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The map label for this gene is cvrA [H]

Identifier: 119775006

GI number: 119775006

Start: 2281277

End: 2283277

Strand: Reverse

Name: cvrA [H]

Synonym: Sama_1871

Alternate gene names: 119775006

Gene position: 2283277-2281277 (Counterclockwise)

Preceding gene: 119775014

Following gene: 119775004

Centisome position: 53.02

GC content: 53.17

Gene sequence:

>2001_bases
ATGGTTGAACATATCACCGGCATTCTGGCGCTTATTGGAGTGCTTTCGTTGTTTTGCCAGTGGCTGGGTTGGAAGTTAAG
GCTTCCAGCCATTTTGCCTCTGCTCCTCTGTGGCCTGCTGCTTGGGCCCGGGCTTGGTTTTCTCAAGCCCGATGCCATTT
TTGGCGATCTTCTGTTCCCGATGATTTCTCTGGGTGTTGCCATCATCTTATTTGAAGGTGCATTGACGCTTAACTTCAAA
GAAATCAAAGACTATGGTCGAATGGTAACCCACCTCGTGACCATAGGTATGGTGGTGACCTGGGTGGCAATCTCCCTTGC
GACTCACTACTTTATGGGATTTGATTGGGCGCTGGCCTGGTTATTCGGTGCTTTGGTGGTGGTGACAGGTCCCACAGTGA
TAGTGCCCATGCTAAGGAGTGTACGTCCCAAGTCCCAGCTTGCCAGTATCCTTCGCTGGGAAGGCATAGTGATTGACCCC
ATTGGCGCTGTGCTGGCGGTATTGGTATTTGAATATATCGCGGCCTCCCAAAATGCCACCGAGCACATTTTGATGTCATT
CGGCTCGATTTTGGCGCTGGGTTTTGGTGTCGGAGCCGCCATGGGATATGTGGTGGGCTGGGTGCTTCGCAAAGATCTCT
TGCCGCATTATCTGAGAAACACCGCCGTGCTCACCGTGATGCTGGGCACCTTTGTGGGCTCGAATCTGCTGCAGGAAGAA
TCGGGTCTGCTCACGGTAACAGTGATGGGTATTTGGCTTGCCAATATGCGCGGGGTAGACATTGCCGATATTCTCGAGTT
TAAAGAAACCCTGACGGTACTGATGATTTCGGCGCTGTTTATTTTGCTGGCGGCAAGGCTCGACTCCACTGCCATGCTGG
ATTTAGGCTGGGGCGGCATTGGAGTGCTCGCCGTTGCCATGCTGATTGCCCGGCCACTCAGCGTGTGGCTGTCAGGCATA
GGCACCAATCTTACGGCCCCCGAAAAGTGGTTTTTAAGTTGGGTGGCGCCACGGGGAATTGTGGCGGCGGCCGTTTCCTC
GCTGTTTGCCATCAAGCTTGAAGAGCAGGGCGTGCCTGGCGCCGAGAAAATTGTGCCTCTGGTGTTTCTGATTATTATCG
GCACTGTGGTTATTCAAAGTCTTTCAGCAGGCACCTGGGCCCGACTGCTTAAAGTCAAGGCCGACTCTGCCCAGGGACTG
CTGCTCTTTGGAGCCTCGAGCTTTTCCCGCACCTTTGCCAAATTGTTGAAGACTAAAAATATCAAAGTCATCCTTGCCGA
TACTAACTGGGACAATATTCGTCTGGCGCGGATGGACAACATCCCTGTTTACTTTGGCAATCCGGCATCGGAACACGCCG
AGACTTATCTGGACTTGACCGGCATCGGTCGGGTGCTGGTGGTATCACCTTACCGGCAGCTAAATCCTTTGGTGAGTTTT
CATTTTCAGGATTATTTTGGCGCCGAAAAGGTTTTTGGGCTGAACAATATGGAAGGCTCCAGCGCCCGTCATCTGGCCTC
TGAAGTTTACATGAAGCGATTGTGCCTGTTTGGCGAAGGGATTTCTTACGCCAAAATCGCCAGCCAGATGGCGAAAGGCG
CCATCTTGAAGAGTACCACCCTGAGGGAAAGTTTTACGCTGGTGGATTTTATGCGCCGCTACGGTGAAAGCGTGCTGCCA
TTGGTGTATCTGCAGGATGAAAAGTTGCGTATTGTCACCGCCGGCAGCGACATCCCGGCCACTGGCATTGAGCTTATCAG
TTTGATCCCGGTTGAGTCGCAGCAATACGCCAAAGAGCAGCAGGAAAAAGAAGCGCTTGAGAAGGCTCTGGCTGAGAAAG
AAGACGCTGAACGCGCTGCGCTTGAAAAGCTGGCCCGTGAGCAGGAAGACGCGGCCCGTGAAGCGGCCAGTGAGGCGAAC
GCAGGCTTTGAAGAAGAAACCGTTGGCAGTCCGGCACTCAAAGAGGGAGGCGGTGAAGGCAATCAACCGCTCAAAGCCTG
A

Upstream 100 bases:

>100_bases
GCCCCGTGGCGCTCTGCATAAAAATAGATAAGATGAAACAGACACATTTGGCTGCTACTGTGATCTTACTTTCAGGGATC
TTCTGTTCAAGGATTAATAC

Downstream 100 bases:

>100_bases
GACAAAACATTCACCAATTGGTGATATCTAAGCAGGAGTCCGACGACCACTTGATCCACTGTTGCAATCAGCAATAACAG
AAAAGGCGCCCAGAGGCGCC

Product: sodium/hydrogen exchanger family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 666; Mature: 666

Protein sequence:

>666_residues
MVEHITGILALIGVLSLFCQWLGWKLRLPAILPLLLCGLLLGPGLGFLKPDAIFGDLLFPMISLGVAIILFEGALTLNFK
EIKDYGRMVTHLVTIGMVVTWVAISLATHYFMGFDWALAWLFGALVVVTGPTVIVPMLRSVRPKSQLASILRWEGIVIDP
IGAVLAVLVFEYIAASQNATEHILMSFGSILALGFGVGAAMGYVVGWVLRKDLLPHYLRNTAVLTVMLGTFVGSNLLQEE
SGLLTVTVMGIWLANMRGVDIADILEFKETLTVLMISALFILLAARLDSTAMLDLGWGGIGVLAVAMLIARPLSVWLSGI
GTNLTAPEKWFLSWVAPRGIVAAAVSSLFAIKLEEQGVPGAEKIVPLVFLIIIGTVVIQSLSAGTWARLLKVKADSAQGL
LLFGASSFSRTFAKLLKTKNIKVILADTNWDNIRLARMDNIPVYFGNPASEHAETYLDLTGIGRVLVVSPYRQLNPLVSF
HFQDYFGAEKVFGLNNMEGSSARHLASEVYMKRLCLFGEGISYAKIASQMAKGAILKSTTLRESFTLVDFMRRYGESVLP
LVYLQDEKLRIVTAGSDIPATGIELISLIPVESQQYAKEQQEKEALEKALAEKEDAERAALEKLAREQEDAAREAASEAN
AGFEEETVGSPALKEGGGEGNQPLKA

Sequences:

>Translated_666_residues
MVEHITGILALIGVLSLFCQWLGWKLRLPAILPLLLCGLLLGPGLGFLKPDAIFGDLLFPMISLGVAIILFEGALTLNFK
EIKDYGRMVTHLVTIGMVVTWVAISLATHYFMGFDWALAWLFGALVVVTGPTVIVPMLRSVRPKSQLASILRWEGIVIDP
IGAVLAVLVFEYIAASQNATEHILMSFGSILALGFGVGAAMGYVVGWVLRKDLLPHYLRNTAVLTVMLGTFVGSNLLQEE
SGLLTVTVMGIWLANMRGVDIADILEFKETLTVLMISALFILLAARLDSTAMLDLGWGGIGVLAVAMLIARPLSVWLSGI
GTNLTAPEKWFLSWVAPRGIVAAAVSSLFAIKLEEQGVPGAEKIVPLVFLIIIGTVVIQSLSAGTWARLLKVKADSAQGL
LLFGASSFSRTFAKLLKTKNIKVILADTNWDNIRLARMDNIPVYFGNPASEHAETYLDLTGIGRVLVVSPYRQLNPLVSF
HFQDYFGAEKVFGLNNMEGSSARHLASEVYMKRLCLFGEGISYAKIASQMAKGAILKSTTLRESFTLVDFMRRYGESVLP
LVYLQDEKLRIVTAGSDIPATGIELISLIPVESQQYAKEQQEKEALEKALAEKEDAERAALEKLAREQEDAAREAASEAN
AGFEEETVGSPALKEGGGEGNQPLKA
>Mature_666_residues
MVEHITGILALIGVLSLFCQWLGWKLRLPAILPLLLCGLLLGPGLGFLKPDAIFGDLLFPMISLGVAIILFEGALTLNFK
EIKDYGRMVTHLVTIGMVVTWVAISLATHYFMGFDWALAWLFGALVVVTGPTVIVPMLRSVRPKSQLASILRWEGIVIDP
IGAVLAVLVFEYIAASQNATEHILMSFGSILALGFGVGAAMGYVVGWVLRKDLLPHYLRNTAVLTVMLGTFVGSNLLQEE
SGLLTVTVMGIWLANMRGVDIADILEFKETLTVLMISALFILLAARLDSTAMLDLGWGGIGVLAVAMLIARPLSVWLSGI
GTNLTAPEKWFLSWVAPRGIVAAAVSSLFAIKLEEQGVPGAEKIVPLVFLIIIGTVVIQSLSAGTWARLLKVKADSAQGL
LLFGASSFSRTFAKLLKTKNIKVILADTNWDNIRLARMDNIPVYFGNPASEHAETYLDLTGIGRVLVVSPYRQLNPLVSF
HFQDYFGAEKVFGLNNMEGSSARHLASEVYMKRLCLFGEGISYAKIASQMAKGAILKSTTLRESFTLVDFMRRYGESVLP
LVYLQDEKLRIVTAGSDIPATGIELISLIPVESQQYAKEQQEKEALEKALAEKEDAERAALEKLAREQEDAAREAASEAN
AGFEEETVGSPALKEGGGEGNQPLKA

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 72282; Mature: 72282

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCC
>Mature Secondary Structure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CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]