEQVVEMTRLAAEEMQRFGVEPRVALLSHSSFGSADSPTAEKMRTALRLLHERHSE
CCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
LQVEGEMHGDSALDAKLRTQIFPNARMREDANLLIFPTLDAANIAFNLLKSAAGEGMTVG
EEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEC
PILLGAAKPVHILTPSATVRRIINMTALTVVEAGQQGA
HHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]