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The map label for this gene is mmgC [H]

Identifier: 119868380

GI number: 119868380

Start: 2456452

End: 2457720

Strand: Reverse

Name: mmgC [H]

Synonym: Mkms_2344

Alternate gene names: 119868380

Gene position: 2457720-2456452 (Counterclockwise)

Preceding gene: 119868381

Following gene: 119868378

Centisome position: 42.84

GC content: 68.48

Gene sequence:

>1269_bases
ATGACCGAGACGTCCACTCGATCCCAGTCCGCCCCGGCCGAAGCCGCCGAGTCGGTCGAGGAGTTCCAGGCCAGGGCCAG
AGCGTGGCTCGCCGACAACATGCCGCGCATCGACCCGGACAATCCGCCGGACGCCGATCGCGGTGAGGAAGGCCCGTGGC
TGCGCGCCCGGGAACTCCAGAAGAAGCTGTACGCGGGCGGGTTCGCCGGCATCTGCTTCCCGAAGGAGTACGGCGGCCTC
GGCCTGCCGATCGCCTACCAGCGCGCCTTCGACCAGGAATCGAAAGCCTATGAGCTGCCGATCATCCTGAACACGCCCAC
CTTCACGATCTGTGCGGCCACCATCCTCGACACCGGTGACGAGGCGCAGAAGCAACAGCACATCGGCGGCGCCATCCGCG
GCGACGAGATCCTGGTGCAGCTCCTGTCCGAACCCAGCGGCGGTTCGGATCTGGCCGGCGTCATCACCCGGGCGGACCGC
CGTGGCGACAAGTGGGTCATCAACGGCGCCAAGACGTGGAGCACCAGCGCATTCGCCGCCGACTACGGCCTCCTGCTGGC
CCGCACCGACTGGGATGTGCCGAAACACGAAGGCCTGACCATGTTTCTGATGCCACTCGACGCGCCCGGCATCACGATGC
GCCGGATCAAGCAGGTCGACGGCGGCAACGAGTTCTGCGAGGAGTTCTTCGACGACCTCGAACTGGGCGACGACGCGGTG
GTCGGCGAGGTCAACAACGGCTGGGAGGTGGCCTCGCGACAGCTCTATCACGAGCGTCGCGCGGTCGGCGGCGGCTCCGA
GTTCGCCAGCGGCATCGGGCCGGAGGGCGTCTCGGATCAGCCTGTCGACTACGTCGCCCTGTTGGCCGCCACCGGCCAGT
CCGACAACGAACGCGTGCGCGAGATGGCCGGGCGGGCGCTGGTCCGGCGCAAGGTGCAGGAACAGCTGATCGACCACGTC
TACCACGGGGTGCTCGACGGGAGCCTGCCGCCGGCGGCCGGATCGATCATCCGCATCACCCACGCCGAGTCGATCCAGTT
CGAACTCGATGCGGCGCTGTCGATCTCGGGGAGTTCGGGAGTGGTCGACGGCGGGGACGGTCTGGCCCAGTTCGGCGACC
GCTACCTGTCGCGGCAGGCCGCGTCGCTGGGTGGCGGCACCACCGAGATCGCCCGCAACATCATCGGCGAACGCGTCCTG
GGCTTCCCCAGGGAACCCGCGGCCGACCGCGGCGTGCCGTTCAAGGACGTCAAGCGCAACAAAGCCTGA

Upstream 100 bases:

>100_bases
CGACGCTGTACCGGTCCCTGTACGGCACACCCGAGGACCACAATCTGCGCGTCTATGCCCTCGCCGAAGAGGCCGCCACC
GACGAGTTGGAGCCCGCCTG

Downstream 100 bases:

>100_bases
CCGCCCGTCAGAACAGCGTGGGCTGCACCGGTCCCGCCGCGGCGGGTACCGAGCCGACGAGCGGCTCGGTGCGGCGCGGA
CCACCGGCCAGCCCGTGCCG

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MTETSTRSQSAPAEAAESVEEFQARARAWLADNMPRIDPDNPPDADRGEEGPWLRARELQKKLYAGGFAGICFPKEYGGL
GLPIAYQRAFDQESKAYELPIILNTPTFTICAATILDTGDEAQKQQHIGGAIRGDEILVQLLSEPSGGSDLAGVITRADR
RGDKWVINGAKTWSTSAFAADYGLLLARTDWDVPKHEGLTMFLMPLDAPGITMRRIKQVDGGNEFCEEFFDDLELGDDAV
VGEVNNGWEVASRQLYHERRAVGGGSEFASGIGPEGVSDQPVDYVALLAATGQSDNERVREMAGRALVRRKVQEQLIDHV
YHGVLDGSLPPAAGSIIRITHAESIQFELDAALSISGSSGVVDGGDGLAQFGDRYLSRQAASLGGGTTEIARNIIGERVL
GFPREPAADRGVPFKDVKRNKA

Sequences:

>Translated_422_residues
MTETSTRSQSAPAEAAESVEEFQARARAWLADNMPRIDPDNPPDADRGEEGPWLRARELQKKLYAGGFAGICFPKEYGGL
GLPIAYQRAFDQESKAYELPIILNTPTFTICAATILDTGDEAQKQQHIGGAIRGDEILVQLLSEPSGGSDLAGVITRADR
RGDKWVINGAKTWSTSAFAADYGLLLARTDWDVPKHEGLTMFLMPLDAPGITMRRIKQVDGGNEFCEEFFDDLELGDDAV
VGEVNNGWEVASRQLYHERRAVGGGSEFASGIGPEGVSDQPVDYVALLAATGQSDNERVREMAGRALVRRKVQEQLIDHV
YHGVLDGSLPPAAGSIIRITHAESIQFELDAALSISGSSGVVDGGDGLAQFGDRYLSRQAASLGGGTTEIARNIIGERVL
GFPREPAADRGVPFKDVKRNKA
>Mature_421_residues
TETSTRSQSAPAEAAESVEEFQARARAWLADNMPRIDPDNPPDADRGEEGPWLRARELQKKLYAGGFAGICFPKEYGGLG
LPIAYQRAFDQESKAYELPIILNTPTFTICAATILDTGDEAQKQQHIGGAIRGDEILVQLLSEPSGGSDLAGVITRADRR
GDKWVINGAKTWSTSAFAADYGLLLARTDWDVPKHEGLTMFLMPLDAPGITMRRIKQVDGGNEFCEEFFDDLELGDDAVV
GEVNNGWEVASRQLYHERRAVGGGSEFASGIGPEGVSDQPVDYVALLAATGQSDNERVREMAGRALVRRKVQEQLIDHVY
HGVLDGSLPPAAGSIIRITHAESIQFELDAALSISGSSGVVDGGDGLAQFGDRYLSRQAASLGGGTTEIARNIIGERVLG
FPREPAADRGVPFKDVKRNKA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=394, Percent_Identity=26.1421319796954, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI226958414, Length=351, Percent_Identity=26.7806267806268, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI4557233, Length=227, Percent_Identity=31.2775330396476, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI187960098, Length=260, Percent_Identity=27.3076923076923, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI4557231, Length=260, Percent_Identity=27.3076923076923, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI21361497, Length=253, Percent_Identity=28.4584980237154, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI4501857, Length=246, Percent_Identity=26.8292682926829, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI4501859, Length=192, Percent_Identity=27.0833333333333, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI4557235, Length=231, Percent_Identity=28.1385281385281, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI76496475, Length=231, Percent_Identity=28.1385281385281, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1786223, Length=356, Percent_Identity=24.7191011235955, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081958, Length=353, Percent_Identity=23.5127478753541, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538396, Length=395, Percent_Identity=27.5949367088608, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17534899, Length=257, Percent_Identity=30.3501945525292, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17570075, Length=261, Percent_Identity=30.6513409961686, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17569725, Length=411, Percent_Identity=25.3041362530414, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17505929, Length=256, Percent_Identity=25.78125, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17506239, Length=231, Percent_Identity=27.7056277056277, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17508101, Length=231, Percent_Identity=28.1385281385281, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32563615, Length=251, Percent_Identity=27.0916334661355, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17551932, Length=224, Percent_Identity=24.5535714285714, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356377, Length=246, Percent_Identity=28.4552845528455, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24646207, Length=366, Percent_Identity=27.0491803278689, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24660351, Length=227, Percent_Identity=28.1938325991189, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21355753, Length=354, Percent_Identity=25.1412429378531, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 45543; Mature: 45412

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETSTRSQSAPAEAAESVEEFQARARAWLADNMPRIDPDNPPDADRGEEGPWLRARELQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
KKLYAGGFAGICFPKEYGGLGLPIAYQRAFDQESKAYELPIILNTPTFTICAATILDTGD
HHHHCCCCCEEECCHHCCCCCCCHHHHHHHCCCCCEEECCEEECCCCHHHHHHHHHCCCH
EAQKQQHIGGAIRGDEILVQLLSEPSGGSDLAGVITRADRRGDKWVINGAKTWSTSAFAA
HHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCHHHH
DYGLLLARTDWDVPKHEGLTMFLMPLDAPGITMRRIKQVDGGNEFCEEFFDDLELGDDAV
CCCEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCE
VGEVNNGWEVASRQLYHERRAVGGGSEFASGIGPEGVSDQPVDYVALLAATGQSDNERVR
EECCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHH
EMAGRALVRRKVQEQLIDHVYHGVLDGSLPPAAGSIIRITHAESIQFELDAALSISGSSG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEEEEEEEECCCCC
VVDGGDGLAQFGDRYLSRQAASLGGGTTEIARNIIGERVLGFPREPAADRGVPFKDVKRN
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCC
KA
CC
>Mature Secondary Structure 
TETSTRSQSAPAEAAESVEEFQARARAWLADNMPRIDPDNPPDADRGEEGPWLRARELQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
KKLYAGGFAGICFPKEYGGLGLPIAYQRAFDQESKAYELPIILNTPTFTICAATILDTGD
HHHHCCCCCEEECCHHCCCCCCCHHHHHHHCCCCCEEECCEEECCCCHHHHHHHHHCCCH
EAQKQQHIGGAIRGDEILVQLLSEPSGGSDLAGVITRADRRGDKWVINGAKTWSTSAFAA
HHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCHHHH
DYGLLLARTDWDVPKHEGLTMFLMPLDAPGITMRRIKQVDGGNEFCEEFFDDLELGDDAV
CCCEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCE
VGEVNNGWEVASRQLYHERRAVGGGSEFASGIGPEGVSDQPVDYVALLAATGQSDNERVR
EECCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHH
EMAGRALVRRKVQEQLIDHVYHGVLDGSLPPAAGSIIRITHAESIQFELDAALSISGSSG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEEEEEEEECCCCC
VVDGGDGLAQFGDRYLSRQAASLGGGTTEIARNIIGERVLGFPREPAADRGVPFKDVKRN
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCC
KA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]