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The map label for this gene is rnr [H]

Identifier: 119716249

GI number: 119716249

Start: 2159651

End: 2161054

Strand: Direct

Name: rnr [H]

Synonym: Noca_2017

Alternate gene names: 119716249

Gene position: 2159651-2161054 (Clockwise)

Preceding gene: 119716247

Following gene: 119716250

Centisome position: 43.32

GC content: 76.0

Gene sequence:

>1404_bases
GTGGCCGCGGCCGCGCTGCGCGACGGGATCGCCCGGATCCAGGCCGACCTCGAGGTCACGCCGGACTTCCCGGCGGAGGT
CGAGCAGGCCGCGGCCGCGGCGGCCGGCGCGCCCCGGCTGCCGGACCTGGACCGCACCGACCTGCCGTTCGTCACCATCG
ACCCGCCGGGGTCCATGGACCTCGACCAGGCGCTGCACCTCGAGCGGGACGGCGAGGGGTACGTCGTCCACTACGCGATC
GCCGACGTCGCCGCGTTCGTGGCGCCCGGCGACCCGATCGACGTCGAGGCGCACCGGCGCGGCGAGACGCTGTACGGCGC
GGACTCGAAGATCCCCCTGCACCCGCCGGCGCTCAGCGAGGACGCCGCCTCGCTGCTGCCCGACCAGGTCCGTCCGGCGC
TGCTGTGGACGATCCGGGTCGACGCCGACGGTGGTCGCACCGCCGTGCACGTCGAGCGGGCGCGGGTACGCTCGACCGCC
CGGTTGTCCTACGAGGAGGCGCAGCGGGCGATCGACGCCGGCACCGGCCCGGAGTCGCTCGCGCTGCTGCGCGAGGTCGG
CGAGCTGCGGCTGGCCCGGGAGGCGGCGCGCGGCGGCGTCTCGCTGCCGCTGCCCGAGCAGGACGTCGACGTCGAGGGCG
ACCACTGGCGGCTGGAGTTCCGCGAGCAGCTGCCCGTGGAGCAGTGGAACGCCCAGATCTCCTTGCTCACCGGATTCGCG
GCCGCCGCGCTGATGGTCTACGCCCGGGTCGGGCTCCTGCGCACCCTCCCGCCGCCGGATCCGCGCGACGTGCAGCGGCT
GCACCGCACGGCCCGGGCGCTGGGCATCGAGTGGCCGGCCGAGCAGCTCTACCCGGACTTCATCCGCTCCCTGGACCCCT
CCCGCCCCAGCCACGCCGCGATGGTCAACGCCTCCGCCCGGCTGCTGCGGGGGAGCGGGTACGTCGCCTTCGACGGCGAG
ACGCCCGCCGACCCCCAGCATGCCGCGCTGGCCTCGGAGTACGCCCATGTCACCGCGCCGCTGCGGCGCCTCGGCGACCG
GTACGCCGGGGAGGTCTGCCTCGCGCTGTGCGCCGGCACCGACGTCCCCGACTGGGTGCTGGCCGCGTTGCCCGGCCTGC
CGAAGACCCTCCAGTCCTCGGGCGCCCGGGCCCGCTCGTACGAGCGGCAGATCGTCGACCTGGTGGAGGCCGGGGTGCTG
CGCGACCGGGTCGGCGAGGTCTTCGACGGGGTGGTCGTCGACGTGGACGAGAAGGACCCGGGCCGTGGTGTCGTCGTGAT
CCAGGACCCCGCCGTCGAGTCCCGGCTGGTCGGCCCCGCGCCGCTGCCGCTCGGCACCGACGTCCGCGCCCGGCTGACCA
CCGCCGACCTCACGACCCGGACCGTCGAGCTCACCGTGGAGTGA

Upstream 100 bases:

>100_bases
CCGCCTTGCCCTCGCTGGGCGGCAGCAGGATCAGCACGGTGGTTATGGTGCCGGTATGCCGTCCAGCCGCGTCGTCCGGG
TCCGCTCCGTCCGCGACGAG

Downstream 100 bases:

>100_bases
GTCGCCCCGGATCGGTTGCTGGCACACCGCCGGCCGACCGACCCCACGGATGGGGACATTAGGCCCCGGGCCGCCGGGCC
ATGGGGCTCTGTCTCGTACG

Product: ribonuclease II

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MAAAALRDGIARIQADLEVTPDFPAEVEQAAAAAAGAPRLPDLDRTDLPFVTIDPPGSMDLDQALHLERDGEGYVVHYAI
ADVAAFVAPGDPIDVEAHRRGETLYGADSKIPLHPPALSEDAASLLPDQVRPALLWTIRVDADGGRTAVHVERARVRSTA
RLSYEEAQRAIDAGTGPESLALLREVGELRLAREAARGGVSLPLPEQDVDVEGDHWRLEFREQLPVEQWNAQISLLTGFA
AAALMVYARVGLLRTLPPPDPRDVQRLHRTARALGIEWPAEQLYPDFIRSLDPSRPSHAAMVNASARLLRGSGYVAFDGE
TPADPQHAALASEYAHVTAPLRRLGDRYAGEVCLALCAGTDVPDWVLAALPGLPKTLQSSGARARSYERQIVDLVEAGVL
RDRVGEVFDGVVVDVDEKDPGRGVVVIQDPAVESRLVGPAPLPLGTDVRARLTTADLTTRTVELTVE

Sequences:

>Translated_467_residues
MAAAALRDGIARIQADLEVTPDFPAEVEQAAAAAAGAPRLPDLDRTDLPFVTIDPPGSMDLDQALHLERDGEGYVVHYAI
ADVAAFVAPGDPIDVEAHRRGETLYGADSKIPLHPPALSEDAASLLPDQVRPALLWTIRVDADGGRTAVHVERARVRSTA
RLSYEEAQRAIDAGTGPESLALLREVGELRLAREAARGGVSLPLPEQDVDVEGDHWRLEFREQLPVEQWNAQISLLTGFA
AAALMVYARVGLLRTLPPPDPRDVQRLHRTARALGIEWPAEQLYPDFIRSLDPSRPSHAAMVNASARLLRGSGYVAFDGE
TPADPQHAALASEYAHVTAPLRRLGDRYAGEVCLALCAGTDVPDWVLAALPGLPKTLQSSGARARSYERQIVDLVEAGVL
RDRVGEVFDGVVVDVDEKDPGRGVVVIQDPAVESRLVGPAPLPLGTDVRARLTTADLTTRTVELTVE
>Mature_466_residues
AAAALRDGIARIQADLEVTPDFPAEVEQAAAAAAGAPRLPDLDRTDLPFVTIDPPGSMDLDQALHLERDGEGYVVHYAIA
DVAAFVAPGDPIDVEAHRRGETLYGADSKIPLHPPALSEDAASLLPDQVRPALLWTIRVDADGGRTAVHVERARVRSTAR
LSYEEAQRAIDAGTGPESLALLREVGELRLAREAARGGVSLPLPEQDVDVEGDHWRLEFREQLPVEQWNAQISLLTGFAA
AALMVYARVGLLRTLPPPDPRDVQRLHRTARALGIEWPAEQLYPDFIRSLDPSRPSHAAMVNASARLLRGSGYVAFDGET
PADPQHAALASEYAHVTAPLRRLGDRYAGEVCLALCAGTDVPDWVLAALPGLPKTLQSSGARARSYERQIVDLVEAGVLR
DRVGEVFDGVVVDVDEKDPGRGVVVIQDPAVESRLVGPAPLPLGTDVRARLTTADLTTRTVELTVE

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=335, Percent_Identity=28.6567164179104, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI190014625, Length=335, Percent_Identity=28.6567164179104, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI19115966, Length=410, Percent_Identity=27.8048780487805, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI219521928, Length=410, Percent_Identity=27.8048780487805, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI134288890, Length=346, Percent_Identity=27.4566473988439, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI87082383, Length=402, Percent_Identity=27.8606965174129, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1787542, Length=150, Percent_Identity=36, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI212645896, Length=328, Percent_Identity=31.4024390243902, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6324552, Length=322, Percent_Identity=28.8819875776398, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24649634, Length=323, Percent_Identity=27.2445820433437, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 50263; Mature: 50132

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAAALRDGIARIQADLEVTPDFPAEVEQAAAAAAGAPRLPDLDRTDLPFVTIDPPGSMD
CCHHHHHHHHHHHEECCEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCC
LDQALHLERDGEGYVVHYAIADVAAFVAPGDPIDVEAHRRGETLYGADSKIPLHPPALSE
HHHHHCCCCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCH
DAASLLPDQVRPALLWTIRVDADGGRTAVHVERARVRSTARLSYEEAQRAIDAGTGPESL
HHHHHCHHHCCCEEEEEEEEECCCCCEEEEEHHHHHHHHHHCCHHHHHHHHHCCCCHHHH
ALLREVGELRLAREAARGGVSLPLPEQDVDVEGDHWRLEFREQLPVEQWNAQISLLTGFA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEHHHCCHHHHCCEEEEHHHHH
AAALMVYARVGLLRTLPPPDPRDVQRLHRTARALGIEWPAEQLYPDFIRSLDPSRPSHAA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCE
MVNASARLLRGSGYVAFDGETPADPQHAALASEYAHVTAPLRRLGDRYAGEVCLALCAGT
EECCCHHEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DVPDWVLAALPGLPKTLQSSGARARSYERQIVDLVEAGVLRDRVGEVFDGVVVDVDEKDP
CCHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCC
GRGVVVIQDPAVESRLVGPAPLPLGTDVRARLTTADLTTRTVELTVE
CCEEEEEECCCCHHCCCCCCCCCCCCCCEEEEEEECCEEEEEEEEEC
>Mature Secondary Structure 
AAAALRDGIARIQADLEVTPDFPAEVEQAAAAAAGAPRLPDLDRTDLPFVTIDPPGSMD
CHHHHHHHHHHHEECCEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCC
LDQALHLERDGEGYVVHYAIADVAAFVAPGDPIDVEAHRRGETLYGADSKIPLHPPALSE
HHHHHCCCCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCH
DAASLLPDQVRPALLWTIRVDADGGRTAVHVERARVRSTARLSYEEAQRAIDAGTGPESL
HHHHHCHHHCCCEEEEEEEEECCCCCEEEEEHHHHHHHHHHCCHHHHHHHHHCCCCHHHH
ALLREVGELRLAREAARGGVSLPLPEQDVDVEGDHWRLEFREQLPVEQWNAQISLLTGFA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEHHHCCHHHHCCEEEEHHHHH
AAALMVYARVGLLRTLPPPDPRDVQRLHRTARALGIEWPAEQLYPDFIRSLDPSRPSHAA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCE
MVNASARLLRGSGYVAFDGETPADPQHAALASEYAHVTAPLRRLGDRYAGEVCLALCAGT
EECCCHHEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DVPDWVLAALPGLPKTLQSSGARARSYERQIVDLVEAGVLRDRVGEVFDGVVVDVDEKDP
CCHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCC
GRGVVVIQDPAVESRLVGPAPLPLGTDVRARLTTADLTTRTVELTVE
CCEEEEEECCCCHHCCCCCCCCCCCCCCEEEEEEECCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7569993; 8253680 [H]