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The map label for this gene is nuoD

Identifier: 119867647

GI number: 119867647

Start: 1719789

End: 1721129

Strand: Reverse

Name: nuoD

Synonym: Mkms_1601

Alternate gene names: 119867647

Gene position: 1721129-1719789 (Counterclockwise)

Preceding gene: 119867648

Following gene: 119867646

Centisome position: 30.0

GC content: 66.96

Gene sequence:

>1341_bases
ATGACCACTCCCCCCGGCCCGCCCAACGCGGGCGGTGACGCGCGCACCGGCACCGACACGGTGATCGTCGTCGGCGGTGA
GGACTGGGAGCAGGTCGTCGCCGCCGCCGAACAGGCGCAGGCCGGTGAGCGCATCGTCGTGAACATGGGACCGCAGCACC
CCTCGACACACGGCGTGCTGCGGTTGATCCTCGAGATCGAGGGCGAGACGATCACCGAAGCCCGTTGCGGTATCGGCTAT
CTGCATACCGGCATCGAGAAGAACCTGGAGTACCGGAACTGGACGCAGGGCGTCACCTTCGTCACCCGGATGGACTACCT
GTCGCCGTTCTTCAACGAGACCGCCTACTGCCTGGGTGTGGAGAAACTGCTCGGCGTCACCGACGCGATCCCGGAGCGCG
TCAACGTGATCCGGGTGATGTTGATGGAACTCAACCGGATCTCCTCGCATCTGGTCGCACTGGCGACCGGCGGGATGGAA
CTCGGGGCGATGAGCGCGATGTTCTACGGCTTCCGGGAGCGCGAGGAGATCCTGTCGGTGTTCGAGATGATCACCGGGTT
GCGGATGAACCACGCGTACATCCGGCCCGGCGGGCTGGCCGCCGACCTGCCCGACGGTGCGGTCCCCCGCATCCGCGAAC
TGCTCGCGCTGCTCCCCGGGCGGCTGCGCGACCTGGAGAACCTGCTCAACGAGAACTACATCTGGAAGGCCCGCACGCAG
GGCATCGGCTACCTCGACCTGGCCGGCTGCATGGCACTCGGCATCACGGGCCCGGTGCTGCGCTCGACCGGGCTGCCGCA
CGATCTGCGCCGGGCCCAACCGTACTGCGGTTACGAGGACTACGAATTCGACGTGATCACCGACGACGGCTGCGACGCCT
ACGGCCGCTACCTCATCCGGGTGAAGGAGATGCGTGAATCGCTCAAGATCGTCGAACAGTGTGTGGACCGATTGAAGCCC
GGACCGGTGATGATCGCGGACAAGAAGCTCGCCTGGCCGGCCGACCTCGAACTGGGACCCGACGGCCTCGGCAACTCCCC
CGCCCACATCGCCCGCATCATGGGGCAGTCGATGGAGGGCCTGATCCACCACTTCAAGCTGGTGACCGAGGGTATCCGGG
TGCCGGCCGGACAGGTGTACACGGCCGTGGAGTCGCCACGCGGCGAACTGGGGGTGCACATGGTCTCCGACGGTGGAACC
CGGCCCTACCGCGTCCACTACCGCGACCCGTCGTTCACGAATCTGCAAGCGGTGGCGGCGATGTGCGAGGGCGGGATGGT
CGCCGACGCCATCTCGGCGGTCGCGTCGATCGACCCGGTCATGGGCGGGGTGGATAGGTGA

Upstream 100 bases:

>100_bases
TCGGGCATCCACAGCGCAAGGACTACCCGCTGGGCGGCATCCCCGTCGAGTACCACGGCGCCCGGATACCACCGCCCGAC
GAGCGGAGGGCCTACAACTG

Downstream 100 bases:

>100_bases
TGAGCGCTTGCGCGAAGAAGAGACGGCCGTGAGCGTCTTCCTGGAACTCGGCCAGCGGCCGGACGAACCGGGACCGCCGG
TCGGCGGCCCCACCGCCTAC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MTTPPGPPNAGGDARTGTDTVIVVGGEDWEQVVAAAEQAQAGERIVVNMGPQHPSTHGVLRLILEIEGETITEARCGIGY
LHTGIEKNLEYRNWTQGVTFVTRMDYLSPFFNETAYCLGVEKLLGVTDAIPERVNVIRVMLMELNRISSHLVALATGGME
LGAMSAMFYGFREREEILSVFEMITGLRMNHAYIRPGGLAADLPDGAVPRIRELLALLPGRLRDLENLLNENYIWKARTQ
GIGYLDLAGCMALGITGPVLRSTGLPHDLRRAQPYCGYEDYEFDVITDDGCDAYGRYLIRVKEMRESLKIVEQCVDRLKP
GPVMIADKKLAWPADLELGPDGLGNSPAHIARIMGQSMEGLIHHFKLVTEGIRVPAGQVYTAVESPRGELGVHMVSDGGT
RPYRVHYRDPSFTNLQAVAAMCEGGMVADAISAVASIDPVMGGVDR

Sequences:

>Translated_446_residues
MTTPPGPPNAGGDARTGTDTVIVVGGEDWEQVVAAAEQAQAGERIVVNMGPQHPSTHGVLRLILEIEGETITEARCGIGY
LHTGIEKNLEYRNWTQGVTFVTRMDYLSPFFNETAYCLGVEKLLGVTDAIPERVNVIRVMLMELNRISSHLVALATGGME
LGAMSAMFYGFREREEILSVFEMITGLRMNHAYIRPGGLAADLPDGAVPRIRELLALLPGRLRDLENLLNENYIWKARTQ
GIGYLDLAGCMALGITGPVLRSTGLPHDLRRAQPYCGYEDYEFDVITDDGCDAYGRYLIRVKEMRESLKIVEQCVDRLKP
GPVMIADKKLAWPADLELGPDGLGNSPAHIARIMGQSMEGLIHHFKLVTEGIRVPAGQVYTAVESPRGELGVHMVSDGGT
RPYRVHYRDPSFTNLQAVAAMCEGGMVADAISAVASIDPVMGGVDR
>Mature_445_residues
TTPPGPPNAGGDARTGTDTVIVVGGEDWEQVVAAAEQAQAGERIVVNMGPQHPSTHGVLRLILEIEGETITEARCGIGYL
HTGIEKNLEYRNWTQGVTFVTRMDYLSPFFNETAYCLGVEKLLGVTDAIPERVNVIRVMLMELNRISSHLVALATGGMEL
GAMSAMFYGFREREEILSVFEMITGLRMNHAYIRPGGLAADLPDGAVPRIRELLALLPGRLRDLENLLNENYIWKARTQG
IGYLDLAGCMALGITGPVLRSTGLPHDLRRAQPYCGYEDYEFDVITDDGCDAYGRYLIRVKEMRESLKIVEQCVDRLKPG
PVMIADKKLAWPADLELGPDGLGNSPAHIARIMGQSMEGLIHHFKLVTEGIRVPAGQVYTAVESPRGELGVHMVSDGGTR
PYRVHYRDPSFTNLQAVAAMCEGGMVADAISAVASIDPVMGGVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=404, Percent_Identity=42.8217821782178, Blast_Score=332, Evalue=5e-91,
Organism=Homo sapiens, GI260898743, Length=394, Percent_Identity=42.3857868020305, Blast_Score=322, Evalue=3e-88,
Organism=Escherichia coli, GI145693162, Length=403, Percent_Identity=40.1985111662531, Blast_Score=297, Evalue=9e-82,
Organism=Escherichia coli, GI1789076, Length=430, Percent_Identity=27.4418604651163, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1788832, Length=403, Percent_Identity=26.302729528536, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17568379, Length=404, Percent_Identity=41.5841584158416, Blast_Score=348, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI17555284, Length=404, Percent_Identity=41.0891089108911, Blast_Score=346, Evalue=1e-95,
Organism=Drosophila melanogaster, GI221459469, Length=401, Percent_Identity=41.3965087281795, Blast_Score=348, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24638644, Length=418, Percent_Identity=40.4306220095694, Blast_Score=344, Evalue=9e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_MYCSJ (A3PWR8)

Other databases:

- EMBL:   CP000580
- RefSeq:   YP_001069836.1
- ProteinModelPortal:   A3PWR8
- SMR:   A3PWR8
- STRING:   A3PWR8
- EnsemblBacteria:   EBMYCT00000051574
- GeneID:   4877279
- GenomeReviews:   CP000580_GR
- KEGG:   mjl:Mjls_1547
- eggNOG:   COG0649
- GeneTree:   EBGT00050000016726
- HOGENOM:   HBG459705
- OMA:   LRMNHAF
- PhylomeDB:   A3PWR8
- ProtClustDB:   PRK06075
- BioCyc:   MSP164757:MJLS_1547-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 48694; Mature: 48562

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPPGPPNAGGDARTGTDTVIVVGGEDWEQVVAAAEQAQAGERIVVNMGPQHPSTHGVL
CCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHE
RLILEIEGETITEARCGIGYLHTGIEKNLEYRNWTQGVTFVTRMDYLSPFFNETAYCLGV
EEEEEECCCEEHHHHCCCHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHCCHHHHEEH
EKLLGVTDAIPERVNVIRVMLMELNRISSHLVALATGGMELGAMSAMFYGFREREEILSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
FEMITGLRMNHAYIRPGGLAADLPDGAVPRIRELLALLPGRLRDLENLLNENYIWKARTQ
HHHHHCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCC
GIGYLDLAGCMALGITGPVLRSTGLPHDLRRAQPYCGYEDYEFDVITDDGCDAYGRYLIR
CCCCHHHHHHHHHCCCCHHHHHCCCCHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHH
VKEMRESLKIVEQCVDRLKPGPVMIADKKLAWPADLELGPDGLGNSPAHIARIMGQSMEG
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LIHHFKLVTEGIRVPAGQVYTAVESPRGELGVHMVSDGGTRPYRVHYRDPSFTNLQAVAA
HHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEECCCCCCCEEEEECCCCCCHHHHHHH
MCEGGMVADAISAVASIDPVMGGVDR
HHCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TTPPGPPNAGGDARTGTDTVIVVGGEDWEQVVAAAEQAQAGERIVVNMGPQHPSTHGVL
CCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHE
RLILEIEGETITEARCGIGYLHTGIEKNLEYRNWTQGVTFVTRMDYLSPFFNETAYCLGV
EEEEEECCCEEHHHHCCCHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHCCHHHHEEH
EKLLGVTDAIPERVNVIRVMLMELNRISSHLVALATGGMELGAMSAMFYGFREREEILSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
FEMITGLRMNHAYIRPGGLAADLPDGAVPRIRELLALLPGRLRDLENLLNENYIWKARTQ
HHHHHCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCC
GIGYLDLAGCMALGITGPVLRSTGLPHDLRRAQPYCGYEDYEFDVITDDGCDAYGRYLIR
CCCCHHHHHHHHHCCCCHHHHHCCCCHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHH
VKEMRESLKIVEQCVDRLKPGPVMIADKKLAWPADLELGPDGLGNSPAHIARIMGQSMEG
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LIHHFKLVTEGIRVPAGQVYTAVESPRGELGVHMVSDGGTRPYRVHYRDPSFTNLQAVAA
HHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEECCCCCCCEEEEECCCCCCHHHHHHH
MCEGGMVADAISAVASIDPVMGGVDR
HHCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA