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The map label for this gene is ycsA [H]

Identifier: 119868653

GI number: 119868653

Start: 2752251

End: 2753303

Strand: Reverse

Name: ycsA [H]

Synonym: Mkms_2618

Alternate gene names: 119868653

Gene position: 2753303-2752251 (Counterclockwise)

Preceding gene: 119868654

Following gene: 119868652

Centisome position: 47.99

GC content: 69.71

Gene sequence:

>1053_bases
ATGAGCGCACACCGTATCGCCGTCATCCCCGGCGACGGGATCGGCACGGAGGCGACGGCCTCGGCGCGCACGGTGCTCGA
CGCGGTCGCCGAGCGCCACGGGATCGACCTGTCCTATGAGGAATTCGACTGGTCCTGCCGACGGTTCGAGCGCGACGGGG
CGATGATGCCGGCCGATGGGTTGGAGACCCTGAGTGGCTTCGACGCGATCCTGCTCGGCGCGGTCGGCTGGCCGGGCGTG
CCCGACCACGTCTCGCTGTGGGGTCTGCTCATCCCGATCCGGCGGGCATTCCGTCAGTACGTGAACCTGCGGCCCATCCG
GGTGTTCGACGGGGTCGCCAGCCCGCTGCGCGACGCCACCGACGTCGACTTCGTGGTCGTCCGAGAGAACGTCGAGGGTG
AGTACAGCGAGATCGGCGGACGGATCAACCGGGGTTTCCCCGACGAGATGGCGGTCCAGGAGTCGGTCTTCACCAGGGTC
GGCGTCACCCGCATCGCCGACTACGCGTTCGACCTCGCCGAGACCCGGCGCCGGTATGTCACCTCCGCGACGAAATCCAA
CGGCATCGTCCACACCCTGCCGTTCTGGGACGAAGTGGTCGCCGAGCGTGCCGCCAACCATCCGGGCGTGCGGTTCGACA
GCGAGCACATCGACGCGCTGGCCGCGAAGTTCGTGCTGCAGCCGGGACGGTTCGACGTGGTGGTCGGCTCGAATCTGTTC
GGCGACATCCTGTCCGACCTCGCGGCGGCCGTGGCGGGGTCGATCGGGATCGCCCCGTCGGCGAATCTCGACCCCACCAA
GCAGTACCCGTCGATGTTCGAACCCGTGCACGGATCGGCGCCCGACATCGCCGGGCGGGGGGTGGCGAATCCGATCGGCG
CGGTGTGGTCGGCGGCGTTGATGCTCGAACACCTCGGGCACGCGTCGGCCGCGGCCGACGTGATGACCGCCGTCGAACGC
ACACTGGCGCAACCGCAGACGCGGACCGTCGACCTCGGCGGGCACGCGTCGACCGCCGACGTCACCGACGCGCTGGTCGC
CCAGTTGCGCTGA

Upstream 100 bases:

>100_bases
TCACGACGATGATCCGCTCCGGTGTCACGTTCGACGTCGCCGGCGCCATCTTGATCATCCTCTTCCTGCCGCTGATGATC
GCCCTGCTCGGGCTCGGAGC

Downstream 100 bases:

>100_bases
CGAGCCGTCGACACCGGTACGGCACACTGAAGGAACCCGAACAGGAAGGTGCCGGTACCGATATGGCGACAGAGGATCCG
TTGCGGCTGGGAGTGGTGGC

Product: tartrate dehydrogenase

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSAHRIAVIPGDGIGTEATASARTVLDAVAERHGIDLSYEEFDWSCRRFERDGAMMPADGLETLSGFDAILLGAVGWPGV
PDHVSLWGLLIPIRRAFRQYVNLRPIRVFDGVASPLRDATDVDFVVVRENVEGEYSEIGGRINRGFPDEMAVQESVFTRV
GVTRIADYAFDLAETRRRYVTSATKSNGIVHTLPFWDEVVAERAANHPGVRFDSEHIDALAAKFVLQPGRFDVVVGSNLF
GDILSDLAAAVAGSIGIAPSANLDPTKQYPSMFEPVHGSAPDIAGRGVANPIGAVWSAALMLEHLGHASAAADVMTAVER
TLAQPQTRTVDLGGHASTADVTDALVAQLR

Sequences:

>Translated_350_residues
MSAHRIAVIPGDGIGTEATASARTVLDAVAERHGIDLSYEEFDWSCRRFERDGAMMPADGLETLSGFDAILLGAVGWPGV
PDHVSLWGLLIPIRRAFRQYVNLRPIRVFDGVASPLRDATDVDFVVVRENVEGEYSEIGGRINRGFPDEMAVQESVFTRV
GVTRIADYAFDLAETRRRYVTSATKSNGIVHTLPFWDEVVAERAANHPGVRFDSEHIDALAAKFVLQPGRFDVVVGSNLF
GDILSDLAAAVAGSIGIAPSANLDPTKQYPSMFEPVHGSAPDIAGRGVANPIGAVWSAALMLEHLGHASAAADVMTAVER
TLAQPQTRTVDLGGHASTADVTDALVAQLR
>Mature_349_residues
SAHRIAVIPGDGIGTEATASARTVLDAVAERHGIDLSYEEFDWSCRRFERDGAMMPADGLETLSGFDAILLGAVGWPGVP
DHVSLWGLLIPIRRAFRQYVNLRPIRVFDGVASPLRDATDVDFVVVRENVEGEYSEIGGRINRGFPDEMAVQESVFTRVG
VTRIADYAFDLAETRRRYVTSATKSNGIVHTLPFWDEVVAERAANHPGVRFDSEHIDALAAKFVLQPGRFDVVVGSNLFG
DILSDLAAAVAGSIGIAPSANLDPTKQYPSMFEPVHGSAPDIAGRGVANPIGAVWSAALMLEHLGHASAAADVMTAVERT
LAQPQTRTVDLGGHASTADVTDALVAQLR

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=346, Percent_Identity=33.2369942196532, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI4758582, Length=359, Percent_Identity=27.8551532033426, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI28178816, Length=351, Percent_Identity=28.2051282051282, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI28178821, Length=352, Percent_Identity=27.2727272727273, Blast_Score=121, Evalue=9e-28,
Organism=Homo sapiens, GI28178838, Length=338, Percent_Identity=28.4023668639053, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI28178819, Length=200, Percent_Identity=31, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1788101, Length=356, Percent_Identity=55.3370786516854, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI87081683, Length=358, Percent_Identity=37.4301675977654, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1787381, Length=395, Percent_Identity=26.0759493670886, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71986051, Length=348, Percent_Identity=32.7586206896552, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17550882, Length=350, Percent_Identity=31.4285714285714, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17505779, Length=354, Percent_Identity=25.7062146892655, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25144293, Length=350, Percent_Identity=26.8571428571429, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322097, Length=358, Percent_Identity=34.3575418994413, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324709, Length=351, Percent_Identity=32.7635327635328, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319830, Length=375, Percent_Identity=33.8666666666667, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6324291, Length=349, Percent_Identity=30.3724928366762, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24643270, Length=347, Percent_Identity=32.5648414985591, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24643268, Length=347, Percent_Identity=32.5648414985591, Blast_Score=181, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24661184, Length=357, Percent_Identity=31.6526610644258, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI161078633, Length=356, Percent_Identity=26.9662921348315, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24650122, Length=356, Percent_Identity=26.9662921348315, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI161078635, Length=356, Percent_Identity=26.9662921348315, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI161078637, Length=356, Percent_Identity=26.9662921348315, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI161078639, Length=352, Percent_Identity=26.9886363636364, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20130355, Length=347, Percent_Identity=27.6657060518732, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI281362242, Length=350, Percent_Identity=25.7142857142857, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24648872, Length=350, Percent_Identity=25.7142857142857, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 37555; Mature: 37423

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAHRIAVIPGDGIGTEATASARTVLDAVAERHGIDLSYEEFDWSCRRFERDGAMMPADG
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHCCCCCCCCCH
LETLSGFDAILLGAVGWPGVPDHVSLWGLLIPIRRAFRQYVNLRPIRVFDGVASPLRDAT
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
DVDFVVVRENVEGEYSEIGGRINRGFPDEMAVQESVFTRVGVTRIADYAFDLAETRRRYV
CCEEEEEECCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSATKSNGIVHTLPFWDEVVAERAANHPGVRFDSEHIDALAAKFVLQPGRFDVVVGSNLF
HHHHCCCCCEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHH
GDILSDLAAAVAGSIGIAPSANLDPTKQYPSMFEPVHGSAPDIAGRGVANPIGAVWSAAL
HHHHHHHHHHHHCCCCCCCCCCCCCCHHCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
MLEHLGHASAAADVMTAVERTLAQPQTRTVDLGGHASTADVTDALVAQLR
HHHHHCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SAHRIAVIPGDGIGTEATASARTVLDAVAERHGIDLSYEEFDWSCRRFERDGAMMPADG
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHCCCCCCCCCH
LETLSGFDAILLGAVGWPGVPDHVSLWGLLIPIRRAFRQYVNLRPIRVFDGVASPLRDAT
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
DVDFVVVRENVEGEYSEIGGRINRGFPDEMAVQESVFTRVGVTRIADYAFDLAETRRRYV
CCEEEEEECCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSATKSNGIVHTLPFWDEVVAERAANHPGVRFDSEHIDALAAKFVLQPGRFDVVVGSNLF
HHHHCCCCCEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHH
GDILSDLAAAVAGSIGIAPSANLDPTKQYPSMFEPVHGSAPDIAGRGVANPIGAVWSAAL
HHHHHHHHHHHHCCCCCCCCCCCCCCHHCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
MLEHLGHASAAADVMTAVERTLAQPQTRTVDLGGHASTADVTDALVAQLR
HHHHHCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 10568751 [H]