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The map label for this gene is yfhQ [H]

Identifier: 119870860

GI number: 119870860

Start: 5061044

End: 5061910

Strand: Direct

Name: yfhQ [H]

Synonym: Mkms_4832

Alternate gene names: 119870860

Gene position: 5061044-5061910 (Clockwise)

Preceding gene: 119870857

Following gene: 119870861

Centisome position: 88.21

GC content: 71.51

Gene sequence:

>867_bases
ATGATCGATCCGGCCGACGTTCTGGCGTGGTACGACCGCGAGCAGCGGGATCTGCCATGGCGCAGACCCGGTGTGACGCC
GTGGCAGATCCTGGTCAGCGAGTTCATGTTGCAGCAGACTCCGGTGGCCCGCGTCGAACCGATCTGGCTGAGCTGGATCG
AGCGCTGGCCGACTCCGTCGGCGACCGCGGCGGCCGGCGTCGCCGACGTGTTGCGGGCGTGGGGCAAGCTCGGATACCCG
CGCCGCGCGAAGCGTCTACATGAGTGCGCGACGGTGATCGCGATCGAACACGGCGACGAGGTGCCCTCGGACGTCGAGGT
GTTGCTGACGCTCCCGGGTATCGGCGCATACACCGCCAGAGCCGTGGCCTGCTTCGCCTACGGGCAGCGGGTCCCGGTGG
TCGACACCAACGTGCGCCGGGTCATCGCCCGGGCGGTGCACGGCCGCGCCGACAGCCCGCCGAGCAGCCGCGACCTCGAC
GATGTCGCCACCCTGCTCCCGGAAGGCCCTGAGGCGCCGCGGTTCTCGGTCGCGGTGATGGAACTGGGCGCGACGGTGTG
CACCGCGCGCACTCCGCGCTGCGGCCTGTGTCCGCTGGGCACCTGCACCTGGCGTTCGCTCGGATATCCGGCCGCGTCCG
CACCCGCACGCAAGGTGCAGCGCTACGCGGGCACCGACCGCCAGGTGAGGGGCCGGCTGCTCGATGTGCTGCGCGGCAGC
AGCTCGCCGGTGTCGCGCGACCAACTCGACGTCGTGTGGCTGACCGACCCGGCACAGCGCGACCGTGCGCTGGATTCGCT
GCTGATCGACGGGCTGGTCGAGCAGACCGCCGACGGCCGCTTCGCGCTCGCGGGAGAGGGTTCGTGA

Upstream 100 bases:

>100_bases
CGACCAGCGACGAAGCGCTCGTTACCCTCTTTGAGTGCCTTCCACGCGGTCACCGGGCTGGAGTTCGGCATGCCGCATAT
TGTGCCTGAGTGGTTGAGAG

Downstream 100 bases:

>100_bases
ACGCAGCCGTACCAGCGTGGTCGCCCACTTGGGCACACCTCTGCGGGATACCGTGATCAGATGACCCGGACCCTCGATCA
GGTCGTCACCGCGGCGGCCG

Product: HhH-GPD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MIDPADVLAWYDREQRDLPWRRPGVTPWQILVSEFMLQQTPVARVEPIWLSWIERWPTPSATAAAGVADVLRAWGKLGYP
RRAKRLHECATVIAIEHGDEVPSDVEVLLTLPGIGAYTARAVACFAYGQRVPVVDTNVRRVIARAVHGRADSPPSSRDLD
DVATLLPEGPEAPRFSVAVMELGATVCTARTPRCGLCPLGTCTWRSLGYPAASAPARKVQRYAGTDRQVRGRLLDVLRGS
SSPVSRDQLDVVWLTDPAQRDRALDSLLIDGLVEQTADGRFALAGEGS

Sequences:

>Translated_288_residues
MIDPADVLAWYDREQRDLPWRRPGVTPWQILVSEFMLQQTPVARVEPIWLSWIERWPTPSATAAAGVADVLRAWGKLGYP
RRAKRLHECATVIAIEHGDEVPSDVEVLLTLPGIGAYTARAVACFAYGQRVPVVDTNVRRVIARAVHGRADSPPSSRDLD
DVATLLPEGPEAPRFSVAVMELGATVCTARTPRCGLCPLGTCTWRSLGYPAASAPARKVQRYAGTDRQVRGRLLDVLRGS
SSPVSRDQLDVVWLTDPAQRDRALDSLLIDGLVEQTADGRFALAGEGS
>Mature_288_residues
MIDPADVLAWYDREQRDLPWRRPGVTPWQILVSEFMLQQTPVARVEPIWLSWIERWPTPSATAAAGVADVLRAWGKLGYP
RRAKRLHECATVIAIEHGDEVPSDVEVLLTLPGIGAYTARAVACFAYGQRVPVVDTNVRRVIARAVHGRADSPPSSRDLD
DVATLLPEGPEAPRFSVAVMELGATVCTARTPRCGLCPLGTCTWRSLGYPAASAPARKVQRYAGTDRQVRGRLLDVLRGS
SSPVSRDQLDVVWLTDPAQRDRALDSLLIDGLVEQTADGRFALAGEGS

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298654, Length=205, Percent_Identity=41.4634146341463, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI115298652, Length=205, Percent_Identity=41.4634146341463, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI115298650, Length=205, Percent_Identity=41.4634146341463, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI115298648, Length=205, Percent_Identity=41.4634146341463, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI6912520, Length=205, Percent_Identity=41.4634146341463, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI190358497, Length=205, Percent_Identity=41.4634146341463, Blast_Score=140, Evalue=9e-34,
Organism=Escherichia coli, GI1789331, Length=198, Percent_Identity=39.8989898989899, Blast_Score=138, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 31496; Mature: 31496

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPADVLAWYDREQRDLPWRRPGVTPWQILVSEFMLQQTPVARVEPIWLSWIERWPTPS
CCCHHHHHHHCCCHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCC
ATAAAGVADVLRAWGKLGYPRRAKRLHECATVIAIEHGDEVPSDVEVLLTLPGIGAYTAR
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEECCCCCCCCEEEEEECCCCCHHHHH
AVACFAYGQRVPVVDTNVRRVIARAVHGRADSPPSSRDLDDVATLLPEGPEAPRFSVAVM
HHHHHHHCCCCCEECHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHH
ELGATVCTARTPRCGLCPLGTCTWRSLGYPAASAPARKVQRYAGTDRQVRGRLLDVLRGS
HHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCC
SSPVSRDQLDVVWLTDPAQRDRALDSLLIDGLVEQTADGRFALAGEGS
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCC
>Mature Secondary Structure
MIDPADVLAWYDREQRDLPWRRPGVTPWQILVSEFMLQQTPVARVEPIWLSWIERWPTPS
CCCHHHHHHHCCCHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCC
ATAAAGVADVLRAWGKLGYPRRAKRLHECATVIAIEHGDEVPSDVEVLLTLPGIGAYTAR
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEECCCCCCCCEEEEEECCCCCHHHHH
AVACFAYGQRVPVVDTNVRRVIARAVHGRADSPPSSRDLDDVATLLPEGPEAPRFSVAVM
HHHHHHHCCCCCEECHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHH
ELGATVCTARTPRCGLCPLGTCTWRSLGYPAASAPARKVQRYAGTDRQVRGRLLDVLRGS
HHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCC
SSPVSRDQLDVVWLTDPAQRDRALDSLLIDGLVEQTADGRFALAGEGS
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]