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The map label for this gene is metC [H]

Identifier: 119775143

GI number: 119775143

Start: 2439769

End: 2440974

Strand: Direct

Name: metC [H]

Synonym: Sama_2008

Alternate gene names: 119775143

Gene position: 2439769-2440974 (Clockwise)

Preceding gene: 119775142

Following gene: 119775146

Centisome position: 56.66

GC content: 54.56

Gene sequence:

>1206_bases
ATGTCAGATAAACCCATGAAAACCGCCACGAAAATCGTAAGTCTTGGCCGAGAAAAGAAATACAGTAAAGGGGTCATAAA
TCCTCCCGTGTTTCGCGCCTCCACCATAGTGTTCGACACCATGGAGGAAATGCGTCATGCCGCCAAAAACAAACACAATG
GTGAAATGTTTTATGGCCGCCGCGGCACGCCAACGCATTTTGGTTTTCAGGCCGCCATTGCCGAGCTGGAAGGTGGTGCG
GGCACGGCGCTCTACCCCAGTGGCGCAGCGGCCATTTCAGCCAGCTTATTGGCCTTTCTCCAGGCAGGCGATCACCTGCT
GATGGTCGACAGCGTGTATGAGCCGACCCGGGACCTGTGTGACAAGGTACTCAAGGGCTACGGTATTGAAACCACCTACT
ACGATCCCTTGATTGGTGCCGGTATCGAGGCCTTAATCCGCCCCAACACCAGGGTGCTCTTTGTTGAGTCCCCAGGCTCT
ATCACCATGGAAGTGCAGGATGTGCCCACCCTCGCCCGTATCGCCCATGAACACGGATTGGTGGTGATACTCGATAACAC
CTGGGCTTCGCCCATCAACAGCCGTCCCTTTGAGCTTGGCGTGGATGTCTCCATTCAGGCCGCCACAAAATACATCGTCG
GTCACTCAGATGTGATGATGGGAACAGCAACCGCCAGCCCACAATATTGGGACAAGCTGCGTGAGCACAGTTATCTCCTG
GGGCAAACAACCTCGCCGGATGACGTGTACCTGGCCGCACGGGGTCTTCGCACCCTGGGGGTACGCATGGCACAGCACGA
AAAAAATGCACTCGCCGTGGCCAACTGGCTTAAGACCCGTCCGGAAGTCGACCACCTTCGCCACCCGGCTTTTGAAGAGT
GCCCCGGCCATGAGTTTTTCAAACGGGACTTTTCTGGCAGTAATGGACTGTTTTCATTCGTATTAAAGCGAGGAACCGTG
GACGCAGTAACTGCCATGGTCGAAGGCATGAGTCACTTTAAAATGGGCTTTTCATGGGGCGGTTTTGAAAGCCTTATCCT
CGGGGTGACAGGAATTCACAACATCCGCTCAGCCACCCGCTGGGACAGCAGTAAACCCCTTATTCGGGTGCACATTGGCC
TGGAAGATCCGGAAGATTTGATTGAGGATCTCAGCGCCGGGTTTGTGCGTTTCAATGAGGTCATGGCCAAAGAAACGCAA
GGGTGA

Upstream 100 bases:

>100_bases
AAAGCTGCCCTGAGACAACCGCTCGGTGCAGTATCTCAGTTTAATTTGGCCATCCATATGGTAAGATGGCCAAAATCTTA
TTCCAGGGGCAGGACGCAGC

Downstream 100 bases:

>100_bases
AAGTCTCAGTCTTGAAGAGACACTGGCCGGTTCCCAGCACGGTCATCTAAGTATCCAAAACAACAGAGTCCGCAGTGTAA
GCTGCGGACTCTTATGATTT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSDKPMKTATKIVSLGREKKYSKGVINPPVFRASTIVFDTMEEMRHAAKNKHNGEMFYGRRGTPTHFGFQAAIAELEGGA
GTALYPSGAAAISASLLAFLQAGDHLLMVDSVYEPTRDLCDKVLKGYGIETTYYDPLIGAGIEALIRPNTRVLFVESPGS
ITMEVQDVPTLARIAHEHGLVVILDNTWASPINSRPFELGVDVSIQAATKYIVGHSDVMMGTATASPQYWDKLREHSYLL
GQTTSPDDVYLAARGLRTLGVRMAQHEKNALAVANWLKTRPEVDHLRHPAFEECPGHEFFKRDFSGSNGLFSFVLKRGTV
DAVTAMVEGMSHFKMGFSWGGFESLILGVTGIHNIRSATRWDSSKPLIRVHIGLEDPEDLIEDLSAGFVRFNEVMAKETQ
G

Sequences:

>Translated_401_residues
MSDKPMKTATKIVSLGREKKYSKGVINPPVFRASTIVFDTMEEMRHAAKNKHNGEMFYGRRGTPTHFGFQAAIAELEGGA
GTALYPSGAAAISASLLAFLQAGDHLLMVDSVYEPTRDLCDKVLKGYGIETTYYDPLIGAGIEALIRPNTRVLFVESPGS
ITMEVQDVPTLARIAHEHGLVVILDNTWASPINSRPFELGVDVSIQAATKYIVGHSDVMMGTATASPQYWDKLREHSYLL
GQTTSPDDVYLAARGLRTLGVRMAQHEKNALAVANWLKTRPEVDHLRHPAFEECPGHEFFKRDFSGSNGLFSFVLKRGTV
DAVTAMVEGMSHFKMGFSWGGFESLILGVTGIHNIRSATRWDSSKPLIRVHIGLEDPEDLIEDLSAGFVRFNEVMAKETQ
G
>Mature_400_residues
SDKPMKTATKIVSLGREKKYSKGVINPPVFRASTIVFDTMEEMRHAAKNKHNGEMFYGRRGTPTHFGFQAAIAELEGGAG
TALYPSGAAAISASLLAFLQAGDHLLMVDSVYEPTRDLCDKVLKGYGIETTYYDPLIGAGIEALIRPNTRVLFVESPGSI
TMEVQDVPTLARIAHEHGLVVILDNTWASPINSRPFELGVDVSIQAATKYIVGHSDVMMGTATASPQYWDKLREHSYLLG
QTTSPDDVYLAARGLRTLGVRMAQHEKNALAVANWLKTRPEVDHLRHPAFEECPGHEFFKRDFSGSNGLFSFVLKRGTVD
AVTAMVEGMSHFKMGFSWGGFESLILGVTGIHNIRSATRWDSSKPLIRVHIGLEDPEDLIEDLSAGFVRFNEVMAKETQG

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=340, Percent_Identity=34.1176470588235, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI299473759, Length=340, Percent_Identity=30.8823529411765, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI25453487, Length=339, Percent_Identity=29.7935103244838, Blast_Score=151, Evalue=8e-37,
Organism=Escherichia coli, GI1789383, Length=396, Percent_Identity=51.010101010101, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1790375, Length=392, Percent_Identity=34.4387755102041, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI71980708, Length=366, Percent_Identity=33.879781420765, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17538055, Length=378, Percent_Identity=32.010582010582, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17560056, Length=375, Percent_Identity=32.2666666666667, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI193202265, Length=85, Percent_Identity=38.8235294117647, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321170, Length=333, Percent_Identity=47.4474474474475, Blast_Score=326, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6319307, Length=344, Percent_Identity=31.1046511627907, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6321904, Length=339, Percent_Identity=25.0737463126844, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321254, Length=419, Percent_Identity=26.2529832935561, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323333, Length=417, Percent_Identity=24.7002398081535, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19922554, Length=390, Percent_Identity=32.8205128205128, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44103; Mature: 43972

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKPMKTATKIVSLGREKKYSKGVINPPVFRASTIVFDTMEEMRHAAKNKHNGEMFYGR
CCCCCHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECC
RGTPTHFGFQAAIAELEGGAGTALYPSGAAAISASLLAFLQAGDHLLMVDSVYEPTRDLC
CCCCCCCHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHH
DKVLKGYGIETTYYDPLIGAGIEALIRPNTRVLFVESPGSITMEVQDVPTLARIAHEHGL
HHHHHCCCCCCEECCCHHHCCHHHEECCCCEEEEEECCCCEEEEECCCCHHHHHHHHCCE
VVILDNTWASPINSRPFELGVDVSIQAATKYIVGHSDVMMGTATASPQYWDKLREHSYLL
EEEECCCCCCCCCCCCEEECCCEEEHHHHEEEECCCCEEEEECCCCHHHHHHHHHCCEEE
GQTTSPDDVYLAARGLRTLGVRMAQHEKNALAVANWLKTRPEVDHLRHPAFEECPGHEFF
CCCCCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHCCCCHHHCCCHHHH
KRDFSGSNGLFSFVLKRGTVDAVTAMVEGMSHFKMGFSWGGFESLILGVTGIHNIRSATR
HHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHC
WDSSKPLIRVHIGLEDPEDLIEDLSAGFVRFNEVMAKETQG
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDKPMKTATKIVSLGREKKYSKGVINPPVFRASTIVFDTMEEMRHAAKNKHNGEMFYGR
CCCCHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECC
RGTPTHFGFQAAIAELEGGAGTALYPSGAAAISASLLAFLQAGDHLLMVDSVYEPTRDLC
CCCCCCCHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHH
DKVLKGYGIETTYYDPLIGAGIEALIRPNTRVLFVESPGSITMEVQDVPTLARIAHEHGL
HHHHHCCCCCCEECCCHHHCCHHHEECCCCEEEEEECCCCEEEEECCCCHHHHHHHHCCE
VVILDNTWASPINSRPFELGVDVSIQAATKYIVGHSDVMMGTATASPQYWDKLREHSYLL
EEEECCCCCCCCCCCCEEECCCEEEHHHHEEEECCCCEEEEECCCCHHHHHHHHHCCEEE
GQTTSPDDVYLAARGLRTLGVRMAQHEKNALAVANWLKTRPEVDHLRHPAFEECPGHEFF
CCCCCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHCCCCHHHCCCHHHH
KRDFSGSNGLFSFVLKRGTVDAVTAMVEGMSHFKMGFSWGGFESLILGVTGIHNIRSATR
HHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHC
WDSSKPLIRVHIGLEDPEDLIEDLSAGFVRFNEVMAKETQG
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659970; 11677609 [H]