Click here to switch to the map view.

The map label for this gene is hisI [H]

Identifier: 119775083

GI number: 119775083

Start: 2375532

End: 2376158

Strand: Direct

Name: hisI [H]

Synonym: Sama_1948

Alternate gene names: 119775083

Gene position: 2375532-2376158 (Clockwise)

Preceding gene: 119775082

Following gene: 119775089

Centisome position: 55.17

GC content: 55.66

Gene sequence:

>627_bases
ATGGCTGACGAAACCCTTTTAAACCGTCTCGATTGGGACAAACAAGACGGGCTCATCCCCGCCATCGTGCAAAACCATTT
AAGCGGCAAGGTGCTGATGCAGGGCTATATGGACAAGGCCGCGCTGGAAAAGACCCTGCAAACCGGCATGGTGACCTTTT
TCAGTCGCAGCAAGCAGCGACTGTGGACCAAGGGCGAGTCATCCGGCAATGTGCTTAGCCTTATCAGCATCGCCGCCGAT
TGCGACAATGACAGCCTCTTGGTGCAGGTTCTGCCCAAAGGCCCCACCTGCCATACAGGGACCGAGTCTTGCTGGCAAGA
TGGCAGCCACAGCTTTATTGCCGGGCTCGAGAGCTTAATTCAGGGTAGGAAAAAAGCCTGTGGTGCCGGCGAAGGCGGCA
GCAGTTATACGGCATCCCTGTTTGCCAGTGGCACCAAGCGCATGGCGCAAAAAGTGGGTGAAGAAGGGCTGGAGACGGCG
CTCGCCGCCGCAACCCACGATAAAGAAGAGCTGGTAGATGAAGCATCGGATTTGCTGTTTCACCTGATGGTACTGCTGGA
GGACCAGGGGCTGTCCCTTGCGGATATCACCGAAAATCTCTATAAGCGTCATCAGGCCAGAAGCTAA

Upstream 100 bases:

>100_bases
TGCCGCAAGCGTGTTTCATAAAGGCATCATCAATATTGGTGAGCTTAAACAATTCCTTGTATCACAGGGGATTGCCATCA
GGTTAACGGAGTAATGGCCC

Downstream 100 bases:

>100_bases
GACTCTGGTTTCCACCCACGTAAAAACGCTGCCATGGCAGCGTTTTTTGTTTGTCTTTTCAAATGGTATTTCTTTCGTCC
GACACCGACGGTGACCGCTA

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MADETLLNRLDWDKQDGLIPAIVQNHLSGKVLMQGYMDKAALEKTLQTGMVTFFSRSKQRLWTKGESSGNVLSLISIAAD
CDNDSLLVQVLPKGPTCHTGTESCWQDGSHSFIAGLESLIQGRKKACGAGEGGSSYTASLFASGTKRMAQKVGEEGLETA
LAAATHDKEELVDEASDLLFHLMVLLEDQGLSLADITENLYKRHQARS

Sequences:

>Translated_208_residues
MADETLLNRLDWDKQDGLIPAIVQNHLSGKVLMQGYMDKAALEKTLQTGMVTFFSRSKQRLWTKGESSGNVLSLISIAAD
CDNDSLLVQVLPKGPTCHTGTESCWQDGSHSFIAGLESLIQGRKKACGAGEGGSSYTASLFASGTKRMAQKVGEEGLETA
LAAATHDKEELVDEASDLLFHLMVLLEDQGLSLADITENLYKRHQARS
>Mature_207_residues
ADETLLNRLDWDKQDGLIPAIVQNHLSGKVLMQGYMDKAALEKTLQTGMVTFFSRSKQRLWTKGESSGNVLSLISIAADC
DNDSLLVQVLPKGPTCHTGTESCWQDGSHSFIAGLESLIQGRKKACGAGEGGSSYTASLFASGTKRMAQKVGEEGLETAL
AAATHDKEELVDEASDLLFHLMVLLEDQGLSLADITENLYKRHQARS

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=207, Percent_Identity=61.3526570048309, Blast_Score=258, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6319819, Length=206, Percent_Identity=33.495145631068, Blast_Score=89, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 22531; Mature: 22400

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADETLLNRLDWDKQDGLIPAIVQNHLSGKVLMQGYMDKAALEKTLQTGMVTFFSRSKQR
CCCHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWTKGESSGNVLSLISIAADCDNDSLLVQVLPKGPTCHTGTESCWQDGSHSFIAGLESLI
HHCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHCCCHHHHHHHHHHH
QGRKKACGAGEGGSSYTASLFASGTKRMAQKVGEEGLETALAAATHDKEELVDEASDLLF
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
HLMVLLEDQGLSLADITENLYKRHQARS
HHHHHHHCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADETLLNRLDWDKQDGLIPAIVQNHLSGKVLMQGYMDKAALEKTLQTGMVTFFSRSKQR
CCHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWTKGESSGNVLSLISIAADCDNDSLLVQVLPKGPTCHTGTESCWQDGSHSFIAGLESLI
HHCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHCCCHHHHHHHHHHH
QGRKKACGAGEGGSSYTASLFASGTKRMAQKVGEEGLETALAAATHDKEELVDEASDLLF
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
HLMVLLEDQGLSLADITENLYKRHQARS
HHHHHHHCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]