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The map label for this gene is gabT [H]

Identifier: 119775768

GI number: 119775768

Start: 3157929

End: 3159206

Strand: Reverse

Name: gabT [H]

Synonym: Sama_2636

Alternate gene names: 119775768

Gene position: 3159206-3157929 (Counterclockwise)

Preceding gene: 119775769

Following gene: 119775767

Centisome position: 73.37

GC content: 58.45

Gene sequence:

>1278_bases
ATGAGCTTGACCAATGATTCATTGATGGTTCGTCGCCGCGCTGCTGTGGCCGGTGGCGTTGGCCAAATCCACCCTGTGTT
TACCGAGCGAGCCGAGAACGCCACCGTATGGGATGTGGAAGGTCGCGAATATATCGACTTTGCCGGCGGCATCGCGGTGC
TGAACACAGGTCACCTGCATCCGAAAGTAAAGGCGGCTGTCGCCGAGCAGCTGGAGAAGTTTTCCCACACCTGTTTTATG
GTGCTGGGCTATGAAAGTTATGTGGCCGTGTGTGAAAAGCTGAACCAACTGGTGCCCGGCGACTTTGCCAAGAAGTCGGC
ACTTTTTACCAGTGGCTCGGAAGCGGTGGAAAACGCCATTAAGGTGGCTCGCGCCTACACCAAGCGTGCAGGGGTGATTG
CCTTTACCTCTGGCTACCATGGCCGCACCATGGCAGCACTGGCCCTGACCGGTAAAGTGGCCCCCTACAGTAAGGGCATG
GGACTGATGCAGGCCAACGTGTTTCGCGCCGAGTTCCCCTGCGCGCTGCACGGGGTGAGCGAAGATGATGCCATGGCCTC
CATCGAGCGCATTTTCAAGAACGACGCCGAGCCAAGCGATATTGCAGCCATTATCCTGGAACCAGTGCAAGGCGAGGGCG
GTTTCTATGCCGCGACACCAGGCTTTATGAAGCGTCTGCGCGAGCTTTGCGACCGGGAAGGCATCATGCTGATTGCCGAT
GAAGTGCAGACCGGCGCTGGCCGCACCGGCACCTTCTTTGCCATGGAACAGATGGGCGTGGCGGCTGATATTACTACTTT
TGCAAAGTCGATTGCTGGTGGCTTCCCACTGTCTGGTATCACCGGCCGCGCCGAGGTGATGGACGCCATTGGCCCCGGTG
GCCTTGGCGGCACGTACGGCGGTAGCCCGCTTGCCTGCGCCGCAGCGCTGGCCGTGATTGAAGTCTTTGAAGAGGAAAAA
CTCCTGGAGCGCTCCAACGCCATCGGTCAGACCATCAAGTCTGCCATCGGTGAGCTGGCCAGCCGGTATCCGCAAATCGC
CGAGGTGCGTGGTCTGGGCTCCATGATTGCCATTGAGCTGATGGAAAACGGTAAGCCTGCGCCTGAGTATTGCCCACAGG
TGCTCACCGAGGCTCGCAATCGCGGCCTTATCCTGCTGTCGTGCGGAACTTACGGCAACGTGCTGCGGATTTTGGTGCCC
ATTACGGCTCCGGATGAACAAATCCAGCGCGGACTTGAAATCATGGCCGAATGCTTTGAGGCCGTACTGGGTAAATAA

Upstream 100 bases:

>100_bases
ATCGGGTCTGGGCCGTGAAGGCTCCAAGTATGGCATCGATGAGTATGTAGAAATCAAATATATCTGTCTGTCGGTGTGAC
CGGCCAAACAGGAGTACCCT

Downstream 100 bases:

>100_bases
CCTTTAAAAAAAGGCGGCCTATGAAGGGCCGCCTTTTTGCTGCAAAAAAAGCACGGACGCAGATAGAGACTATACTCAGT
CATACGTTAGTCTACCTATG

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSLTNDSLMVRRRAAVAGGVGQIHPVFTERAENATVWDVEGREYIDFAGGIAVLNTGHLHPKVKAAVAEQLEKFSHTCFM
VLGYESYVAVCEKLNQLVPGDFAKKSALFTSGSEAVENAIKVARAYTKRAGVIAFTSGYHGRTMAALALTGKVAPYSKGM
GLMQANVFRAEFPCALHGVSEDDAMASIERIFKNDAEPSDIAAIILEPVQGEGGFYAATPGFMKRLRELCDREGIMLIAD
EVQTGAGRTGTFFAMEQMGVAADITTFAKSIAGGFPLSGITGRAEVMDAIGPGGLGGTYGGSPLACAAALAVIEVFEEEK
LLERSNAIGQTIKSAIGELASRYPQIAEVRGLGSMIAIELMENGKPAPEYCPQVLTEARNRGLILLSCGTYGNVLRILVP
ITAPDEQIQRGLEIMAECFEAVLGK

Sequences:

>Translated_425_residues
MSLTNDSLMVRRRAAVAGGVGQIHPVFTERAENATVWDVEGREYIDFAGGIAVLNTGHLHPKVKAAVAEQLEKFSHTCFM
VLGYESYVAVCEKLNQLVPGDFAKKSALFTSGSEAVENAIKVARAYTKRAGVIAFTSGYHGRTMAALALTGKVAPYSKGM
GLMQANVFRAEFPCALHGVSEDDAMASIERIFKNDAEPSDIAAIILEPVQGEGGFYAATPGFMKRLRELCDREGIMLIAD
EVQTGAGRTGTFFAMEQMGVAADITTFAKSIAGGFPLSGITGRAEVMDAIGPGGLGGTYGGSPLACAAALAVIEVFEEEK
LLERSNAIGQTIKSAIGELASRYPQIAEVRGLGSMIAIELMENGKPAPEYCPQVLTEARNRGLILLSCGTYGNVLRILVP
ITAPDEQIQRGLEIMAECFEAVLGK
>Mature_424_residues
SLTNDSLMVRRRAAVAGGVGQIHPVFTERAENATVWDVEGREYIDFAGGIAVLNTGHLHPKVKAAVAEQLEKFSHTCFMV
LGYESYVAVCEKLNQLVPGDFAKKSALFTSGSEAVENAIKVARAYTKRAGVIAFTSGYHGRTMAALALTGKVAPYSKGMG
LMQANVFRAEFPCALHGVSEDDAMASIERIFKNDAEPSDIAAIILEPVQGEGGFYAATPGFMKRLRELCDREGIMLIADE
VQTGAGRTGTFFAMEQMGVAADITTFAKSIAGGFPLSGITGRAEVMDAIGPGGLGGTYGGSPLACAAALAVIEVFEEEKL
LERSNAIGQTIKSAIGELASRYPQIAEVRGLGSMIAIELMENGKPAPEYCPQVLTEARNRGLILLSCGTYGNVLRILVPI
TAPDEQIQRGLEIMAECFEAVLGK

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=405, Percent_Identity=32.0987654320988, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI13994255, Length=423, Percent_Identity=31.4420803782506, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI37574042, Length=420, Percent_Identity=27.6190476190476, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI284507298, Length=316, Percent_Identity=31.6455696202532, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI24119277, Length=394, Percent_Identity=27.9187817258883, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI226442705, Length=420, Percent_Identity=27.1428571428571, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI226442709, Length=388, Percent_Identity=27.8350515463918, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI188536080, Length=401, Percent_Identity=27.1820448877805, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI38679950, Length=401, Percent_Identity=27.1820448877805, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI38679946, Length=401, Percent_Identity=27.1820448877805, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1789016, Length=420, Percent_Identity=68.0952380952381, Blast_Score=611, Evalue=1e-176,
Organism=Escherichia coli, GI1787560, Length=419, Percent_Identity=50.8353221957041, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1789759, Length=406, Percent_Identity=34.4827586206897, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI1788044, Length=407, Percent_Identity=34.6437346437346, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI145693181, Length=420, Percent_Identity=35.4761904761905, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1786349, Length=345, Percent_Identity=32.1739130434783, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1786991, Length=350, Percent_Identity=32.5714285714286, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI32564660, Length=421, Percent_Identity=33.0166270783848, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI25144271, Length=411, Percent_Identity=30.9002433090024, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71992977, Length=433, Percent_Identity=27.9445727482679, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI25144274, Length=320, Percent_Identity=29.0625, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17541228, Length=382, Percent_Identity=25.9162303664921, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71981843, Length=184, Percent_Identity=28.804347826087, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324432, Length=405, Percent_Identity=31.1111111111111, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6323470, Length=412, Percent_Identity=29.8543689320388, Blast_Score=189, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6324386, Length=331, Percent_Identity=26.5861027190332, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321456, Length=379, Percent_Identity=24.2744063324538, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI161085790, Length=442, Percent_Identity=30.9954751131222, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI28574759, Length=418, Percent_Identity=31.8181818181818, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI21357415, Length=405, Percent_Identity=30.8641975308642, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI21356575, Length=420, Percent_Identity=28.0952380952381, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI281366494, Length=247, Percent_Identity=29.9595141700405, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24667139, Length=247, Percent_Identity=29.9595141700405, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24667143, Length=247, Percent_Identity=29.9595141700405, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 45157; Mature: 45025

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTNDSLMVRRRAAVAGGVGQIHPVFTERAENATVWDVEGREYIDFAGGIAVLNTGHLH
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEECCCCEEEECCCCEEEEECCCCC
PKVKAAVAEQLEKFSHTCFMVLGYESYVAVCEKLNQLVPGDFAKKSALFTSGSEAVENAI
HHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHH
KVARAYTKRAGVIAFTSGYHGRTMAALALTGKVAPYSKGMGLMQANVFRAEFPCALHGVS
HHHHHHHHCCCEEEEECCCCCCCEEHHHHHCCCCCHHCCCCHHHHHHHHHCCCCCCCCCC
EDDAMASIERIFKNDAEPSDIAAIILEPVQGEGGFYAATPGFMKRLRELCDREGIMLIAD
CHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEECCHHHHHHHHHHHCCCCEEEEEE
EVQTGAGRTGTFFAMEQMGVAADITTFAKSIAGGFPLSGITGRAEVMDAIGPGGLGGTYG
CCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCC
GSPLACAAALAVIEVFEEEKLLERSNAIGQTIKSAIGELASRYPQIAEVRGLGSMIAIEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHH
MENGKPAPEYCPQVLTEARNRGLILLSCGTYGNVLRILVPITAPDEQIQRGLEIMAECFE
HHCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
AVLGK
HHHCC
>Mature Secondary Structure 
SLTNDSLMVRRRAAVAGGVGQIHPVFTERAENATVWDVEGREYIDFAGGIAVLNTGHLH
CCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEECCCCEEEECCCCEEEEECCCCC
PKVKAAVAEQLEKFSHTCFMVLGYESYVAVCEKLNQLVPGDFAKKSALFTSGSEAVENAI
HHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHH
KVARAYTKRAGVIAFTSGYHGRTMAALALTGKVAPYSKGMGLMQANVFRAEFPCALHGVS
HHHHHHHHCCCEEEEECCCCCCCEEHHHHHCCCCCHHCCCCHHHHHHHHHCCCCCCCCCC
EDDAMASIERIFKNDAEPSDIAAIILEPVQGEGGFYAATPGFMKRLRELCDREGIMLIAD
CHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEECCHHHHHHHHHHHCCCCEEEEEE
EVQTGAGRTGTFFAMEQMGVAADITTFAKSIAGGFPLSGITGRAEVMDAIGPGGLGGTYG
CCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCC
GSPLACAAALAVIEVFEEEKLLERSNAIGQTIKSAIGELASRYPQIAEVRGLGSMIAIEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHH
MENGKPAPEYCPQVLTEARNRGLILLSCGTYGNVLRILVPITAPDEQIQRGLEIMAECFE
HHCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
AVLGK
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]