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The map label for this gene is ethR [H]

Identifier: 119871173

GI number: 119871173

Start: 5391928

End: 5392557

Strand: Direct

Name: ethR [H]

Synonym: Mkms_5146

Alternate gene names: 119871173

Gene position: 5391928-5392557 (Clockwise)

Preceding gene: 119871171

Following gene: 119871174

Centisome position: 93.98

GC content: 70.95

Gene sequence:

>630_bases
GTGACCACCGCCAGCCAGGCCCGCGCCCCCCGTGGCCGCCGGTCGGCCCGCCCGTCGGGCGACGACCGCGAACAGGCCAT
CCTGGCGACCGCCGAACAACTCCTCGAGGCCCGCCCGTTCGCCGAGATCTCCGTCGACGACCTGGCCAAGGGCGCGGGCA
TCTCCCGCCCCACCTTCTACTTCTACTTCGGCTCCAAGGAAGCGGTGCTGCTGACGCTGTGGGAGCGGGTCATCCGGGAG
GCCGATGCGGCACTCGAGAACGCCGCCTCCAACGCGACGTCGGAGGACGTGTGGCGGCCGGGCATCAAGGTGTTCTTCGA
TACGTTCGGCGCCCACCGGGGCGTCACCGTCGCGGCATCCGGATCCGACAACGCCGAGGTCCGCGACGTCTTCGCGAGGT
TCATGCAGAAGTGGATCGATTTCACCGCAGCGACCATCGAGGCCGAACGCCGGCGCGGCGCGGCCCCGCAGACGCTGCCC
GCCCGCGACATCGCCACCGCGCTCAACCTGATGAACGAGCGCACCCTGCTCGCGGCGTTCGCCGCCGAGACACCCGGCAT
CCCGCCCGACCGGGTCCTCGACTCGCTCGTGCACGTGTGGACGTGTGCGGTGTACGGGGAATGCCGCTGA

Upstream 100 bases:

>100_bases
CACTACGTCGACAAATTCGGTCATGGTGTCAAGCTATCAACACCTCGTCGACATCGTCAACAGTGTGTTGAGAATTTCGA
CGGCGTGTAAAGTATCCGGC

Downstream 100 bases:

>100_bases
CACGTCGGACCCTCATGCGAACATATGTTCGTGTCGGCTCCGGCTCGTGGTCACGCGCAGGCCAGCATCCTGCACGCTGA
CCTCGACTCCTTCTACGCCT

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MTTASQARAPRGRRSARPSGDDREQAILATAEQLLEARPFAEISVDDLAKGAGISRPTFYFYFGSKEAVLLTLWERVIRE
ADAALENAASNATSEDVWRPGIKVFFDTFGAHRGVTVAASGSDNAEVRDVFARFMQKWIDFTAATIEAERRRGAAPQTLP
ARDIATALNLMNERTLLAAFAAETPGIPPDRVLDSLVHVWTCAVYGECR

Sequences:

>Translated_209_residues
MTTASQARAPRGRRSARPSGDDREQAILATAEQLLEARPFAEISVDDLAKGAGISRPTFYFYFGSKEAVLLTLWERVIRE
ADAALENAASNATSEDVWRPGIKVFFDTFGAHRGVTVAASGSDNAEVRDVFARFMQKWIDFTAATIEAERRRGAAPQTLP
ARDIATALNLMNERTLLAAFAAETPGIPPDRVLDSLVHVWTCAVYGECR
>Mature_208_residues
TTASQARAPRGRRSARPSGDDREQAILATAEQLLEARPFAEISVDDLAKGAGISRPTFYFYFGSKEAVLLTLWERVIREA
DAALENAASNATSEDVWRPGIKVFFDTFGAHRGVTVAASGSDNAEVRDVFARFMQKWIDFTAATIEAERRRGAAPQTLPA
RDIATALNLMNERTLLAAFAAETPGIPPDRVLDSLVHVWTCAVYGECR

Specific function: Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 22876; Mature: 22745

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTASQARAPRGRRSARPSGDDREQAILATAEQLLEARPFAEISVDDLAKGAGISRPTFY
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCEEE
FYFGSKEAVLLTLWERVIREADAALENAASNATSEDVWRPGIKVFFDTFGAHRGVTVAAS
EEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHCCCCCEEEEEC
GSDNAEVRDVFARFMQKWIDFTAATIEAERRRGAAPQTLPARDIATALNLMNERTLLAAF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
AAETPGIPPDRVLDSLVHVWTCAVYGECR
HHCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTASQARAPRGRRSARPSGDDREQAILATAEQLLEARPFAEISVDDLAKGAGISRPTFY
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCEEE
FYFGSKEAVLLTLWERVIREADAALENAASNATSEDVWRPGIKVFFDTFGAHRGVTVAAS
EEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHCCCCCEEEEEC
GSDNAEVRDVFARFMQKWIDFTAATIEAERRRGAAPQTLPARDIATALNLMNERTLLAAF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
AAETPGIPPDRVLDSLVHVWTCAVYGECR
HHCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]