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The map label for this gene is fkpA [H]

Identifier: 119773780

GI number: 119773780

Start: 797333

End: 798097

Strand: Direct

Name: fkpA [H]

Synonym: Sama_0642

Alternate gene names: 119773780

Gene position: 797333-798097 (Clockwise)

Preceding gene: 119773774

Following gene: 119773781

Centisome position: 18.52

GC content: 53.59

Gene sequence:

>765_bases
ATGAAATCTATTTATAAATACTCACTGGTCGCCCTGGCCGTAGTAGGTTTAACTGCCTGTAATAAAGAAGAAAAAGCAGC
AGAAGTTGCACCAGCTGTTTCCCTGACCACTGAGGCCCAGAAAGAAGCTTACAGTGTTGGCGCTTCCATCGGCAGCTACA
TGTCTGGCCACATCAAGGAGCAGGAAGCTCTTGGTCTGCCAGCCGATCGCGCTCTGATCGTTGAAGGTTTTGCCAACGGC
CTGAATGGTTCCCTGAAGCTGACCGAAGAAGAAATGCAGACTGTGCTGCAGAATCTGGACAAGAAGCTGAACGACAAGCG
TGTGGCTCAGGCTGAAGCGATGGCCGCCAAGAACCTGGAAGACGGTAAAAAGTATCAGGAAACCAACAAGGCCAAAGAAG
GCGTAACCACCACTGAGTCTGGTCTCCAGTACGAAGTATTGGTTGCCGGTGAAGGCGACAAGCCAGCCGCCGAAGATGTG
GTTGAAGTTCACTATGCCGGTACCCTGATCGACGGCACGCCATTCGACAGCTCTTACGATCGTGGCCAAACCGCGAAGTT
CCCTCTGAACCGCGTTATCGCCGGTTGGACTGAGGGTGTGCAGCTGATGTCTGTAGGTTCCAAGTATCGCTTCGTGATCC
CGGCTGAGCTGGCCTATGGTGAGCGTGACAACGGTACCATTCCTGCCAACTCGACTCTGGTGTTTGAGGTGGAACTGGTG
TCCATCGAAAAAGCCGCCGCTGCCGAAGCCGCTCCCGCACAGTAA

Upstream 100 bases:

>100_bases
GTGCTGCCCATGGCATAAGCTTAGTAACTAGTATAAAGTGGGGCGGTTTGATGAATAACAAAGGTTATTGTAACCACTTG
AGGACGCTAAGGAAGCTTCA

Downstream 100 bases:

>100_bases
TAGTGACTGTTGGAGTACAAAGACGCCTCAGGGCGTCTTTTTTTTGGGGAAAAACCACCTCAAATGTCCGGAAAGTGATT
GAGCAAGATTTTGAATTTGG

Product: FKBP-type peptidyl-prolyl cis-trans isomerase FkpA

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MKSIYKYSLVALAVVGLTACNKEEKAAEVAPAVSLTTEAQKEAYSVGASIGSYMSGHIKEQEALGLPADRALIVEGFANG
LNGSLKLTEEEMQTVLQNLDKKLNDKRVAQAEAMAAKNLEDGKKYQETNKAKEGVTTTESGLQYEVLVAGEGDKPAAEDV
VEVHYAGTLIDGTPFDSSYDRGQTAKFPLNRVIAGWTEGVQLMSVGSKYRFVIPAELAYGERDNGTIPANSTLVFEVELV
SIEKAAAAEAAPAQ

Sequences:

>Translated_254_residues
MKSIYKYSLVALAVVGLTACNKEEKAAEVAPAVSLTTEAQKEAYSVGASIGSYMSGHIKEQEALGLPADRALIVEGFANG
LNGSLKLTEEEMQTVLQNLDKKLNDKRVAQAEAMAAKNLEDGKKYQETNKAKEGVTTTESGLQYEVLVAGEGDKPAAEDV
VEVHYAGTLIDGTPFDSSYDRGQTAKFPLNRVIAGWTEGVQLMSVGSKYRFVIPAELAYGERDNGTIPANSTLVFEVELV
SIEKAAAAEAAPAQ
>Mature_254_residues
MKSIYKYSLVALAVVGLTACNKEEKAAEVAPAVSLTTEAQKEAYSVGASIGSYMSGHIKEQEALGLPADRALIVEGFANG
LNGSLKLTEEEMQTVLQNLDKKLNDKRVAQAEAMAAKNLEDGKKYQETNKAKEGVTTTESGLQYEVLVAGEGDKPAAEDV
VEVHYAGTLIDGTPFDSSYDRGQTAKFPLNRVIAGWTEGVQLMSVGSKYRFVIPAELAYGERDNGTIPANSTLVFEVELV
SIEKAAAAEAAPAQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=89, Percent_Identity=50.561797752809, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI17149844, Length=89, Percent_Identity=50.561797752809, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI17149842, Length=89, Percent_Identity=50.561797752809, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=44.8598130841121, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=44.8598130841121, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI33469985, Length=90, Percent_Identity=40, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=38.3177570093458, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4503727, Length=123, Percent_Identity=41.4634146341463, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI192448443, Length=96, Percent_Identity=39.5833333333333, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4503729, Length=91, Percent_Identity=43.956043956044, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI224809329, Length=91, Percent_Identity=40.6593406593407, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI224809327, Length=91, Percent_Identity=40.6593406593407, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4758384, Length=91, Percent_Identity=40.6593406593407, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI224809331, Length=133, Percent_Identity=33.8345864661654, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1789745, Length=258, Percent_Identity=39.922480620155, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI87082390, Length=209, Percent_Identity=46.4114832535885, Blast_Score=156, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=46.2264150943396, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17540882, Length=89, Percent_Identity=46.0674157303371, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17561782, Length=101, Percent_Identity=46.5346534653465, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320727, Length=92, Percent_Identity=53.2608695652174, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6324194, Length=109, Percent_Identity=43.1192660550459, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323566, Length=132, Percent_Identity=38.6363636363636, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323482, Length=119, Percent_Identity=39.4957983193277, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=45.7943925233645, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281363946, Length=91, Percent_Identity=46.1538461538462, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17352457, Length=91, Percent_Identity=46.1538461538462, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21356629, Length=95, Percent_Identity=47.3684210526316, Blast_Score=77, Evalue=9e-15,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 27083; Mature: 27083

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIYKYSLVALAVVGLTACNKEEKAAEVAPAVSLTTEAQKEAYSVGASIGSYMSGHIKE
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
QEALGLPADRALIVEGFANGLNGSLKLTEEEMQTVLQNLDKKLNDKRVAQAEAMAAKNLE
HHHCCCCCCCEEEEECHHCCCCCCEEECHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCC
DGKKYQETNKAKEGVTTTESGLQYEVLVAGEGDKPAAEDVVEVHYAGTLIDGTPFDSSYD
CHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEECCCCCCCCCC
RGQTAKFPLNRVIAGWTEGVQLMSVGSKYRFVIPAELAYGERDNGTIPANSTLVFEVELV
CCCCCCCCHHHHHHHHHCCEEEEECCCCEEEEEEHHHHCCCCCCCCCCCCCEEEEEEEEE
SIEKAAAAEAAPAQ
EEHHHHHCCCCCCC
>Mature Secondary Structure
MKSIYKYSLVALAVVGLTACNKEEKAAEVAPAVSLTTEAQKEAYSVGASIGSYMSGHIKE
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
QEALGLPADRALIVEGFANGLNGSLKLTEEEMQTVLQNLDKKLNDKRVAQAEAMAAKNLE
HHHCCCCCCCEEEEECHHCCCCCCEEECHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCC
DGKKYQETNKAKEGVTTTESGLQYEVLVAGEGDKPAAEDVVEVHYAGTLIDGTPFDSSYD
CHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEECCCCCCCCCC
RGQTAKFPLNRVIAGWTEGVQLMSVGSKYRFVIPAELAYGERDNGTIPANSTLVFEVELV
CCCCCCCCHHHHHHHHHCCEEEEECCCCEEEEEEHHHHCCCCCCCCCCCCCEEEEEEEEE
SIEKAAAAEAAPAQ
EEHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]