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The map label for this gene is ispA [H]

Identifier: 119775569

GI number: 119775569

Start: 2928664

End: 2929545

Strand: Direct

Name: ispA [H]

Synonym: Sama_2435

Alternate gene names: 119775569

Gene position: 2928664-2929545 (Clockwise)

Preceding gene: 119775568

Following gene: 119775570

Centisome position: 68.01

GC content: 57.37

Gene sequence:

>882_bases
ATGCTCAAACTTGCCCTCGCCGACTGTCAGTCCCGGGTCGACGCTGTCCTTGCCGCACATATAGATGCATTGCCTCAAAC
CGCCCCCGCGTTGAAGGCCGCCATGCGCCATGGTGCCCTGATTGGCGGTAAACGTATACGCCCCTTCCTTGTATACGCCG
TGGGTGAATTGCTCGGGGTAGATAAGGCCAAGCTGGACCGACTCGCCGCCGCCGTTGAATGTGTTCATGCCTATTCCCTT
ATCCATGATGATTTGCCCGCCATGGATGACGACAACCTGCGCCGTGGCAAGCCTACGGTACACATTGCCTTCGATGAAGC
CACGGCAATACTCGCCGGTGATGCGTTGCAAACACTGGCCTTTGAAATCATCAGTGAATCCGATGCAGGCCTCGCCCCAA
AAGCGCAGGTCGCCATGATTGCGGCCCTGGCAAGGGCATCGGGATATCTGGGTATGTGTGGCGGGCAGGCACTGGATCTT
GCTGGTGAAGGCAAGAGCATCAGCCTCGATGAACTGACCCGGCTGCACAACCTGAAAACCGGCGCCCTTATTCGTGCTGC
CGTGGAGCTTGCGCTGATTGCCGCCGATGCCTCCGATGCCGACACGGCGGCACTTCGTGCCTATGCCGATGCCATTGGTC
TTGCGTTTCAGGTTCAGGACGACATCCTGGATATCACGGCTACCACCGAAGAAATCGGTAAGCCGCAGGGTTCTGATCTG
GATGCCAACAAGAGCACGTATCCTAAGTTGTTGGGACTCGATGGCGCCCGGCAAACTGCCGATGCACTGGTAGCCGACGC
ACTATCAGCGCTGGCCAAAATGCCATACAATAGTCAGCTACTTGCAGACTTCGCCCGTTATATCGTCGCGCGACGAGTAT
AA

Upstream 100 bases:

>100_bases
CCAGTCAGGCCAAGCTGGAACAGGCCCAACAAAAAGTGGCCATCTTGCTGACTCAGGCCCCGGATGCCCCACTCGACGAC
TTTTTACCCGAGGGAGAATA

Downstream 100 bases:

>100_bases
GAAAGAAAAGAATCTCGCTATGAGTTTGGACATTTCGAATTATCCATTGCTTGCCCTGGCGAGCACCCCGGAAGAGCTGC
GCCAGCTGCCTCAGTCGGCA

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MLKLALADCQSRVDAVLAAHIDALPQTAPALKAAMRHGALIGGKRIRPFLVYAVGELLGVDKAKLDRLAAAVECVHAYSL
IHDDLPAMDDDNLRRGKPTVHIAFDEATAILAGDALQTLAFEIISESDAGLAPKAQVAMIAALARASGYLGMCGGQALDL
AGEGKSISLDELTRLHNLKTGALIRAAVELALIAADASDADTAALRAYADAIGLAFQVQDDILDITATTEEIGKPQGSDL
DANKSTYPKLLGLDGARQTADALVADALSALAKMPYNSQLLADFARYIVARRV

Sequences:

>Translated_293_residues
MLKLALADCQSRVDAVLAAHIDALPQTAPALKAAMRHGALIGGKRIRPFLVYAVGELLGVDKAKLDRLAAAVECVHAYSL
IHDDLPAMDDDNLRRGKPTVHIAFDEATAILAGDALQTLAFEIISESDAGLAPKAQVAMIAALARASGYLGMCGGQALDL
AGEGKSISLDELTRLHNLKTGALIRAAVELALIAADASDADTAALRAYADAIGLAFQVQDDILDITATTEEIGKPQGSDL
DANKSTYPKLLGLDGARQTADALVADALSALAKMPYNSQLLADFARYIVARRV
>Mature_293_residues
MLKLALADCQSRVDAVLAAHIDALPQTAPALKAAMRHGALIGGKRIRPFLVYAVGELLGVDKAKLDRLAAAVECVHAYSL
IHDDLPAMDDDNLRRGKPTVHIAFDEATAILAGDALQTLAFEIISESDAGLAPKAQVAMIAALARASGYLGMCGGQALDL
AGEGKSISLDELTRLHNLKTGALIRAAVELALIAADASDADTAALRAYADAIGLAFQVQDDILDITATTEEIGKPQGSDL
DANKSTYPKLLGLDGARQTADALVADALSALAKMPYNSQLLADFARYIVARRV

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=217, Percent_Identity=27.6497695852535, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786623, Length=289, Percent_Identity=55.363321799308, Blast_Score=261, Evalue=3e-71,
Organism=Escherichia coli, GI1789578, Length=210, Percent_Identity=30.952380952381, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 30679; Mature: 30679

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKLALADCQSRVDAVLAAHIDALPQTAPALKAAMRHGALIGGKRIRPFLVYAVGELLGV
CCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
DKAKLDRLAAAVECVHAYSLIHDDLPAMDDDNLRRGKPTVHIAFDEATAILAGDALQTLA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
FEIISESDAGLAPKAQVAMIAALARASGYLGMCGGQALDLAGEGKSISLDELTRLHNLKT
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCCEEEECCCCCEECHHHHHHHHCCCH
GALIRAAVELALIAADASDADTAALRAYADAIGLAFQVQDDILDITATTEEIGKPQGSDL
HHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHEEEEECCCCEEEEECHHHHCCCCCCCC
DANKSTYPKLLGLDGARQTADALVADALSALAKMPYNSQLLADFARYIVARRV
CCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLKLALADCQSRVDAVLAAHIDALPQTAPALKAAMRHGALIGGKRIRPFLVYAVGELLGV
CCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
DKAKLDRLAAAVECVHAYSLIHDDLPAMDDDNLRRGKPTVHIAFDEATAILAGDALQTLA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
FEIISESDAGLAPKAQVAMIAALARASGYLGMCGGQALDLAGEGKSISLDELTRLHNLKT
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCCEEEECCCCCEECHHHHHHHHCCCH
GALIRAAVELALIAADASDADTAALRAYADAIGLAFQVQDDILDITATTEEIGKPQGSDL
HHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHEEEEECCCCEEEEECHHHHCCCCCCCC
DANKSTYPKLLGLDGARQTADALVADALSALAKMPYNSQLLADFARYIVARRV
CCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]