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The map label for this gene is tpm

Identifier: 119773683

GI number: 119773683

Start: 668701

End: 669357

Strand: Direct

Name: tpm

Synonym: Sama_0543

Alternate gene names: 119773683

Gene position: 668701-669357 (Clockwise)

Preceding gene: 119773682

Following gene: 119773686

Centisome position: 15.53

GC content: 54.19

Gene sequence:

>657_bases
ATGGAGCCCGGATTCTGGCACGACAAGTGGCAGTCACAACAGATTGGATTTCACCAATCGGATATCAACCCATTCTTGGT
CAAACACTGGGAAAGCCTGAAACTTGAAGGTAAAGGCAAGGTGTTTGTCCCCCTGTGCGGCAAATCCCTCGACATGGAAT
TTCTGGCCGCCCAGGGACACGAAGTTATCGGCAGTGAACTGTCTGCGTTGGCTGTGAGCCAGTTTTTTGAGGCTGCAGGT
GCAAAGCCGCAAAGCCGTACCCAGGGGGAACACGTACACCACAGTGCGCAGGGTGTGACCTTGATAGAGGGTGACTTTTT
CACTCTGGATGAGGAGTTGGTTGCCGGGTGCAGTGGTTTTTACGATCGCGCCGCTCTCATCGCCTGGCCAGCCGAGATGC
GCATCGATTATGTGCGTAAGCTTGCCGCCTTAATTCCCGCCGGTACTCCGGGATTGCTGATTACTCTCGACTATCCCCAG
GAAGCCCTGATAGGCCCACCCTTTGCGGTTTCCCCCAATTGGGTGGAAGAGTTTGTGGGAGAATATTTCGAGGTCGTAGT
GCTTGAGAGCCAGGATGTGCTGGCCGATAATCCGCGCTTTGTGAAAAAAGCCGTGCCCTGGCTCAATGAGGCGGCTTATC
TGCTGGTGCGTAAGTAA

Upstream 100 bases:

>100_bases
GTCAGGTGAACGAGGCATTGAACGCGCCCTGAAGCGCGCTTTGCATCCCCCAGACTTTGCCGCTAGAGTAAGGCGTCTTT
TTTCGTCATAGGGGATGGTC

Downstream 100 bases:

>100_bases
TCTCTTTATTTCCGTTCATATCTGGCAAGGCCAGCATAAAAAAAGCGACCCATGGGGTCGCTTTTTTTGCCTTTACGGCG
GTCTGGTATTTTCAGCCAGA

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MEPGFWHDKWQSQQIGFHQSDINPFLVKHWESLKLEGKGKVFVPLCGKSLDMEFLAAQGHEVIGSELSALAVSQFFEAAG
AKPQSRTQGEHVHHSAQGVTLIEGDFFTLDEELVAGCSGFYDRAALIAWPAEMRIDYVRKLAALIPAGTPGLLITLDYPQ
EALIGPPFAVSPNWVEEFVGEYFEVVVLESQDVLADNPRFVKKAVPWLNEAAYLLVRK

Sequences:

>Translated_218_residues
MEPGFWHDKWQSQQIGFHQSDINPFLVKHWESLKLEGKGKVFVPLCGKSLDMEFLAAQGHEVIGSELSALAVSQFFEAAG
AKPQSRTQGEHVHHSAQGVTLIEGDFFTLDEELVAGCSGFYDRAALIAWPAEMRIDYVRKLAALIPAGTPGLLITLDYPQ
EALIGPPFAVSPNWVEEFVGEYFEVVVLESQDVLADNPRFVKKAVPWLNEAAYLLVRK
>Mature_218_residues
MEPGFWHDKWQSQQIGFHQSDINPFLVKHWESLKLEGKGKVFVPLCGKSLDMEFLAAQGHEVIGSELSALAVSQFFEAAG
AKPQSRTQGEHVHHSAQGVTLIEGDFFTLDEELVAGCSGFYDRAALIAWPAEMRIDYVRKLAALIPAGTPGLLITLDYPQ
EALIGPPFAVSPNWVEEFVGEYFEVVVLESQDVLADNPRFVKKAVPWLNEAAYLLVRK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family

Homologues:

Organism=Homo sapiens, GI4507653, Length=220, Percent_Identity=30.9090909090909, Blast_Score=98, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TPMT_SHEAM (A1S2Z7)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_926423.1
- ProteinModelPortal:   A1S2Z7
- SMR:   A1S2Z7
- STRING:   A1S2Z7
- GeneID:   4602798
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0543
- NMPDR:   fig|326297.7.peg.512
- eggNOG:   COG0500
- HOGENOM:   HBG444929
- OMA:   PPFAVSP
- ProtClustDB:   PRK13255
- GO:   GO:0005737
- HAMAP:   MF_00812
- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822
- PIRSF:   PIRSF023956
- TIGRFAMs:   TIGR03840

Pfam domain/function: PF05724 TPMT

EC number: =2.1.1.67

Molecular weight: Translated: 24240; Mature: 24240

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: BINDING 10-10 BINDING 45-45 BINDING 66-66 BINDING 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPGFWHDKWQSQQIGFHQSDINPFLVKHWESLKLEGKGKVFVPLCGKSLDMEFLAAQGH
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCCEEEEECCCCCCHHHHHHCCC
EVIGSELSALAVSQFFEAAGAKPQSRTQGEHVHHSAQGVTLIEGDFFTLDEELVAGCSGF
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCEEEECCCCEEECHHHHHHHCCH
YDRAALIAWPAEMRIDYVRKLAALIPAGTPGLLITLDYPQEALIGPPFAVSPNWVEEFVG
HHCCEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHCCCCCCCCCHHHHHHHH
EYFEVVVLESQDVLADNPRFVKKAVPWLNEAAYLLVRK
HHHEEEEECCCCCCCCCCHHHHHHCCHHCCCEEEEEEC
>Mature Secondary Structure
MEPGFWHDKWQSQQIGFHQSDINPFLVKHWESLKLEGKGKVFVPLCGKSLDMEFLAAQGH
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCCEEEEECCCCCCHHHHHHCCC
EVIGSELSALAVSQFFEAAGAKPQSRTQGEHVHHSAQGVTLIEGDFFTLDEELVAGCSGF
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCEEEECCCCEEECHHHHHHHCCH
YDRAALIAWPAEMRIDYVRKLAALIPAGTPGLLITLDYPQEALIGPPFAVSPNWVEEFVG
HHCCEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHCCCCCCCCCHHHHHHHH
EYFEVVVLESQDVLADNPRFVKKAVPWLNEAAYLLVRK
HHHEEEEECCCCCCCCCCHHHHHHCCHHCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA