Click here to switch to the map view.

The map label for this gene is crt [H]

Identifier: 119870260

GI number: 119870260

Start: 4457470

End: 4458507

Strand: Direct

Name: crt [H]

Synonym: Mkms_4230

Alternate gene names: 119870260

Gene position: 4457470-4458507 (Clockwise)

Preceding gene: 119870257

Following gene: 119870261

Centisome position: 77.69

GC content: 69.85

Gene sequence:

>1038_bases
GTGGCGGAAAACGAGGATGTCCTAGTTTCTGTGGAGAACGGCGTTGGCCTCGTCACGCTGAACCGGCCGAAGGCGATCAA
CTCGCTGACCCACGGCATGGTGACCACACTGGCCGACGCGCTGCACGCCTGGGAGAAGGACGACGGTGTCCGGACCGTCC
TGCTCACCGGCGCCGGCGAACGGGGTCTGTGCGCGGGCGGCGACGTGATCGCGCTCTATCACAGCGCCAAGGCCGGCGGC
GCGGACGCGCGGCGGTTCTGGTTCGAGGAGTACCAGCTCAACTCCTACATCGGCGGCTATCCCAAACCGTATGTGGCGGT
GATGGACGGCATCGTCATGGGCGGCGGCGTCGGGGTCAGCGCGCACGGCGACGTGCGGGTGGTCACCGACACCACGAAGA
TGGGCATGCCGGAGGTCGGTATCGGCTTCATCCCCGACGTCGGCGGCACCTACCTGCTCTCCCGCGCCCCCGGCCTGCTC
GGCCTCCACGCCGCGCTCACCGGCGCCCCGTTCTCCGGGGCCGACGCGATCGCCATGGGATTCGCCGACCACTTCGTCCC
CCACGACCAGCTCGACGCCTTCAAGGCCGCGGTCGTCGCCGACGGGGTCGACGCCGCGCTGGCCGCCCACACCACCGAGC
CGCCGCCCAGTCAGCTCCTCACCCAACGTGACTGGATCGACGAGTGCTACGCGGGTGACACCGTCGCCGACATCATCGCC
GCCCTGCGCGGCCACGCCGCCGGCCCGGCCAACGACGCCGCCGACCTCATCGCGTCGCGCTCGCCCGTCGCGCTGGCCGT
CACGCTCGAATCCGTCCGCCGGGCAGGCCGACTCGACACACTGGAGGACGTGCTCCGCGACGAATACCGCGTCTCGTGTG
CGTCGCTGCGCTCACACGACTTCGTCGAGGGCATCCGCGCCCAACTGGTCGACAAGGACCGCAACCCGAAGTGGTCGCAT
CAGTCGGTCGACGAGGTCACCGCCGCGGACGTCGACGCCTATTTCGCACCCGCCGATCCCGAACTCACCTTTCCCTGA

Upstream 100 bases:

>100_bases
CCGAAATCGGTGTCAAGATCTCACAGGAACTTCCCAGGACAGTCGAGCGAAACCTTACCCGTCGTGCGCCGGGCACGGGC
GACGATCTACATTGCTTCCC

Downstream 100 bases:

>100_bases
CGACCCCTAAGGAGCAGCCATGGACTACGAGACCATCCTCGTCACCCGCGAGGGCCGGGTCGGCACGATCACGCTGAACC
GCCCCAAGGCGCTCAATGCG

Product: 3-hydroxyisobutyryl-CoA hydrolase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MAENEDVLVSVENGVGLVTLNRPKAINSLTHGMVTTLADALHAWEKDDGVRTVLLTGAGERGLCAGGDVIALYHSAKAGG
ADARRFWFEEYQLNSYIGGYPKPYVAVMDGIVMGGGVGVSAHGDVRVVTDTTKMGMPEVGIGFIPDVGGTYLLSRAPGLL
GLHAALTGAPFSGADAIAMGFADHFVPHDQLDAFKAAVVADGVDAALAAHTTEPPPSQLLTQRDWIDECYAGDTVADIIA
ALRGHAAGPANDAADLIASRSPVALAVTLESVRRAGRLDTLEDVLRDEYRVSCASLRSHDFVEGIRAQLVDKDRNPKWSH
QSVDEVTAADVDAYFAPADPELTFP

Sequences:

>Translated_345_residues
MAENEDVLVSVENGVGLVTLNRPKAINSLTHGMVTTLADALHAWEKDDGVRTVLLTGAGERGLCAGGDVIALYHSAKAGG
ADARRFWFEEYQLNSYIGGYPKPYVAVMDGIVMGGGVGVSAHGDVRVVTDTTKMGMPEVGIGFIPDVGGTYLLSRAPGLL
GLHAALTGAPFSGADAIAMGFADHFVPHDQLDAFKAAVVADGVDAALAAHTTEPPPSQLLTQRDWIDECYAGDTVADIIA
ALRGHAAGPANDAADLIASRSPVALAVTLESVRRAGRLDTLEDVLRDEYRVSCASLRSHDFVEGIRAQLVDKDRNPKWSH
QSVDEVTAADVDAYFAPADPELTFP
>Mature_344_residues
AENEDVLVSVENGVGLVTLNRPKAINSLTHGMVTTLADALHAWEKDDGVRTVLLTGAGERGLCAGGDVIALYHSAKAGGA
DARRFWFEEYQLNSYIGGYPKPYVAVMDGIVMGGGVGVSAHGDVRVVTDTTKMGMPEVGIGFIPDVGGTYLLSRAPGLLG
LHAALTGAPFSGADAIAMGFADHFVPHDQLDAFKAAVVADGVDAALAAHTTEPPPSQLLTQRDWIDECYAGDTVADIIAA
LRGHAAGPANDAADLIASRSPVALAVTLESVRRAGRLDTLEDVLRDEYRVSCASLRSHDFVEGIRAQLVDKDRNPKWSHQ
SVDEVTAADVDAYFAPADPELTFP

Specific function: Could Possibly Oxidizes Fatty Acids Using Specific Components (By Similarity). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=342, Percent_Identity=38.8888888888889, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI37594469, Length=303, Percent_Identity=37.2937293729373, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI194097323, Length=182, Percent_Identity=31.8681318681319, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4502327, Length=179, Percent_Identity=29.608938547486, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1787660, Length=194, Percent_Identity=35.5670103092784, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787659, Length=185, Percent_Identity=28.6486486486486, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788682, Length=220, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87082183, Length=206, Percent_Identity=23.7864077669903, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI221142681, Length=175, Percent_Identity=26.8571428571429, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790281, Length=329, Percent_Identity=21.580547112462, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI25144157, Length=348, Percent_Identity=37.6436781609195, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI25144160, Length=348, Percent_Identity=37.6436781609195, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17554946, Length=316, Percent_Identity=26.2658227848101, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17540714, Length=186, Percent_Identity=26.8817204301075, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25145438, Length=192, Percent_Identity=30.2083333333333, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17534483, Length=277, Percent_Identity=26.7148014440433, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17560910, Length=188, Percent_Identity=28.1914893617021, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6320241, Length=355, Percent_Identity=31.830985915493, Blast_Score=171, Evalue=1e-43,
Organism=Drosophila melanogaster, GI28571730, Length=338, Percent_Identity=36.3905325443787, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI28571729, Length=338, Percent_Identity=36.3905325443787, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI20129971, Length=180, Percent_Identity=32.7777777777778, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24653477, Length=180, Percent_Identity=32.7777777777778, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24653139, Length=180, Percent_Identity=34.4444444444444, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI19922422, Length=189, Percent_Identity=29.1005291005291, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 36345; Mature: 36214

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAENEDVLVSVENGVGLVTLNRPKAINSLTHGMVTTLADALHAWEKDDGVRTVLLTGAGE
CCCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
RGLCAGGDVIALYHSAKAGGADARRFWFEEYQLNSYIGGYPKPYVAVMDGIVMGGGVGVS
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCEEEC
AHGDVRVVTDTTKMGMPEVGIGFIPDVGGTYLLSRAPGLLGLHAALTGAPFSGADAIAMG
CCCCEEEEECHHHCCCCCCCCCCCCCCCCHHHHHCCCCCEEHHHHHCCCCCCCCCHHHHH
FADHFVPHDQLDAFKAAVVADGVDAALAAHTTEPPPSQLLTQRDWIDECYAGDTVADIIA
HHHHCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
ALRGHAAGPANDAADLIASRSPVALAVTLESVRRAGRLDTLEDVLRDEYRVSCASLRSHD
HHHCCCCCCCCHHHHHHHCCCCEEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
FVEGIRAQLVDKDRNPKWSHQSVDEVTAADVDAYFAPADPELTFP
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCEEECCCCCCCCCC
>Mature Secondary Structure 
AENEDVLVSVENGVGLVTLNRPKAINSLTHGMVTTLADALHAWEKDDGVRTVLLTGAGE
CCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
RGLCAGGDVIALYHSAKAGGADARRFWFEEYQLNSYIGGYPKPYVAVMDGIVMGGGVGVS
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCEEEC
AHGDVRVVTDTTKMGMPEVGIGFIPDVGGTYLLSRAPGLLGLHAALTGAPFSGADAIAMG
CCCCEEEEECHHHCCCCCCCCCCCCCCCCHHHHHCCCCCEEHHHHHCCCCCCCCCHHHHH
FADHFVPHDQLDAFKAAVVADGVDAALAAHTTEPPPSQLLTQRDWIDECYAGDTVADIIA
HHHHCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
ALRGHAAGPANDAADLIASRSPVALAVTLESVRRAGRLDTLEDVLRDEYRVSCASLRSHD
HHHCCCCCCCCHHHHHHHCCCCEEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
FVEGIRAQLVDKDRNPKWSHQSVDEVTAADVDAYFAPADPELTFP
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]