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The map label for this gene is gabT [H]

Identifier: 119776738

GI number: 119776738

Start: 4243116

End: 4244534

Strand: Direct

Name: gabT [H]

Synonym: Sama_3606

Alternate gene names: 119776738

Gene position: 4243116-4244534 (Clockwise)

Preceding gene: 119776735

Following gene: 119776751

Centisome position: 98.54

GC content: 51.16

Gene sequence:

>1419_bases
ATGATGAATTCGATAATGAAAATGAACTATAAGCTCCCGGGCCCGAAATCAAAGGCGATGCTGGAGCGGGGCATTCCCTT
GTTCCGCAACGGGTTACGTTATGAAGAAGAGTGTAAGAAAGCGGCACGCCGTGGCTATAGAGGGGCAAGCCAGGTTGTGG
TGGGCCGCGCTCAGGGCAGCTTCGTGTGGGACCTGGATGACAACCAGTACATCGATTTTCAAAACGGTTGGGCATCCAAT
CCCTTTGGTAATGCGCACCCTGAAATTGTCGAGGCAGTACATTGGGCCCATACACGTTATGGCTTTCACTATGACACGCC
TCATCGTTATGAATTGGCCGAAAAGCTCGTGCAAATCATGCCAAATAGGGCGTTAACAAGAATTAACTTTGAAATCTCAG
GTACTGAGGCGGCAGAGGCCGCAGTTAATTTAGCCCTCACCCACACCAAACGCCGTTATATTATTTCCTTTAGCTCAAGT
TTCCATGGCGAAGCTCTGGGGTCAAAAATGCTCTCGGGCACCAGTAATAACAATCACTACATGGAAGCCTGGTCCGGCGG
GGTGATCACAGCGCCTTATCCCTATAGTGGTGAAATTCCCGCAGGCATGACCCAGGAGCAATATGTCGAGTATTGCCTTT
GGTACATCGACAACCACATAACCAGCAGCATTGTACCGGCAAATAACATTGCCGGACTCATCATTGAACCCGGCTTAGCC
GAAGGCGGGAACTGGATCCCACCCAAGCGATTTATGCAGGGCTTGCGTGAGTTATGCAATAAACACGACTGGGTCATGAT
AGTGGATGAAGTGCTGACCGGCCTGGGGCGCACTGGCAAAATGTGGGCCATAGAGCACTACGATGTGATCCCGGATGTTT
TGGTGTTTGGCAAAAATATTTCCGGAGGGATTGAGCCTTGTGCCGGCATCGCCGCCCGAGATGAAATAATGGGAGACAAT
GAGCATTATCATACTGGCTCAACCTATGCCGGCTCACCGGCCGCTTGCTGTGCCGGGCTTAAAACGCTGGAGCTGTATGA
GCGGGAAAACATCGTGGAATACGTGGCGTACCTTGGCGAGATTGCAAAAGGGATCATGCAGAAATGGACCCGCTACAGCA
TAGTGAATGAAGTACGCTGCAACGGTTTATTACTCGGTGTCAATTTTGTCAGCCCGGATGAACATCAAAAAGATTGGTGG
TTTGCCCGTGAAGTACGCAGCCGCATGATGGAAAACGGCGTTTGGGCCATCAATGATCGCCAAACCAATGTTCGCTTGTA
CCCGGCATTAAACATGGAAGAATCGGTATTACGCGAAGGCCTGGCCATTATGGAAGAGGCCATTGCCCATGTGGATAGCA
TCAGGCAATCCTCGTTTGGGGACAGTCCCGCCTGGCCCACTGGTGACGCCGGCTTTTAG

Upstream 100 bases:

>100_bases
GACTATATTTGACTAAAACTCAAACGAGCTTGGATATCAAATCAATTTTTATCTTGTTATCAACTTCATATATTGAAAGC
ACACACGGTTAAGAGGCTTC

Downstream 100 bases:

>100_bases
CAAGCATGGCGCACGAATAACTGACTCCTCTTCGCGCCGGCGACTGAGTGCAGGTGTAGTAGCCACCGCTTTATGCCAGA
CAATTCTGAACACATTGTGA

Product: aminotransferase, class III; 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MMNSIMKMNYKLPGPKSKAMLERGIPLFRNGLRYEEECKKAARRGYRGASQVVVGRAQGSFVWDLDDNQYIDFQNGWASN
PFGNAHPEIVEAVHWAHTRYGFHYDTPHRYELAEKLVQIMPNRALTRINFEISGTEAAEAAVNLALTHTKRRYIISFSSS
FHGEALGSKMLSGTSNNNHYMEAWSGGVITAPYPYSGEIPAGMTQEQYVEYCLWYIDNHITSSIVPANNIAGLIIEPGLA
EGGNWIPPKRFMQGLRELCNKHDWVMIVDEVLTGLGRTGKMWAIEHYDVIPDVLVFGKNISGGIEPCAGIAARDEIMGDN
EHYHTGSTYAGSPAACCAGLKTLELYERENIVEYVAYLGEIAKGIMQKWTRYSIVNEVRCNGLLLGVNFVSPDEHQKDWW
FAREVRSRMMENGVWAINDRQTNVRLYPALNMEESVLREGLAIMEEAIAHVDSIRQSSFGDSPAWPTGDAGF

Sequences:

>Translated_472_residues
MMNSIMKMNYKLPGPKSKAMLERGIPLFRNGLRYEEECKKAARRGYRGASQVVVGRAQGSFVWDLDDNQYIDFQNGWASN
PFGNAHPEIVEAVHWAHTRYGFHYDTPHRYELAEKLVQIMPNRALTRINFEISGTEAAEAAVNLALTHTKRRYIISFSSS
FHGEALGSKMLSGTSNNNHYMEAWSGGVITAPYPYSGEIPAGMTQEQYVEYCLWYIDNHITSSIVPANNIAGLIIEPGLA
EGGNWIPPKRFMQGLRELCNKHDWVMIVDEVLTGLGRTGKMWAIEHYDVIPDVLVFGKNISGGIEPCAGIAARDEIMGDN
EHYHTGSTYAGSPAACCAGLKTLELYERENIVEYVAYLGEIAKGIMQKWTRYSIVNEVRCNGLLLGVNFVSPDEHQKDWW
FAREVRSRMMENGVWAINDRQTNVRLYPALNMEESVLREGLAIMEEAIAHVDSIRQSSFGDSPAWPTGDAGF
>Mature_472_residues
MMNSIMKMNYKLPGPKSKAMLERGIPLFRNGLRYEEECKKAARRGYRGASQVVVGRAQGSFVWDLDDNQYIDFQNGWASN
PFGNAHPEIVEAVHWAHTRYGFHYDTPHRYELAEKLVQIMPNRALTRINFEISGTEAAEAAVNLALTHTKRRYIISFSSS
FHGEALGSKMLSGTSNNNHYMEAWSGGVITAPYPYSGEIPAGMTQEQYVEYCLWYIDNHITSSIVPANNIAGLIIEPGLA
EGGNWIPPKRFMQGLRELCNKHDWVMIVDEVLTGLGRTGKMWAIEHYDVIPDVLVFGKNISGGIEPCAGIAARDEIMGDN
EHYHTGSTYAGSPAACCAGLKTLELYERENIVEYVAYLGEIAKGIMQKWTRYSIVNEVRCNGLLLGVNFVSPDEHQKDWW
FAREVRSRMMENGVWAINDRQTNVRLYPALNMEESVLREGLAIMEEAIAHVDSIRQSSFGDSPAWPTGDAGF

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=410, Percent_Identity=28.0487804878049, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI284507298, Length=220, Percent_Identity=34.5454545454545, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI24119277, Length=387, Percent_Identity=27.390180878553, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI13994255, Length=368, Percent_Identity=29.0760869565217, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI37574042, Length=362, Percent_Identity=26.7955801104972, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI226442705, Length=358, Percent_Identity=25.9776536312849, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI188536080, Length=428, Percent_Identity=23.3644859813084, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI38679950, Length=428, Percent_Identity=23.3644859813084, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI38679946, Length=428, Percent_Identity=23.3644859813084, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI226442709, Length=326, Percent_Identity=26.9938650306748, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1789016, Length=417, Percent_Identity=30.6954436450839, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1787560, Length=405, Percent_Identity=30.1234567901235, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1788044, Length=417, Percent_Identity=32.6139088729017, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI145693181, Length=383, Percent_Identity=30.0261096605744, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1789759, Length=408, Percent_Identity=28.1862745098039, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1786349, Length=354, Percent_Identity=28.5310734463277, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1786991, Length=299, Percent_Identity=25.752508361204, Blast_Score=96, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI25144271, Length=404, Percent_Identity=26.7326732673267, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI25144274, Length=220, Percent_Identity=30.9090909090909, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI71992977, Length=421, Percent_Identity=24.9406175771971, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI32564660, Length=386, Percent_Identity=26.6839378238342, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17541228, Length=429, Percent_Identity=25.4079254079254, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324432, Length=435, Percent_Identity=28.735632183908, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323470, Length=415, Percent_Identity=26.2650602409639, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321456, Length=357, Percent_Identity=24.9299719887955, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324386, Length=338, Percent_Identity=23.0769230769231, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357415, Length=411, Percent_Identity=27.9805352798054, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI161085790, Length=367, Percent_Identity=25.6130790190736, Blast_Score=115, Evalue=9e-26,
Organism=Drosophila melanogaster, GI28574759, Length=369, Percent_Identity=25.4742547425474, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21356575, Length=387, Percent_Identity=26.6149870801034, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI281366494, Length=426, Percent_Identity=24.8826291079812, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24667139, Length=426, Percent_Identity=24.8826291079812, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24667143, Length=426, Percent_Identity=24.8826291079812, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 53020; Mature: 53020

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNSIMKMNYKLPGPKSKAMLERGIPLFRNGLRYEEECKKAARRGYRGASQVVVGRAQGS
CCCCCEEECCCCCCCCHHHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEECCCC
FVWDLDDNQYIDFQNGWASNPFGNAHPEIVEAVHWAHTRYGFHYDTPHRYELAEKLVQIM
EEEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
PNRALTRINFEISGTEAAEAAVNLALTHTKRRYIISFSSSFHGEALGSKMLSGTSNNNHY
CCCCEEEEEEEECCCHHHHHHHHHHEEECCCEEEEEECCCCCCHHHHHHHHCCCCCCCEE
MEAWSGGVITAPYPYSGEIPAGMTQEQYVEYCLWYIDNHITSSIVPANNIAGLIIEPGLA
EEECCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCC
EGGNWIPPKRFMQGLRELCNKHDWVMIVDEVLTGLGRTGKMWAIEHYDVIPDVLVFGKNI
CCCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHCCCCCCCEEEEECHHHHHHHHHCCCCC
SGGIEPCAGIAARDEIMGDNEHYHTGSTYAGSPAACCAGLKTLELYERENIVEYVAYLGE
CCCCCHHHCCHHHHHHCCCCCCEECCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHH
IAKGIMQKWTRYSIVNEVRCNGLLLGVNFVSPDEHQKDWWFAREVRSRMMENGVWAINDR
HHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEECC
QTNVRLYPALNMEESVLREGLAIMEEAIAHVDSIRQSSFGDSPAWPTGDAGF
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MMNSIMKMNYKLPGPKSKAMLERGIPLFRNGLRYEEECKKAARRGYRGASQVVVGRAQGS
CCCCCEEECCCCCCCCHHHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEECCCC
FVWDLDDNQYIDFQNGWASNPFGNAHPEIVEAVHWAHTRYGFHYDTPHRYELAEKLVQIM
EEEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
PNRALTRINFEISGTEAAEAAVNLALTHTKRRYIISFSSSFHGEALGSKMLSGTSNNNHY
CCCCEEEEEEEECCCHHHHHHHHHHEEECCCEEEEEECCCCCCHHHHHHHHCCCCCCCEE
MEAWSGGVITAPYPYSGEIPAGMTQEQYVEYCLWYIDNHITSSIVPANNIAGLIIEPGLA
EEECCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCC
EGGNWIPPKRFMQGLRELCNKHDWVMIVDEVLTGLGRTGKMWAIEHYDVIPDVLVFGKNI
CCCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHCCCCCCCEEEEECHHHHHHHHHCCCCC
SGGIEPCAGIAARDEIMGDNEHYHTGSTYAGSPAACCAGLKTLELYERENIVEYVAYLGE
CCCCCHHHCCHHHHHHCCCCCCEECCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHH
IAKGIMQKWTRYSIVNEVRCNGLLLGVNFVSPDEHQKDWWFAREVRSRMMENGVWAINDR
HHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEECC
QTNVRLYPALNMEESVLREGLAIMEEAIAHVDSIRQSSFGDSPAWPTGDAGF
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]