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The map label for this gene is glcD [H]

Identifier: 119717501

GI number: 119717501

Start: 3483153

End: 3484514

Strand: Reverse

Name: glcD [H]

Synonym: Noca_3277

Alternate gene names: 119717501

Gene position: 3484514-3483153 (Counterclockwise)

Preceding gene: 119717502

Following gene: 119717499

Centisome position: 69.89

GC content: 75.33

Gene sequence:

>1362_bases
ATGCACGCGTTGACCGACCTGCTCGAGGCGCTCCCGGCCGGCGTCGTCGTGACCGACGGCGACGCCATGGAGAAGTACCG
CTTCGACTGGTCCCGCGACCCGGCCGCCGGCACCCCGCTGGCCGTCGTGCGGGCCGAGGATGCCGGCCAGGTGCAGACCG
CGGTGCGGTGGGCGGCCGAGCACCGGGTGCCGCTCGTGCCACGCGGCGCGGGCAGCGGCCTGTCCGGTGGCTCGACGGCC
GTCGATGGCGGCCTGGTGCTCAGCCTGGAGCGGATGCGCGCCGTCGAGATCGACGTCGACTGCCGGGTGGCGGTCGTCGA
GCCGGGCGCCCTCAACGCCGAGGTCAAGGCGGCCGCGGCCGAGCACGGGCTGTGGTACCCGCCCGACCCCTCGTCGTACG
AGATCTGCTCGATCGGTGGCAACGTGGCCACCAACGCCGGCGGCCTGTGCTGCGTGAAGTACGGCGTCACCACCGACTAC
GTGCTCGGCCTGGACGTGGTGCTCGCGGACGGCACCCTGGTCACGCTCGGCGGTCGCCGGATCAAGGACGTCGCGGGACT
GAGCCTGCTGAAGCTCTTCGTCGGCAGCGAGGGGACCCTCGGCGTCGTGACCCGGGCGGTGCTGCGGCTGGTGCCGGCGC
AGGAGGCGCGCTCGACGCTGGTCGCGACCTTCGCCGACGTCGACGGCGCCGCCCGGGCCGTGCTCGCGGTCGGGCGGCGG
CTGCGGCCCTCGATGATGGAGCTGATGGACCGGGCCTCGATCAACGCGGTCGAGGACTACAAGCCGATGGGTCTGGACCG
CGCCGCCGGCGCGCTGCTGGTGGCCCAGTCCGACGCCCCCGCCGCGGCCCGGGCCGTCGAGGTCGAGGCCATGCGCGCGG
CCTGCGAGGGCGCGGGCGCGACCGCGGTCTTCGTGACCGACGATCCCGAGGAGGGGGAGCTGTTCGTGGCGGCCCGCCGC
GCGGCGTTCCCCGCGATCGAGGCCCGCGGCGCGCTGCTGCTCGAGGACGTCGGTGCCCCGGTGCCCCAGCTGCCGGCGCT
GCTCGCAGCGATCGCGGCCGTGGCCGCCGAGCACCGCGTGGAGATCCCGGTCGTCGCCCACGCCGGCGACGGCAACACCC
ACCCGATCATCGTCTACGACCCCGCCGACGCCGACTCCGAGCGGCGGGCCCGGGCGGCGTTCGCCGACATCATGCGGGTC
GCCATCGGACTCGGCGGCACGATCACCGGCGAGCACGGCGTGGGCCGGGCGAAGAAGGGCGCCCTCCCGGACCAGCTGGG
CCCGGACGTGATGGCGCTGACCCGCCGGGTCAAGGACGCCCTCGACCCGCTCGGGATCCTGAACCCGGGGGCCGTGCTCT
AA

Upstream 100 bases:

>100_bases
CCGCGGTCTTCGTCGTGCTGATCTGGGGCCAGCTGGTCCACATCGCGCACGCCGACGAGCAGGGGCAGCCGGCGGGGGCC
TGAGGTGGTTGCATGAACCC

Downstream 100 bases:

>100_bases
CCGGGTGTGTCGCTATTGACCGCCGGCGCGCTGGGCACACCGTTGCCGAGGTTGCCGAGGTTGCCGAGGTTGCCGATGAG
TGTCCGCGGAGCGCGTCGAT

Product: FAD linked oxidase domain-containing protein

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MHALTDLLEALPAGVVVTDGDAMEKYRFDWSRDPAAGTPLAVVRAEDAGQVQTAVRWAAEHRVPLVPRGAGSGLSGGSTA
VDGGLVLSLERMRAVEIDVDCRVAVVEPGALNAEVKAAAAEHGLWYPPDPSSYEICSIGGNVATNAGGLCCVKYGVTTDY
VLGLDVVLADGTLVTLGGRRIKDVAGLSLLKLFVGSEGTLGVVTRAVLRLVPAQEARSTLVATFADVDGAARAVLAVGRR
LRPSMMELMDRASINAVEDYKPMGLDRAAGALLVAQSDAPAAARAVEVEAMRAACEGAGATAVFVTDDPEEGELFVAARR
AAFPAIEARGALLLEDVGAPVPQLPALLAAIAAVAAEHRVEIPVVAHAGDGNTHPIIVYDPADADSERRARAAFADIMRV
AIGLGGTITGEHGVGRAKKGALPDQLGPDVMALTRRVKDALDPLGILNPGAVL

Sequences:

>Translated_453_residues
MHALTDLLEALPAGVVVTDGDAMEKYRFDWSRDPAAGTPLAVVRAEDAGQVQTAVRWAAEHRVPLVPRGAGSGLSGGSTA
VDGGLVLSLERMRAVEIDVDCRVAVVEPGALNAEVKAAAAEHGLWYPPDPSSYEICSIGGNVATNAGGLCCVKYGVTTDY
VLGLDVVLADGTLVTLGGRRIKDVAGLSLLKLFVGSEGTLGVVTRAVLRLVPAQEARSTLVATFADVDGAARAVLAVGRR
LRPSMMELMDRASINAVEDYKPMGLDRAAGALLVAQSDAPAAARAVEVEAMRAACEGAGATAVFVTDDPEEGELFVAARR
AAFPAIEARGALLLEDVGAPVPQLPALLAAIAAVAAEHRVEIPVVAHAGDGNTHPIIVYDPADADSERRARAAFADIMRV
AIGLGGTITGEHGVGRAKKGALPDQLGPDVMALTRRVKDALDPLGILNPGAVL
>Mature_453_residues
MHALTDLLEALPAGVVVTDGDAMEKYRFDWSRDPAAGTPLAVVRAEDAGQVQTAVRWAAEHRVPLVPRGAGSGLSGGSTA
VDGGLVLSLERMRAVEIDVDCRVAVVEPGALNAEVKAAAAEHGLWYPPDPSSYEICSIGGNVATNAGGLCCVKYGVTTDY
VLGLDVVLADGTLVTLGGRRIKDVAGLSLLKLFVGSEGTLGVVTRAVLRLVPAQEARSTLVATFADVDGAARAVLAVGRR
LRPSMMELMDRASINAVEDYKPMGLDRAAGALLVAQSDAPAAARAVEVEAMRAACEGAGATAVFVTDDPEEGELFVAARR
AAFPAIEARGALLLEDVGAPVPQLPALLAAIAAVAAEHRVEIPVVAHAGDGNTHPIIVYDPADADSERRARAAFADIMRV
AIGLGGTITGEHGVGRAKKGALPDQLGPDVMALTRRVKDALDPLGILNPGAVL

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=461, Percent_Identity=32.9718004338395, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI37595754, Length=448, Percent_Identity=32.1428571428571, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI119964728, Length=464, Percent_Identity=29.0948275862069, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI4501993, Length=216, Percent_Identity=26.3888888888889, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789351, Length=415, Percent_Identity=38.0722891566265, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1787977, Length=504, Percent_Identity=24.6031746031746, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI48994907, Length=486, Percent_Identity=24.2798353909465, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71992373, Length=449, Percent_Identity=32.293986636971, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI71992381, Length=445, Percent_Identity=31.4606741573034, Blast_Score=178, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI71992392, Length=361, Percent_Identity=33.5180055401662, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17534361, Length=441, Percent_Identity=25.8503401360544, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6320027, Length=454, Percent_Identity=27.3127753303965, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320023, Length=453, Percent_Identity=27.3730684326711, Blast_Score=142, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6320764, Length=460, Percent_Identity=24.7826086956522, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI18921117, Length=426, Percent_Identity=28.169014084507, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24639277, Length=426, Percent_Identity=28.169014084507, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24639275, Length=426, Percent_Identity=28.169014084507, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24653753, Length=231, Percent_Identity=29.004329004329, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 46690; Mature: 46690

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHALTDLLEALPAGVVVTDGDAMEKYRFDWSRDPAAGTPLAVVRAEDAGQVQTAVRWAAE
CCHHHHHHHHCCCCEEEECCCHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
HRVPLVPRGAGSGLSGGSTAVDGGLVLSLERMRAVEIDVDCRVAVVEPGALNAEVKAAAA
CCCCEEECCCCCCCCCCCCEECCCEEEEEECCEEEEECCCEEEEEECCCCCCCHHHHHHH
EHGLWYPPDPSSYEICSIGGNVATNAGGLCCVKYGVTTDYVLGLDVVLADGTLVTLGGRR
HCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEEEEEEEEECCEEEEECCCH
IKDVAGLSLLKLFVGSEGTLGVVTRAVLRLVPAQEARSTLVATFADVDGAARAVLAVGRR
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHEEEHHHCCCHHHHHHHHHHHC
LRPSMMELMDRASINAVEDYKPMGLDRAAGALLVAQSDAPAAARAVEVEAMRAACEGAGA
CCHHHHHHHHHCCCCCHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCC
TAVFVTDDPEEGELFVAARRAAFPAIEARGALLLEDVGAPVPQLPALLAAIAAVAAEHRV
EEEEEECCCCCCCEEEEEHHHHCCCHHCCCCEEEHHCCCCCCHHHHHHHHHHHHHHHCCE
EIPVVAHAGDGNTHPIIVYDPADADSERRARAAFADIMRVAIGLGGTITGEHGVGRAKKG
EEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCC
ALPDQLGPDVMALTRRVKDALDPLGILNPGAVL
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MHALTDLLEALPAGVVVTDGDAMEKYRFDWSRDPAAGTPLAVVRAEDAGQVQTAVRWAAE
CCHHHHHHHHCCCCEEEECCCHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
HRVPLVPRGAGSGLSGGSTAVDGGLVLSLERMRAVEIDVDCRVAVVEPGALNAEVKAAAA
CCCCEEECCCCCCCCCCCCEECCCEEEEEECCEEEEECCCEEEEEECCCCCCCHHHHHHH
EHGLWYPPDPSSYEICSIGGNVATNAGGLCCVKYGVTTDYVLGLDVVLADGTLVTLGGRR
HCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEEEEEEEEECCEEEEECCCH
IKDVAGLSLLKLFVGSEGTLGVVTRAVLRLVPAQEARSTLVATFADVDGAARAVLAVGRR
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHEEEHHHCCCHHHHHHHHHHHC
LRPSMMELMDRASINAVEDYKPMGLDRAAGALLVAQSDAPAAARAVEVEAMRAACEGAGA
CCHHHHHHHHHCCCCCHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCC
TAVFVTDDPEEGELFVAARRAAFPAIEARGALLLEDVGAPVPQLPALLAAIAAVAAEHRV
EEEEEECCCCCCCEEEEEHHHHCCCHHCCCCEEEHHCCCCCCHHHHHHHHHHHHHHHCCE
EIPVVAHAGDGNTHPIIVYDPADADSERRARAAFADIMRVAIGLGGTITGEHGVGRAKKG
EEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCC
ALPDQLGPDVMALTRRVKDALDPLGILNPGAVL
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]