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The map label for this gene is fadA [H]

Identifier: 119870257

GI number: 119870257

Start: 4454109

End: 4455326

Strand: Direct

Name: fadA [H]

Synonym: Mkms_4227

Alternate gene names: 119870257

Gene position: 4454109-4455326 (Clockwise)

Preceding gene: 119870256

Following gene: 119870260

Centisome position: 77.64

GC content: 68.72

Gene sequence:

>1218_bases
ATGCCTGAAGCCGTCATCGTCTCGACCGCGCGTTCGCCGATCGGCCGCGCCAACAAGGGGTCGCTGGTCGACATGCGGCC
CGACGACCTCGCCGCCCAGATGGTGCGCGCCGCGTTGGACAAGGTGCCCTCGCTGGATCCGCGCGACATCGACGACCTGA
TCATGGGCTGCGGTCAGCCCGCAGGCGAGTCCGGCTTCAACATCGGCCGCGCGGTGGCCGTGCAGCTGGGTTACGACTTC
ATGCCGGGCACCACCGTGAACCGGTACTGCTCGTCGTCGCTGCAGACCTCCCGGATGGCGTTCCACGCGATCAAGGCCGG
CGAGGGCCACGCGTTCATCTCGGCGGGCGTCGAGACGGTGTCGCGCTTCGCGAAGGGCAACGCCGACGGCTGGCCCGACA
CCAAGAACCCGAAGTTCGCCGACGCCCAGGAACGGTCCAACCAGGCCGCCGCCGGGGGCGACGAGTGGCACGACCCCCGC
GAGGACGGCAACCTGCCGGACGTCTACATCGCGATGGGCCAGACCGCCGAGAACGTCGCGCTCTTCACGGGCGTCAGCCG
CGAGGACCAGGACCACTGGGGGGTTCGTTCGCAGAACCGCGCCGAGGAGGCCATCAACAACGGCTTCTTCGAGCGGGAGA
TCTCGCCGGTGACGCTGCCGGACGGCACGGTCGTGTCCAAGGACGACGGCCCGCGCGCCGGCACCACCTACGAGAAGATC
AGCCAGCTCAAGCCGGTTTTCCGGCCCAACGGCACGATCACCGCCGGTAACGCCTGCCCGCTGAACGACGGCGCCGTCGC
GGTGGTCATCATGAGCGACGAGAAGGCCCGCGACCTGGGCCTGACGCCGTTGGCGCGCATCGTCGCGACCGGGGTGTCCG
GGCTGTCGCCGGAGATCATGGGCCTGGGTCCGATCGAGGCCGTCAAGAAGGCGCTGGGCAATGCCGGGATGGGCATCGCC
GACATCGACCTCTACGAGATCAACGAGGCGTTCGCCGTCCAGGTGCTGGGCTCCGCGCGGGCGCTGGGCATGGACGAGGA
CAGGCTCAACGTCTCGGGCGGCGCGATCGCGCTGGGGCATCCGTTCGGTATGACCGGCGCCCGGATCACCGCCACGCTGC
TGAACAATCTGCAGACCCACGACAAGCAGTTCGGTCTGGAGACGATGTGTGTGGGCGGCGGTCAGGGCATGGCGATGATC
ATCGAACGGCTCTCCTAA

Upstream 100 bases:

>100_bases
GCGGGATCACCCGGCTGTGGCGGCGCACCACCGGGGTGCCCGCTCCGGTCATCGCATCCCCAGGCTAGGTTTCACCTAGC
CAGCGAAACGAGGAGCCGTC

Downstream 100 bases:

>100_bases
CCCTTTTCGTTGACTCTGCGCTCACGGCGCAAACGTGCGAGTGGCGAATGCCGTCAGCGCAGAGTCAACTGGTGCGTAGC
CGCCAAGCGCGGGTCACGCG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MPEAVIVSTARSPIGRANKGSLVDMRPDDLAAQMVRAALDKVPSLDPRDIDDLIMGCGQPAGESGFNIGRAVAVQLGYDF
MPGTTVNRYCSSSLQTSRMAFHAIKAGEGHAFISAGVETVSRFAKGNADGWPDTKNPKFADAQERSNQAAAGGDEWHDPR
EDGNLPDVYIAMGQTAENVALFTGVSREDQDHWGVRSQNRAEEAINNGFFEREISPVTLPDGTVVSKDDGPRAGTTYEKI
SQLKPVFRPNGTITAGNACPLNDGAVAVVIMSDEKARDLGLTPLARIVATGVSGLSPEIMGLGPIEAVKKALGNAGMGIA
DIDLYEINEAFAVQVLGSARALGMDEDRLNVSGGAIALGHPFGMTGARITATLLNNLQTHDKQFGLETMCVGGGQGMAMI
IERLS

Sequences:

>Translated_405_residues
MPEAVIVSTARSPIGRANKGSLVDMRPDDLAAQMVRAALDKVPSLDPRDIDDLIMGCGQPAGESGFNIGRAVAVQLGYDF
MPGTTVNRYCSSSLQTSRMAFHAIKAGEGHAFISAGVETVSRFAKGNADGWPDTKNPKFADAQERSNQAAAGGDEWHDPR
EDGNLPDVYIAMGQTAENVALFTGVSREDQDHWGVRSQNRAEEAINNGFFEREISPVTLPDGTVVSKDDGPRAGTTYEKI
SQLKPVFRPNGTITAGNACPLNDGAVAVVIMSDEKARDLGLTPLARIVATGVSGLSPEIMGLGPIEAVKKALGNAGMGIA
DIDLYEINEAFAVQVLGSARALGMDEDRLNVSGGAIALGHPFGMTGARITATLLNNLQTHDKQFGLETMCVGGGQGMAMI
IERLS
>Mature_404_residues
PEAVIVSTARSPIGRANKGSLVDMRPDDLAAQMVRAALDKVPSLDPRDIDDLIMGCGQPAGESGFNIGRAVAVQLGYDFM
PGTTVNRYCSSSLQTSRMAFHAIKAGEGHAFISAGVETVSRFAKGNADGWPDTKNPKFADAQERSNQAAAGGDEWHDPRE
DGNLPDVYIAMGQTAENVALFTGVSREDQDHWGVRSQNRAEEAINNGFFEREISPVTLPDGTVVSKDDGPRAGTTYEKIS
QLKPVFRPNGTITAGNACPLNDGAVAVVIMSDEKARDLGLTPLARIVATGVSGLSPEIMGLGPIEAVKKALGNAGMGIAD
IDLYEINEAFAVQVLGSARALGMDEDRLNVSGGAIALGHPFGMTGARITATLLNNLQTHDKQFGLETMCVGGGQGMAMII
ERLS

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=407, Percent_Identity=38.3292383292383, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI167614485, Length=403, Percent_Identity=35.9801488833747, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI4501853, Length=409, Percent_Identity=35.4523227383863, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI4557237, Length=415, Percent_Identity=33.9759036144578, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI4504327, Length=429, Percent_Identity=30.0699300699301, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI194353979, Length=401, Percent_Identity=27.6807980049875, Blast_Score=123, Evalue=4e-28,
Organism=Escherichia coli, GI1787663, Length=420, Percent_Identity=42.8571428571429, Blast_Score=287, Evalue=7e-79,
Organism=Escherichia coli, GI1788554, Length=410, Percent_Identity=42.6829268292683, Blast_Score=278, Evalue=3e-76,
Organism=Escherichia coli, GI48994986, Length=413, Percent_Identity=39.7094430992736, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI87082165, Length=409, Percent_Identity=38.6308068459658, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1788683, Length=429, Percent_Identity=30.3030303030303, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI133906874, Length=405, Percent_Identity=35.3086419753086, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17535921, Length=404, Percent_Identity=34.4059405940594, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI25147385, Length=410, Percent_Identity=32.4390243902439, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=436, Percent_Identity=32.1100917431193, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17535917, Length=420, Percent_Identity=27.6190476190476, Blast_Score=118, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6322031, Length=410, Percent_Identity=36.3414634146341, Blast_Score=219, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6325229, Length=415, Percent_Identity=35.6626506024096, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24655093, Length=415, Percent_Identity=38.3132530120482, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI17648125, Length=365, Percent_Identity=36.4383561643836, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24640423, Length=415, Percent_Identity=33.4939759036145, Blast_Score=197, Evalue=8e-51,
Organism=Drosophila melanogaster, GI17137578, Length=431, Percent_Identity=30.6264501160093, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42714; Mature: 42582

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00737 THIOLASE_2 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEAVIVSTARSPIGRANKGSLVDMRPDDLAAQMVRAALDKVPSLDPRDIDDLIMGCGQP
CCCCEEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC
AGESGFNIGRAVAVQLGYDFMPGTTVNRYCSSSLQTSRMAFHAIKAGEGHAFISAGVETV
CCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCEEHHHHHHHH
SRFAKGNADGWPDTKNPKFADAQERSNQAAAGGDEWHDPREDGNLPDVYIAMGQTAENVA
HHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEE
LFTGVSREDQDHWGVRSQNRAEEAINNGFFEREISPVTLPDGTVVSKDDGPRAGTTYEKI
EEECCCCCCCHHCCCCCCHHHHHHHHCCCHHCCCCCEECCCCCEEECCCCCCCCCHHHHH
SQLKPVFRPNGTITAGNACPLNDGAVAVVIMSDEKARDLGLTPLARIVATGVSGLSPEIM
HHCCCCCCCCCCEECCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCC
GLGPIEAVKKALGNAGMGIADIDLYEINEAFAVQVLGSARALGMDEDRLNVSGGAIALGH
CCCHHHHHHHHHCCCCCCEEECCCEECCCHHEEEECCCHHHCCCCCCCEECCCCEEEECC
PFGMTGARITATLLNNLQTHDKQFGLETMCVGGGQGMAMIIERLS
CCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCC
>Mature Secondary Structure 
PEAVIVSTARSPIGRANKGSLVDMRPDDLAAQMVRAALDKVPSLDPRDIDDLIMGCGQP
CCCEEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC
AGESGFNIGRAVAVQLGYDFMPGTTVNRYCSSSLQTSRMAFHAIKAGEGHAFISAGVETV
CCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCEEHHHHHHHH
SRFAKGNADGWPDTKNPKFADAQERSNQAAAGGDEWHDPREDGNLPDVYIAMGQTAENVA
HHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEE
LFTGVSREDQDHWGVRSQNRAEEAINNGFFEREISPVTLPDGTVVSKDDGPRAGTTYEKI
EEECCCCCCCHHCCCCCCHHHHHHHHCCCHHCCCCCEECCCCCEEECCCCCCCCCHHHHH
SQLKPVFRPNGTITAGNACPLNDGAVAVVIMSDEKARDLGLTPLARIVATGVSGLSPEIM
HHCCCCCCCCCCEECCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCC
GLGPIEAVKKALGNAGMGIADIDLYEINEAFAVQVLGSARALGMDEDRLNVSGGAIALGH
CCCHHHHHHHHHCCCCCCEEECCCEECCCHHEEEECCCHHHCCCCCCCEECCCCEEEECC
PFGMTGARITATLLNNLQTHDKQFGLETMCVGGGQGMAMIIERLS
CCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]