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The map label for this gene is mutT1 [H]

Identifier: 119718483

GI number: 119718483

Start: 4504666

End: 4505526

Strand: Reverse

Name: mutT1 [H]

Synonym: Noca_4264

Alternate gene names: 119718483

Gene position: 4505526-4504666 (Counterclockwise)

Preceding gene: 119718486

Following gene: 119718482

Centisome position: 90.37

GC content: 74.1

Gene sequence:

>861_bases
ATGCCCGGGAAGGACGTGCTCTCCGCCGGTGTCGTCGTCTTCCGTCCGGGGAAGCGGGTGCTGCTCGTGCACCGGCCCCG
CTACGACGACTGGTCCTTCCCCAAGGGCAAGCTCGACCCCGGCGAGCACGCCGCGGCCGCGGCGGTGCGCGAGGTCGAGG
AGGAGACCGGGCTGCACGTGCGGCTCGGCCCGCCGCTGACCGGCCAGCGCTACCCGATCGCCGGCGGCCGGACGAAGGCC
GTCTCCTACTGGACCGGTCGGGTCGTCGGCGCCGACGACGTCAGCGGCTACCGCCCGAACGCCGAGATCGACCAGGTGCG
CTGGTTCGAGTACGACGCGGCCGTCGACCGGCTGAGCTACGACTACGACCGCGACACCCTCGCGCAGGCCCGCCCGCTGC
GCCGCAAGACCCACACCCTCGTGGTGCTCCGCCACGGCGAGGCCCGCTCGCGCAAGGCCTGGCGCCAGGACGACCGGCTG
CGCCCGCTGGTCCAGGCCGGCCGGCACCAGGCCCAGCGGCTGGTGCCGCTGCTGGCGGCGTACGACGTCACCCGCATCGT
CTCCTCCAGCAGCGCGCGCTGCGTGGAGACCGTGGGCCCGTACGCCGACACCACGGGCTGGAAGCTCGAGCTCGAGGACG
GCCTGAGCGAGGAGGACGCGACCGCTCCGTCGGTGGTGGCTGTCGTCGACGAGCTGGTCGCCGCGGAGGAGGGCGCGGTG
GTCTGCACCCACCGGCCGGTGCTGCCGGCGGTCTTCGACGCCCTCGGCGTCTCCGACCCGCAGCTGGCGCCCGGCGCGAT
GCTGGTCGCGCACCTGCGCCAGGGCAAGGTGGTCGCCACCGAAACGCACCAAATACACTAG

Upstream 100 bases:

>100_bases
CCAGGACCGCGAGCGCCGCGACCACGGCGACCGTCACGATCGCGCGACGTCTGCCCACCTGGGTCTCCTGTTCCGGCCGG
GGTGGTGTGACACTAGCGGC

Downstream 100 bases:

>100_bases
TGGTCAAGTGGTTCTGGCCGAGTTCACGTGATGTCCGTCTCGTGACCGGCTCGCGGTTTCCGACTGGGCGGTTCGAGTTC
ACCGCTCGTTCACCGACGAC

Product: NUDIX hydrolase

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MPGKDVLSAGVVVFRPGKRVLLVHRPRYDDWSFPKGKLDPGEHAAAAAVREVEEETGLHVRLGPPLTGQRYPIAGGRTKA
VSYWTGRVVGADDVSGYRPNAEIDQVRWFEYDAAVDRLSYDYDRDTLAQARPLRRKTHTLVVLRHGEARSRKAWRQDDRL
RPLVQAGRHQAQRLVPLLAAYDVTRIVSSSSARCVETVGPYADTTGWKLELEDGLSEEDATAPSVVAVVDELVAAEEGAV
VCTHRPVLPAVFDALGVSDPQLAPGAMLVAHLRQGKVVATETHQIH

Sequences:

>Translated_286_residues
MPGKDVLSAGVVVFRPGKRVLLVHRPRYDDWSFPKGKLDPGEHAAAAAVREVEEETGLHVRLGPPLTGQRYPIAGGRTKA
VSYWTGRVVGADDVSGYRPNAEIDQVRWFEYDAAVDRLSYDYDRDTLAQARPLRRKTHTLVVLRHGEARSRKAWRQDDRL
RPLVQAGRHQAQRLVPLLAAYDVTRIVSSSSARCVETVGPYADTTGWKLELEDGLSEEDATAPSVVAVVDELVAAEEGAV
VCTHRPVLPAVFDALGVSDPQLAPGAMLVAHLRQGKVVATETHQIH
>Mature_285_residues
PGKDVLSAGVVVFRPGKRVLLVHRPRYDDWSFPKGKLDPGEHAAAAAVREVEEETGLHVRLGPPLTGQRYPIAGGRTKAV
SYWTGRVVGADDVSGYRPNAEIDQVRWFEYDAAVDRLSYDYDRDTLAQARPLRRKTHTLVVLRHGEARSRKAWRQDDRLR
PLVQAGRHQAQRLVPLLAAYDVTRIVSSSSARCVETVGPYADTTGWKLELEDGLSEEDATAPSVVAVVDELVAAEEGAVV
CTHRPVLPAVFDALGVSDPQLAPGAMLVAHLRQGKVVATETHQIH

Specific function: May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo- dGTP is inserted opposite dA and dC residues of template DNA with almost equa

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX; PF00300 PGAM [H]

EC number: NA

Molecular weight: Translated: 31413; Mature: 31282

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGKDVLSAGVVVFRPGKRVLLVHRPRYDDWSFPKGKLDPGEHAAAAAVREVEEETGLHV
CCCHHHHHCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEE
RLGPPLTGQRYPIAGGRTKAVSYWTGRVVGADDVSGYRPNAEIDQVRWFEYDAAVDRLSY
EECCCCCCCCCCCCCCCCEEEEEEECEEECCCCCCCCCCCCCCCCEEEEEHHHHHHHHCC
DYDRDTLAQARPLRRKTHTLVVLRHGEARSRKAWRQDDRLRPLVQAGRHQAQRLVPLLAA
CCCHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
YDVTRIVSSSSARCVETVGPYADTTGWKLELEDGLSEEDATAPSVVAVVDELVAAEEGAV
HHHHHHHHCCCCHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCE
VCTHRPVLPAVFDALGVSDPQLAPGAMLVAHLRQGKVVATETHQIH
EEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEECCCCCC
>Mature Secondary Structure 
PGKDVLSAGVVVFRPGKRVLLVHRPRYDDWSFPKGKLDPGEHAAAAAVREVEEETGLHV
CCHHHHHCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEE
RLGPPLTGQRYPIAGGRTKAVSYWTGRVVGADDVSGYRPNAEIDQVRWFEYDAAVDRLSY
EECCCCCCCCCCCCCCCCEEEEEEECEEECCCCCCCCCCCCCCCCEEEEEHHHHHHHHCC
DYDRDTLAQARPLRRKTHTLVVLRHGEARSRKAWRQDDRLRPLVQAGRHQAQRLVPLLAA
CCCHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
YDVTRIVSSSSARCVETVGPYADTTGWKLELEDGLSEEDATAPSVVAVVDELVAAEEGAV
HHHHHHHHCCCCHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCE
VCTHRPVLPAVFDALGVSDPQLAPGAMLVAHLRQGKVVATETHQIH
EEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]