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The map label for this gene is tlpA [H]

Identifier: 119773172

GI number: 119773172

Start: 31147

End: 33129

Strand: Direct

Name: tlpA [H]

Synonym: Sama_0030

Alternate gene names: 119773172

Gene position: 31147-33129 (Clockwise)

Preceding gene: 119773169

Following gene: 119773175

Centisome position: 0.72

GC content: 50.58

Gene sequence:

>1983_bases
ATGTCATTTAAAAAGGGGATTTGGTATGGGCTGCTGTGCATCGGCTTGTTGCCGCTGGTCATTGCGGGGGTTGTATCGGA
ACAGCTTGCCGAGCGGGCATTGAAAGCCCAGGTATATAACAAGTTGGAAGCTGTCAGGCAGCTGAAGGAAAACCAGCTGA
CAGAGTACTTTGCCGATAACAGAGCCGATCTTAAGATGCTGGCTGCCGCCATGGTGGATATGGTGAGCTTCAGTGATGGC
TCGTCTTTGAAAACTATTACCCATGCACACGAGGACTACTTCACCCAGCTGGTGAAAGAGTATGGTTACTATGATGTGTT
TGTCATAGACCCGGATGGTGACCTGGCATACAGCTACGCAAAGGAAGCCGACTATGGTTCAAATCTTATCTCCGGGCCAT
TTAAAGAGACAAACCTCGCGGATCTATTCAGAAGTGTATTATCAAGCCAACAGATTGAAATGGTTGATTTTATGCCTTAC
ACGCCCAGCGGGGGCAAACCGGCAGCTTTCATCGGGATGCCGGTTGTTTATCATGGCCAACTATTAGCCGTGGTAGCGCT
TCAGCTGTCGATTGATCGTATAAATCAGCTAATGAGTCAAAGAGCGGGAATGGGGGAAACGGGAGAAAGTTATCTGGTCG
GTAACGACTATCGCATGCGTTCTAACTCGTTTCTGGACCCCATAAGACGCTCAGTGATTGCCAGCTTTAGCGGTTCTGTG
GATGAAAACGGCATCAACACAGTCGCATCCAGAAAGGCGCTCAACGGTGAAAGTGGCATGGAAGTCATAACCGACTACCA
GGATAATTTAGTCCTGTCAGCGTTCAGGCCAATCAGTCCCGATTTTGCAGGTAAAATTCGCTGGGCTCTGATTGTGGAAA
TCGATGAGGCAGAAGCGCTGGAATCTGTTGTGGCTATTAAAAATAGCCTGTGGATAGTATTGGGGATTTCTGTGTTGGTG
GTGGTTGGTTTTGCACGACTGATCCTGCGTTCGGTATTACGTCCTTTAGGGGGCGAGCCGGCTGTTATGCAGCACATTTC
AGAGCGAGTGGCAGGCGGTGATTTGGCCATTGATTTTTGCCAGTCCGAAAAGACAGGTGTTTATCTTGCCATGGAAACCA
TGTCCCACAATCTGAGAGAATTGGTCTCACGGATTGTAGGTATCACCGAGCAGCTTTCTGCCGCATCGGAGCAAACCCGC
GTTGCAAGTGAAGAAACCAATCAAAGCTTGTTCCAACAACAAGCTAATATTGAACGGGTTTCGGCGTCTATAAATGAGAT
GACGGCGACTATCGCTGACGTGGCCCACAATGCGCGTCAGGTCGCTGACTCGACTCAGGCGGCCTACGGTTTGTCGCAAA
TCGCCGATAAACAGGTGCGCAGCAACATAGGCACAATCAACGGCCTGGCATCGGCGATTACCGAGGCAACCAATGTCATT
CGCAGTGTTGAATTGCAAAGTCAGGGGATAAGCAAGGTGCTGGAGGTGATCCGTGGCATTGCAGACCAAACCAATTTGCT
CGCCCTTAACGCTGCAATTGAGGCTGCCCGCGCAGGAGAACAGGGGCGTGGTTTTGCCGTTGTTGCAGATGAGGTACGGC
AGCTGGCTCAAAAGACAGCACAATCGACCCGTGACATTGAAGAGATGATTGCTTTGTTGCAGCAGGGCACACAAAACGCC
GTTGGGGTAATGGGGGAAAGTACAGTGCATCTTCAGCAAACTGTCGACAGCGCCGAATGTACCGCCGAAGCCATTCGTAA
CACGCACATAGAGATAGAATCTATCGCAGCCAATGCTGAACAAATTGCCACGGCGGCCTCTCAGCAAACCCTGGCCGCAG
AGGAAATCAGTCAAAGTCTGGCCGTAATAAGCGATGCCGCATCTGTGAATGCGGCCAGCTCTGAGCAGACAGCCGTGGCC
TCAACGCAACTCAGCGAGCTTGCCTTGGATTTAAAGAGCATTACTGGCCGCTTTAACATCTGA

Upstream 100 bases:

>100_bases
CAAATAACCATTTGATAGTTGCGGACATCAGTTTGATTGCTAGTGTTGCTCGCCATACAAGCAATACACATTCAGCAGAC
TATGGAGTGGTGATAAGGCA

Downstream 100 bases:

>100_bases
TGCTGTTTCACGTGAAACAAAAAGCCGACCCAAAGGTCGGCTTTTTTATTTGGTTTTGGTGGTGTTAAACACGTTCAAAC
ACAGTGGCTATGCCTTGACC

Product: putative methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MSFKKGIWYGLLCIGLLPLVIAGVVSEQLAERALKAQVYNKLEAVRQLKENQLTEYFADNRADLKMLAAAMVDMVSFSDG
SSLKTITHAHEDYFTQLVKEYGYYDVFVIDPDGDLAYSYAKEADYGSNLISGPFKETNLADLFRSVLSSQQIEMVDFMPY
TPSGGKPAAFIGMPVVYHGQLLAVVALQLSIDRINQLMSQRAGMGETGESYLVGNDYRMRSNSFLDPIRRSVIASFSGSV
DENGINTVASRKALNGESGMEVITDYQDNLVLSAFRPISPDFAGKIRWALIVEIDEAEALESVVAIKNSLWIVLGISVLV
VVGFARLILRSVLRPLGGEPAVMQHISERVAGGDLAIDFCQSEKTGVYLAMETMSHNLRELVSRIVGITEQLSAASEQTR
VASEETNQSLFQQQANIERVSASINEMTATIADVAHNARQVADSTQAAYGLSQIADKQVRSNIGTINGLASAITEATNVI
RSVELQSQGISKVLEVIRGIADQTNLLALNAAIEAARAGEQGRGFAVVADEVRQLAQKTAQSTRDIEEMIALLQQGTQNA
VGVMGESTVHLQQTVDSAECTAEAIRNTHIEIESIAANAEQIATAASQQTLAAEEISQSLAVISDAASVNAASSEQTAVA
STQLSELALDLKSITGRFNI

Sequences:

>Translated_660_residues
MSFKKGIWYGLLCIGLLPLVIAGVVSEQLAERALKAQVYNKLEAVRQLKENQLTEYFADNRADLKMLAAAMVDMVSFSDG
SSLKTITHAHEDYFTQLVKEYGYYDVFVIDPDGDLAYSYAKEADYGSNLISGPFKETNLADLFRSVLSSQQIEMVDFMPY
TPSGGKPAAFIGMPVVYHGQLLAVVALQLSIDRINQLMSQRAGMGETGESYLVGNDYRMRSNSFLDPIRRSVIASFSGSV
DENGINTVASRKALNGESGMEVITDYQDNLVLSAFRPISPDFAGKIRWALIVEIDEAEALESVVAIKNSLWIVLGISVLV
VVGFARLILRSVLRPLGGEPAVMQHISERVAGGDLAIDFCQSEKTGVYLAMETMSHNLRELVSRIVGITEQLSAASEQTR
VASEETNQSLFQQQANIERVSASINEMTATIADVAHNARQVADSTQAAYGLSQIADKQVRSNIGTINGLASAITEATNVI
RSVELQSQGISKVLEVIRGIADQTNLLALNAAIEAARAGEQGRGFAVVADEVRQLAQKTAQSTRDIEEMIALLQQGTQNA
VGVMGESTVHLQQTVDSAECTAEAIRNTHIEIESIAANAEQIATAASQQTLAAEEISQSLAVISDAASVNAASSEQTAVA
STQLSELALDLKSITGRFNI
>Mature_659_residues
SFKKGIWYGLLCIGLLPLVIAGVVSEQLAERALKAQVYNKLEAVRQLKENQLTEYFADNRADLKMLAAAMVDMVSFSDGS
SLKTITHAHEDYFTQLVKEYGYYDVFVIDPDGDLAYSYAKEADYGSNLISGPFKETNLADLFRSVLSSQQIEMVDFMPYT
PSGGKPAAFIGMPVVYHGQLLAVVALQLSIDRINQLMSQRAGMGETGESYLVGNDYRMRSNSFLDPIRRSVIASFSGSVD
ENGINTVASRKALNGESGMEVITDYQDNLVLSAFRPISPDFAGKIRWALIVEIDEAEALESVVAIKNSLWIVLGISVLVV
VGFARLILRSVLRPLGGEPAVMQHISERVAGGDLAIDFCQSEKTGVYLAMETMSHNLRELVSRIVGITEQLSAASEQTRV
ASEETNQSLFQQQANIERVSASINEMTATIADVAHNARQVADSTQAAYGLSQIADKQVRSNIGTINGLASAITEATNVIR
SVELQSQGISKVLEVIRGIADQTNLLALNAAIEAARAGEQGRGFAVVADEVRQLAQKTAQSTRDIEEMIALLQQGTQNAV
GVMGESTVHLQQTVDSAECTAEAIRNTHIEIESIAANAEQIATAASQQTLAAEEISQSLAVISDAASVNAASSEQTAVAS
TQLSELALDLKSITGRFNI

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788194, Length=359, Percent_Identity=30.08356545961, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI2367378, Length=252, Percent_Identity=38.4920634920635, Blast_Score=116, Evalue=6e-27,
Organism=Escherichia coli, GI1788195, Length=226, Percent_Identity=38.0530973451327, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1787690, Length=421, Percent_Identity=27.5534441805226, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1789453, Length=250, Percent_Identity=30.8, Blast_Score=86, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 71194; Mature: 71063

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFKKGIWYGLLCIGLLPLVIAGVVSEQLAERALKAQVYNKLEAVRQLKENQLTEYFADN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RADLKMLAAAMVDMVSFSDGSSLKTITHAHEDYFTQLVKEYGYYDVFVIDPDGDLAYSYA
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHH
KEADYGSNLISGPFKETNLADLFRSVLSSQQIEMVDFMPYTPSGGKPAAFIGMPVVYHGQ
HHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEHHEECCCCCCCCCCCEEECCCHHHHHH
LLAVVALQLSIDRINQLMSQRAGMGETGESYLVGNDYRMRSNSFLDPIRRSVIASFSGSV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEECCCCHHHHHHHHHHHHHCCCC
DENGINTVASRKALNGESGMEVITDYQDNLVLSAFRPISPDFAGKIRWALIVEIDEAEAL
CCCCHHHHHHHHHCCCCCCCHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEEEECHHHHH
ESVVAIKNSLWIVLGISVLVVVGFARLILRSVLRPLGGEPAVMQHISERVAGGDLAIDFC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEC
QSEKTGVYLAMETMSHNLRELVSRIVGITEQLSAASEQTRVASEETNQSLFQQQANIERV
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SASINEMTATIADVAHNARQVADSTQAAYGLSQIADKQVRSNIGTINGLASAITEATNVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RSVELQSQGISKVLEVIRGIADQTNLLALNAAIEAARAGEQGRGFAVVADEVRQLAQKTA
HHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHH
QSTRDIEEMIALLQQGTQNAVGVMGESTVHLQQTVDSAECTAEAIRNTHIEIESIAANAE
HHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHCHHHHHHHHHHCCCCCHHHHHCCHH
QIATAASQQTLAAEEISQSLAVISDAASVNAASSEQTAVASTQLSELALDLKSITGRFNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SFKKGIWYGLLCIGLLPLVIAGVVSEQLAERALKAQVYNKLEAVRQLKENQLTEYFADN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RADLKMLAAAMVDMVSFSDGSSLKTITHAHEDYFTQLVKEYGYYDVFVIDPDGDLAYSYA
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHH
KEADYGSNLISGPFKETNLADLFRSVLSSQQIEMVDFMPYTPSGGKPAAFIGMPVVYHGQ
HHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEHHEECCCCCCCCCCCEEECCCHHHHHH
LLAVVALQLSIDRINQLMSQRAGMGETGESYLVGNDYRMRSNSFLDPIRRSVIASFSGSV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEECCCCHHHHHHHHHHHHHCCCC
DENGINTVASRKALNGESGMEVITDYQDNLVLSAFRPISPDFAGKIRWALIVEIDEAEAL
CCCCHHHHHHHHHCCCCCCCHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEEEECHHHHH
ESVVAIKNSLWIVLGISVLVVVGFARLILRSVLRPLGGEPAVMQHISERVAGGDLAIDFC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEC
QSEKTGVYLAMETMSHNLRELVSRIVGITEQLSAASEQTRVASEETNQSLFQQQANIERV
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SASINEMTATIADVAHNARQVADSTQAAYGLSQIADKQVRSNIGTINGLASAITEATNVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RSVELQSQGISKVLEVIRGIADQTNLLALNAAIEAARAGEQGRGFAVVADEVRQLAQKTA
HHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHH
QSTRDIEEMIALLQQGTQNAVGVMGESTVHLQQTVDSAECTAEAIRNTHIEIESIAANAE
HHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHCHHHHHHHHHHCCCCCHHHHHCCHH
QIATAASQQTLAAEEISQSLAVISDAASVNAASSEQTAVASTQLSELALDLKSITGRFNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]