Click here to switch to the map view.

The map label for this gene is purD [H]

Identifier: 119718561

GI number: 119718561

Start: 4590349

End: 4591599

Strand: Reverse

Name: purD [H]

Synonym: Noca_4342

Alternate gene names: 119718561

Gene position: 4591599-4590349 (Counterclockwise)

Preceding gene: 119718562

Following gene: 119718560

Centisome position: 92.09

GC content: 75.38

Gene sequence:

>1251_bases
GTGAAGACCCTCGTCATCGGCACCGGCGGACGCGAACACGCACTGGCCCGCGCGCTCTCCCAGGACCCCGCCGTGACCGA
GGTGCACGCCGCCCCCGGCAACCCCGGCATCGCCGCGGTCGCCACGCTGCACGCCGTGGACCCGATGTCGGGGGAGGCCG
TCGCCGACCTGGCCGTCGCGCTCGGCATCGACCTCGTGGTCGTCGGCCCCGAGGCGCCGCTGGTCGCAGGCGTCGCGGAC
GCGGTGCGTTCGAAGGGGATCGCGGTGTTCGGCCCCTCCGGCGCGGCCGCGCAGCTGGAGGGCTCGAAGGCGTTCGCGAA
GGACGTGATGCAGGCGGCCGGCGTCCCCACCGCCGCGGCCCGCGTCTGCGCCGACGCCGAGGCCGTCGCGGCCGCGCTGG
ACGAGTTCGGGCCGCCGTACGTCGTGAAGGACGACGGGCTCGCCGCCGGCAAGGGCGTGGTGGTGACGTCGTCGCGCGAG
GACGGCCGCACGCACGCCGCCGGCTGTGCTCGCGTCGTCGTCGAGGAGTACCTCGACGGCCCCGAGGTGTCGCTGTTCGC
GATCACCGATGGCAGCACGGTCTATCCGCTCCTGCCGGCCCAGGACTTCAAGCGGATCTTCGACGGCGACGGGGGGCCGA
ACACCGGCGGCATGGGCGCCTACACGCCGCTGCCGTGGACGGAACCCGGCCTCGTCGACGAGGTACTGCGCGAGGTGCTG
CAGCCGACCGTCGACGAGATGGCCCGCCGCGGCACGCCGTTTTCCGGGCTCCTGTACGCCGGCCTCGCGCTGACCTCGCG
CGGCATCCGGGTCGTGGAGTTCAACGCCCGCTGGGGCGACCCGGAGACCCAACCGCTCCTCGCGCTCCTCGAGTCCCCGC
TCGCGCCGCTGCTGATGGGCGCGGCCACCGGCACCCTGGCCTCCGTGCCGGCTCCGGTGTGGAAGGACGGCGCGGCCGTG
GCCGTCGTGCTGGCCAGCGCCGGCTACCCGGAGACCTCGTCCTCGGGCGACGTCATCACCGGGGTCGAGGAGGCCGAGGC
GGTCGAGGGCGTCCATGTGATCCAGGCCGGCACCGCGCTCGCCGGCGGCGAGCTCGTCACCGCCGGCGGCCGAGTCCTGG
CCGTCGTCGGCACCGGGGCGGATGTCGCCGCGGCCCGGACGGCGGCGTACGACGGCGTCGCCCGCATCTCGTTCCGCGGC
GCCCAGCACCGCACCGACATCGCGGCCGGCGTGACCGCCGCTCAACTGTAA

Upstream 100 bases:

>100_bases
GGGTGGTGGACGGTATCGAGCTCTCCGACGATCCCATCCTGCGATACCGACCGGCGGCCTACACCGAGTCCGTCTCCCGC
CGCGGATAGGGTTGCGGCCC

Downstream 100 bases:

>100_bases
CGCCCGTTTACATCTTGTACCGACCCCGCTGCAACCTGGTGGGAACAGCAGGTAACCCGGCGTTACAGCCGGCGGCCGGG
CCCGTGGGAGAATGACCGCT

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKTLVIGTGGREHALARALSQDPAVTEVHAAPGNPGIAAVATLHAVDPMSGEAVADLAVALGIDLVVVGPEAPLVAGVAD
AVRSKGIAVFGPSGAAAQLEGSKAFAKDVMQAAGVPTAAARVCADAEAVAAALDEFGPPYVVKDDGLAAGKGVVVTSSRE
DGRTHAAGCARVVVEEYLDGPEVSLFAITDGSTVYPLLPAQDFKRIFDGDGGPNTGGMGAYTPLPWTEPGLVDEVLREVL
QPTVDEMARRGTPFSGLLYAGLALTSRGIRVVEFNARWGDPETQPLLALLESPLAPLLMGAATGTLASVPAPVWKDGAAV
AVVLASAGYPETSSSGDVITGVEEAEAVEGVHVIQAGTALAGGELVTAGGRVLAVVGTGADVAAARTAAYDGVARISFRG
AQHRTDIAAGVTAAQL

Sequences:

>Translated_416_residues
MKTLVIGTGGREHALARALSQDPAVTEVHAAPGNPGIAAVATLHAVDPMSGEAVADLAVALGIDLVVVGPEAPLVAGVAD
AVRSKGIAVFGPSGAAAQLEGSKAFAKDVMQAAGVPTAAARVCADAEAVAAALDEFGPPYVVKDDGLAAGKGVVVTSSRE
DGRTHAAGCARVVVEEYLDGPEVSLFAITDGSTVYPLLPAQDFKRIFDGDGGPNTGGMGAYTPLPWTEPGLVDEVLREVL
QPTVDEMARRGTPFSGLLYAGLALTSRGIRVVEFNARWGDPETQPLLALLESPLAPLLMGAATGTLASVPAPVWKDGAAV
AVVLASAGYPETSSSGDVITGVEEAEAVEGVHVIQAGTALAGGELVTAGGRVLAVVGTGADVAAARTAAYDGVARISFRG
AQHRTDIAAGVTAAQL
>Mature_416_residues
MKTLVIGTGGREHALARALSQDPAVTEVHAAPGNPGIAAVATLHAVDPMSGEAVADLAVALGIDLVVVGPEAPLVAGVAD
AVRSKGIAVFGPSGAAAQLEGSKAFAKDVMQAAGVPTAAARVCADAEAVAAALDEFGPPYVVKDDGLAAGKGVVVTSSRE
DGRTHAAGCARVVVEEYLDGPEVSLFAITDGSTVYPLLPAQDFKRIFDGDGGPNTGGMGAYTPLPWTEPGLVDEVLREVL
QPTVDEMARRGTPFSGLLYAGLALTSRGIRVVEFNARWGDPETQPLLALLESPLAPLLMGAATGTLASVPAPVWKDGAAV
AVVLASAGYPETSSSGDVITGVEEAEAVEGVHVIQAGTALAGGELVTAGGRVLAVVGTGADVAAARTAAYDGVARISFRG
AQHRTDIAAGVTAAQL

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI28416899, Length=420, Percent_Identity=45.7142857142857, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI4503915, Length=420, Percent_Identity=45.7142857142857, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI209869995, Length=420, Percent_Identity=45.7142857142857, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI209869993, Length=420, Percent_Identity=45.7142857142857, Blast_Score=332, Evalue=4e-91,
Organism=Escherichia coli, GI1790438, Length=421, Percent_Identity=43.9429928741093, Blast_Score=307, Evalue=7e-85,
Organism=Caenorhabditis elegans, GI17567511, Length=427, Percent_Identity=37.2365339578454, Blast_Score=239, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6321203, Length=436, Percent_Identity=39.6788990825688, Blast_Score=283, Evalue=4e-77,
Organism=Drosophila melanogaster, GI62471619, Length=428, Percent_Identity=44.1588785046729, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24582400, Length=428, Percent_Identity=44.1588785046729, Blast_Score=276, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 41688; Mature: 41688

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLVIGTGGREHALARALSQDPAVTEVHAAPGNPGIAAVATLHAVDPMSGEAVADLAVA
CCEEEEECCCHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEEEHHCCCCCCHHHHHHHHH
LGIDLVVVGPEAPLVAGVADAVRSKGIAVFGPSGAAAQLEGSKAFAKDVMQAAGVPTAAA
HCCEEEEECCCCCHHHHHHHHHHHCCEEEECCCCCCEEECCHHHHHHHHHHHCCCCHHHH
RVCADAEAVAAALDEFGPPYVVKDDGLAAGKGVVVTSSREDGRTHAAGCARVVVEEYLDG
HHHCCHHHHHHHHHHCCCCEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCC
PEVSLFAITDGSTVYPLLPAQDFKRIFDGDGGPNTGGMGAYTPLPWTEPGLVDEVLREVL
CCEEEEEEECCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
QPTVDEMARRGTPFSGLLYAGLALTSRGIRVVEFNARWGDPETQPLLALLESPLAPLLMG
HHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHCCHHHHHHH
AATGTLASVPAPVWKDGAAVAVVLASAGYPETSSSGDVITGVEEAEAVEGVHVIQAGTAL
HCCCCHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEECCHHHHHHCCEEEEECCCEE
AGGELVTAGGRVLAVVGTGADVAAARTAAYDGVARISFRGAQHRTDIAAGVTAAQL
CCCCEEECCCEEEEEEECCCCHHHHHHHHHCCEEEEEECCCCCCCHHHHCCHHHCC
>Mature Secondary Structure
MKTLVIGTGGREHALARALSQDPAVTEVHAAPGNPGIAAVATLHAVDPMSGEAVADLAVA
CCEEEEECCCHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEEEHHCCCCCCHHHHHHHHH
LGIDLVVVGPEAPLVAGVADAVRSKGIAVFGPSGAAAQLEGSKAFAKDVMQAAGVPTAAA
HCCEEEEECCCCCHHHHHHHHHHHCCEEEECCCCCCEEECCHHHHHHHHHHHCCCCHHHH
RVCADAEAVAAALDEFGPPYVVKDDGLAAGKGVVVTSSREDGRTHAAGCARVVVEEYLDG
HHHCCHHHHHHHHHHCCCCEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCC
PEVSLFAITDGSTVYPLLPAQDFKRIFDGDGGPNTGGMGAYTPLPWTEPGLVDEVLREVL
CCEEEEEEECCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
QPTVDEMARRGTPFSGLLYAGLALTSRGIRVVEFNARWGDPETQPLLALLESPLAPLLMG
HHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHCCHHHHHHH
AATGTLASVPAPVWKDGAAVAVVLASAGYPETSSSGDVITGVEEAEAVEGVHVIQAGTAL
HCCCCHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEECCHHHHHHCCEEEEECCCEE
AGGELVTAGGRVLAVVGTGADVAAARTAAYDGVARISFRGAQHRTDIAAGVTAAQL
CCCCEEECCCEEEEEEECCCCHHHHHHHHHCCEEEEEECCCCCCCHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]