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The map label for this gene is uraA [H]

Identifier: 119775053

GI number: 119775053

Start: 2344815

End: 2346044

Strand: Direct

Name: uraA [H]

Synonym: Sama_1918

Alternate gene names: 119775053

Gene position: 2344815-2346044 (Clockwise)

Preceding gene: 119775050

Following gene: 119775055

Centisome position: 54.45

GC content: 55.93

Gene sequence:

>1230_bases
ATGAATAGACTCCTGCTTCCCCTGCAGGGCGCACAAATGTTGTTTGTCGCCTTTGGGGCACTGGTGTTGATGCCGCTGTT
GACGGGCCTGGATACCAGTGTTGCGCTCTTTACCGCCGGCATAGGCACCTTGTTGTTTCAGCTGATCACCCGCCGTCAGG
TACCCATATTCCTCGCTTCCTCCTTCGCGTTCATTGCCCCGATCATGTACTCAGTGCAGATGTGGGGTGTGGCTGCAACT
ATGGGCGGCTTGGTCGCGGCTGGCTGTGTGTATCTGGTATTGTCCACGCTGGTAAAACTGCGGGGAGTTGGCTTTATCCA
TCGCCTGTTACCCCCCGTGGTGGTTGGTCCCGTGATCATTATCATTGGCTTGGGACTGGCGCCCGTCGCTGTGAATATGG
CGCTCGGTAAGAGTGGCGATGGCAGCCTGGTATTGGTTGAAGGAAACACAGCCCTTATCATCTCGCTGCTGTCCCTTATC
ACCACAGTCTTGGTTGCCGTGCTGGCAAAAGGCCTACTAAAACTCATGCCCATTCTCGCCGGGATTTTGGTGGGTTATGT
GGCCAGCCTTTTTTATGGCGTAGTAAGCTTTGATGCCATGACCAATGCCCCCTGGTTTTCCCTGCCAAGCTTTACAGCAC
CGGAATTCCACTGGCAGGCCATCCTCTTCATGATCCCCGTGGCCATTGCTCCTGCGGTCGAGCACATCGGCGACATCCTG
GCTATCTCCAACGTGACCCGTAAAGACTTTATGAAAGACCCTGGCCTGCACCGCACCCTTGCCGGCGACGGGGTAGCCAC
CATTGCTGCAGCCGCCTTTGGCGGACCACCCAATACCACCTACTCGGAAGTGACAGGCGCGGTCACCTTAACCCGCAACT
TCGACCCCAGGATCATGACCTGGGCAGCGATTGTGGCCATTTTGCTGGCCTTCGTTGGCAAACTTGGTGCCTTGATGCAA
ACCATACCCGTGCCTGTGATGGGCGGTATCATGTGCTTGCTGTTCGGCTCGATTGCCGCAGTGGGCCTTAATACCCTCAT
TCGCAATCAGGTGGATTTGGCCTGCCCACGCAATCTGGCCATTGTAGGCGTGACCCTGGTATTCGGTATTGGCGGCATGG
CCTTTGGTATTGGCTCATTCAGCCTCACCGGCATCAGTTTGTGCGGCATTGTGGCGATTTTAATGAATCTGGTATTGCCA
CCGTCAGCGCCCGAGCCTGAAAGCCCATAA

Upstream 100 bases:

>100_bases
CCTTGTAAGCCAAGGAGTTCACAAAAAAACGATCCTGACTTATCAAAATGCCAACAACTGGTAGAATGGGAAGATTTTTA
ACCCTACAGGATATAACAAA

Downstream 100 bases:

>100_bases
TCCCCAAAGCCGATGCGCGATGTCACTCAGTGCCAAAGATTACTACACTGAATTACAGCCACAAAAAAGCCCCGCTTGGC
GGGGCTTTTCTTACAAGGCA

Product: uracil-xanthine permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MNRLLLPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITRRQVPIFLASSFAFIAPIMYSVQMWGVAAT
MGGLVAAGCVYLVLSTLVKLRGVGFIHRLLPPVVVGPVIIIIGLGLAPVAVNMALGKSGDGSLVLVEGNTALIISLLSLI
TTVLVAVLAKGLLKLMPILAGILVGYVASLFYGVVSFDAMTNAPWFSLPSFTAPEFHWQAILFMIPVAIAPAVEHIGDIL
AISNVTRKDFMKDPGLHRTLAGDGVATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPRIMTWAAIVAILLAFVGKLGALMQ
TIPVPVMGGIMCLLFGSIAAVGLNTLIRNQVDLACPRNLAIVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAILMNLVLP
PSAPEPESP

Sequences:

>Translated_409_residues
MNRLLLPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITRRQVPIFLASSFAFIAPIMYSVQMWGVAAT
MGGLVAAGCVYLVLSTLVKLRGVGFIHRLLPPVVVGPVIIIIGLGLAPVAVNMALGKSGDGSLVLVEGNTALIISLLSLI
TTVLVAVLAKGLLKLMPILAGILVGYVASLFYGVVSFDAMTNAPWFSLPSFTAPEFHWQAILFMIPVAIAPAVEHIGDIL
AISNVTRKDFMKDPGLHRTLAGDGVATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPRIMTWAAIVAILLAFVGKLGALMQ
TIPVPVMGGIMCLLFGSIAAVGLNTLIRNQVDLACPRNLAIVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAILMNLVLP
PSAPEPESP
>Mature_409_residues
MNRLLLPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITRRQVPIFLASSFAFIAPIMYSVQMWGVAAT
MGGLVAAGCVYLVLSTLVKLRGVGFIHRLLPPVVVGPVIIIIGLGLAPVAVNMALGKSGDGSLVLVEGNTALIISLLSLI
TTVLVAVLAKGLLKLMPILAGILVGYVASLFYGVVSFDAMTNAPWFSLPSFTAPEFHWQAILFMIPVAIAPAVEHIGDIL
AISNVTRKDFMKDPGLHRTLAGDGVATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPRIMTWAAIVAILLAFVGKLGALMQ
TIPVPVMGGIMCLLFGSIAAVGLNTLIRNQVDLACPRNLAIVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAILMNLVLP
PSAPEPESP

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=401, Percent_Identity=24.4389027431421, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI40316845, Length=401, Percent_Identity=24.4389027431421, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI44680145, Length=435, Percent_Identity=25.2873563218391, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI44680143, Length=438, Percent_Identity=25.5707762557078, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788843, Length=402, Percent_Identity=40.2985074626866, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI87081818, Length=417, Percent_Identity=36.9304556354916, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI87082181, Length=395, Percent_Identity=29.3670886075949, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI87082178, Length=318, Percent_Identity=28.9308176100629, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790087, Length=372, Percent_Identity=25.5376344086022, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17558856, Length=180, Percent_Identity=26.1111111111111, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17542262, Length=179, Percent_Identity=26.8156424581006, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356175, Length=392, Percent_Identity=26.7857142857143, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 42516; Mature: 42516

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]