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The map label for this gene is pdhB [H]

Identifier: 119718727

GI number: 119718727

Start: 4767874

End: 4768854

Strand: Reverse

Name: pdhB [H]

Synonym: Noca_4508

Alternate gene names: 119718727

Gene position: 4768854-4767874 (Counterclockwise)

Preceding gene: 119718728

Following gene: 119718726

Centisome position: 95.65

GC content: 69.62

Gene sequence:

>981_bases
ATGACGCAGAAGATCACGTTGGCCAAGGGCCTCAACATGGGGCTGCGCAAGGCGATGGAGGACGACCCCAAGGTCCTGCT
CATGGGCGAGGACGTCGGCAAGCTCGGCGGCGTCTTCCGGATCACCGACGGACTGCAGAAGGACTTCGGCGAGGACCGGG
TGATCGACAGCCCGCTGGCCGAGTCCGGCATCGTCGGCACCGCCGTCGGGCTGGCGCTGCGCGGCTACCGGCCCGTCGTC
GAGATCCAGTTCGACGGGTTCGTCTACCCGGCGTACGACCAGATCGTCTGCCAGGTCGCGAAGATGACCTTCCGCAGCCA
GGGCAAGTCCCGGATGCCGATGGTGATCCGGATCCCGTTCGGCGGCGGCATCGGCGCGGTCGAGCACCACAGCGAGAGCC
CGGAGGCGCAATTCGCGCACACGCCGGGGCTCAAGGTGGTCGCCTGTTCCAACCCCGTCGACGGCTACTGGATGATCCAG
CAGGCGATCGCCTGCGACGACCCGGTGATCTTCCTCGAGCCCAAGCGGCAGTACCACGCCGACAAGGCCGACCTCGAGGA
GACCGCCACCCCCGACCCGCTGTTCAGCTCCCGGGTGGTGCGGCGCGGCACCGACATCACGGTGCTCGCCTACGGCCCGA
CGGTGAAGACCGCGATGGCCGCAGCCGAGGCCGCCGCCACCGAGGGCCGCTCGCTCGAGGTGATCGACCTGCGCACGCTC
TCGCCGCTGGACATGACGCCGGTCTACGAGTCCGTACGCCGCACCGGCCGCGTGGTCGTGACCCACGAGGCGCACGTCAA
CCTCGGCCTCGGGGCGGAGCTCGCGGCCCGGATCACCGAGCAGTGCTTCTACTCCCTGGAGGCACCGGTGCTGCGGGTCG
GAGCCTTCGACACGCCGTACCCGGCGTCCCGGATCGAGGAGGACTACCTCCCCGACCTGGACCGGGTCCTGGACGCCGTC
GACCGCTCGCTCGAGTTCTGA

Upstream 100 bases:

>100_bases
GTCTACACAGAGCTCACCGAGGAGCTCGAGCAGCAGCGGGAGGCGTTCGCCGCCTACCTTGCCAGCTTCGATGGCGCGGA
CTTCGAGGGGGCGCACTGAC

Downstream 100 bases:

>100_bases
AGGAGGCCTGCGTGCCTGAGTACAAGCTGCCCGACCCGGGCGAGGGCCTGACCGAGGCCGAGATCGTCAAGTGGCACGTC
GCCGTCGGCGACGTCGTCGA

Product: transketolase, central region

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTQKITLAKGLNMGLRKAMEDDPKVLLMGEDVGKLGGVFRITDGLQKDFGEDRVIDSPLAESGIVGTAVGLALRGYRPVV
EIQFDGFVYPAYDQIVCQVAKMTFRSQGKSRMPMVIRIPFGGGIGAVEHHSESPEAQFAHTPGLKVVACSNPVDGYWMIQ
QAIACDDPVIFLEPKRQYHADKADLEETATPDPLFSSRVVRRGTDITVLAYGPTVKTAMAAAEAAATEGRSLEVIDLRTL
SPLDMTPVYESVRRTGRVVVTHEAHVNLGLGAELAARITEQCFYSLEAPVLRVGAFDTPYPASRIEEDYLPDLDRVLDAV
DRSLEF

Sequences:

>Translated_326_residues
MTQKITLAKGLNMGLRKAMEDDPKVLLMGEDVGKLGGVFRITDGLQKDFGEDRVIDSPLAESGIVGTAVGLALRGYRPVV
EIQFDGFVYPAYDQIVCQVAKMTFRSQGKSRMPMVIRIPFGGGIGAVEHHSESPEAQFAHTPGLKVVACSNPVDGYWMIQ
QAIACDDPVIFLEPKRQYHADKADLEETATPDPLFSSRVVRRGTDITVLAYGPTVKTAMAAAEAAATEGRSLEVIDLRTL
SPLDMTPVYESVRRTGRVVVTHEAHVNLGLGAELAARITEQCFYSLEAPVLRVGAFDTPYPASRIEEDYLPDLDRVLDAV
DRSLEF
>Mature_325_residues
TQKITLAKGLNMGLRKAMEDDPKVLLMGEDVGKLGGVFRITDGLQKDFGEDRVIDSPLAESGIVGTAVGLALRGYRPVVE
IQFDGFVYPAYDQIVCQVAKMTFRSQGKSRMPMVIRIPFGGGIGAVEHHSESPEAQFAHTPGLKVVACSNPVDGYWMIQQ
AIACDDPVIFLEPKRQYHADKADLEETATPDPLFSSRVVRRGTDITVLAYGPTVKTAMAAAEAAATEGRSLEVIDLRTLS
PLDMTPVYESVRRTGRVVVTHEAHVNLGLGAELAARITEQCFYSLEAPVLRVGAFDTPYPASRIEEDYLPDLDRVLDAVD
RSLEF

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=328, Percent_Identity=39.3292682926829, Blast_Score=238, Evalue=5e-63,
Organism=Homo sapiens, GI34101272, Length=328, Percent_Identity=39.3292682926829, Blast_Score=238, Evalue=5e-63,
Organism=Homo sapiens, GI156564403, Length=328, Percent_Identity=34.4512195121951, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI291084858, Length=328, Percent_Identity=32.6219512195122, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17506935, Length=326, Percent_Identity=42.638036809816, Blast_Score=239, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17538422, Length=326, Percent_Identity=35.2760736196319, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6319698, Length=328, Percent_Identity=33.2317073170732, Blast_Score=192, Evalue=5e-50,
Organism=Drosophila melanogaster, GI160714828, Length=327, Percent_Identity=38.8379204892966, Blast_Score=231, Evalue=3e-61,
Organism=Drosophila melanogaster, GI160714832, Length=327, Percent_Identity=38.8379204892966, Blast_Score=231, Evalue=4e-61,
Organism=Drosophila melanogaster, GI21358145, Length=328, Percent_Identity=36.890243902439, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24650940, Length=328, Percent_Identity=36.890243902439, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24650943, Length=92, Percent_Identity=36.9565217391304, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650945, Length=92, Percent_Identity=36.9565217391304, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35614; Mature: 35483

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKITLAKGLNMGLRKAMEDDPKVLLMGEDVGKLGGVFRITDGLQKDFGEDRVIDSPLA
CCCEEEHHHCCCHHHHHHHCCCCCEEEEECCHHHHCCEEEECCCHHHHCCCCCCCCCCCH
ESGIVGTAVGLALRGYRPVVEIQFDGFVYPAYDQIVCQVAKMTFRSQGKSRMPMVIRIPF
HCCCHHHHHHHHHCCCCCEEEEEECCEEECHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GGGIGAVEHHSESPEAQFAHTPGLKVVACSNPVDGYWMIQQAIACDDPVIFLEPKRQYHA
CCCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEECCCHHHCC
DKADLEETATPDPLFSSRVVRRGTDITVLAYGPTVKTAMAAAEAAATEGRSLEVIDLRTL
CHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEECC
SPLDMTPVYESVRRTGRVVVTHEAHVNLGLGAELAARITEQCFYSLEAPVLRVGAFDTPY
CCCCCCHHHHHHHHCCCEEEEEECEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCC
PASRIEEDYLPDLDRVLDAVDRSLEF
CHHHCCHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQKITLAKGLNMGLRKAMEDDPKVLLMGEDVGKLGGVFRITDGLQKDFGEDRVIDSPLA
CCEEEHHHCCCHHHHHHHCCCCCEEEEECCHHHHCCEEEECCCHHHHCCCCCCCCCCCH
ESGIVGTAVGLALRGYRPVVEIQFDGFVYPAYDQIVCQVAKMTFRSQGKSRMPMVIRIPF
HCCCHHHHHHHHHCCCCCEEEEEECCEEECHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GGGIGAVEHHSESPEAQFAHTPGLKVVACSNPVDGYWMIQQAIACDDPVIFLEPKRQYHA
CCCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEECCCHHHCC
DKADLEETATPDPLFSSRVVRRGTDITVLAYGPTVKTAMAAAEAAATEGRSLEVIDLRTL
CHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEECC
SPLDMTPVYESVRRTGRVVVTHEAHVNLGLGAELAARITEQCFYSLEAPVLRVGAFDTPY
CCCCCCHHHHHHHHCCCEEEEEECEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCC
PASRIEEDYLPDLDRVLDAVDRSLEF
CHHHCCHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA