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The map label for this gene is guaB [C]

Identifier: 119868889

GI number: 119868889

Start: 2976348

End: 2977784

Strand: Direct

Name: guaB [C]

Synonym: Mkms_2857

Alternate gene names: 119868889

Gene position: 2976348-2977784 (Clockwise)

Preceding gene: 119868888

Following gene: 119868890

Centisome position: 51.88

GC content: 70.91

Gene sequence:

>1437_bases
ATGAGATTCCTCGACGGGCACCACCCGGTCTTCGACCTGACCTACGACGACGTGTTCGTCGTCCCGCAGCGGTCCGACGT
GACGTCGCGGTTCGACGTCGACCTGTCGACCGTGGACGGCTCGGGCACCACGATCCCGGTCGTGGTCGCCAACATGACCG
CCGTCGCCGGACGCCGGATGGCCGAAACCGTGGCGCGCCGCGGCGGTCTGGTGGTGCTGCCGCAGGATCTGCCGATCTCG
GCCGTGCAGCAGACCGTCGACTTCGTCAAGAGCCGCGACCTGGTGGTCGACACGCCGGTCACGCTGGCACCCGACGATTC
GGTGTCCGACGCGATCGCGCTGATCCACAAGCGCGCACACGGGGCGGCGGTCGTGGTGTTCGAGGGCCGTCCCATCGGCC
TGGTGACCGAGTCGACCTGCGCCGACGTCGACCGGTTCACCCGGGTCCGCGACGTCGCCATCACCGATTTCGTCACCGCG
CCGGTCGGCACCGATCCGCGCAAGGTCTTCGATCTGCTCGAACACGCGCCGGTGGACGTCGCGGTCCTCACCGAGCCGGA
CGGCACGCTGTCCGGTGTGCTCACCCGGACCGCGGCGATCCGGGCGGGTATCTACTCCCCTGCCGTCGACCGGCACGGGA
GGCTGCGCATCGCCGCAGCGGTCGGCATCAACGGCGACGTCGGGGCGAAGGCGCGGGCGCTGGCCGAGGTCGGAGTCGAC
CTGTTGGTGATCGACACCGCCCACGGTCATCAGACCAAGATGCTCGAGGCGATCCGGGCGGTGGCCTCCCTCGACCTCGG
TGTGCCGATCGCGGCGGGCAACGTGGTGTCGGCCGAGGGCACCCGCGACCTCGTCGCGGCGGGCGCGTCGATCATCAAGG
TCGGCGTCGGCCCCGGCGCGATGTGCACCACCCGGATGATGACCGGTGTCGGTCGGCCGCAGTTCTCGTCGGTCGTCGAA
TGTGCCGCGGCGGCAAAGGATCTGGGCGCGCACGTCTGGGCGGACGGCGGGGTCCGCCATCCGCGCGACGTGGCGCTCGC
GCTGGCGGCGGGGGCGGCCAACGTGATGATCGGCTCCTGGTTCGCCGGCACGTACGAGTCGCCCGGCGACCTGATGCACG
ACCGCGACAACCAGCCGTACAAGGAGAGCTACGGGATGGCGTCGAAGCGGGCGGTCGCGGCCCGGACAGCCGGCGACAGC
GCGTTCGACCGCGCCCGCAAGGCACTGTTCGAGGAGGGCATCTCCAGATCGCGGATGAGCCTCGACCCGACCAAAGGCGG
TGTCGAGGACCTGCTCGACCACATCACCTCCGGGGTCCGCAGCACCTGCACCTACGTCGGGGCCACGACGCTGCCCGAAC
TGCACGACAAAGTGGTGCTCGGGGTGCAGTCGGCGGCCGGGTTCGCCGAGGGCCGCCCGCTGCCCACCGGTTGGTGA

Upstream 100 bases:

>100_bases
GCGAAGTCGAGGCCTGATTTCGCCGAGACTGCGGCCAGATCGCGATTCCGCAGCGAAGCATGATCTGGCAGCAGTCCCGG
GGTAACTAGACTGGCCGACG

Downstream 100 bases:

>100_bases
TAGTCCAGTTACGATTGGGCATTCGCGCCGTCGGTCGTCTGACGTCCGACATCCGACCGAGGAAGGGATCACGTGCCGCA
GGCACCCGCCGAGGCCCGGT

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MRFLDGHHPVFDLTYDDVFVVPQRSDVTSRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGLVVLPQDLPIS
AVQQTVDFVKSRDLVVDTPVTLAPDDSVSDAIALIHKRAHGAAVVVFEGRPIGLVTESTCADVDRFTRVRDVAITDFVTA
PVGTDPRKVFDLLEHAPVDVAVLTEPDGTLSGVLTRTAAIRAGIYSPAVDRHGRLRIAAAVGINGDVGAKARALAEVGVD
LLVIDTAHGHQTKMLEAIRAVASLDLGVPIAAGNVVSAEGTRDLVAAGASIIKVGVGPGAMCTTRMMTGVGRPQFSSVVE
CAAAAKDLGAHVWADGGVRHPRDVALALAAGAANVMIGSWFAGTYESPGDLMHDRDNQPYKESYGMASKRAVAARTAGDS
AFDRARKALFEEGISRSRMSLDPTKGGVEDLLDHITSGVRSTCTYVGATTLPELHDKVVLGVQSAAGFAEGRPLPTGW

Sequences:

>Translated_478_residues
MRFLDGHHPVFDLTYDDVFVVPQRSDVTSRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGLVVLPQDLPIS
AVQQTVDFVKSRDLVVDTPVTLAPDDSVSDAIALIHKRAHGAAVVVFEGRPIGLVTESTCADVDRFTRVRDVAITDFVTA
PVGTDPRKVFDLLEHAPVDVAVLTEPDGTLSGVLTRTAAIRAGIYSPAVDRHGRLRIAAAVGINGDVGAKARALAEVGVD
LLVIDTAHGHQTKMLEAIRAVASLDLGVPIAAGNVVSAEGTRDLVAAGASIIKVGVGPGAMCTTRMMTGVGRPQFSSVVE
CAAAAKDLGAHVWADGGVRHPRDVALALAAGAANVMIGSWFAGTYESPGDLMHDRDNQPYKESYGMASKRAVAARTAGDS
AFDRARKALFEEGISRSRMSLDPTKGGVEDLLDHITSGVRSTCTYVGATTLPELHDKVVLGVQSAAGFAEGRPLPTGW
>Mature_478_residues
MRFLDGHHPVFDLTYDDVFVVPQRSDVTSRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGLVVLPQDLPIS
AVQQTVDFVKSRDLVVDTPVTLAPDDSVSDAIALIHKRAHGAAVVVFEGRPIGLVTESTCADVDRFTRVRDVAITDFVTA
PVGTDPRKVFDLLEHAPVDVAVLTEPDGTLSGVLTRTAAIRAGIYSPAVDRHGRLRIAAAVGINGDVGAKARALAEVGVD
LLVIDTAHGHQTKMLEAIRAVASLDLGVPIAAGNVVSAEGTRDLVAAGASIIKVGVGPGAMCTTRMMTGVGRPQFSSVVE
CAAAAKDLGAHVWADGGVRHPRDVALALAAGAANVMIGSWFAGTYESPGDLMHDRDNQPYKESYGMASKRAVAARTAGDS
AFDRARKALFEEGISRSRMSLDPTKGGVEDLLDHITSGVRSTCTYVGATTLPELHDKVVLGVQSAAGFAEGRPLPTGW

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI50541954, Length=216, Percent_Identity=44.9074074074074, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541952, Length=216, Percent_Identity=44.9074074074074, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541948, Length=216, Percent_Identity=44.9074074074074, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541956, Length=216, Percent_Identity=44.9074074074074, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI156104880, Length=216, Percent_Identity=41.6666666666667, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI66933016, Length=461, Percent_Identity=26.8980477223427, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI156616279, Length=470, Percent_Identity=26.5957446808511, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI217035146, Length=470, Percent_Identity=26.5957446808511, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI34328928, Length=470, Percent_Identity=26.5957446808511, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI34328930, Length=470, Percent_Identity=26.5957446808511, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI217035148, Length=469, Percent_Identity=26.865671641791, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI217035152, Length=466, Percent_Identity=26.1802575107296, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI217035150, Length=467, Percent_Identity=25.2676659528908, Blast_Score=129, Evalue=8e-30,
Organism=Escherichia coli, GI1788855, Length=468, Percent_Identity=33.974358974359, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI1786293, Length=222, Percent_Identity=37.8378378378378, Blast_Score=141, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17560440, Length=216, Percent_Identity=41.2037037037037, Blast_Score=155, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI71994385, Length=482, Percent_Identity=25.5186721991701, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71994389, Length=420, Percent_Identity=26.6666666666667, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322012, Length=464, Percent_Identity=26.7241379310345, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323464, Length=465, Percent_Identity=26.8817204301075, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323585, Length=465, Percent_Identity=26.0215053763441, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319352, Length=364, Percent_Identity=25.8241758241758, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24641071, Length=464, Percent_Identity=27.3706896551724, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24641073, Length=464, Percent_Identity=27.3706896551724, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI28571163, Length=423, Percent_Identity=26.7139479905437, Blast_Score=135, Evalue=8e-32,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR018529
- InterPro:   IPR001093
- InterPro:   IPR005991 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 50080; Mature: 50080

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFLDGHHPVFDLTYDDVFVVPQRSDVTSRFDVDLSTVDGSGTTIPVVVANMTAVAGRRM
CCCCCCCCCEEEEECCCEEEEECCCCCCCEEEEEEEEECCCCCEEEEEEECHHHHHHHHH
AETVARRGGLVVLPQDLPISAVQQTVDFVKSRDLVVDTPVTLAPDDSVSDAIALIHKRAH
HHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCEEEECCEEECCCCCHHHHHHHHHHHCC
GAAVVVFEGRPIGLVTESTCADVDRFTRVRDVAITDFVTAPVGTDPRKVFDLLEHAPVDV
CCEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHCCCCCE
AVLTEPDGTLSGVLTRTAAIRAGIYSPAVDRHGRLRIAAAVGINGDVGAKARALAEVGVD
EEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCE
LLVIDTAHGHQTKMLEAIRAVASLDLGVPIAAGNVVSAEGTRDLVAAGASIIKVGVGPGA
EEEEECCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCCCHHHHHCCCEEEEECCCCCH
MCTTRMMTGVGRPQFSSVVECAAAAKDLGAHVWADGGVRHPRDVALALAAGAANVMIGSW
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHCCCCCEEEECE
FAGTYESPGDLMHDRDNQPYKESYGMASKRAVAARTAGDSAFDRARKALFEEGISRSRMS
ECCCCCCCCCHHCCCCCCCHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
LDPTKGGVEDLLDHITSGVRSTCTYVGATTLPELHDKVVLGVQSAAGFAEGRPLPTGW
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHEEEEEHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRFLDGHHPVFDLTYDDVFVVPQRSDVTSRFDVDLSTVDGSGTTIPVVVANMTAVAGRRM
CCCCCCCCCEEEEECCCEEEEECCCCCCCEEEEEEEEECCCCCEEEEEEECHHHHHHHHH
AETVARRGGLVVLPQDLPISAVQQTVDFVKSRDLVVDTPVTLAPDDSVSDAIALIHKRAH
HHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCEEEECCEEECCCCCHHHHHHHHHHHCC
GAAVVVFEGRPIGLVTESTCADVDRFTRVRDVAITDFVTAPVGTDPRKVFDLLEHAPVDV
CCEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHCCCCCE
AVLTEPDGTLSGVLTRTAAIRAGIYSPAVDRHGRLRIAAAVGINGDVGAKARALAEVGVD
EEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCE
LLVIDTAHGHQTKMLEAIRAVASLDLGVPIAAGNVVSAEGTRDLVAAGASIIKVGVGPGA
EEEEECCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCCCHHHHHCCCEEEEECCCCCH
MCTTRMMTGVGRPQFSSVVECAAAAKDLGAHVWADGGVRHPRDVALALAAGAANVMIGSW
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHCCCCCEEEECE
FAGTYESPGDLMHDRDNQPYKESYGMASKRAVAARTAGDSAFDRARKALFEEGISRSRMS
ECCCCCCCCCHHCCCCCCCHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
LDPTKGGVEDLLDHITSGVRSTCTYVGATTLPELHDKVVLGVQSAAGFAEGRPLPTGW
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHEEEEEHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]