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The map label for this gene is disA [H]

Identifier: 119870857

GI number: 119870857

Start: 5058444

End: 5059559

Strand: Direct

Name: disA [H]

Synonym: Mkms_4829

Alternate gene names: 119870857

Gene position: 5058444-5059559 (Clockwise)

Preceding gene: 119870856

Following gene: 119870860

Centisome position: 88.17

GC content: 67.47

Gene sequence:

>1116_bases
ATGGCCGTGAAGAACGCCAGGACGAGCAGTAACGTCGTCCAGCTGGCCCGTCCGACGCTGCGGGAGACGCTGGGCCGGCT
GGCACCCGGGACACCCTTGCGCGACGGTCTGGAGCGCATCCTGCGTGGCCGCACCGGCGCTCTGATCGTGCTGGGTTACG
ACGACAGCGTCGAGACGATCTGCGACGGTGGTTTCGAACTCGACGTGCGCTACGCCCCGACCCGGTTACGCGAGCTGTCG
AAGATGGATGGCGCCGTCGTGCTCTCCAGCGACGGCACGCGGATCCTGCGGGCCAACGTCCAGCTCGTGCCCGATCCCTC
GATCCCGACCGACGAATCCGGGACGCGTCACCGCTCCGCCGAACGCACCGCGATCCAGACCGGGTATCCGGTGATCTCCG
TCAGCCACTCGATGAGCATCGTGACGGTGTACGTGGCCGGCGAGCGGCACGTGGTTCCCGACACCCCGACGATCCTGTCG
CGCGCCAACCAGACCATCGCGACGCTCGAGCGCTACAAATCCCGCCTCGACGAGGTGAGCCGCCAGCTGTCGACCGCGGA
GATCGAGGACTTCGTGACCCTGCGCGACGTGATGACCGTCGTGCAGCGGTTGGAGATGGTGCGGCGGATCAGCCTGGAGA
TCGACGCCGACGTGGTCGAACTCGGCACCGACGGCCGTCAGCTCAAACTGCAGCTCGAGGAGCTCGTGGGGGACAACGAC
ACCGCCCGCGAGCTGATCGTGCGCGACTACCACGCCAACCCCGACCCGCCCACTCCCGCCCAGGTCAGCGCGACACTCGA
GGAACTGGACTCGCTGTCGGACAACGAGCTGCTCGACTTCACCACGCTGGCAAGGGTTTTCGGTTATCCGTCCACCCTCG
AGGCGCAGGATTCGGCGATGAGCTCCCGCGGTTACCGCGCGATGGCCGGCATCCCCCGCCTGCAGTTCGCCCACGTGGAT
CTGTTGGTGCGTTCGTTCGGCTCACTGCAGGGCCTACTGGCCGCCAGCGCCGACGATCTGCAGTCGGTGGAGGGCATCGG
TTCGATGTGGGCGCGCCACATCAGGGAAGGTCTGTCGCTGCTGGCCGAGTCGACGATCGCCGACCGGCTGGCCTGA

Upstream 100 bases:

>100_bases
CGCGAAGAGCAGACAGCAGCGATGAGCGCTTGCGCGAAGAGCAGACAGCAGCGATGAGCGCTTGCGCGAAGAGCAGACAG
CAGCGCGCCCGGGAGGAATG

Downstream 100 bases:

>100_bases
TCGACCTCAGCCCGCGCCTGCGGCGGGCGGCTGCGCACCCGGGGCGCCGGGCGCCGGCGCCTGACCCGGCGGCGTGGCCG
GGGCCAAGATGAACGGCACC

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MAVKNARTSSNVVQLARPTLRETLGRLAPGTPLRDGLERILRGRTGALIVLGYDDSVETICDGGFELDVRYAPTRLRELS
KMDGAVVLSSDGTRILRANVQLVPDPSIPTDESGTRHRSAERTAIQTGYPVISVSHSMSIVTVYVAGERHVVPDTPTILS
RANQTIATLERYKSRLDEVSRQLSTAEIEDFVTLRDVMTVVQRLEMVRRISLEIDADVVELGTDGRQLKLQLEELVGDND
TARELIVRDYHANPDPPTPAQVSATLEELDSLSDNELLDFTTLARVFGYPSTLEAQDSAMSSRGYRAMAGIPRLQFAHVD
LLVRSFGSLQGLLAASADDLQSVEGIGSMWARHIREGLSLLAESTIADRLA

Sequences:

>Translated_371_residues
MAVKNARTSSNVVQLARPTLRETLGRLAPGTPLRDGLERILRGRTGALIVLGYDDSVETICDGGFELDVRYAPTRLRELS
KMDGAVVLSSDGTRILRANVQLVPDPSIPTDESGTRHRSAERTAIQTGYPVISVSHSMSIVTVYVAGERHVVPDTPTILS
RANQTIATLERYKSRLDEVSRQLSTAEIEDFVTLRDVMTVVQRLEMVRRISLEIDADVVELGTDGRQLKLQLEELVGDND
TARELIVRDYHANPDPPTPAQVSATLEELDSLSDNELLDFTTLARVFGYPSTLEAQDSAMSSRGYRAMAGIPRLQFAHVD
LLVRSFGSLQGLLAASADDLQSVEGIGSMWARHIREGLSLLAESTIADRLA
>Mature_370_residues
AVKNARTSSNVVQLARPTLRETLGRLAPGTPLRDGLERILRGRTGALIVLGYDDSVETICDGGFELDVRYAPTRLRELSK
MDGAVVLSSDGTRILRANVQLVPDPSIPTDESGTRHRSAERTAIQTGYPVISVSHSMSIVTVYVAGERHVVPDTPTILSR
ANQTIATLERYKSRLDEVSRQLSTAEIEDFVTLRDVMTVVQRLEMVRRISLEIDADVVELGTDGRQLKLQLEELVGDNDT
ARELIVRDYHANPDPPTPAQVSATLEELDSLSDNELLDFTTLARVFGYPSTLEAQDSAMSSRGYRAMAGIPRLQFAHVDL
LVRSFGSLQGLLAASADDLQSVEGIGSMWARHIREGLSLLAESTIADRLA

Specific function: Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions [H]

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR010994 [H]

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N [H]

EC number: NA

Molecular weight: Translated: 40649; Mature: 40517

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVKNARTSSNVVQLARPTLRETLGRLAPGTPLRDGLERILRGRTGALIVLGYDDSVETI
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHH
CDGGFELDVRYAPTRLRELSKMDGAVVLSSDGTRILRANVQLVPDPSIPTDESGTRHRSA
HCCCCEEEEEECCHHHHHHHHCCCEEEEECCCCEEEEECEEEECCCCCCCCCCCCCCCHH
ERTAIQTGYPVISVSHSMSIVTVYVAGERHVVPDTPTILSRANQTIATLERYKSRLDEVS
HHHHHHCCCCEEEECCCCEEEEEEEECCCEECCCCHHHHHHCCHHHHHHHHHHHHHHHHH
RQLSTAEIEDFVTLRDVMTVVQRLEMVRRISLEIDADVVELGTDGRQLKLQLEELVGDND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEECCCCCHHHHEEHHHHCCCCH
TARELIVRDYHANPDPPTPAQVSATLEELDSLSDNELLDFTTLARVFGYPSTLEAQDSAM
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHH
SSRGYRAMAGIPRLQFAHVDLLVRSFGSLQGLLAASADDLQSVEGIGSMWARHIREGLSL
HHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LAESTIADRLA
HHHHHHHHHCC
>Mature Secondary Structure 
AVKNARTSSNVVQLARPTLRETLGRLAPGTPLRDGLERILRGRTGALIVLGYDDSVETI
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHH
CDGGFELDVRYAPTRLRELSKMDGAVVLSSDGTRILRANVQLVPDPSIPTDESGTRHRSA
HCCCCEEEEEECCHHHHHHHHCCCEEEEECCCCEEEEECEEEECCCCCCCCCCCCCCCHH
ERTAIQTGYPVISVSHSMSIVTVYVAGERHVVPDTPTILSRANQTIATLERYKSRLDEVS
HHHHHHCCCCEEEECCCCEEEEEEEECCCEECCCCHHHHHHCCHHHHHHHHHHHHHHHHH
RQLSTAEIEDFVTLRDVMTVVQRLEMVRRISLEIDADVVELGTDGRQLKLQLEELVGDND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEECCCCCHHHHEEHHHHCCCCH
TARELIVRDYHANPDPPTPAQVSATLEELDSLSDNELLDFTTLARVFGYPSTLEAQDSAM
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHH
SSRGYRAMAGIPRLQFAHVDLLVRSFGSLQGLLAASADDLQSVEGIGSMWARHIREGLSL
HHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LAESTIADRLA
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]