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The map label for this gene is pepQ

Identifier: 119773175

GI number: 119773175

Start: 36808

End: 38127

Strand: Direct

Name: pepQ

Synonym: Sama_0033

Alternate gene names: 119773175

Gene position: 36808-38127 (Clockwise)

Preceding gene: 119773172

Following gene: 119773176

Centisome position: 0.85

GC content: 52.95

Gene sequence:

>1320_bases
ATGGAAAATTTGGCCCCGCTGTACGTCAATCACATCAATGAACAAAACCGCCGGGTGGCCGATGTGTTGGCCCGGGAACA
ACTTGAAGGCCTGGCCATTCATTCAGGCCAATATCACCGTCAGTTTTTGGATGACATCAACTATCCCTTTAAGGCAAATC
CGCATTTCAAGGCCTGGCTGCCGGTGCTGGATATTCCCAACTGCTGGATACTAACCAATGGGCGTGATAAGCCTGTGTTG
GTGTTCTATCGCCCTGTGGATTTCTGGCATAAGGTCAGCGATGTGCCCGAGAGTTTCTGGACCGAGCATTTTGAAATTAA
GCTGCTGACTAAGGCAGAGAAGGTGGCGGATTTGCTGCCAAAGAACCTCGATACCTGGGCTTATATTGGTGAACATCTGG
ATGTGGCCGACGTGCTGGGCTTCAAGAATCGCAATCCCGATGGAGTGATGAACTACTTCCATTGGCACAGAAGCTTCAAG
ACAGACTATGAGCTTGCCTGTATGCGTGAGGCAAACCGAGTCGCGGTGGCAGGCCATAATGCTGCGAGAGAAGCCTTCTA
CAAGGGCGCCAGTGAGTTTGAAATACAGCAGCAATATTTGTCGGCCATAGGTCAGGGCGAGAATGACGTGCCTTACGGCA
ACATCATTGCTCTGAACCAAAATGCGGCCATCCTGCACTACACCGCGCTGGAGCACGCGGCGCCTGCCAACCGGCATTCG
TTTTTAATCGATGCAGGCGCTTCTTTTAATGGCTACGCCGCAGACATAACCCGCACCTATGCATTTGAAAAAAATGTGTT
TGATGAGCTTATCAAGGCAATGGACAAGATGCAGCGGGAGCTGGTGGACATGATGCGTCCCGGTGTGCGCTTTACCGATC
TGCATCTGGCTACACATCACAAATTGGCTCAGCTGCTGCTGGAGTTTGGTATCGCCAGGGGCGAGGCCAGCGACTTGGTG
GAGCAGGGGGTGACCAGTGTGTTCTTCCCTCATGGGCTTGGGCATATGTTGGGCTTACAGGTGCACGATGTGGCTGGGTT
TGCCCATGATGAGCGTGGCACCCATTTGGCTGCGCCAGAGCGTCATCCCTTCCTGCGCTGTACCCGAGTTCTTGCGCCAC
GCCATGTGCTGACCATAGAGCCTGGTTTTTACATCATCGACAGTCTGTTGACCGAACTGAAGGCCGATGGCCGGGCTGAA
GCAGTGAACTGGGACATGGTAAATACACTGCGTCCCTTTGGCGGCATACGTATTGAGGATAACGTGATTGTGCATCAGGA
GCGCAACGAGAATATGACCCGGGATCTGGGGCTTAACTGA

Upstream 100 bases:

>100_bases
ACACTGCACAGCACACAGAATAGTTCGCCAAGACGGTGTTTGGGATGTGGTTTTTCAAAAATTCCGTCAGGTGTCGTACA
TCGCAGACAGGATAATTCAC

Downstream 100 bases:

>100_bases
CAGTGGCTGAGAAGTACCCTATTCCAGCAGGTGAGCTGGTATTTGAAGAAGAAATCAAAGCCAGCCGATTTATTACCCTG
CTGGATCACTGTGACTCAGA

Product: proline dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MENLAPLYVNHINEQNRRVADVLAREQLEGLAIHSGQYHRQFLDDINYPFKANPHFKAWLPVLDIPNCWILTNGRDKPVL
VFYRPVDFWHKVSDVPESFWTEHFEIKLLTKAEKVADLLPKNLDTWAYIGEHLDVADVLGFKNRNPDGVMNYFHWHRSFK
TDYELACMREANRVAVAGHNAAREAFYKGASEFEIQQQYLSAIGQGENDVPYGNIIALNQNAAILHYTALEHAAPANRHS
FLIDAGASFNGYAADITRTYAFEKNVFDELIKAMDKMQRELVDMMRPGVRFTDLHLATHHKLAQLLLEFGIARGEASDLV
EQGVTSVFFPHGLGHMLGLQVHDVAGFAHDERGTHLAAPERHPFLRCTRVLAPRHVLTIEPGFYIIDSLLTELKADGRAE
AVNWDMVNTLRPFGGIRIEDNVIVHQERNENMTRDLGLN

Sequences:

>Translated_439_residues
MENLAPLYVNHINEQNRRVADVLAREQLEGLAIHSGQYHRQFLDDINYPFKANPHFKAWLPVLDIPNCWILTNGRDKPVL
VFYRPVDFWHKVSDVPESFWTEHFEIKLLTKAEKVADLLPKNLDTWAYIGEHLDVADVLGFKNRNPDGVMNYFHWHRSFK
TDYELACMREANRVAVAGHNAAREAFYKGASEFEIQQQYLSAIGQGENDVPYGNIIALNQNAAILHYTALEHAAPANRHS
FLIDAGASFNGYAADITRTYAFEKNVFDELIKAMDKMQRELVDMMRPGVRFTDLHLATHHKLAQLLLEFGIARGEASDLV
EQGVTSVFFPHGLGHMLGLQVHDVAGFAHDERGTHLAAPERHPFLRCTRVLAPRHVLTIEPGFYIIDSLLTELKADGRAE
AVNWDMVNTLRPFGGIRIEDNVIVHQERNENMTRDLGLN
>Mature_439_residues
MENLAPLYVNHINEQNRRVADVLAREQLEGLAIHSGQYHRQFLDDINYPFKANPHFKAWLPVLDIPNCWILTNGRDKPVL
VFYRPVDFWHKVSDVPESFWTEHFEIKLLTKAEKVADLLPKNLDTWAYIGEHLDVADVLGFKNRNPDGVMNYFHWHRSFK
TDYELACMREANRVAVAGHNAAREAFYKGASEFEIQQQYLSAIGQGENDVPYGNIIALNQNAAILHYTALEHAAPANRHS
FLIDAGASFNGYAADITRTYAFEKNVFDELIKAMDKMQRELVDMMRPGVRFTDLHLATHHKLAQLLLEFGIARGEASDLV
EQGVTSVFFPHGLGHMLGLQVHDVAGFAHDERGTHLAAPERHPFLRCTRVLAPRHVLTIEPGFYIIDSLLTELKADGRAE
AVNWDMVNTLRPFGGIRIEDNVIVHQERNENMTRDLGLN

Specific function: Splits dipeptides with a prolyl residue in the C- terminal position

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily

Homologues:

Organism=Homo sapiens, GI149589008, Length=299, Percent_Identity=33.4448160535117, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI260593665, Length=299, Percent_Identity=33.4448160535117, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI260593663, Length=286, Percent_Identity=32.5174825174825, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1790282, Length=442, Percent_Identity=52.7149321266968, Blast_Score=473, Evalue=1e-134,
Organism=Escherichia coli, GI1789275, Length=288, Percent_Identity=29.1666666666667, Blast_Score=122, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17508215, Length=368, Percent_Identity=31.7934782608696, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6321118, Length=407, Percent_Identity=30.2211302211302, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320922, Length=282, Percent_Identity=25.886524822695, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21357079, Length=462, Percent_Identity=29.2207792207792, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI19920384, Length=290, Percent_Identity=26.8965517241379, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PEPQ_SHEAM (A1S1I9)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_925915.1
- ProteinModelPortal:   A1S1I9
- SMR:   A1S1I9
- STRING:   A1S1I9
- MEROPS:   M24.003
- GeneID:   4602290
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0033
- NMPDR:   fig|326297.7.peg.29
- eggNOG:   COG0006
- HOGENOM:   HBG296884
- OMA:   PYGNIVA
- PhylomeDB:   A1S1I9
- ProtClustDB:   PRK13607
- GO:   GO:0006508
- HAMAP:   MF_01279
- InterPro:   IPR000994
- InterPro:   IPR001131
- InterPro:   IPR022846
- Gene3D:   G3DSA:3.90.230.10
- PANTHER:   PTHR10804

Pfam domain/function: PF00557 Peptidase_M24; SSF55920 Peptidase_M24_cat_core

EC number: =3.4.13.9

Molecular weight: Translated: 50035; Mature: 50035

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENLAPLYVNHINEQNRRVADVLAREQLEGLAIHSGQYHRQFLDDINYPFKANPHFKAWL
CCCCCCHHHHHCCCCHHHHHHHHHHHHHCCEEECCCHHHHHHHHHCCCCCCCCCCCEEEE
PVLDIPNCWILTNGRDKPVLVFYRPVDFWHKVSDVPESFWTEHFEIKLLTKAEKVADLLP
EEECCCCEEEEECCCCCCEEEEECCHHHHHHHHCCCHHHCCCCEEEEEEHHHHHHHHHHC
KNLDTWAYIGEHLDVADVLGFKNRNPDGVMNYFHWHRSFKTDYELACMREANRVAVAGHN
CCCCHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCEEEEECCH
AAREAFYKGASEFEIQQQYLSAIGQGENDVPYGNIIALNQNAAILHYTALEHAAPANRHS
HHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEHHHHCCCCCCCE
FLIDAGASFNGYAADITRTYAFEKNVFDELIKAMDKMQRELVDMMRPGVRFTDLHLATHH
EEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHH
KLAQLLLEFGIARGEASDLVEQGVTSVFFPHGLGHMLGLQVHDVAGFAHDERGTHLAAPE
HHHHHHHHHCCCCCCHHHHHHHCHHHEECCCCHHHHHCCEEEHHHCCCCCCCCCCCCCCC
RHPFLRCTRVLAPRHVLTIEPGFYIIDSLLTELKADGRAEAVNWDMVNTLRPFGGIRIED
CCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCEEECCHHHHHHCCCCCEEEEC
NVIVHQERNENMTRDLGLN
CEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MENLAPLYVNHINEQNRRVADVLAREQLEGLAIHSGQYHRQFLDDINYPFKANPHFKAWL
CCCCCCHHHHHCCCCHHHHHHHHHHHHHCCEEECCCHHHHHHHHHCCCCCCCCCCCEEEE
PVLDIPNCWILTNGRDKPVLVFYRPVDFWHKVSDVPESFWTEHFEIKLLTKAEKVADLLP
EEECCCCEEEEECCCCCCEEEEECCHHHHHHHHCCCHHHCCCCEEEEEEHHHHHHHHHHC
KNLDTWAYIGEHLDVADVLGFKNRNPDGVMNYFHWHRSFKTDYELACMREANRVAVAGHN
CCCCHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCEEEEECCH
AAREAFYKGASEFEIQQQYLSAIGQGENDVPYGNIIALNQNAAILHYTALEHAAPANRHS
HHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEHHHHCCCCCCCE
FLIDAGASFNGYAADITRTYAFEKNVFDELIKAMDKMQRELVDMMRPGVRFTDLHLATHH
EEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHH
KLAQLLLEFGIARGEASDLVEQGVTSVFFPHGLGHMLGLQVHDVAGFAHDERGTHLAAPE
HHHHHHHHHCCCCCCHHHHHHHCHHHEECCCCHHHHHCCEEEHHHCCCCCCCCCCCCCCC
RHPFLRCTRVLAPRHVLTIEPGFYIIDSLLTELKADGRAEAVNWDMVNTLRPFGGIRIED
CCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCEEECCHHHHHHCCCCCEEEEC
NVIVHQERNENMTRDLGLN
CEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA