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The map label for this gene is bcr [H]

Identifier: 119775152

GI number: 119775152

Start: 2451798

End: 2453003

Strand: Direct

Name: bcr [H]

Synonym: Sama_2017

Alternate gene names: 119775152

Gene position: 2451798-2453003 (Clockwise)

Preceding gene: 119775151

Following gene: 119775153

Centisome position: 56.94

GC content: 54.89

Gene sequence:

>1206_bases
GTGGGTTCACCGACAGAAGCGCAAGCACGCACATCAGGGCTCAACCGGGCCTTTTTAATTCCCTTGCTGGCCGCCATTGT
GGCCATTACGCCGCTGGCCATTGATATGTATTTGCCGGCGATGTCGGTCATTGCGCTGAGTCTGGGCTCGGATGTTACCC
ATGTGCAGCAGAGTCTCAGTGTGTACCTTGCCGGATACGCCTGTGGCTTGTTGCTTTTTGGCCCAATGGCAGACAGATAC
GGCCGCCGTCCGCTGGTGCTGTTTGGTCTTACCGGTTTTGGGATTTGCAGCTTGCTCCTGTCCCATGTCAGCACACCCGA
CGCCTTTTTTGGGCTGCGTTTTGTGCAGGCCATGATAGGCTCGGCCGCCACTGTGGTGGTACCCGGCTATGTAAAAATTC
TCTATGGGGACAATACGGCCAAGGGCATGTCCTATGTGAGCCTTATTATGATGCTGGCGCCCTTGATTGCCCCCAGTATC
GGCAGCTTTATTCTTGGCTTCAGCCATTGGGAGATGATTTTCTATGTTCTCTCGGGCTATGCGCTGCTTGCGCTGACGTT
GGTATATTTCGGCTTACAAATTCCTGAGGTAAAAACCGAAAAGCATCAAAGACCCGGTTTTATTGAAGCCTATCGCACCG
TACTGACCCGCGCCGGAGTGAAGGGTTTTATCGCCAGCGGCGTACTCACCTCCTTCGCGTTTTTCTGCTACCTCACCGCC
TCTCCCTTTGTGTTTATGGAGGTTTACGGGCTGGACAGTCAGCATTTTGCCATGGTGTTTGCATCAAATGTGGGCGCCCT
GATGCTCGCCAATATTCTCAACTCCCGGATTGTGGGTCGTTTCGGCTCGCTGCGGCTACTTAGAGCCTCGACCCTGTGCG
GTCTGGTATTCGCCCTGCTGCTGTGCGCCGCTAACACCATTGAACTGGGGCTGTATGGTACTCTGCTGACGCTGGTCCCC
TTGATGGCTTGCCTCGGCATTATGTCGGTGAATGCTGACGCTATTGTGCTGCTCAAGTTTCAGCGGGAAACCGGCACTGC
AACCGCCGTGATAGGCACCCTCAGATTTGGGATTGGTGCATTGGCCGGGCCTTTGCTGGCTGCATTTTACACAGGCACTG
CCCTGCCATTTTCGGCACTGATGTTGTTTGCCGTACTGCTGGCCGGTGCCTGTCAGCACCTCGCCAGACGCACCTCGATT
GAATAA

Upstream 100 bases:

>100_bases
TGCGGGCTCAGTCACCTAGGATCGGAGATTCGCCGCGGCTGGGGAGCCGCCGCACATAGCTTTATCGCCTGATTATTCAT
TTTCACCACGAGAGGTAACA

Downstream 100 bases:

>100_bases
TCTGCAATTGCTTGCTTTCAGGCCAAATCCCGTACATCCGGCCTGAAAGCGATTTATTTACCTTATAATTCATTACTTTA
TAAACAAAATGCTTACACAT

Product: bicyclomycin resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Sulfonamide resistance protein [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MGSPTEAQARTSGLNRAFLIPLLAAIVAITPLAIDMYLPAMSVIALSLGSDVTHVQQSLSVYLAGYACGLLLFGPMADRY
GRRPLVLFGLTGFGICSLLLSHVSTPDAFFGLRFVQAMIGSAATVVVPGYVKILYGDNTAKGMSYVSLIMMLAPLIAPSI
GSFILGFSHWEMIFYVLSGYALLALTLVYFGLQIPEVKTEKHQRPGFIEAYRTVLTRAGVKGFIASGVLTSFAFFCYLTA
SPFVFMEVYGLDSQHFAMVFASNVGALMLANILNSRIVGRFGSLRLLRASTLCGLVFALLLCAANTIELGLYGTLLTLVP
LMACLGIMSVNADAIVLLKFQRETGTATAVIGTLRFGIGALAGPLLAAFYTGTALPFSALMLFAVLLAGACQHLARRTSI
E

Sequences:

>Translated_401_residues
MGSPTEAQARTSGLNRAFLIPLLAAIVAITPLAIDMYLPAMSVIALSLGSDVTHVQQSLSVYLAGYACGLLLFGPMADRY
GRRPLVLFGLTGFGICSLLLSHVSTPDAFFGLRFVQAMIGSAATVVVPGYVKILYGDNTAKGMSYVSLIMMLAPLIAPSI
GSFILGFSHWEMIFYVLSGYALLALTLVYFGLQIPEVKTEKHQRPGFIEAYRTVLTRAGVKGFIASGVLTSFAFFCYLTA
SPFVFMEVYGLDSQHFAMVFASNVGALMLANILNSRIVGRFGSLRLLRASTLCGLVFALLLCAANTIELGLYGTLLTLVP
LMACLGIMSVNADAIVLLKFQRETGTATAVIGTLRFGIGALAGPLLAAFYTGTALPFSALMLFAVLLAGACQHLARRTSI
E
>Mature_400_residues
GSPTEAQARTSGLNRAFLIPLLAAIVAITPLAIDMYLPAMSVIALSLGSDVTHVQQSLSVYLAGYACGLLLFGPMADRYG
RRPLVLFGLTGFGICSLLLSHVSTPDAFFGLRFVQAMIGSAATVVVPGYVKILYGDNTAKGMSYVSLIMMLAPLIAPSIG
SFILGFSHWEMIFYVLSGYALLALTLVYFGLQIPEVKTEKHQRPGFIEAYRTVLTRAGVKGFIASGVLTSFAFFCYLTAS
PFVFMEVYGLDSQHFAMVFASNVGALMLANILNSRIVGRFGSLRLLRASTLCGLVFALLLCAANTIELGLYGTLLTLVPL
MACLGIMSVNADAIVLLKFQRETGTATAVIGTLRFGIGALAGPLLAAFYTGTALPFSALMLFAVLLAGACQHLARRTSIE

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=368, Percent_Identity=33.1521739130435, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI48994889, Length=343, Percent_Identity=30.9037900874636, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1790146, Length=297, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787065, Length=356, Percent_Identity=26.685393258427, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790794, Length=282, Percent_Identity=23.758865248227, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87082312, Length=341, Percent_Identity=25.8064516129032, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42698; Mature: 42567

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSPTEAQARTSGLNRAFLIPLLAAIVAITPLAIDMYLPAMSVIALSLGSDVTHVQQSLS
CCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VYLAGYACGLLLFGPMADRYGRRPLVLFGLTGFGICSLLLSHVSTPDAFFGLRFVQAMIG
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
SAATVVVPGYVKILYGDNTAKGMSYVSLIMMLAPLIAPSIGSFILGFSHWEMIFYVLSGY
CCCEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLALTLVYFGLQIPEVKTEKHQRPGFIEAYRTVLTRAGVKGFIASGVLTSFAFFCYLTA
HHHHHHHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHC
SPFVFMEVYGLDSQHFAMVFASNVGALMLANILNSRIVGRFGSLRLLRASTLCGLVFALL
CCEEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LCAANTIELGLYGTLLTLVPLMACLGIMSVNADAIVLLKFQRETGTATAVIGTLRFGIGA
HHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
LAGPLLAAFYTGTALPFSALMLFAVLLAGACQHLARRTSIE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GSPTEAQARTSGLNRAFLIPLLAAIVAITPLAIDMYLPAMSVIALSLGSDVTHVQQSLS
CCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VYLAGYACGLLLFGPMADRYGRRPLVLFGLTGFGICSLLLSHVSTPDAFFGLRFVQAMIG
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
SAATVVVPGYVKILYGDNTAKGMSYVSLIMMLAPLIAPSIGSFILGFSHWEMIFYVLSGY
CCCEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLALTLVYFGLQIPEVKTEKHQRPGFIEAYRTVLTRAGVKGFIASGVLTSFAFFCYLTA
HHHHHHHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHC
SPFVFMEVYGLDSQHFAMVFASNVGALMLANILNSRIVGRFGSLRLLRASTLCGLVFALL
CCEEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LCAANTIELGLYGTLLTLVPLMACLGIMSVNADAIVLLKFQRETGTATAVIGTLRFGIGA
HHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
LAGPLLAAFYTGTALPFSALMLFAVLLAGACQHLARRTSIE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8486276; 9278503; 2694948 [H]