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The map label for this gene is maeA

Identifier: 119775753

GI number: 119775753

Start: 3138612

End: 3140300

Strand: Direct

Name: maeA

Synonym: Sama_2621

Alternate gene names: 119775753

Gene position: 3138612-3140300 (Clockwise)

Preceding gene: 119775752

Following gene: 119775755

Centisome position: 72.89

GC content: 55.0

Gene sequence:

>1689_bases
ATGGACGATAACAAACGCCCGCTCTATTTGCCGTTCGCCGGTCCAGCCATTCTTGAAGCACCGCTCATTAACAAAGGCAG
CGCCTTTACCGAAGAAGAGCGGATATTCTTCAACCTTGAAGGCCTGTTACCTTACGCGATTGAAACCATCGAAGAGCAGG
CATCAAGGGCCTACGATCAGTTCCGCAGTTTCAACAATGATTTGGATAAGCACATCTACCTGCGCAACATTCAGGACACC
AACGAAACCCTGTTTTACCGCCTGGTGCAAAACAACATTGCCGAGATGATGCCCATCATCTACACCCCCACGGTGGGCCT
GGCCTGTGAGCGGTTCTCCAAAAACTATCGCCGCAACCGCGGACTGTTTATCTCCTATCCCAACAAGGACAGGATTGACG
ACATCCTCAATAACTCCACCCGCCACAAGGTGAAAATCATCGTTGTGACGGACGGCGAGCGGATTCTGGGTCTGGGCGAT
CAGGGGATTGGCGGCATGGGCATCCCAATTGGAAAGCTGTCACTGTACACCAGCTGCGGTGGTATCAGCCCGGCCTATAC
CCTGCCTATCACCCTGGATGTGGGCACTGACAATCCGCACCTGCTCGAAGACCCCATGTACATGGGCTGGCGCCATCCCC
GCATTGGTGGCGAAGAGTACAGCGAGTTTATTGAAGCCTTTATGGAAGCCGTACACCGCCGCTGGCCTGATGTGCTGATT
CAGTTTGAAGACTTTGCCCAGAAGAATGCCATGCCAATTCTGGAGCGCTACAAGGACAGATACTGCTGTTTTAACGACGA
TATTCAAGGTACGGCTGCGGTGACCGTTGGCTCCTTATTGGCCGCCTGCCAGGCCGCTGGAACCAAGCTCAGTGATCAGC
GCATCACCTTCCTGGGTGCAGGCAGCGCCGGTTGCGGTATTGCTGAAGCAATTGTGGCGCAAATGGTATCTGAAGGCATC
AGCGATGATCAGGCCCGCAGCCAGGTGTTTATGGTTGACCGCTGGGGTCTGCTGCTGGACAACATGCCTAACCTGCTGCC
ATTCCAGCAAAAACTGGCACAGAAAATTGATAACATTAACCACTGGGATGACTTCAGCGACAATGTCTCACTGCTGAACG
TCGTGAACAATGCCAAGCCGACGGTACTTATCGGCGTGTCAGGCGCCCCTGGCCTCTTTACTGAAGAGATCATCCGCGCC
ATGCACAGCCACTGCGCCCGTCCAATCGTATTCCCGCTGTCCAACCCCACCAGCAGGGTTGAGGCGACACCGAAAGATAT
ACTCCACTGGACCAGCGGTCAGGCGTTGGTAGCAACCGGTAGCCCGTTCGAGCCCGTGGTAGTGGACGACGTGACTTACG
ATATCGCCCAGTGCAACAACAGCTACATCTTCCCCGGCATTGGTCTTGGGGTGCTGGCGTGCGGAGCCAACCGGGTATCA
AACGAGATGCTCATGGCCTCCAGCCGCGCGCTTGCGGAGTGTTCTCCATTGGCAAAAGACGGCTCAGGACCTCTGCTGCC
ACCGCTGGAAGAAATTCACGATGTAAGCAAACACATCGCCTTTGCCGTTGCCAAGGTGGCCATTGAACAGGGACATGCGC
TGGATACCACTGATGAGCTGCTGATGCAGTCCATCGAGGCCAACTTCTGGTATCCCGAGTACCGCCGTTACAAACGGACC
TCGTTCTAA

Upstream 100 bases:

>100_bases
CAAAGCTACAAAGATCACATTTCGTGATAATCTTCTTGCTATTGACAGCACATTTCATGCCCAGAAAGCACACACCCAAA
AAGCATACAAAAGGTAGCCC

Downstream 100 bases:

>100_bases
CAAAAAAGCCCGGCATAGCCGGGCTTTTTTATGGGGTAAGCTTCATGGCTCATAAAGCCATCGCATCAAATGCCCATCAC
CTCGCGCATGCTGTTGTACA

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MDDNKRPLYLPFAGPAILEAPLINKGSAFTEEERIFFNLEGLLPYAIETIEEQASRAYDQFRSFNNDLDKHIYLRNIQDT
NETLFYRLVQNNIAEMMPIIYTPTVGLACERFSKNYRRNRGLFISYPNKDRIDDILNNSTRHKVKIIVVTDGERILGLGD
QGIGGMGIPIGKLSLYTSCGGISPAYTLPITLDVGTDNPHLLEDPMYMGWRHPRIGGEEYSEFIEAFMEAVHRRWPDVLI
QFEDFAQKNAMPILERYKDRYCCFNDDIQGTAAVTVGSLLAACQAAGTKLSDQRITFLGAGSAGCGIAEAIVAQMVSEGI
SDDQARSQVFMVDRWGLLLDNMPNLLPFQQKLAQKIDNINHWDDFSDNVSLLNVVNNAKPTVLIGVSGAPGLFTEEIIRA
MHSHCARPIVFPLSNPTSRVEATPKDILHWTSGQALVATGSPFEPVVVDDVTYDIAQCNNSYIFPGIGLGVLACGANRVS
NEMLMASSRALAECSPLAKDGSGPLLPPLEEIHDVSKHIAFAVAKVAIEQGHALDTTDELLMQSIEANFWYPEYRRYKRT
SF

Sequences:

>Translated_562_residues
MDDNKRPLYLPFAGPAILEAPLINKGSAFTEEERIFFNLEGLLPYAIETIEEQASRAYDQFRSFNNDLDKHIYLRNIQDT
NETLFYRLVQNNIAEMMPIIYTPTVGLACERFSKNYRRNRGLFISYPNKDRIDDILNNSTRHKVKIIVVTDGERILGLGD
QGIGGMGIPIGKLSLYTSCGGISPAYTLPITLDVGTDNPHLLEDPMYMGWRHPRIGGEEYSEFIEAFMEAVHRRWPDVLI
QFEDFAQKNAMPILERYKDRYCCFNDDIQGTAAVTVGSLLAACQAAGTKLSDQRITFLGAGSAGCGIAEAIVAQMVSEGI
SDDQARSQVFMVDRWGLLLDNMPNLLPFQQKLAQKIDNINHWDDFSDNVSLLNVVNNAKPTVLIGVSGAPGLFTEEIIRA
MHSHCARPIVFPLSNPTSRVEATPKDILHWTSGQALVATGSPFEPVVVDDVTYDIAQCNNSYIFPGIGLGVLACGANRVS
NEMLMASSRALAECSPLAKDGSGPLLPPLEEIHDVSKHIAFAVAKVAIEQGHALDTTDELLMQSIEANFWYPEYRRYKRT
SF
>Mature_562_residues
MDDNKRPLYLPFAGPAILEAPLINKGSAFTEEERIFFNLEGLLPYAIETIEEQASRAYDQFRSFNNDLDKHIYLRNIQDT
NETLFYRLVQNNIAEMMPIIYTPTVGLACERFSKNYRRNRGLFISYPNKDRIDDILNNSTRHKVKIIVVTDGERILGLGD
QGIGGMGIPIGKLSLYTSCGGISPAYTLPITLDVGTDNPHLLEDPMYMGWRHPRIGGEEYSEFIEAFMEAVHRRWPDVLI
QFEDFAQKNAMPILERYKDRYCCFNDDIQGTAAVTVGSLLAACQAAGTKLSDQRITFLGAGSAGCGIAEAIVAQMVSEGI
SDDQARSQVFMVDRWGLLLDNMPNLLPFQQKLAQKIDNINHWDDFSDNVSLLNVVNNAKPTVLIGVSGAPGLFTEEIIRA
MHSHCARPIVFPLSNPTSRVEATPKDILHWTSGQALVATGSPFEPVVVDDVTYDIAQCNNSYIFPGIGLGVLACGANRVS
NEMLMASSRALAECSPLAKDGSGPLLPPLEEIHDVSKHIAFAVAKVAIEQGHALDTTDELLMQSIEANFWYPEYRRYKRT
SF

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family

Homologues:

Organism=Homo sapiens, GI4505143, Length=522, Percent_Identity=43.8697318007663, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI62420882, Length=530, Percent_Identity=42.8301886792453, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI62420880, Length=530, Percent_Identity=42.8301886792453, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI239049447, Length=530, Percent_Identity=42.8301886792453, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI4505145, Length=557, Percent_Identity=42.3698384201077, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI270265879, Length=468, Percent_Identity=45.7264957264957, Blast_Score=397, Evalue=1e-110,
Organism=Escherichia coli, GI87081919, Length=559, Percent_Identity=67.6207513416816, Blast_Score=782, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17537199, Length=546, Percent_Identity=42.6739926739927, Blast_Score=411, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6322823, Length=565, Percent_Identity=42.6548672566372, Blast_Score=439, Evalue=1e-124,
Organism=Drosophila melanogaster, GI281362674, Length=519, Percent_Identity=45.0867052023121, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI21356279, Length=519, Percent_Identity=45.0867052023121, Blast_Score=445, Evalue=1e-125,
Organism=Drosophila melanogaster, GI281362672, Length=519, Percent_Identity=45.0867052023121, Blast_Score=445, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24646388, Length=512, Percent_Identity=43.1640625, Blast_Score=425, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24646386, Length=512, Percent_Identity=43.1640625, Blast_Score=425, Evalue=1e-119,
Organism=Drosophila melanogaster, GI78707232, Length=509, Percent_Identity=38.1139489194499, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI281363505, Length=508, Percent_Identity=37.992125984252, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI78707236, Length=508, Percent_Identity=37.992125984252, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI78707242, Length=537, Percent_Identity=39.1061452513966, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI78707238, Length=537, Percent_Identity=39.1061452513966, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI78707240, Length=516, Percent_Identity=39.7286821705426, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI281363503, Length=509, Percent_Identity=37.721021611002, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI19922384, Length=538, Percent_Identity=30.2973977695167, Blast_Score=254, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MAO1_SHEAM (A1S8W7)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_928493.1
- ProteinModelPortal:   A1S8W7
- SMR:   A1S8W7
- STRING:   A1S8W7
- GeneID:   4604868
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_2621
- NMPDR:   fig|326297.7.peg.2458
- eggNOG:   COG0281
- HOGENOM:   HBG289821
- OMA:   NARNIMK
- PhylomeDB:   A1S8W7
- ProtClustDB:   PRK13529
- HAMAP:   MF_01619
- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000106
- PRINTS:   PR00072
- SMART:   SM00919

Pfam domain/function: PF00390 malic; PF03949 Malic_M

EC number: =1.1.1.38

Molecular weight: Translated: 62484; Mature: 62484

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: ACT_SITE 101-101 ACT_SITE 172-172 BINDING 154-154 BINDING 267-267 BINDING 415-415

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDNKRPLYLPFAGPAILEAPLINKGSAFTEEERIFFNLEGLLPYAIETIEEQASRAYDQ
CCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
FRSFNNDLDKHIYLRNIQDTNETLFYRLVQNNIAEMMPIIYTPTVGLACERFSKNYRRNR
HHHHCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHCC
GLFISYPNKDRIDDILNNSTRHKVKIIVVTDGERILGLGDQGIGGMGIPIGKLSLYTSCG
CEEEECCCCHHHHHHHCCCCCCEEEEEEEECCCEEEECCCCCCCCCCCCCCCEEEEECCC
GISPAYTLPITLDVGTDNPHLLEDPMYMGWRHPRIGGEEYSEFIEAFMEAVHRRWPDVLI
CCCCCEEEEEEEEECCCCCCEECCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHEE
QFEDFAQKNAMPILERYKDRYCCFNDDIQGTAAVTVGSLLAACQAAGTKLSDQRITFLGA
EHHHHHCCCCCHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GSAGCGIAEAIVAQMVSEGISDDQARSQVFMVDRWGLLLDNMPNLLPFQQKLAQKIDNIN
CCCCCHHHHHHHHHHHHCCCCCCCHHCEEEEEEHHHHHHHCCCCCCHHHHHHHHHHCCCC
HWDDFSDNVSLLNVVNNAKPTVLIGVSGAPGLFTEEIIRAMHSHCARPIVFPLSNPTSRV
CCCCCCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHC
EATPKDILHWTSGQALVATGSPFEPVVVDDVTYDIAQCNNSYIFPGIGLGVLACGANRVS
CCCHHHHHEECCCCEEEECCCCCCCEEECCCHHHHHHCCCCEECCCCCHHHHHCCCHHHH
NEMLMASSRALAECSPLAKDGSGPLLPPLEEIHDVSKHIAFAVAKVAIEQGHALDTTDEL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LMQSIEANFWYPEYRRYKRTSF
HHHHHHCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MDDNKRPLYLPFAGPAILEAPLINKGSAFTEEERIFFNLEGLLPYAIETIEEQASRAYDQ
CCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
FRSFNNDLDKHIYLRNIQDTNETLFYRLVQNNIAEMMPIIYTPTVGLACERFSKNYRRNR
HHHHCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHCC
GLFISYPNKDRIDDILNNSTRHKVKIIVVTDGERILGLGDQGIGGMGIPIGKLSLYTSCG
CEEEECCCCHHHHHHHCCCCCCEEEEEEEECCCEEEECCCCCCCCCCCCCCCEEEEECCC
GISPAYTLPITLDVGTDNPHLLEDPMYMGWRHPRIGGEEYSEFIEAFMEAVHRRWPDVLI
CCCCCEEEEEEEEECCCCCCEECCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHEE
QFEDFAQKNAMPILERYKDRYCCFNDDIQGTAAVTVGSLLAACQAAGTKLSDQRITFLGA
EHHHHHCCCCCHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GSAGCGIAEAIVAQMVSEGISDDQARSQVFMVDRWGLLLDNMPNLLPFQQKLAQKIDNIN
CCCCCHHHHHHHHHHHHCCCCCCCHHCEEEEEEHHHHHHHCCCCCCHHHHHHHHHHCCCC
HWDDFSDNVSLLNVVNNAKPTVLIGVSGAPGLFTEEIIRAMHSHCARPIVFPLSNPTSRV
CCCCCCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHC
EATPKDILHWTSGQALVATGSPFEPVVVDDVTYDIAQCNNSYIFPGIGLGVLACGANRVS
CCCHHHHHEECCCCEEEECCCCCCCEEECCCHHHHHHCCCCEECCCCCHHHHHCCCHHHH
NEMLMASSRALAECSPLAKDGSGPLLPPLEEIHDVSKHIAFAVAKVAIEQGHALDTTDEL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LMQSIEANFWYPEYRRYKRTSF
HHHHHHCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA