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The map label for this gene is dxr

Identifier: 119774282

GI number: 119774282

Start: 1394170

End: 1395357

Strand: Direct

Name: dxr

Synonym: Sama_1145

Alternate gene names: 119774282

Gene position: 1394170-1395357 (Clockwise)

Preceding gene: 119774281

Following gene: 119774283

Centisome position: 32.38

GC content: 55.39

Gene sequence:

>1188_bases
ATGCAAAATCTGGTGATCCTTGGGGCCACAGGCTCTATCGGTAAAAGTACTCTGGATGTCATCAAACGTAACCCCGAGCG
TTATCGGGCGTTTGCCTTGGTGGCGGCAACCAGCGTGGAGCGGATGCGGGACCTTTGCATTGAGCATCGCCCTCGTTACG
CCCACATGGTGGATGAGTCAGCGGCAAAACGCCTGGCCGATGCTTTGCCGACCGGTCTTGGGATTGAGGTTTCCAGCGGT
GATGAAGCGCTGCTTGGGCTTGTGACGGCCGCCGAGGTAGATACTGTCATGGCTGCCATCGTAGGCGCGGCGGGACTTCT
GCCGACCCTCGCTGCGGTTCGTGCCGGTAAGCGGGTGTTGCTTGCCAATAAAGAAGCGCTGGTCATGTCAGGTGAGCTCT
TTATGGAGGAAACCAAAAAGAGCGGCGCCCAGCTCTTGCCGGTGGACAGTGAACACAATGCGATATTCCAGTGCCTGCCA
GAGCAGGTACAGCGAGAAATCGGTCACTGTGATTTATCCGCAGCCGGTATTTCCCACATCTTACTGACCGGCTCCGGTGG
CCCCTTTTTAACATCTCCGCTGGACACCCTGGCCACCATGACGCCTGCCCAGGCCTGCAAACATCCCAATTGGTCCATGG
GCCCGAAAATCTCAGTAGACTCAGCCACCATGATGAACAAGGGGCTGGAGTTCATAGAGGCTCGTTGGCTGTTCAACACC
GCCAGGGACGAACTCAAGGTCGTTATTCATCCGCAAAGTGTCATTCACTCAATGGTCCAGTACCGTGATGGCAGTGTGCT
CGCACAAATGGGTAACCCGGATATGCGCACACCCATAGCCCATGCCATGGCGTATCCGCAGCGAATTTCAGCCGGTGTGG
AACCTTTGGACTTTTTCAAAGTCGGACACTTAAGCTTTTGTGAGCCCGATTACAGCCGTTTCCCTTGCCTGAAACTCGCC
ATGGATGCTTGCCATCAAGGACAGGAGGCTACCACAGTGCTCAATGCCGCCAACGAAGTGGCTGTGGCTGCGTTTTTGGA
CGGACGGATTGGATTTACCGATATCGCTGTGATTAATGGCGAATGTCTGGGTAAGATAGCCAAGACTCATCTGGACTCAC
TGGATGCCATACTCGCGCTGGATTGGGAAGCGCGCCGACTGGCGAACCAACTGATTAGCCGGGTTTAA

Upstream 100 bases:

>100_bases
CCATATTGCCGGGCCACGGTGGGGTGCTCGATCGCATCGACAGCCTCACAGCTGCGTTGCCAGTCTTTACCCTTATCTAC
ATCGCCTTCTGGATGTAATC

Downstream 100 bases:

>100_bases
TAGGAATATACTCGAAGGAGAGACATGTACGACATCCTCTGGAATGCCGCATCTTTCATCGTTGCGCTGGGTTTGCTTAT
CACTGCGCACGAATACGGAC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MQNLVILGATGSIGKSTLDVIKRNPERYRAFALVAATSVERMRDLCIEHRPRYAHMVDESAAKRLADALPTGLGIEVSSG
DEALLGLVTAAEVDTVMAAIVGAAGLLPTLAAVRAGKRVLLANKEALVMSGELFMEETKKSGAQLLPVDSEHNAIFQCLP
EQVQREIGHCDLSAAGISHILLTGSGGPFLTSPLDTLATMTPAQACKHPNWSMGPKISVDSATMMNKGLEFIEARWLFNT
ARDELKVVIHPQSVIHSMVQYRDGSVLAQMGNPDMRTPIAHAMAYPQRISAGVEPLDFFKVGHLSFCEPDYSRFPCLKLA
MDACHQGQEATTVLNAANEVAVAAFLDGRIGFTDIAVINGECLGKIAKTHLDSLDAILALDWEARRLANQLISRV

Sequences:

>Translated_395_residues
MQNLVILGATGSIGKSTLDVIKRNPERYRAFALVAATSVERMRDLCIEHRPRYAHMVDESAAKRLADALPTGLGIEVSSG
DEALLGLVTAAEVDTVMAAIVGAAGLLPTLAAVRAGKRVLLANKEALVMSGELFMEETKKSGAQLLPVDSEHNAIFQCLP
EQVQREIGHCDLSAAGISHILLTGSGGPFLTSPLDTLATMTPAQACKHPNWSMGPKISVDSATMMNKGLEFIEARWLFNT
ARDELKVVIHPQSVIHSMVQYRDGSVLAQMGNPDMRTPIAHAMAYPQRISAGVEPLDFFKVGHLSFCEPDYSRFPCLKLA
MDACHQGQEATTVLNAANEVAVAAFLDGRIGFTDIAVINGECLGKIAKTHLDSLDAILALDWEARRLANQLISRV
>Mature_395_residues
MQNLVILGATGSIGKSTLDVIKRNPERYRAFALVAATSVERMRDLCIEHRPRYAHMVDESAAKRLADALPTGLGIEVSSG
DEALLGLVTAAEVDTVMAAIVGAAGLLPTLAAVRAGKRVLLANKEALVMSGELFMEETKKSGAQLLPVDSEHNAIFQCLP
EQVQREIGHCDLSAAGISHILLTGSGGPFLTSPLDTLATMTPAQACKHPNWSMGPKISVDSATMMNKGLEFIEARWLFNT
ARDELKVVIHPQSVIHSMVQYRDGSVLAQMGNPDMRTPIAHAMAYPQRISAGVEPLDFFKVGHLSFCEPDYSRFPCLKLA
MDACHQGQEATTVLNAANEVAVAAFLDGRIGFTDIAVINGECLGKIAKTHLDSLDAILALDWEARRLANQLISRV

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=396, Percent_Identity=61.3636363636364, Blast_Score=477, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_SHEAM (A1S4P6)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_927022.1
- ProteinModelPortal:   A1S4P6
- SMR:   A1S4P6
- STRING:   A1S4P6
- GeneID:   4603397
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_1145
- NMPDR:   fig|326297.7.peg.1077
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   A1S4P6
- ProtClustDB:   PRK05447
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42549; Mature: 42549

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: BINDING 124-124 BINDING 151-151 BINDING 185-185 BINDING 208-208 BINDING 230-230

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNLVILGATGSIGKSTLDVIKRNPERYRAFALVAATSVERMRDLCIEHRPRYAHMVDES
CCCEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AAKRLADALPTGLGIEVSSGDEALLGLVTAAEVDTVMAAIVGAAGLLPTLAAVRAGKRVL
HHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
LANKEALVMSGELFMEETKKSGAQLLPVDSEHNAIFQCLPEQVQREIGHCDLSAAGISHI
EECCCEEEEEHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEE
LLTGSGGPFLTSPLDTLATMTPAQACKHPNWSMGPKISVDSATMMNKGLEFIEARWLFNT
EEECCCCCCCCCCHHHHHHCCCHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHC
ARDELKVVIHPQSVIHSMVQYRDGSVLAQMGNPDMRTPIAHAMAYPQRISAGVEPLDFFK
CCCCEEEEECCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHE
VGHLSFCEPDYSRFPCLKLAMDACHQGQEATTVLNAANEVAVAAFLDGRIGFTDIAVING
ECCCEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCHHEEEEEECCCCCCEEEEEECC
ECLGKIAKTHLDSLDAILALDWEARRLANQLISRV
HHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHCC
>Mature Secondary Structure
MQNLVILGATGSIGKSTLDVIKRNPERYRAFALVAATSVERMRDLCIEHRPRYAHMVDES
CCCEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AAKRLADALPTGLGIEVSSGDEALLGLVTAAEVDTVMAAIVGAAGLLPTLAAVRAGKRVL
HHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
LANKEALVMSGELFMEETKKSGAQLLPVDSEHNAIFQCLPEQVQREIGHCDLSAAGISHI
EECCCEEEEEHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEE
LLTGSGGPFLTSPLDTLATMTPAQACKHPNWSMGPKISVDSATMMNKGLEFIEARWLFNT
EEECCCCCCCCCCHHHHHHCCCHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHC
ARDELKVVIHPQSVIHSMVQYRDGSVLAQMGNPDMRTPIAHAMAYPQRISAGVEPLDFFK
CCCCEEEEECCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHE
VGHLSFCEPDYSRFPCLKLAMDACHQGQEATTVLNAANEVAVAAFLDGRIGFTDIAVING
ECCCEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCHHEEEEEECCCCCCEEEEEECC
ECLGKIAKTHLDSLDAILALDWEARRLANQLISRV
HHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA