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The map label for this gene is yqjI [H]

Identifier: 119868888

GI number: 119868888

Start: 2974804

End: 2976264

Strand: Direct

Name: yqjI [H]

Synonym: Mkms_2856

Alternate gene names: 119868888

Gene position: 2974804-2976264 (Clockwise)

Preceding gene: 119868887

Following gene: 119868889

Centisome position: 51.85

GC content: 67.49

Gene sequence:

>1461_bases
ATGAGCTCATCCGAGAAGTCCACCGCCGGCACCGCGCAGATCGGGGTCACCGGCCTGGCCGTGATGGGTTCGAACATCGC
ACGCAACTTCGCCAGGCACGGCTACACCGTCGCCCTGCACAACCGGTCGGTGGCCAAGACCGACGCGCTGCTGGCCGAAC
ACGGTTCCGAGGGCTCCTTCGTGCGGACCGAGACCATCCCGGAATTCCTGGCCGCCCTGGAGAAACCGCGCCGCGTGCTG
ATCATGGTCAAGGCCGGCGAGGCGACCGATGCGGTGATCAACGAGCTCGCCGACGCGATGGAAGACGGCGACATCATCAT
CGACGGCGGCAACGCGCTCTACACCGACACGATCCGCCGTGAGAAGGCGATCCGGGAACGCGGTCTGCACTTCGTCGGCG
CCGGCATCTCCGGCGGCGAGGAGGGTGCGCTCAACGGGCCGTCGATCATGCCCGGCGGCCCCGCGGAGTCCTACGAGAGC
CTCGGTCCGCTGCTGGAGGAGATCTCCGCGCACGTCGACGGTGTCCCGTGCTGTACGCACATCGGACCCGACGGCGCGGG
CCACTTCGTGAAGATGGTGCACAACGGCATCGAGTACTCCGACATGCAGCTCATCGGCGAGGCCTACCAGCTGCTGCGCG
ACGGGCTCGGCAAGTCCGCCCCCGAGATCGCCGAGGTCTTCGACGAGTGGAACCGCGGCGACCTCGACAGCTTCCTGGTC
GAGATCACCGCGCAGGTGCTGCGTCAGATCGACGAGAAGACCGGCAAACCGCTCGTCGACCTCATCCTCGACGAGGCCGA
GCAGAAGGGCACCGGCCGCTGGACGGTGAAGTCGGCGCTCGACCTGGGTGTGCCCGTCACCGGTATCGCCGAGGCGGTGT
TCGCCCGCGCGCTGTCGGGATCGGTCGCCCAGCGCCAGGCCACCACCGGGTTGGCCTCCGGCGACCTGGGCGAAAAGCCC
AGTGACGCAGAGCAGTTCACCGAGGACATCCGACAGGCCCTCTACGCGTCGAAGATCATCGCCTACGCGCAGGGCTTCAA
CCAGATCCAGGCAGGCAGTGCCGAGTACGACTGGGGCATCACCCCCGGCGACATGGCCACCATCTGGCGCGGCGGCTGCA
TCATCCGGGCGAAGTTCCTCAACCGCATCAAGGACGCATTCGACAACGATCCCGATCTGCCCACGCTGATCGTCGACCCG
TACTTCCGCGACGCGATCGAGAACGCCATCGACAGCTGGCGCCGTGTGGTGGTCAAGGCCACCGAACTCGGCATCCCGAT
CCCCGGCTTCTCGTCGGCGCTGTCGTACTACGACGGGCTGCGCACCGAACGCCTGCCCGCCGCACTCACGCAGGGGCTGC
GCGACTTCTTCGGCGCCCACACCTACGGCCGCATCGACACCGACCGGGATAAGCGGTTCCACACGCTGTGGAGCGGTGAC
CGCAGCGAAGTCGAGGCCTGA

Upstream 100 bases:

>100_bases
GGCCGTCGCCGTGCCGTGGCTGACCGAACTGCACCGCCTGTTCATCCGCTAGGCCCATCGGAATCACCTCCCTCACAACA
GAACACGAAAGGCTGCGCCC

Downstream 100 bases:

>100_bases
TTTCGCCGAGACTGCGGCCAGATCGCGATTCCGCAGCGAAGCATGATCTGGCAGCAGTCCCGGGGTAACTAGACTGGCCG
ACGATGAGATTCCTCGACGG

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MSSSEKSTAGTAQIGVTGLAVMGSNIARNFARHGYTVALHNRSVAKTDALLAEHGSEGSFVRTETIPEFLAALEKPRRVL
IMVKAGEATDAVINELADAMEDGDIIIDGGNALYTDTIRREKAIRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYES
LGPLLEEISAHVDGVPCCTHIGPDGAGHFVKMVHNGIEYSDMQLIGEAYQLLRDGLGKSAPEIAEVFDEWNRGDLDSFLV
EITAQVLRQIDEKTGKPLVDLILDEAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALSGSVAQRQATTGLASGDLGEKP
SDAEQFTEDIRQALYASKIIAYAQGFNQIQAGSAEYDWGITPGDMATIWRGGCIIRAKFLNRIKDAFDNDPDLPTLIVDP
YFRDAIENAIDSWRRVVVKATELGIPIPGFSSALSYYDGLRTERLPAALTQGLRDFFGAHTYGRIDTDRDKRFHTLWSGD
RSEVEA

Sequences:

>Translated_486_residues
MSSSEKSTAGTAQIGVTGLAVMGSNIARNFARHGYTVALHNRSVAKTDALLAEHGSEGSFVRTETIPEFLAALEKPRRVL
IMVKAGEATDAVINELADAMEDGDIIIDGGNALYTDTIRREKAIRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYES
LGPLLEEISAHVDGVPCCTHIGPDGAGHFVKMVHNGIEYSDMQLIGEAYQLLRDGLGKSAPEIAEVFDEWNRGDLDSFLV
EITAQVLRQIDEKTGKPLVDLILDEAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALSGSVAQRQATTGLASGDLGEKP
SDAEQFTEDIRQALYASKIIAYAQGFNQIQAGSAEYDWGITPGDMATIWRGGCIIRAKFLNRIKDAFDNDPDLPTLIVDP
YFRDAIENAIDSWRRVVVKATELGIPIPGFSSALSYYDGLRTERLPAALTQGLRDFFGAHTYGRIDTDRDKRFHTLWSGD
RSEVEA
>Mature_485_residues
SSSEKSTAGTAQIGVTGLAVMGSNIARNFARHGYTVALHNRSVAKTDALLAEHGSEGSFVRTETIPEFLAALEKPRRVLI
MVKAGEATDAVINELADAMEDGDIIIDGGNALYTDTIRREKAIRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYESL
GPLLEEISAHVDGVPCCTHIGPDGAGHFVKMVHNGIEYSDMQLIGEAYQLLRDGLGKSAPEIAEVFDEWNRGDLDSFLVE
ITAQVLRQIDEKTGKPLVDLILDEAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALSGSVAQRQATTGLASGDLGEKPS
DAEQFTEDIRQALYASKIIAYAQGFNQIQAGSAEYDWGITPGDMATIWRGGCIIRAKFLNRIKDAFDNDPDLPTLIVDPY
FRDAIENAIDSWRRVVVKATELGIPIPGFSSALSYYDGLRTERLPAALTQGLRDFFGAHTYGRIDTDRDKRFHTLWSGDR
SEVEA

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=470, Percent_Identity=50.2127659574468, Blast_Score=455, Evalue=1e-128,
Organism=Escherichia coli, GI1788341, Length=466, Percent_Identity=51.7167381974249, Blast_Score=494, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17542558, Length=471, Percent_Identity=47.5583864118896, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6321695, Length=475, Percent_Identity=48.6315789473684, Blast_Score=461, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6321977, Length=486, Percent_Identity=48.9711934156379, Blast_Score=452, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24639279, Length=479, Percent_Identity=46.7640918580376, Blast_Score=421, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52428; Mature: 52297

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSEKSTAGTAQIGVTGLAVMGSNIARNFARHGYTVALHNRSVAKTDALLAEHGSEGSF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCE
VRTETIPEFLAALEKPRRVLIMVKAGEATDAVINELADAMEDGDIIIDGGNALYTDTIRR
EEHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCEEEHHHHHH
EKAIRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYESLGPLLEEISAHVDGVPCCTH
HHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
IGPDGAGHFVKMVHNGIEYSDMQLIGEAYQLLRDGLGKSAPEIAEVFDEWNRGDLDSFLV
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHH
EITAQVLRQIDEKTGKPLVDLILDEAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALSG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEHHHHHCCCCHHHHHHHHHHHHHHC
SVAQRQATTGLASGDLGEKPSDAEQFTEDIRQALYASKIIAYAQGFNQIQAGSAEYDWGI
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCC
TPGDMATIWRGGCIIRAKFLNRIKDAFDNDPDLPTLIVDPYFRDAIENAIDSWRRVVVKA
CCCCHHHHHCCCCEEHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHH
TELGIPIPGFSSALSYYDGLRTERLPAALTQGLRDFFGAHTYGRIDTDRDKRFHTLWSGD
HHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCC
RSEVEA
HHCCCC
>Mature Secondary Structure 
SSSEKSTAGTAQIGVTGLAVMGSNIARNFARHGYTVALHNRSVAKTDALLAEHGSEGSF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCE
VRTETIPEFLAALEKPRRVLIMVKAGEATDAVINELADAMEDGDIIIDGGNALYTDTIRR
EEHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCEEEHHHHHH
EKAIRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYESLGPLLEEISAHVDGVPCCTH
HHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
IGPDGAGHFVKMVHNGIEYSDMQLIGEAYQLLRDGLGKSAPEIAEVFDEWNRGDLDSFLV
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHH
EITAQVLRQIDEKTGKPLVDLILDEAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALSG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEHHHHHCCCCHHHHHHHHHHHHHHC
SVAQRQATTGLASGDLGEKPSDAEQFTEDIRQALYASKIIAYAQGFNQIQAGSAEYDWGI
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCC
TPGDMATIWRGGCIIRAKFLNRIKDAFDNDPDLPTLIVDPYFRDAIENAIDSWRRVVVKA
CCCCHHHHHCCCCEEHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHH
TELGIPIPGFSSALSYYDGLRTERLPAALTQGLRDFFGAHTYGRIDTDRDKRFHTLWSGD
HHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCC
RSEVEA
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]