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The map label for this gene is gutB [H]

Identifier: 119855239

GI number: 119855239

Start: 60749

End: 61780

Strand: Reverse

Name: gutB [H]

Synonym: Mkms_5853

Alternate gene names: 119855239

Gene position: 61780-60749 (Counterclockwise)

Preceding gene: 119855240

Following gene: 119855238

Centisome position: 28.5

GC content: 62.69

Gene sequence:

>1032_bases
GTGCGCGCAGCTATTTATCACGGCCGCGAAGACGTGCGGATTGAAGAGCTTCCCGACCCGAGTCCACGTGCGGGCGAAGT
GGTCATCGAGGTGGCCCGAGCGGGGATCTGCGGCACAGACCTGCATGAGTACATCGCCGGTCCGATGCATGCTGCGCCAG
GGGTCGTCATTGGACACGAATATTCCGGGACGGTGGTCGGCGTCGGGTCCGGCGTGCGCGAGTTCACCGAAGGTGACCGA
GTCTGCGGCGTCGGCGTTTTCGGCTGCGGTGAATGCGGCTTCTGCAAACAGGGCGCTGAAGCACTCTGCGGAGCAGTCGG
TTTCATCGGCTTCGCTGTCAACGGAGCGCTTGCCCGCTACGCGTCGTTGCCGACGAAGGCGTTGTTTCGCATCCCGGATG
AGATCAGTCTCGCCGAGGCTGCCGTCGTTGAACCGATCGCGTCGGCGTACCACGCTGTCCGCCGTAGCGGGTTGGCAGCG
GGTGGGACCGTCTTCATCGCCGGCGCTGGCCCGATCGGCCTCGCCCTGGTGCAGTTCTCACTTGCCAAAGGTGCGACTCA
GGTCATCGTCAATGAGGTTTCGGCGACGCGCCGCGTTGCCGCTCACCGGGTCGGGGCTACGCGCGTAATCGATCCTCTGG
CGGAGGATGCAGTTGAGGTGGTTCGGACGTTGACGAACGGAAACGGCGTCGACATCTCCTTCGACGCTGCGGGCGTACAA
CCCGCGCTTGATGCGGCGCTGGGCGTTCTGCGCCCCCGCGGTCGATTGATGGTCGTGGCGATTTGGGAGGCCCCGGCCGG
TATCGACATCAATCGAAGCGTCATGCGCGAAGCAGATATTGGCTTCTCATTTTGTTACGAAGCGCAAAGGCAGGTCCCGG
CGATTCTTGACTTACTAGCTACGGGGGCGATCAACCTCGGTGAACTCATCACCGACGAGATCCCGTTGGATGCCGTGGTC
AGTCAGGGTCTCGAGGAACTGCGCGTCAACCGCGATGCACACGTAAAAATTCTGATCGACCCATCGGCATAG

Upstream 100 bases:

>100_bases
GGTGAGCTTGACATCATTACGGCGGCGCCTCCGCCGAAACTCCGGCCCACGAACGTTGTGGCCGAGCGAATTTGGGTCTG
TCCTTAAGGTAGGCCGGTAG

Downstream 100 bases:

>100_bases
CACGACCGGTATCGCGCCGTCGATTGTCACGCCGCCCCACCAAAGGAGTTAAGTGTCCGCGAATATGGAGAGTCTGTTCG
ACGGTCTGACGATCCTCGAG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Glucitol dehydrogenase; L-iditol 2-dehydrogenase [H]

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MRAAIYHGREDVRIEELPDPSPRAGEVVIEVARAGICGTDLHEYIAGPMHAAPGVVIGHEYSGTVVGVGSGVREFTEGDR
VCGVGVFGCGECGFCKQGAEALCGAVGFIGFAVNGALARYASLPTKALFRIPDEISLAEAAVVEPIASAYHAVRRSGLAA
GGTVFIAGAGPIGLALVQFSLAKGATQVIVNEVSATRRVAAHRVGATRVIDPLAEDAVEVVRTLTNGNGVDISFDAAGVQ
PALDAALGVLRPRGRLMVVAIWEAPAGIDINRSVMREADIGFSFCYEAQRQVPAILDLLATGAINLGELITDEIPLDAVV
SQGLEELRVNRDAHVKILIDPSA

Sequences:

>Translated_343_residues
MRAAIYHGREDVRIEELPDPSPRAGEVVIEVARAGICGTDLHEYIAGPMHAAPGVVIGHEYSGTVVGVGSGVREFTEGDR
VCGVGVFGCGECGFCKQGAEALCGAVGFIGFAVNGALARYASLPTKALFRIPDEISLAEAAVVEPIASAYHAVRRSGLAA
GGTVFIAGAGPIGLALVQFSLAKGATQVIVNEVSATRRVAAHRVGATRVIDPLAEDAVEVVRTLTNGNGVDISFDAAGVQ
PALDAALGVLRPRGRLMVVAIWEAPAGIDINRSVMREADIGFSFCYEAQRQVPAILDLLATGAINLGELITDEIPLDAVV
SQGLEELRVNRDAHVKILIDPSA
>Mature_343_residues
MRAAIYHGREDVRIEELPDPSPRAGEVVIEVARAGICGTDLHEYIAGPMHAAPGVVIGHEYSGTVVGVGSGVREFTEGDR
VCGVGVFGCGECGFCKQGAEALCGAVGFIGFAVNGALARYASLPTKALFRIPDEISLAEAAVVEPIASAYHAVRRSGLAA
GGTVFIAGAGPIGLALVQFSLAKGATQVIVNEVSATRRVAAHRVGATRVIDPLAEDAVEVVRTLTNGNGVDISFDAAGVQ
PALDAALGVLRPRGRLMVVAIWEAPAGIDINRSVMREADIGFSFCYEAQRQVPAILDLLATGAINLGELITDEIPLDAVV
SQGLEELRVNRDAHVKILIDPSA

Specific function: Reduces glucitol to fructose [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=346, Percent_Identity=29.7687861271676, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI4501933, Length=358, Percent_Identity=25.4189944134078, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI4501929, Length=358, Percent_Identity=24.5810055865922, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI34577061, Length=358, Percent_Identity=24.8603351955307, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI156523966, Length=354, Percent_Identity=24.8587570621469, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4501939, Length=346, Percent_Identity=25.1445086705202, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI262073058, Length=354, Percent_Identity=24.8587570621469, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI71743840, Length=354, Percent_Identity=24.8587570621469, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI71565154, Length=270, Percent_Identity=27.7777777777778, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1788073, Length=329, Percent_Identity=32.5227963525836, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI1790045, Length=336, Percent_Identity=29.4642857142857, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI1788075, Length=338, Percent_Identity=29.8816568047337, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI226510992, Length=245, Percent_Identity=31.8367346938775, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1787863, Length=326, Percent_Identity=30.3680981595092, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788407, Length=234, Percent_Identity=29.9145299145299, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1790718, Length=324, Percent_Identity=28.7037037037037, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786825, Length=396, Percent_Identity=26.5151515151515, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082125, Length=275, Percent_Identity=29.8181818181818, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI87081918, Length=277, Percent_Identity=28.8808664259928, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1786552, Length=340, Percent_Identity=30, Blast_Score=85, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17562876, Length=319, Percent_Identity=30.7210031347962, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17562878, Length=349, Percent_Identity=28.6532951289398, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71988145, Length=306, Percent_Identity=28.4313725490196, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562584, Length=261, Percent_Identity=28.735632183908, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562582, Length=268, Percent_Identity=29.8507462686567, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI25146526, Length=354, Percent_Identity=25.4237288135593, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=356, Percent_Identity=25.2808988764045, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17565904, Length=205, Percent_Identity=28.2926829268293, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319258, Length=380, Percent_Identity=30, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6319257, Length=382, Percent_Identity=30.1047120418848, Blast_Score=162, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6319955, Length=322, Percent_Identity=30.7453416149068, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322619, Length=322, Percent_Identity=30.7453416149068, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323099, Length=343, Percent_Identity=25.9475218658892, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319621, Length=316, Percent_Identity=27.5316455696203, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=361, Percent_Identity=24.6537396121884, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=281, Percent_Identity=28.8256227758007, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=346, Percent_Identity=26.878612716763, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=281, Percent_Identity=28.8256227758007, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17737897, Length=347, Percent_Identity=31.700288184438, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17137530, Length=347, Percent_Identity=30.835734870317, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI17737895, Length=351, Percent_Identity=26.2108262108262, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221457811, Length=180, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45550770, Length=180, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45551930, Length=180, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.14 [H]

Molecular weight: Translated: 35651; Mature: 35651

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAAIYHGREDVRIEELPDPSPRAGEVVIEVARAGICGTDLHEYIAGPMHAAPGVVIGHE
CCCCEECCCCCCEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEECC
YSGTVVGVGSGVREFTEGDRVCGVGVFGCGECGFCKQGAEALCGAVGFIGFAVNGALARY
CCCEEEECCCCHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ASLPTKALFRIPDEISLAEAAVVEPIASAYHAVRRSGLAAGGTVFIAGAGPIGLALVQFS
HCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHH
LAKGATQVIVNEVSATRRVAAHRVGATRVIDPLAEDAVEVVRTLTNGNGVDISFDAAGVQ
HHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
PALDAALGVLRPRGRLMVVAIWEAPAGIDINRSVMREADIGFSFCYEAQRQVPAILDLLA
HHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
TGAINLGELITDEIPLDAVVSQGLEELRVNRDAHVKILIDPSA
HCCCCHHHHHHCCCCHHHHHHHCHHHHHCCCCCEEEEEECCCC
>Mature Secondary Structure
MRAAIYHGREDVRIEELPDPSPRAGEVVIEVARAGICGTDLHEYIAGPMHAAPGVVIGHE
CCCCEECCCCCCEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEECC
YSGTVVGVGSGVREFTEGDRVCGVGVFGCGECGFCKQGAEALCGAVGFIGFAVNGALARY
CCCEEEECCCCHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ASLPTKALFRIPDEISLAEAAVVEPIASAYHAVRRSGLAAGGTVFIAGAGPIGLALVQFS
HCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHH
LAKGATQVIVNEVSATRRVAAHRVGATRVIDPLAEDAVEVVRTLTNGNGVDISFDAAGVQ
HHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
PALDAALGVLRPRGRLMVVAIWEAPAGIDINRSVMREADIGFSFCYEAQRQVPAILDLLA
HHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
TGAINLGELITDEIPLDAVVSQGLEELRVNRDAHVKILIDPSA
HCCCCHHHHHHCCCCHHHHHHHCHHHHHCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1460002; 9384377; 8195086 [H]