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The map label for this gene is ccmA [H]

Identifier: 119773386

GI number: 119773386

Start: 268742

End: 269395

Strand: Reverse

Name: ccmA [H]

Synonym: Sama_0245

Alternate gene names: 119773386

Gene position: 269395-268742 (Counterclockwise)

Preceding gene: 119773388

Following gene: 119773385

Centisome position: 6.26

GC content: 51.53

Gene sequence:

>654_bases
GTGACACTACCAACAAAAACAGCCCACTCACTGGTATCCGCCGAAAAGCTGACTTGCATTCGTGAAGAAAGGATCCTCTT
TGACGAACTGAGTTTCAGTGTGAACGAAGGCGATATCATCCAAATTGAAGGCCCCAATGGCGCGGGCAAAACCAGCTTGC
TGCGCATCCTTGCAGGACTCTCCCGCCCTTACGCCGGCAGTGTGTTTTACCGCGACGAAGAAATTGGCCGTTGCCGCGAT
GAATTTAACGAAGACCTACTTTATTTAGGCCATTTGGCGGGTGTCAAAAGCGAGCTGACAGCCGAAGAGAACCTTAACTT
CAATTTAAGGCTCAGTGGCTATGATGATTTCGACACCGGCGAGGTCCTCGCCAAGGTCAATCTGAAGGGATTTGAAGAAG
CGCTTGCAGGTCATTTATCTGCGGGGCAGCACAGACGCACCGCGCTTGCACGGCTTTGGCACAGCAACTGTAAAGTGTGG
ATCCTGGACGAGCCTTTTACCGCCATTGACAAACGCGGCGTTGCTGAGCTTGAACAACTGTTTCTCAAGCATGCCGATAA
CGGCGGCTGTGTGATCCTGACGACTCACCAGGATATGGGACTCATCAAGGATGAGCGGCTTCGCAAACTCAAGCTTGAGT
ACAGGTTCGTATAA

Upstream 100 bases:

>100_bases
AACTGCATCAAATTGCTGATACTTAGTCTACTTCATCGGTAAACCCCGGATTTCAAGTATGTTAGTATCAGCACAGGATT
ACGCGGTATTAGAGGTCTCA

Downstream 100 bases:

>100_bases
GGTTGGCTCGCATGAAAAGAGGCATTAGTTTTACCCAGGCATTTGGCACTGTACTCAAGCGGGATTTAAAAATTGCCATC
CGTCATCGCGGCGATATCTT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MTLPTKTAHSLVSAEKLTCIREERILFDELSFSVNEGDIIQIEGPNGAGKTSLLRILAGLSRPYAGSVFYRDEEIGRCRD
EFNEDLLYLGHLAGVKSELTAEENLNFNLRLSGYDDFDTGEVLAKVNLKGFEEALAGHLSAGQHRRTALARLWHSNCKVW
ILDEPFTAIDKRGVAELEQLFLKHADNGGCVILTTHQDMGLIKDERLRKLKLEYRFV

Sequences:

>Translated_217_residues
MTLPTKTAHSLVSAEKLTCIREERILFDELSFSVNEGDIIQIEGPNGAGKTSLLRILAGLSRPYAGSVFYRDEEIGRCRD
EFNEDLLYLGHLAGVKSELTAEENLNFNLRLSGYDDFDTGEVLAKVNLKGFEEALAGHLSAGQHRRTALARLWHSNCKVW
ILDEPFTAIDKRGVAELEQLFLKHADNGGCVILTTHQDMGLIKDERLRKLKLEYRFV
>Mature_216_residues
TLPTKTAHSLVSAEKLTCIREERILFDELSFSVNEGDIIQIEGPNGAGKTSLLRILAGLSRPYAGSVFYRDEEIGRCRDE
FNEDLLYLGHLAGVKSELTAEENLNFNLRLSGYDDFDTGEVLAKVNLKGFEEALAGHLSAGQHRRTALARLWHSNCKVWI
LDEPFTAIDKRGVAELEQLFLKHADNGGCVILTTHQDMGLIKDERLRKLKLEYRFV

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI27436953, Length=203, Percent_Identity=31.5270935960591, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI47078218, Length=195, Percent_Identity=29.2307692307692, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI45446740, Length=195, Percent_Identity=29.2307692307692, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI153792144, Length=208, Percent_Identity=27.4038461538462, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI21536376, Length=199, Percent_Identity=28.1407035175879, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI150417984, Length=175, Percent_Identity=32, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI30795238, Length=183, Percent_Identity=25.6830601092896, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI27881501, Length=183, Percent_Identity=25.6830601092896, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI27262624, Length=175, Percent_Identity=28, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI27262626, Length=175, Percent_Identity=28, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI105990541, Length=178, Percent_Identity=29.2134831460674, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI87082064, Length=205, Percent_Identity=48.780487804878, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI87081709, Length=149, Percent_Identity=30.2013422818792, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081791, Length=191, Percent_Identity=27.2251308900524, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1786563, Length=178, Percent_Identity=29.7752808988764, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI2367384, Length=175, Percent_Identity=28, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1789593, Length=199, Percent_Identity=27.1356783919598, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788165, Length=194, Percent_Identity=29.8969072164948, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI87081782, Length=170, Percent_Identity=30.5882352941176, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1788761, Length=180, Percent_Identity=27.2222222222222, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787370, Length=175, Percent_Identity=28, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI87081834, Length=187, Percent_Identity=26.7379679144385, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786253, Length=152, Percent_Identity=30.9210526315789, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082267, Length=151, Percent_Identity=25.8278145695364, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1787089, Length=185, Percent_Identity=26.4864864864865, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1787029, Length=182, Percent_Identity=28.021978021978, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788897, Length=191, Percent_Identity=29.3193717277487, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1787164, Length=175, Percent_Identity=29.7142857142857, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1787105, Length=196, Percent_Identity=26.0204081632653, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790467, Length=164, Percent_Identity=25, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789991, Length=182, Percent_Identity=25.2747252747253, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87082268, Length=144, Percent_Identity=29.8611111111111, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1789032, Length=176, Percent_Identity=25.5681818181818, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1789873, Length=195, Percent_Identity=26.1538461538462, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=199, Percent_Identity=28.1407035175879, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17565586, Length=176, Percent_Identity=26.1363636363636, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24666092, Length=172, Percent_Identity=32.5581395348837, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19920532, Length=182, Percent_Identity=29.1208791208791, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24580930, Length=182, Percent_Identity=29.1208791208791, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24648314, Length=178, Percent_Identity=26.9662921348315, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574744, Length=191, Percent_Identity=29.3193717277487, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 24421; Mature: 24290

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPTKTAHSLVSAEKLTCIREERILFDELSFSVNEGDIIQIEGPNGAGKTSLLRILAGL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHC
SRPYAGSVFYRDEEIGRCRDEFNEDLLYLGHLAGVKSELTAEENLNFNLRLSGYDDFDTG
CCCCCCEEEEECHHHHHHHHHHCHHHEEHHHHHCCHHHCCHHCCCCEEEEECCCCCCCCC
EVLAKVNLKGFEEALAGHLSAGQHRRTALARLWHSNCKVWILDEPFTAIDKRGVAELEQL
CEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCHHHHHHH
FLKHADNGGCVILTTHQDMGLIKDERLRKLKLEYRFV
HHHCCCCCCEEEEEECCCCCCHHHHHHHHHHEEEECC
>Mature Secondary Structure 
TLPTKTAHSLVSAEKLTCIREERILFDELSFSVNEGDIIQIEGPNGAGKTSLLRILAGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHC
SRPYAGSVFYRDEEIGRCRDEFNEDLLYLGHLAGVKSELTAEENLNFNLRLSGYDDFDTG
CCCCCCEEEEECHHHHHHHHHHCHHHEEHHHHHCCHHHCCHHCCCCEEEEECCCCCCCCC
EVLAKVNLKGFEEALAGHLSAGQHRRTALARLWHSNCKVWILDEPFTAIDKRGVAELEQL
CEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCHHHHHHH
FLKHADNGGCVILTTHQDMGLIKDERLRKLKLEYRFV
HHHCCCCCCEEEEEECCCCCCHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]