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The map label for this gene is pdhC [H]

Identifier: 119718726

GI number: 119718726

Start: 4766438

End: 4767862

Strand: Reverse

Name: pdhC [H]

Synonym: Noca_4507

Alternate gene names: 119718726

Gene position: 4767862-4766438 (Counterclockwise)

Preceding gene: 119718727

Following gene: 119718724

Centisome position: 95.63

GC content: 72.56

Gene sequence:

>1425_bases
GTGCCTGAGTACAAGCTGCCCGACCCGGGCGAGGGCCTGACCGAGGCCGAGATCGTCAAGTGGCACGTCGCCGTCGGCGA
CGTCGTCGAGATCAACCAGGTCGTCGTCGAGATCGAGACCGCGAAGTCGATCGTCGAGCTGCCCTCGCCGTACGCCGGTG
AGGTGAGCGCGATCCTGGTCGCCGAGGGCGAGCTGGTCCCGGTCGGTACGCCGATCATCGCGATCGGCGACGACGTGGCC
GCCGAGCCGGCGGCCGGTGCCGCTCCCGAGGCGCGCGCCGCGGCGCCGGTGGAGATCGACCTGTCCAACCCCGCCGCGTC
CGGTGGCGGCGAGGGCGAGAGCCTGGTCGGGCGCAACAAGGCCGACCGGGGCCCGGTCCGCCGGGCCCGCAAGGTCACCT
CCGGGGCGATGGCCGCGCACATGCAGGCGCAGGCCGCGTTCGAGACCGGCGGCGCGCCGATGGTGGAGGCCGACGAGGAG
CCGGTGCCGGCCACCGCCGCGGCCCCGCTGGACGCTCCGGCGGCGGTGCGCACCCTGGCCAAGCCGCCGGTGCGCAAGCT
CGCCAAGGACCTCGGCGTCGACCTCACCACGCTCACCCCGAGCGGGCCGAACGGGACCGTGTCGCGCGAGGACGTCGAGG
CCGCGGCCGGCGGCGATGCCGTTCTCGGCGGTCGGGTAGCCGCCGGCGAACGAGGCGGCGAGTCGAGACCCGCTGAGCGG
GAGTGGCGCGAGCCGATCAAGGGCGTGCGCAAGATGATGGGCCAGGCGATGGTCCAGTCGGCGTTCACGCTGCCGCACGT
GACCGAGTGGGTCACCGTCGACGTCACCGCGACGATGGAGCTCGTCGAGCGGCTGAAGACGCGCCGGGAGTTCCGCGAGG
TCCGGGTCTCACCGCTGCTGGTGCTTGCCCGCGCGGTGATGCTGGCGATGCGGCGCACACCGGAGATCAACTCGTGGTGG
GACGACGCGGCGCACGAGGTCGTCTACAAGCGGTACGTGAACCTCGGCATCGCCGCGGCCACCCCGCGCGGGCTGGTCGT
GCCGAACGTCAAGGACGCCGAGTCGATGACCCTCCTCGAGCTCGCCCAGGCGATCAACGCGGTGACCGCGACCGCCCGGG
AGGGCAAGACCCAGCCCGCGGAGATGAGCGGCGGCACCTTCACGATCACGAACGTCGGCGTCTTCGGCGTCGACTCCGGC
ACGCCGATCATCAACCCCGGCGAGTCCGCGATCCTGGCGTTCGGCGCGGTGCGCAAGCAGCCCTGGGTGGTCGAGACCGA
CGGCCAGGACACCATCGTGCCGCGCCAGATCTGCACGCTGGCGCTGGCCTTCGACCACCGCCACATCGATGGGGAGAAGG
GCTCGCGGTTCCTCGCCGACGTCGCCGAGATCATGGCCGATCCCGCCACCGCGCTGCTGTATTGA

Upstream 100 bases:

>100_bases
CGCCGTACCCGGCGTCCCGGATCGAGGAGGACTACCTCCCCGACCTGGACCGGGTCCTGGACGCCGTCGACCGCTCGCTC
GAGTTCTGAAGGAGGCCTGC

Downstream 100 bases:

>100_bases
GTCGTGTGCCTGAGCACGCGCCATGGCGCGTGCTCAGGCACACGACCCGTCCGGGCTAGGCGCAGGCGCGCACCAGGGCG
AGCACCAGGCTCTCGGTGAC

Product: dehydrogenase catalytic domain-containing protein

Products: NA

Alternate protein names: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2 [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MPEYKLPDPGEGLTEAEIVKWHVAVGDVVEINQVVVEIETAKSIVELPSPYAGEVSAILVAEGELVPVGTPIIAIGDDVA
AEPAAGAAPEARAAAPVEIDLSNPAASGGGEGESLVGRNKADRGPVRRARKVTSGAMAAHMQAQAAFETGGAPMVEADEE
PVPATAAAPLDAPAAVRTLAKPPVRKLAKDLGVDLTTLTPSGPNGTVSREDVEAAAGGDAVLGGRVAAGERGGESRPAER
EWREPIKGVRKMMGQAMVQSAFTLPHVTEWVTVDVTATMELVERLKTRREFREVRVSPLLVLARAVMLAMRRTPEINSWW
DDAAHEVVYKRYVNLGIAAATPRGLVVPNVKDAESMTLLELAQAINAVTATAREGKTQPAEMSGGTFTITNVGVFGVDSG
TPIINPGESAILAFGAVRKQPWVVETDGQDTIVPRQICTLALAFDHRHIDGEKGSRFLADVAEIMADPATALLY

Sequences:

>Translated_474_residues
MPEYKLPDPGEGLTEAEIVKWHVAVGDVVEINQVVVEIETAKSIVELPSPYAGEVSAILVAEGELVPVGTPIIAIGDDVA
AEPAAGAAPEARAAAPVEIDLSNPAASGGGEGESLVGRNKADRGPVRRARKVTSGAMAAHMQAQAAFETGGAPMVEADEE
PVPATAAAPLDAPAAVRTLAKPPVRKLAKDLGVDLTTLTPSGPNGTVSREDVEAAAGGDAVLGGRVAAGERGGESRPAER
EWREPIKGVRKMMGQAMVQSAFTLPHVTEWVTVDVTATMELVERLKTRREFREVRVSPLLVLARAVMLAMRRTPEINSWW
DDAAHEVVYKRYVNLGIAAATPRGLVVPNVKDAESMTLLELAQAINAVTATAREGKTQPAEMSGGTFTITNVGVFGVDSG
TPIINPGESAILAFGAVRKQPWVVETDGQDTIVPRQICTLALAFDHRHIDGEKGSRFLADVAEIMADPATALLY
>Mature_473_residues
PEYKLPDPGEGLTEAEIVKWHVAVGDVVEINQVVVEIETAKSIVELPSPYAGEVSAILVAEGELVPVGTPIIAIGDDVAA
EPAAGAAPEARAAAPVEIDLSNPAASGGGEGESLVGRNKADRGPVRRARKVTSGAMAAHMQAQAAFETGGAPMVEADEEP
VPATAAAPLDAPAAVRTLAKPPVRKLAKDLGVDLTTLTPSGPNGTVSREDVEAAAGGDAVLGGRVAAGERGGESRPAERE
WREPIKGVRKMMGQAMVQSAFTLPHVTEWVTVDVTATMELVERLKTRREFREVRVSPLLVLARAVMLAMRRTPEINSWWD
DAAHEVVYKRYVNLGIAAATPRGLVVPNVKDAESMTLLELAQAINAVTATAREGKTQPAEMSGGTFTITNVGVFGVDSGT
PIINPGESAILAFGAVRKQPWVVETDGQDTIVPRQICTLALAFDHRHIDGEKGSRFLADVAEIMADPATALLY

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0508

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI31711992, Length=476, Percent_Identity=27.5210084033613, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI19923748, Length=236, Percent_Identity=33.0508474576271, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI110671329, Length=352, Percent_Identity=27.5568181818182, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI203098816, Length=227, Percent_Identity=29.9559471365639, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI203098753, Length=227, Percent_Identity=29.9559471365639, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI260898739, Length=169, Percent_Identity=33.1360946745562, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1786946, Length=294, Percent_Identity=32.6530612244898, Blast_Score=155, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17560088, Length=467, Percent_Identity=28.4796573875803, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17537937, Length=308, Percent_Identity=27.2727272727273, Blast_Score=135, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI25146366, Length=239, Percent_Identity=33.4728033472803, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17538894, Length=238, Percent_Identity=31.5126050420168, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6320352, Length=241, Percent_Identity=34.0248962655602, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6324258, Length=480, Percent_Identity=25.2083333333333, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI18859875, Length=305, Percent_Identity=29.8360655737705, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24582497, Length=231, Percent_Identity=32.034632034632, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI20129315, Length=231, Percent_Identity=32.034632034632, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24645909, Length=230, Percent_Identity=32.1739130434783, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3096 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001078
- InterPro:   IPR000089
- InterPro:   IPR023213
- InterPro:   IPR004167
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00198 2-oxoacid_dh; PF00364 Biotin_lipoyl; PF02817 E3_binding [H]

EC number: =2.3.1.12 [H]

Molecular weight: Translated: 49829; Mature: 49698

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEYKLPDPGEGLTEAEIVKWHVAVGDVVEINQVVVEIETAKSIVELPSPYAGEVSAILV
CCCCCCCCCCCCCCCCCEEEEEEECCCCEEECEEEEEEHHHHHHHHCCCCCCCCEEEEEE
AEGELVPVGTPIIAIGDDVAAEPAAGAAPEARAAAPVEIDLSNPAASGGGEGESLVGRNK
ECCCEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHCCCCC
ADRGPVRRARKVTSGAMAAHMQAQAAFETGGAPMVEADEEPVPATAAAPLDAPAAVRTLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHC
KPPVRKLAKDLGVDLTTLTPSGPNGTVSREDVEAAAGGDAVLGGRVAAGERGGESRPAER
CCHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHCCCCCEECCEEECCCCCCCCCCCHH
EWREPIKGVRKMMGQAMVQSAFTLPHVTEWVTVDVTATMELVERLKTRREFREVRVSPLL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
VLARAVMLAMRRTPEINSWWDDAAHEVVYKRYVNLGIAAATPRGLVVPNVKDAESMTLLE
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEECCCCCEECCCCCCCHHHHHHH
LAQAINAVTATAREGKTQPAEMSGGTFTITNVGVFGVDSGTPIINPGESAILAFGAVRKQ
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCEEEHHHHCCC
PWVVETDGQDTIVPRQICTLALAFDHRHIDGEKGSRFLADVAEIMADPATALLY
CEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure 
PEYKLPDPGEGLTEAEIVKWHVAVGDVVEINQVVVEIETAKSIVELPSPYAGEVSAILV
CCCCCCCCCCCCCCCCEEEEEEECCCCEEECEEEEEEHHHHHHHHCCCCCCCCEEEEEE
AEGELVPVGTPIIAIGDDVAAEPAAGAAPEARAAAPVEIDLSNPAASGGGEGESLVGRNK
ECCCEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHCCCCC
ADRGPVRRARKVTSGAMAAHMQAQAAFETGGAPMVEADEEPVPATAAAPLDAPAAVRTLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHC
KPPVRKLAKDLGVDLTTLTPSGPNGTVSREDVEAAAGGDAVLGGRVAAGERGGESRPAER
CCHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHCCCCCEECCEEECCCCCCCCCCCHH
EWREPIKGVRKMMGQAMVQSAFTLPHVTEWVTVDVTATMELVERLKTRREFREVRVSPLL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
VLARAVMLAMRRTPEINSWWDDAAHEVVYKRYVNLGIAAATPRGLVVPNVKDAESMTLLE
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEECCCCCEECCCCCCCHHHHHHH
LAQAINAVTATAREGKTQPAEMSGGTFTITNVGVFGVDSGTPIINPGESAILAFGAVRKQ
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCEEEHHHHCCC
PWVVETDGQDTIVPRQICTLALAFDHRHIDGEKGSRFLADVAEIMADPATALLY
CEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA