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The map label for this gene is ruvC

Identifier: 119716612

GI number: 119716612

Start: 2540828

End: 2541361

Strand: Direct

Name: ruvC

Synonym: Noca_2385

Alternate gene names: 119716612

Gene position: 2540828-2541361 (Clockwise)

Preceding gene: 119716610

Following gene: 119716613

Centisome position: 50.96

GC content: 72.85

Gene sequence:

>534_bases
ATGCGCGTGCTCGGGATCGATCCCGGCCTGACCCGCTGTGGGATGGGCGTCGTGGACGGCTCGGTCGGTCGACCGCTGAC
GCTGGTCGACGTGAACGTGCTGCGCACCTCCGCCGATCTACCGGTGCCCGAGCGCCTGGTGACCATCGAGCGGGGCGTGG
AGGCCTGGATCGAGGAGCACGCCCCGGACGCGGTCGCGATCGAGCGGGTCTTCGCCCGGTCCGACGTCAGCACGGTGATG
GGCACGGCGCAGGCGAGTGGCGTCGCGATGGTGGTTGCCGCGCGGCGTGGCCTGCCGATCGGGCTGCACACGCCCAGCGA
GGTCAAGGCCGCCGTGTCGGGCAACGGCCGGGCGGGCAAGGCCCAGGTCGGCGCGATGGTGACCCGGATCCTCCGGCTCG
ACGTGATGCCCAAGCCGGCCGACGCCGCCGACGCGCTGGCACTGGCCATCACCCACATCTGGCGCGGTGGCGCCCAGGCC
CGGATCGACGCCGCGGTGACCGCAGCCCGACAGCAAGTGAGGAGCAGACGATGA

Upstream 100 bases:

>100_bases
ACGATCCGCAACCCGCGCACCCGGGCGTGTCCTGCAGGCATCGGAGGGACTCGCCGGATAGCGTGGCCTCCGAACACCTG
TTCGGACGGAGGCTGGCGGC

Downstream 100 bases:

>100_bases
TCGCGTTCGTGCGCGGCCAGGTGGCGGCCGTGACCCTGTCGAGCGCCGTGCTCGAGGTCGGCGGCGTCGGCCTCGACATC
ATGTGCACACCCGGCACGCT

Product: Holliday junction endonuclease RuvC

Products: NA

Alternate protein names: Holliday junction nuclease ruvC; Holliday junction resolvase ruvC

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MRVLGIDPGLTRCGMGVVDGSVGRPLTLVDVNVLRTSADLPVPERLVTIERGVEAWIEEHAPDAVAIERVFARSDVSTVM
GTAQASGVAMVVAARRGLPIGLHTPSEVKAAVSGNGRAGKAQVGAMVTRILRLDVMPKPADAADALALAITHIWRGGAQA
RIDAAVTAARQQVRSRR

Sequences:

>Translated_177_residues
MRVLGIDPGLTRCGMGVVDGSVGRPLTLVDVNVLRTSADLPVPERLVTIERGVEAWIEEHAPDAVAIERVFARSDVSTVM
GTAQASGVAMVVAARRGLPIGLHTPSEVKAAVSGNGRAGKAQVGAMVTRILRLDVMPKPADAADALALAITHIWRGGAQA
RIDAAVTAARQQVRSRR
>Mature_177_residues
MRVLGIDPGLTRCGMGVVDGSVGRPLTLVDVNVLRTSADLPVPERLVTIERGVEAWIEEHAPDAVAIERVFARSDVSTVM
GTAQASGVAMVVAARRGLPIGLHTPSEVKAAVSGNGRAGKAQVGAMVTRILRLDVMPKPADAADALALAITHIWRGGAQA
RIDAAVTAARQQVRSRR

Specific function: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leav

COG id: COG0817

COG function: function code L; Holliday junction resolvasome, endonuclease subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ruvC family

Homologues:

Organism=Escherichia coli, GI1788170, Length=136, Percent_Identity=38.9705882352941, Blast_Score=86, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUVC_NOCSJ (A1SJA5)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_923577.1
- ProteinModelPortal:   A1SJA5
- SMR:   A1SJA5
- STRING:   A1SJA5
- GeneID:   4599485
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_2385
- eggNOG:   COG0817
- HOGENOM:   HBG437552
- OMA:   RTGWGVI
- PhylomeDB:   A1SJA5
- ProtClustDB:   CLSK2783553
- BioCyc:   NSP35761:NOCA_2385-MONOMER
- HAMAP:   MF_00034
- InterPro:   IPR012337
- InterPro:   IPR020563
- InterPro:   IPR002176
- PRINTS:   PR00696
- TIGRFAMs:   TIGR00228

Pfam domain/function: PF02075 RuvC; SSF53098 RNaseH_fold

EC number: =3.1.22.4

Molecular weight: Translated: 18526; Mature: 18526

Theoretical pI: Translated: 11.19; Mature: 11.19

Prosite motif: PS01321 RUVC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLGIDPGLTRCGMGVVDGSVGRPLTLVDVNVLRTSADLPVPERLVTIERGVEAWIEEH
CEEEECCCCHHHCCCCCCCCCCCCCEEEEEEEEHHCCCCCCCCHHHHHHHHHHHHHHHHC
APDAVAIERVFARSDVSTVMGTAQASGVAMVVAARRGLPIGLHTPSEVKAAVSGNGRAGK
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEECCCCHHHHHHHHCCCCCCCH
AQVGAMVTRILRLDVMPKPADAADALALAITHIWRGGAQARIDAAVTAARQQVRSRR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRVLGIDPGLTRCGMGVVDGSVGRPLTLVDVNVLRTSADLPVPERLVTIERGVEAWIEEH
CEEEECCCCHHHCCCCCCCCCCCCCEEEEEEEEHHCCCCCCCCHHHHHHHHHHHHHHHHC
APDAVAIERVFARSDVSTVMGTAQASGVAMVVAARRGLPIGLHTPSEVKAAVSGNGRAGK
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEECCCCHHHHHHHHCCCCCCCH
AQVGAMVTRILRLDVMPKPADAADALALAITHIWRGGAQARIDAAVTAARQQVRSRR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA