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The map label for this gene is dxs

Identifier: 119775570

GI number: 119775570

Start: 2929565

End: 2931433

Strand: Direct

Name: dxs

Synonym: Sama_2436

Alternate gene names: 119775570

Gene position: 2929565-2931433 (Clockwise)

Preceding gene: 119775569

Following gene: 119775572

Centisome position: 68.03

GC content: 56.07

Gene sequence:

>1869_bases
ATGAGTTTGGACATTTCGAATTATCCATTGCTTGCCCTGGCGAGCACCCCGGAAGAGCTGCGCCAGCTGCCTCAGTCGGC
ATTGAAACAGCTTTCAGATGAACTCAGGCAGTTTTTGCTGACCTCAGTGGGCATCTCCAGCGGCCATTTCGCCTCTGGCC
TCGGCACGGTCGAACTGACCGTTGCGCTGCATTATGTGTACAACACCCCCTTTGACCGTCTGATTTGGGACGTGGGCCAT
CAGGCCTATCCCCATAAAATTCTCACCGGCCGCCGTGACAAGATGCACACCATTCGCCAAAAGAATGGCCTGCACCCTTT
CCCCTGGCGCGAAGAGAGTCAATACGACACCTTCAGCGTGGGCCATTCCAGTACCTCGATTTCTGCCGCCCTTGGCATGG
CAGTGACCGCCGAAAAGGAAGCCCTGGGCCGCAAAGTGGTTGCCGTGATAGGTGATGGTGCCATTACCGGTGGTATGGCC
TTCGAGGCCCTCAACCATGCGGGTGACCTGCACAAAGACATGTTAGTGGTGCTCAATGACAATGAGATGTCTATCTCTGA
AAACGTCGGTGCACTCAATAACCATCTGGCCAAACTCATGTCCGGCCGCCTCTACACCACCATTCGCGAAGGTGGCAAGA
AGGTACTCAAGGGCATGCCTGTGATTAAGGAAATGGCCAAGCGTACCGAAGAGCACCTCAAGGGTATGGTAGTACCTGGC
ACCCTGTTCGAAGAGCTTGGCTTTAACTACATAGGCCCCATCGATGGCCATGATGTTAATGGGCTGGTGGAAACCCTGAG
TAACATGCGTGATCTCAAGGGCCCGCAGTTCCTGCACATCATGACTAAAAAGGGCAAGGGGTACGAACCCGCCGAGAAAG
ATCCTATCGGTTGGCACGCTGTACCCAAGTTCGACCCAACCCAGTTCCGTAAACCGGCGACCAAGCCTGGTTTACCCACC
TTCTCGCAAGTTTTCGGCAAGTGGCTGTGCGATATCGCCGCCAAAGACGAAAAAGTGCTCGCCATTACCCCGGCCATGCG
CGAAGGCTCAGGCATGGTGGAATTCTCCCAGCGCTTTCCACAACAATACTTTGATGCGGCCATCGCAGAGCAGCATGCCG
TGACATTGGGCGCCGGTTTCGCCTGTGAAGGCTACAAAGCCGTAGTGGCCATCTATTCCAGCTTCCTGCAGCGCGGCTAC
GACCAGCTTATCCACGATGTGGCGTTGCAACGACTGCCAGTGCTCTTTGCCATCGACCGCGGTGGTATTGTCGGTGCCGA
TGGTGCCACCCACCAGGGCGCATTCGACTTAAGCTACATGCGCTGCATTCCCAATATGGTGATTATGGCGCCAAGCGATG
AAAACGAATGCCGCCAGATGTTCTACACCGGTTACTGCTACAACGAAGGCCCGAGCGCCGTGCGTTATCCAAGGGGCAGC
GCCACAGGTGCCGAGCAGATTGAAGAGATGACTGCCCTGCCCATCGGCAAAGGGGTAATGCGTCGTCAGGGGCAGAAGAT
TGCCATTCTGAACTTTGGCACCACACTGGCCGCCGCCTTGACGGCAGCAGAGTCACTCAATGCCACAGTGGCCGATATGC
GCTTCGTTAAGCCGCTGGATGAAGCCTTGCTGCTGGAGCTTGCTGCCAGCCACGATGTACTGGTGACTGTGGAAGAAAAC
GCCATTATGGGTGGCGCAGGCTCTGGTGTGCTTGAGTTCCTTGCAAGCAAGAACCGCCTGAAGCCCCTGCTGCAAATCGG
CATACCCGATGAATTTATCAAGCACGGTGGCCCGGAAGAGATCCTGAGCGAGCTGGGTCTGGATGCGGCCGGTATTGAGG
GGCAAATCCGCGCCTTTATTGAGCGCTGA

Upstream 100 bases:

>100_bases
CTATCAGCGCTGGCCAAAATGCCATACAATAGTCAGCTACTTGCAGACTTCGCCCGTTATATCGTCGCGCGACGAGTATA
AGAAAGAAAAGAATCTCGCT

Downstream 100 bases:

>100_bases
TATTAAGCCGCAATCAAAAAAGGACTGCACAGGCAGTCCTTTTTGCTATCTGACAGCTTATCAGGCCTGGGTGTCTACAC
CGCCGCCCTGGGATACCATC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 622; Mature: 621

Protein sequence:

>622_residues
MSLDISNYPLLALASTPEELRQLPQSALKQLSDELRQFLLTSVGISSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGH
QAYPHKILTGRRDKMHTIRQKNGLHPFPWREESQYDTFSVGHSSTSISAALGMAVTAEKEALGRKVVAVIGDGAITGGMA
FEALNHAGDLHKDMLVVLNDNEMSISENVGALNNHLAKLMSGRLYTTIREGGKKVLKGMPVIKEMAKRTEEHLKGMVVPG
TLFEELGFNYIGPIDGHDVNGLVETLSNMRDLKGPQFLHIMTKKGKGYEPAEKDPIGWHAVPKFDPTQFRKPATKPGLPT
FSQVFGKWLCDIAAKDEKVLAITPAMREGSGMVEFSQRFPQQYFDAAIAEQHAVTLGAGFACEGYKAVVAIYSSFLQRGY
DQLIHDVALQRLPVLFAIDRGGIVGADGATHQGAFDLSYMRCIPNMVIMAPSDENECRQMFYTGYCYNEGPSAVRYPRGS
ATGAEQIEEMTALPIGKGVMRRQGQKIAILNFGTTLAAALTAAESLNATVADMRFVKPLDEALLLELAASHDVLVTVEEN
AIMGGAGSGVLEFLASKNRLKPLLQIGIPDEFIKHGGPEEILSELGLDAAGIEGQIRAFIER

Sequences:

>Translated_622_residues
MSLDISNYPLLALASTPEELRQLPQSALKQLSDELRQFLLTSVGISSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGH
QAYPHKILTGRRDKMHTIRQKNGLHPFPWREESQYDTFSVGHSSTSISAALGMAVTAEKEALGRKVVAVIGDGAITGGMA
FEALNHAGDLHKDMLVVLNDNEMSISENVGALNNHLAKLMSGRLYTTIREGGKKVLKGMPVIKEMAKRTEEHLKGMVVPG
TLFEELGFNYIGPIDGHDVNGLVETLSNMRDLKGPQFLHIMTKKGKGYEPAEKDPIGWHAVPKFDPTQFRKPATKPGLPT
FSQVFGKWLCDIAAKDEKVLAITPAMREGSGMVEFSQRFPQQYFDAAIAEQHAVTLGAGFACEGYKAVVAIYSSFLQRGY
DQLIHDVALQRLPVLFAIDRGGIVGADGATHQGAFDLSYMRCIPNMVIMAPSDENECRQMFYTGYCYNEGPSAVRYPRGS
ATGAEQIEEMTALPIGKGVMRRQGQKIAILNFGTTLAAALTAAESLNATVADMRFVKPLDEALLLELAASHDVLVTVEEN
AIMGGAGSGVLEFLASKNRLKPLLQIGIPDEFIKHGGPEEILSELGLDAAGIEGQIRAFIER
>Mature_621_residues
SLDISNYPLLALASTPEELRQLPQSALKQLSDELRQFLLTSVGISSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGHQ
AYPHKILTGRRDKMHTIRQKNGLHPFPWREESQYDTFSVGHSSTSISAALGMAVTAEKEALGRKVVAVIGDGAITGGMAF
EALNHAGDLHKDMLVVLNDNEMSISENVGALNNHLAKLMSGRLYTTIREGGKKVLKGMPVIKEMAKRTEEHLKGMVVPGT
LFEELGFNYIGPIDGHDVNGLVETLSNMRDLKGPQFLHIMTKKGKGYEPAEKDPIGWHAVPKFDPTQFRKPATKPGLPTF
SQVFGKWLCDIAAKDEKVLAITPAMREGSGMVEFSQRFPQQYFDAAIAEQHAVTLGAGFACEGYKAVVAIYSSFLQRGYD
QLIHDVALQRLPVLFAIDRGGIVGADGATHQGAFDLSYMRCIPNMVIMAPSDENECRQMFYTGYCYNEGPSAVRYPRGSA
TGAEQIEEMTALPIGKGVMRRQGQKIAILNFGTTLAAALTAAESLNATVADMRFVKPLDEALLLELAASHDVLVTVEENA
IMGGAGSGVLEFLASKNRLKPLLQIGIPDEFIKHGGPEEILSELGLDAAGIEGQIRAFIER

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=651, Percent_Identity=21.3517665130568, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI4507521, Length=651, Percent_Identity=21.3517665130568, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI225637459, Length=428, Percent_Identity=23.8317757009346, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI225637461, Length=428, Percent_Identity=23.8317757009346, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI225637463, Length=428, Percent_Identity=23.8317757009346, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI133778974, Length=573, Percent_Identity=24.2582897033159, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=73.2258064516129, Blast_Score=963, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=425, Percent_Identity=24.7058823529412, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24666278, Length=662, Percent_Identity=23.8670694864048, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI45551847, Length=653, Percent_Identity=24.0428790199081, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45550715, Length=653, Percent_Identity=24.0428790199081, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24645119, Length=613, Percent_Identity=23.8172920065253, Blast_Score=93, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_SHEAM (A1S8D4)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_928310.1
- ProteinModelPortal:   A1S8D4
- SMR:   A1S8D4
- STRING:   A1S8D4
- GeneID:   4604685
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_2436
- NMPDR:   fig|326297.7.peg.2280
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- PhylomeDB:   A1S8D4
- ProtClustDB:   PRK05444
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67800; Mature: 67669

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDISNYPLLALASTPEELRQLPQSALKQLSDELRQFLLTSVGISSGHFASGLGTVELT
CCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
VALHYVYNTPFDRLIWDVGHQAYPHKILTGRRDKMHTIRQKNGLHPFPWREESQYDTFSV
EEEEHHHCCCHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEC
GHSSTSISAALGMAVTAEKEALGRKVVAVIGDGAITGGMAFEALNHAGDLHKDMLVVLND
CCCCCHHHHHHHHHEEHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECC
NEMSISENVGALNNHLAKLMSGRLYTTIREGGKKVLKGMPVIKEMAKRTEEHLKGMVVPG
CCCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPIDGHDVNGLVETLSNMRDLKGPQFLHIMTKKGKGYEPAEKDPIGWHA
HHHHHCCCCEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCC
VPKFDPTQFRKPATKPGLPTFSQVFGKWLCDIAAKDEKVLAITPAMREGSGMVEFSQRFP
CCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHCC
QQYFDAAIAEQHAVTLGAGFACEGYKAVVAIYSSFLQRGYDQLIHDVALQRLPVLFAIDR
HHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
GGIVGADGATHQGAFDLSYMRCIPNMVIMAPSDENECRQMFYTGYCYNEGPSAVRYPRGS
CCEECCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHCCEEECCCCCCEECCCCC
ATGAEQIEEMTALPIGKGVMRRQGQKIAILNFGTTLAAALTAAESLNATVADMRFVKPLD
CCCHHHHHHHHHCCCCCHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHH
EALLLELAASHDVLVTVEENAIMGGAGSGVLEFLASKNRLKPLLQIGIPDEFIKHGGPEE
HHHHHHHHCCCCEEEEEECCEEECCCCHHHHHHHHHHHHCCHHHHCCCCHHHHHCCCHHH
ILSELGLDAAGIEGQIRAFIER
HHHHCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
SLDISNYPLLALASTPEELRQLPQSALKQLSDELRQFLLTSVGISSGHFASGLGTVELT
CCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
VALHYVYNTPFDRLIWDVGHQAYPHKILTGRRDKMHTIRQKNGLHPFPWREESQYDTFSV
EEEEHHHCCCHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEC
GHSSTSISAALGMAVTAEKEALGRKVVAVIGDGAITGGMAFEALNHAGDLHKDMLVVLND
CCCCCHHHHHHHHHEEHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECC
NEMSISENVGALNNHLAKLMSGRLYTTIREGGKKVLKGMPVIKEMAKRTEEHLKGMVVPG
CCCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPIDGHDVNGLVETLSNMRDLKGPQFLHIMTKKGKGYEPAEKDPIGWHA
HHHHHCCCCEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCC
VPKFDPTQFRKPATKPGLPTFSQVFGKWLCDIAAKDEKVLAITPAMREGSGMVEFSQRFP
CCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHCC
QQYFDAAIAEQHAVTLGAGFACEGYKAVVAIYSSFLQRGYDQLIHDVALQRLPVLFAIDR
HHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
GGIVGADGATHQGAFDLSYMRCIPNMVIMAPSDENECRQMFYTGYCYNEGPSAVRYPRGS
CCEECCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHCCEEECCCCCCEECCCCC
ATGAEQIEEMTALPIGKGVMRRQGQKIAILNFGTTLAAALTAAESLNATVADMRFVKPLD
CCCHHHHHHHHHCCCCCHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHH
EALLLELAASHDVLVTVEENAIMGGAGSGVLEFLASKNRLKPLLQIGIPDEFIKHGGPEE
HHHHHHHHCCCCEEEEEECCEEECCCCHHHHHHHHHHHHCCHHHHCCCCHHHHHCCCHHH
ILSELGLDAAGIEGQIRAFIER
HHHHCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA