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The map label for this gene is ycdW [C]

Identifier: 119776171

GI number: 119776171

Start: 3616048

End: 3616974

Strand: Direct

Name: ycdW [C]

Synonym: Sama_3039

Alternate gene names: 119776171

Gene position: 3616048-3616974 (Clockwise)

Preceding gene: 119776169

Following gene: 119776172

Centisome position: 83.97

GC content: 56.2

Gene sequence:

>927_bases
TTGAGACACAAGCTACTGCTTCTGACCCGCGAAAATGAGCGTTACCGCAGCTTGCTCGCGTCCTGCCATCTGCCGGAGCT
TGAGCTGTTGGATGACAATCCGGCCAATATCCGACTGGCTGACATCTGGCTGGCCGAGCCTGGGCTGGCCGCCCCCCTTG
TAAACCACGCCTCCGGGCTGCGCTGGATGCAGTCCACCTTCGCCGGAGTCGATCTGTTGGTTAAACCCCGCCAACGTCGA
GACTATTTGCTCACCAACGTGCGGGGCATTTTCGGTCCTCTGATGAGTGAGTACCTCTTTGGCTACCTGCTCGCCCGCCA
ACGGGAACACGACCTCTATAAGAGCCAACAACAACAAAAACTGTGGCTGCCGGGCAGTTACAAGACCCTGCAAGGGTCAG
AGCTGTTATTGCTTGGTACAGGCTCCATCGCCAAGCATCTGGCACAAACCGCAAAACACTTCGGCATGAAAGTGGCTGGC
ATCAATCGCAGCGCCAAGGCCACTGAGGGCTTTGATGAAGTGGCCACCCTGGAGGCCTTGCCGACACTCATGGCAAGGGC
CGATGCCATTGCCAGCATTTTGCCGAGTACCGAGGCCACCCGGGGAATTTTAAATGAAAACATTCTGGCCCGGATGAAAC
CCGATGCTGTGCTGTTCAATCTCGGCCGGGGGGATGTGCTGGATTTGGATGCACTTGAGCGTCAGCTCAGGCAACATCCA
CAGCAGCAGGCGGTGTTGGATGTGTTCAATCAGGAGCCACTGCCGGAAGATCATCCTATCTGGGGTCTTGGCAACGTCAT
AGTCACTCCACATATCGCGGCGCCGAGCTTTCCTGAGCAAGTTGCGGAAATCTTCAGCAGCAATTACCACAAGTTTCTGC
TCGGAGAGACCCTGTCTCACCGTGTGAATTTCGAGCGGGGCTATTAA

Upstream 100 bases:

>100_bases
GAAGGGATGCCGCCAACTTATTACAGAGTACTTGAATTGTTTCCATACGACTAAAGTAGTTATGATAGCGCGATAACTAC
AAGAATAAGGGGAACATACC

Downstream 100 bases:

>100_bases
GCCAACCCGCTGAACGAAAGCAAGGTTTTGATTTGATATGTTGTAAAAAGGCGCCAATTGCGCTTTTTTGTTTTTGACCA
ACTTTAAGAGCGAGAAGCGT

Product: D-isomer specific 2-hydroxyacid dehydrogenase family protein

Products: NADPH; glyoxylate; glycerate [C]

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MRHKLLLLTRENERYRSLLASCHLPELELLDDNPANIRLADIWLAEPGLAAPLVNHASGLRWMQSTFAGVDLLVKPRQRR
DYLLTNVRGIFGPLMSEYLFGYLLARQREHDLYKSQQQQKLWLPGSYKTLQGSELLLLGTGSIAKHLAQTAKHFGMKVAG
INRSAKATEGFDEVATLEALPTLMARADAIASILPSTEATRGILNENILARMKPDAVLFNLGRGDVLDLDALERQLRQHP
QQQAVLDVFNQEPLPEDHPIWGLGNVIVTPHIAAPSFPEQVAEIFSSNYHKFLLGETLSHRVNFERGY

Sequences:

>Translated_308_residues
MRHKLLLLTRENERYRSLLASCHLPELELLDDNPANIRLADIWLAEPGLAAPLVNHASGLRWMQSTFAGVDLLVKPRQRR
DYLLTNVRGIFGPLMSEYLFGYLLARQREHDLYKSQQQQKLWLPGSYKTLQGSELLLLGTGSIAKHLAQTAKHFGMKVAG
INRSAKATEGFDEVATLEALPTLMARADAIASILPSTEATRGILNENILARMKPDAVLFNLGRGDVLDLDALERQLRQHP
QQQAVLDVFNQEPLPEDHPIWGLGNVIVTPHIAAPSFPEQVAEIFSSNYHKFLLGETLSHRVNFERGY
>Mature_308_residues
MRHKLLLLTRENERYRSLLASCHLPELELLDDNPANIRLADIWLAEPGLAAPLVNHASGLRWMQSTFAGVDLLVKPRQRR
DYLLTNVRGIFGPLMSEYLFGYLLARQREHDLYKSQQQQKLWLPGSYKTLQGSELLLLGTGSIAKHLAQTAKHFGMKVAG
INRSAKATEGFDEVATLEALPTLMARADAIASILPSTEATRGILNENILARMKPDAVLFNLGRGDVLDLDALERQLRQHP
QQQAVLDVFNQEPLPEDHPIWGLGNVIVTPHIAAPSFPEQVAEIFSSNYHKFLLGETLSHRVNFERGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=159, Percent_Identity=33.9622641509434, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI23308577, Length=266, Percent_Identity=26.6917293233083, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI87081824, Length=248, Percent_Identity=29.8387096774194, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI87082289, Length=236, Percent_Identity=29.6610169491525, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789279, Length=156, Percent_Identity=28.8461538461538, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=174, Percent_Identity=29.8850574712644, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321253, Length=176, Percent_Identity=30.1136363636364, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574286, Length=272, Percent_Identity=26.1029411764706, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571528, Length=187, Percent_Identity=29.4117647058824, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI45552429, Length=265, Percent_Identity=27.5471698113208, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574284, Length=300, Percent_Identity=27, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585514, Length=265, Percent_Identity=27.5471698113208, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574282, Length=265, Percent_Identity=27.5471698113208, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45551003, Length=251, Percent_Identity=27.4900398406374, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585516, Length=224, Percent_Identity=23.6607142857143, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: NA

Molecular weight: Translated: 34581; Mature: 34581

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHKLLLLTRENERYRSLLASCHLPELELLDDNPANIRLADIWLAEPGLAAPLVNHASGL
CCCEEEEEECCCHHHHHHHHHCCCCCEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHH
RWMQSTFAGVDLLVKPRQRRDYLLTNVRGIFGPLMSEYLFGYLLARQREHDLYKSQQQQK
HHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCE
LWLPGSYKTLQGSELLLLGTGSIAKHLAQTAKHFGMKVAGINRSAKATEGFDEVATLEAL
ECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEECCCCCCCCCCCHHHHHHHHHH
PTLMARADAIASILPSTEATRGILNENILARMKPDAVLFNLGRGDVLDLDALERQLRQHP
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEECHHHHHHHHHHCC
QQQAVLDVFNQEPLPEDHPIWGLGNVIVTPHIAAPSFPEQVAEIFSSNYHKFLLGETLSH
HHHHHHHHHCCCCCCCCCCCEECCCEEEECCCCCCCCHHHHHHHHHCCCCEEHHHHHHHH
RVNFERGY
HCCCCCCC
>Mature Secondary Structure
MRHKLLLLTRENERYRSLLASCHLPELELLDDNPANIRLADIWLAEPGLAAPLVNHASGL
CCCEEEEEECCCHHHHHHHHHCCCCCEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHH
RWMQSTFAGVDLLVKPRQRRDYLLTNVRGIFGPLMSEYLFGYLLARQREHDLYKSQQQQK
HHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCE
LWLPGSYKTLQGSELLLLGTGSIAKHLAQTAKHFGMKVAGINRSAKATEGFDEVATLEAL
ECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEECCCCCCCCCCCHHHHHHHHHH
PTLMARADAIASILPSTEATRGILNENILARMKPDAVLFNLGRGDVLDLDALERQLRQHP
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEECHHHHHHHHHHCC
QQQAVLDVFNQEPLPEDHPIWGLGNVIVTPHIAAPSFPEQVAEIFSSNYHKFLLGETLSH
HHHHHHHHHCCCCCCCCCCCEECCCEEEECCCCCCCCHHHHHHHHHCCCCEEHHHHHHHH
RVNFERGY
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycolate; NADP; hydroxypyruvate; NADPH [C]

Specific reaction: glycolate + NADP = NADPH + glyoxylate hydroxypyruvate + NADPH = glycerate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]