BacMap

Definition	Mycobacterium sp. KMS chromosome, complete genome.
Accession	NC_008705
Length	5,737,227

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The map label for this gene is xecD [H]

Identifier: 119870527

GI number: 119870527

Start: 4731274

End: 4732044

Strand: Direct

Name: xecD [H]

Synonym: Mkms_4498

Alternate gene names: 119870527

Gene position: 4731274-4732044 (Clockwise)

Preceding gene: 119870526

Following gene: 119870528

Centisome position: 82.47

GC content: 68.22

Gene sequence:

>771_bases
GTGCAGGTAGCGATCGTCACGGGTGCCAGCAGCGGCATCGGGTTCGGTTGTGCCACAACGCTGGCCGAGCAGGGTATGGC
GGTGCTGGGCACCGGACGAGACGAGGAACGGCTCGCCGAACTGGAGAAGGCCGTCGGCTCCGACCGGATCGCCACGGTCG
CGGTGGATCTGACCGACGACGACGGTCCCGCCCGGGTCGTCGCGGCCGCACTGGAGCGGTGGGGGCGGATCGACTTCCTG
GTCAACAACGCCGGGGTGGGCAGTCCCAAACCCCTGCACGAGACCGACGACGAATCGCTGGACTATTTCCTGAACCTGAT
GCTGCGGGCGCCGTTCCGGTTGTCGCGCGACGTGATCCCGCACATGCAGCCGGGCTCGGCGATCATCAACGTGACGTCCA
CGTTCGCGGTCGTCGGTGGGCTGCGCGGCGGCGCGTACTCGGCGGCCAAGGGCGGGCTGACCGCACTGACCGCCCACATC
GCGTGCCAATACGGTGCGCAGGGCATCCGGTGCAACGCGGTGGCGCCCGGCGTCACGCTCACCCCCATGGTGGCGACGCG
GCTCGAGGACGAGCGGTTCCGCAAGATCAACACCGAGATGACACCGCACCAGCGGTTGGGCCGGGTCGAGGACATCGCCG
CCACCGTGGCGTTCCTCTGCTCCGAGGGCGGCAGTTTCATCAACGGCCAGACCATCGTCGTCGACGGTGGCTGGAGTTCG
ACGAAGTACCTGTCCGATTTCGCGCTGAACTCCGACTGGGTGCCCAGGTGA

Upstream 100 bases:

>100_bases
GTGCCCGAACAGGTGGTGCTGGTGGAGGCGTTGCCGAAGAACGATGCGGGCAAGGTGCTCAAGCACAAGATCAGGGCATC
GCTGACGGAAGGTGGATGAC

Downstream 100 bases:

>100_bases
ACCTGTTCGCACTGCTCGACCAGACCGCGGCGCGCCACGCCGACCGCGGCGCGGTGTATCACGGTGAGCGCCAGGTGCAC
ACGTGGTCGTCGCTGCGGGA

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: R-HPCDH; Aliphatic epoxide carboxylation component III [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MQVAIVTGASSGIGFGCATTLAEQGMAVLGTGRDEERLAELEKAVGSDRIATVAVDLTDDDGPARVVAAALERWGRIDFL
VNNAGVGSPKPLHETDDESLDYFLNLMLRAPFRLSRDVIPHMQPGSAIINVTSTFAVVGGLRGGAYSAAKGGLTALTAHI
ACQYGAQGIRCNAVAPGVTLTPMVATRLEDERFRKINTEMTPHQRLGRVEDIAATVAFLCSEGGSFINGQTIVVDGGWSS
TKYLSDFALNSDWVPR

Sequences:

>Translated_256_residues
MQVAIVTGASSGIGFGCATTLAEQGMAVLGTGRDEERLAELEKAVGSDRIATVAVDLTDDDGPARVVAAALERWGRIDFL
VNNAGVGSPKPLHETDDESLDYFLNLMLRAPFRLSRDVIPHMQPGSAIINVTSTFAVVGGLRGGAYSAAKGGLTALTAHI
ACQYGAQGIRCNAVAPGVTLTPMVATRLEDERFRKINTEMTPHQRLGRVEDIAATVAFLCSEGGSFINGQTIVVDGGWSS
TKYLSDFALNSDWVPR
>Mature_256_residues
MQVAIVTGASSGIGFGCATTLAEQGMAVLGTGRDEERLAELEKAVGSDRIATVAVDLTDDDGPARVVAAALERWGRIDFL
VNNAGVGSPKPLHETDDESLDYFLNLMLRAPFRLSRDVIPHMQPGSAIINVTSTFAVVGGLRGGAYSAAKGGLTALTAHI
ACQYGAQGIRCNAVAPGVTLTPMVATRLEDERFRKINTEMTPHQRLGRVEDIAATVAFLCSEGGSFINGQTIVVDGGWSS
TKYLSDFALNSDWVPR

Specific function: Catalyzes the oxidation of 2-(R)-hydroxyalkyl thioesters of CoM to 2-oxoalkyl thioesters of CoM. The enzyme highly specific for the R enantiomers [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI5031737, Length=242, Percent_Identity=33.0578512396694, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI32483357, Length=247, Percent_Identity=30.7692307692308, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI19923817, Length=267, Percent_Identity=28.4644194756554, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI66933014, Length=245, Percent_Identity=30.2040816326531, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI7705925, Length=238, Percent_Identity=32.7731092436975, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI10190704, Length=263, Percent_Identity=30.7984790874525, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=29.9610894941634, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI59889578, Length=193, Percent_Identity=30.5699481865285, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI40254992, Length=240, Percent_Identity=29.5833333333333, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI126723750, Length=247, Percent_Identity=27.5303643724696, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4504505, Length=251, Percent_Identity=28.6852589641434, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4503301, Length=227, Percent_Identity=25.9911894273128, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI33667109, Length=187, Percent_Identity=32.0855614973262, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI4758504, Length=248, Percent_Identity=29.4354838709677, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1789208, Length=241, Percent_Identity=32.3651452282158, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI87082160, Length=242, Percent_Identity=31.8181818181818, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788459, Length=244, Percent_Identity=34.4262295081967, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787335, Length=239, Percent_Identity=33.0543933054393, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=30.9803921568627, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1787905, Length=242, Percent_Identity=32.2314049586777, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790717, Length=237, Percent_Identity=29.1139240506329, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1786812, Length=242, Percent_Identity=31.404958677686, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=28.5140562248996, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787545, Length=259, Percent_Identity=26.2548262548263, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787820, Length=195, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789378, Length=239, Percent_Identity=25.5230125523013, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI2367365, Length=246, Percent_Identity=26.0162601626016, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=248, Percent_Identity=33.8709677419355, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=34.412955465587, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17559104, Length=271, Percent_Identity=33.5793357933579, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17562904, Length=260, Percent_Identity=33.8461538461538, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17551412, Length=258, Percent_Identity=34.1085271317829, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17562910, Length=260, Percent_Identity=32.3076923076923, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17538480, Length=258, Percent_Identity=32.9457364341085, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17560676, Length=244, Percent_Identity=29.0983606557377, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI72000259, Length=254, Percent_Identity=34.251968503937, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17560332, Length=258, Percent_Identity=32.9457364341085, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17561402, Length=246, Percent_Identity=32.1138211382114, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17565030, Length=258, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=30.5660377358491, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI193204405, Length=262, Percent_Identity=31.2977099236641, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17560150, Length=252, Percent_Identity=31.7460317460317, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI115534694, Length=240, Percent_Identity=29.5833333333333, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17563726, Length=253, Percent_Identity=30.8300395256917, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17538486, Length=258, Percent_Identity=31.3953488372093, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17562908, Length=255, Percent_Identity=31.3725490196078, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17560220, Length=261, Percent_Identity=29.5019157088123, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562990, Length=253, Percent_Identity=31.2252964426877, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=30, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17544670, Length=259, Percent_Identity=29.3436293436293, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25147288, Length=244, Percent_Identity=29.0983606557377, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17555706, Length=249, Percent_Identity=28.5140562248996, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17538182, Length=250, Percent_Identity=29.2, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17536651, Length=259, Percent_Identity=25.8687258687259, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17508651, Length=255, Percent_Identity=30.1960784313725, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=260, Percent_Identity=26.5384615384615, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25152911, Length=190, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17555612, Length=217, Percent_Identity=31.7972350230415, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17561272, Length=233, Percent_Identity=26.6094420600858, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=256, Percent_Identity=27.34375, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322861, Length=244, Percent_Identity=27.0491803278689, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI23397609, Length=243, Percent_Identity=34.9794238683128, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28571526, Length=249, Percent_Identity=35.7429718875502, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24643142, Length=238, Percent_Identity=31.9327731092437, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24644339, Length=249, Percent_Identity=34.136546184739, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI21357041, Length=248, Percent_Identity=34.2741935483871, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21355319, Length=246, Percent_Identity=29.6747967479675, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24639444, Length=243, Percent_Identity=30.4526748971193, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI17737361, Length=251, Percent_Identity=29.4820717131474, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI18859837, Length=254, Percent_Identity=27.1653543307087, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24644337, Length=176, Percent_Identity=32.3863636363636, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356301, Length=187, Percent_Identity=28.8770053475936, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.268 [H]

Molecular weight: Translated: 27069; Mature: 27069

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVAIVTGASSGIGFGCATTLAEQGMAVLGTGRDEERLAELEKAVGSDRIATVAVDLTDD
CEEEEEECCCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEEEEECC
DGPARVVAAALERWGRIDFLVNNAGVGSPKPLHETDDESLDYFLNLMLRAPFRLSRDVIP
CCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCC
HMQPGSAIINVTSTFAVVGGLRGGAYSAAKGGLTALTAHIACQYGAQGIRCNAVAPGVTL
CCCCCCEEEEHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEE
TPMVATRLEDERFRKINTEMTPHQRLGRVEDIAATVAFLCSEGGSFINGQTIVVDGGWSS
HHHHHHHCCHHHHHHHCCCCCCHHHHCHHHHHHHHHHHHHHCCCCEECCCEEEEECCCCC
TKYLSDFALNSDWVPR
HHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQVAIVTGASSGIGFGCATTLAEQGMAVLGTGRDEERLAELEKAVGSDRIATVAVDLTDD
CEEEEEECCCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEEEEECC
DGPARVVAAALERWGRIDFLVNNAGVGSPKPLHETDDESLDYFLNLMLRAPFRLSRDVIP
CCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCC
HMQPGSAIINVTSTFAVVGGLRGGAYSAAKGGLTALTAHIACQYGAQGIRCNAVAPGVTL
CCCCCCEEEEHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEE
TPMVATRLEDERFRKINTEMTPHQRLGRVEDIAATVAFLCSEGGSFINGQTIVVDGGWSS
HHHHHHHCCHHHHHHHCCCCCCHHHHCHHHHHHHHHHHHHHCCCCEECCCEEEEECCCCC
TKYLSDFALNSDWVPR
HHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7704278; 9405410; 12524213 [H]