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The map label for this gene is nhaA

Identifier: 119774005

GI number: 119774005

Start: 1059157

End: 1060332

Strand: Direct

Name: nhaA

Synonym: Sama_0868

Alternate gene names: 119774005

Gene position: 1059157-1060332 (Clockwise)

Preceding gene: 119774004

Following gene: 119774006

Centisome position: 24.6

GC content: 54.0

Gene sequence:

>1176_bases
ATGGAAAAAGCTATTCGTAATTTTTTGAGCCAGGAGTCTGCCGGTGGCATTTTGCTGCTGGTGGCTGTTGCACTGGCCAT
GTTGCTCGCCAACTCACCGCTTTCCGGCTTGTATCAAGGGTTTCTCAATACCGAAATGCAGGTTCGTTTTGGGGCGCTGG
ACATCAACAAACCTCTGCTGCTGTGGATTAACGACGGCCTGATGGCTCTGTTCTTCCTGCTGATTGGTTTGGAAGTTAAA
CGTGAGTTGCTGGAAGGGGCCTTGTCGAGCCCATCCAAAGCATCCCTGCCTACCTTTGCCGCCATCGGCGGTATGTTGGT
TCCTGCAGCCATCTACTTGTTTTTCAATTTTGACGATCCTGTTACCAAGGTCGGCTGGGCCATTCCCGCTGCCACGGATA
TTGCCTTTGCCCTGGGTATTATGGCGCTTCTGGGTAACCGGGTGCCGGTGGCGCTGAAAGTATTCCTGCTGGCGCTCGCC
ATCATCGATGACCTGGGTGTGATTGTGATTATCGCGCTCTTCTACAGCACCGACTTATCTATGCTGAGCCTGGTGATTGC
GGCGATTGCTGTTACTGGGTTGGTGGCACTTAATCGTAAGGGCGTTACGTCCCTCGCGCCTTATGGGGTACTCGGCATCA
TATTGTGGATAGCCGTGCTCAAGTCCGGCGTGCACGCCACCCTCGCCGGTGTGGTCATTGCCTTCTGTATTCCGCTCAGG
GCTAAAGACGGCAGTTCACCTTCTGAGCACCTTGAGCACAGCCTGCACCCCTGGAGTAACTTCCTCATTCTACCGGTGTT
TGCCTTTGCCAATGCCGGGGTGCCGCTGGGCAACGTTGGATTTGACAGCATACTGTCGCCCGTACCGGTTGGTATTGCCC
TGGGTCTGCTGCTGGGTAAACCCATAGGTGTGCTGCTGTTCAGTTATGCAGCGGTGAAGCTGCGACTGGCCGAGCTGCCC
AAGGGGATTGGCTGGCACCAGATAGCGCCGGTGGCCGTCATGTGTGGTATCGGTTTCACCATGTCGATGTTTATTGCTTC
TCTGGCCTTTGAGCATGGCGGAGAACTCTATGGCGATTTGGCCCGTATTGGCATCTTGCTGGGTTCACTGTTTGCTGCGG
TAATTGGCTATTTTTGGTTGTCCAAAGTGTTGCCTAAAGCAGGAGAAAGAATATGA

Upstream 100 bases:

>100_bases
TACCTCGGAAATTTCGAGGTTTCAGGCAGAAACTTACGATTATTTTTGATAGTCTTAATTCGCTACACTCAATGCATTCG
CTTTATTTGGGGGTAACGAA

Downstream 100 bases:

>100_bases
GACTCACTATTGTATCTGCCCTCGGATTATCCTTGTTGCCGCTATTTTCCTCGGCATCCGCGCTCGACACCTGTTCGGAA
GACAGTCGCTCTCCAGGTTG

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MEKAIRNFLSQESAGGILLLVAVALAMLLANSPLSGLYQGFLNTEMQVRFGALDINKPLLLWINDGLMALFFLLIGLEVK
RELLEGALSSPSKASLPTFAAIGGMLVPAAIYLFFNFDDPVTKVGWAIPAATDIAFALGIMALLGNRVPVALKVFLLALA
IIDDLGVIVIIALFYSTDLSMLSLVIAAIAVTGLVALNRKGVTSLAPYGVLGIILWIAVLKSGVHATLAGVVIAFCIPLR
AKDGSSPSEHLEHSLHPWSNFLILPVFAFANAGVPLGNVGFDSILSPVPVGIALGLLLGKPIGVLLFSYAAVKLRLAELP
KGIGWHQIAPVAVMCGIGFTMSMFIASLAFEHGGELYGDLARIGILLGSLFAAVIGYFWLSKVLPKAGERI

Sequences:

>Translated_391_residues
MEKAIRNFLSQESAGGILLLVAVALAMLLANSPLSGLYQGFLNTEMQVRFGALDINKPLLLWINDGLMALFFLLIGLEVK
RELLEGALSSPSKASLPTFAAIGGMLVPAAIYLFFNFDDPVTKVGWAIPAATDIAFALGIMALLGNRVPVALKVFLLALA
IIDDLGVIVIIALFYSTDLSMLSLVIAAIAVTGLVALNRKGVTSLAPYGVLGIILWIAVLKSGVHATLAGVVIAFCIPLR
AKDGSSPSEHLEHSLHPWSNFLILPVFAFANAGVPLGNVGFDSILSPVPVGIALGLLLGKPIGVLLFSYAAVKLRLAELP
KGIGWHQIAPVAVMCGIGFTMSMFIASLAFEHGGELYGDLARIGILLGSLFAAVIGYFWLSKVLPKAGERI
>Mature_391_residues
MEKAIRNFLSQESAGGILLLVAVALAMLLANSPLSGLYQGFLNTEMQVRFGALDINKPLLLWINDGLMALFFLLIGLEVK
RELLEGALSSPSKASLPTFAAIGGMLVPAAIYLFFNFDDPVTKVGWAIPAATDIAFALGIMALLGNRVPVALKVFLLALA
IIDDLGVIVIIALFYSTDLSMLSLVIAAIAVTGLVALNRKGVTSLAPYGVLGIILWIAVLKSGVHATLAGVVIAFCIPLR
AKDGSSPSEHLEHSLHPWSNFLILPVFAFANAGVPLGNVGFDSILSPVPVGIALGLLLGKPIGVLLFSYAAVKLRLAELP
KGIGWHQIAPVAVMCGIGFTMSMFIASLAFEHGGELYGDLARIGILLGSLFAAVIGYFWLSKVLPKAGERI

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=379, Percent_Identity=59.1029023746702, Blast_Score=410, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA_SHEAM (A1S3W9)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_926745.1
- ProteinModelPortal:   A1S3W9
- SMR:   A1S3W9
- STRING:   A1S3W9
- GeneID:   4603120
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0868
- NMPDR:   fig|326297.7.peg.818
- eggNOG:   COG3004
- HOGENOM:   HBG665619
- OMA:   LIHWIND
- PhylomeDB:   A1S3W9
- ProtClustDB:   PRK09561
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 41239; Mature: 41239

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x116bba68)-; HASH(0x10e6b058)-; HASH(0x11e6fa98)-; HASH(0x12395e7c)-; HASH(0x10fe31fc)-; HASH(0x1226e324)-; HASH(0x11fcbe30)-; HASH(0x1203a210)-; HASH(0x12209c28)-; HASH(0x1268776c)-; HASH(0x11ce517c)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKAIRNFLSQESAGGILLLVAVALAMLLANSPLSGLYQGFLNTEMQVRFGALDINKPLL
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCCEE
LWINDGLMALFFLLIGLEVKRELLEGALSSPSKASLPTFAAIGGMLVPAAIYLFFNFDDP
EEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCH
VTKVGWAIPAATDIAFALGIMALLGNRVPVALKVFLLALAIIDDLGVIVIIALFYSTDLS
HHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
MLSLVIAAIAVTGLVALNRKGVTSLAPYGVLGIILWIAVLKSGVHATLAGVVIAFCIPLR
HHHHHHHHHHHHHHHHHCCCCCCHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
AKDGSSPSEHLEHSLHPWSNFLILPVFAFANAGVPLGNVGFDSILSPVPVGIALGLLLGK
CCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHCHHHHHHHHHHHHCC
PIGVLLFSYAAVKLRLAELPKGIGWHQIAPVAVMCGIGFTMSMFIASLAFEHGGELYGDL
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ARIGILLGSLFAAVIGYFWLSKVLPKAGERI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure
MEKAIRNFLSQESAGGILLLVAVALAMLLANSPLSGLYQGFLNTEMQVRFGALDINKPLL
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCCEE
LWINDGLMALFFLLIGLEVKRELLEGALSSPSKASLPTFAAIGGMLVPAAIYLFFNFDDP
EEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCH
VTKVGWAIPAATDIAFALGIMALLGNRVPVALKVFLLALAIIDDLGVIVIIALFYSTDLS
HHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
MLSLVIAAIAVTGLVALNRKGVTSLAPYGVLGIILWIAVLKSGVHATLAGVVIAFCIPLR
HHHHHHHHHHHHHHHHHCCCCCCHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
AKDGSSPSEHLEHSLHPWSNFLILPVFAFANAGVPLGNVGFDSILSPVPVGIALGLLLGK
CCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHCHHHHHHHHHHHHCC
PIGVLLFSYAAVKLRLAELPKGIGWHQIAPVAVMCGIGFTMSMFIASLAFEHGGELYGDL
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ARIGILLGSLFAAVIGYFWLSKVLPKAGERI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA