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The map label for this gene is hisG [H]

Identifier: 119775076

GI number: 119775076

Start: 2368941

End: 2369834

Strand: Direct

Name: hisG [H]

Synonym: Sama_1941

Alternate gene names: 119775076

Gene position: 2368941-2369834 (Clockwise)

Preceding gene: 119775067

Following gene: 119775077

Centisome position: 55.01

GC content: 55.37

Gene sequence:

>894_bases
ATGACTGCCAGACTGAGAATCGCCATTCAAAAATCCGGACGCCTGTCCACCGAGTCCCAACAGCTGCTGAAAAGCTGCGG
GGTAAAATTCAGCGTGAATGAACAGCGGCTTATCGCCCACGCCGACAATATGCCCGTGGATATTTTGCGGGTGCGCGACG
ATGACATCCCCGGCCTGGTGATGGATGGTGTGGTCGATTTAGGCATAGTCGGTGAAAACGTGCTGGAAGAAGAGCAGCTT
GAGCGCGACTGCCTGGGCAATGCCTCTGACGTCGTTAAGCTCAGACAACTGGACTTTGGCGCCTGCCGTCTGTCGCTGGC
GGTACCGACCGAATTTGTCTATGGCGATGCCAGCTCACTGGAAGGCCTTAGGATCGCGACCTCCTACCCCAACCTGCTCC
GCCGTTTTATGCAGAATAAAGGCATATCCTATCAGGACTGCCAATTAAAAGGATCTGTGGAAGTGGCGCCCCGTGCTGGC
CTTGCCGATGGTATCTGCGATCTGGTGTCGACCGGTGCCACCCTCGAAGCCAACGGCCTGTACGAAACTGAAGTCATCTT
CCGCTCCATGGCTTGTATTATTCAGTCCACTACACCGCAAAGTGATACCAAGCAGGCACTTATCAACAAAATCCTCTCCC
GGGTCAATGGGGTTATCCGTGCCCGTGAAAGCAAATACATCCTGCTGCACGCCCCAACAGAAACCCTGGAGCAAATCGTC
GCCCTGCTGCCCGGCGCCGAAAACCCAACCGTACTGCCGCTGAACGACGAAACCAACCGTGTTGCCATCCACGCGGTCAG
CACCGAAGACTTGTTCTGGGACACCATGGAAGAACTGACGGCCCTCGGTGCCAGCTCGATTCTGGTGATGCCAATCGAAA
AAATGATGGGGTAA

Upstream 100 bases:

>100_bases
TCTAAAGTTTCAGGACAACCCCCGGAAGGAATTCCGGGGGTTTTTCTTTGCACCAAAGTTTTTGATTTTAAACATTACTT
TAGATACAGGATATTTCGCC

Downstream 100 bases:

>100_bases
GCGATGGAAACCTTGGTCTGGAACACCTTAAGCGAGGATGCCAAGCGCCAGGCGCTGTCCCGCTCACCTCTGGTGGGGGA
TGATAGTCTGGCGACATCCG

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MTARLRIAIQKSGRLSTESQQLLKSCGVKFSVNEQRLIAHADNMPVDILRVRDDDIPGLVMDGVVDLGIVGENVLEEEQL
ERDCLGNASDVVKLRQLDFGACRLSLAVPTEFVYGDASSLEGLRIATSYPNLLRRFMQNKGISYQDCQLKGSVEVAPRAG
LADGICDLVSTGATLEANGLYETEVIFRSMACIIQSTTPQSDTKQALINKILSRVNGVIRARESKYILLHAPTETLEQIV
ALLPGAENPTVLPLNDETNRVAIHAVSTEDLFWDTMEELTALGASSILVMPIEKMMG

Sequences:

>Translated_297_residues
MTARLRIAIQKSGRLSTESQQLLKSCGVKFSVNEQRLIAHADNMPVDILRVRDDDIPGLVMDGVVDLGIVGENVLEEEQL
ERDCLGNASDVVKLRQLDFGACRLSLAVPTEFVYGDASSLEGLRIATSYPNLLRRFMQNKGISYQDCQLKGSVEVAPRAG
LADGICDLVSTGATLEANGLYETEVIFRSMACIIQSTTPQSDTKQALINKILSRVNGVIRARESKYILLHAPTETLEQIV
ALLPGAENPTVLPLNDETNRVAIHAVSTEDLFWDTMEELTALGASSILVMPIEKMMG
>Mature_296_residues
TARLRIAIQKSGRLSTESQQLLKSCGVKFSVNEQRLIAHADNMPVDILRVRDDDIPGLVMDGVVDLGIVGENVLEEEQLE
RDCLGNASDVVKLRQLDFGACRLSLAVPTEFVYGDASSLEGLRIATSYPNLLRRFMQNKGISYQDCQLKGSVEVAPRAGL
ADGICDLVSTGATLEANGLYETEVIFRSMACIIQSTTPQSDTKQALINKILSRVNGVIRARESKYILLHAPTETLEQIVA
LLPGAENPTVLPLNDETNRVAIHAVSTEDLFWDTMEELTALGASSILVMPIEKMMG

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=293, Percent_Identity=66.8941979522184, Blast_Score=407, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6320896, Length=298, Percent_Identity=31.5436241610738, Blast_Score=133, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 32447; Mature: 32316

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARLRIAIQKSGRLSTESQQLLKSCGVKFSVNEQRLIAHADNMPVDILRVRDDDIPGLV
CCCEEEEEEECCCCCCHHHHHHHHHCCCEEECCCCEEEEECCCCCEEEEEECCCCCCCHH
MDGVVDLGIVGENVLEEEQLERDCLGNASDVVKLRQLDFGACRLSLAVPTEFVYGDASSL
HHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCC
EGLRIATSYPNLLRRFMQNKGISYQDCQLKGSVEVAPRAGLADGICDLVSTGATLEANGL
CCEEEECCCHHHHHHHHHHCCCCEECEEECCCEEECCCCCCHHHHHHHHHCCCEEECCCC
YETEVIFRSMACIIQSTTPQSDTKQALINKILSRVNGVIRARESKYILLHAPTETLEQIV
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCEEEEECCHHHHHHHH
ALLPGAENPTVLPLNDETNRVAIHAVSTEDLFWDTMEELTALGASSILVMPIEKMMG
HHCCCCCCCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEHHHHCC
>Mature Secondary Structure 
TARLRIAIQKSGRLSTESQQLLKSCGVKFSVNEQRLIAHADNMPVDILRVRDDDIPGLV
CCEEEEEEECCCCCCHHHHHHHHHCCCEEECCCCEEEEECCCCCEEEEEECCCCCCCHH
MDGVVDLGIVGENVLEEEQLERDCLGNASDVVKLRQLDFGACRLSLAVPTEFVYGDASSL
HHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCC
EGLRIATSYPNLLRRFMQNKGISYQDCQLKGSVEVAPRAGLADGICDLVSTGATLEANGL
CCEEEECCCHHHHHHHHHHCCCCEECEEECCCEEECCCCCCHHHHHHHHHCCCEEECCCC
YETEVIFRSMACIIQSTTPQSDTKQALINKILSRVNGVIRARESKYILLHAPTETLEQIV
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCEEEEECCHHHHHHHH
ALLPGAENPTVLPLNDETNRVAIHAVSTEDLFWDTMEELTALGASSILVMPIEKMMG
HHCCCCCCCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA