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The map label for this gene is hemA2

Identifier: 119716194

GI number: 119716194

Start: 2091934

End: 2093280

Strand: Direct

Name: hemA2

Synonym: Noca_1962

Alternate gene names: 119716194

Gene position: 2091934-2093280 (Clockwise)

Preceding gene: 119716193

Following gene: 119716196

Centisome position: 41.96

GC content: 77.51

Gene sequence:

>1347_bases
ATGAGCCGGCTGACCTGCCTCGCGTTCCCGGGCCGCAGCATCCCGATGGCGGTCCTGGAGCGGCTCTCCGTCGCGGCGCG
CGAGCTGCCCGCCAGCGTCCGGGCGCTCCGGGCGGTGCCGGGGGTCGACCAGGTGCTGGTGCTCTCGACCTGCGAGCGCA
CGGAGGTCTACGCGTGGTGGACCGACGAGGCGGACCCGGCGGCGCTGCTGCGGGCACTCGCCGGGCAGCGCGGGCTGGGG
CCGGAGCCGCTGCTCGAGCACGCCGTCGGCCTGACGGGTCGTGAGGCCGTGCAACACCTGCTCCGGGTCACCGCCGGACT
CGACTCCTTCGTCCGCGGCGAGTCCGACATCGTCGGCCAGGTGCGGGCGGCGGTCCAGGCCGCTCGGGCGGAGGGTGCGG
TCGGGCTGGAGGTGCAGCGGCTGGTCGACGCCGCCGTGAACACCTCGCGCCGGGTGCACCGCAGCACGGGCGCCGGGCTG
GCCGCCGGCTCGGTCGCGTCGACCGCCGTCGCCGCCGTGGCCGGGCTGCTCCCCGACGGACTGGCCGGACGCGACCTGCT
GGTCGTCGGCACCGGCCAGGTGGCCGTGAGCGTCGTCGCCGCCGCTCGGGAGGCCGGTGCCCGCCTGACGGTGTGCGGGC
GGGACCCGGAGCGGGCCGCCGCGATCGCGCCGGCCGGGGCGCGGGTGCTCGGGTTGGACGATCTCCCGGGCGCGCTCCTC
GACGCGGACGCCGTCGTGTTCGGCACGTCGTCGCCCGAGCGGCTGCTCCGTGCCGGCGACCTCGGACCGGGGTTGAGCGA
GCACCGGTCCGGTCGTGAGCTCGTGGTCGTCGACCTGTGCGTGCCGCGCAACGTCGACCCGGACGTGCGGGGTGTGCCCG
GGGTGCGACTGCTGGACCTCACCGACCTCCGCGGCGCCGCCGTACCGGGCCGGCGTCCGTCCGCCCCGGCGCCGGCGGCG
CTGGAGCTGGCCGAGCAGATCGTCGCGCAGGAGGTGGACCGCTTCCTGCACTGGTGGGTGGACCGTGCGGCCGCGGAGCC
GGTACGCCGCCTGCGCGCAGACGTCGAGGCGTGCGTCCGCGAGGAGGTCGCGCGAGCCACCCGGGGTCTCTCGCCCGACC
TCGAGCCGCTCGTCGCCGAGGGGATCCGCCGGGCGGTGCAGCACCTCGCGCACGGGCCGACGCGTCGGCTCCTCGACGCC
GCGGCAGCAGGCGAGGACGAGGTCGTCGCGCTGCTCGCCGGGCTGTTCGCGCCGTCGGCCGAGGAGGACCAGGCTGTCCC
GGCCTACTCGCCCCAGCCCATCGGGAACACCTCGAACGCCGCGGCGAGCGCGACGCCGAGGCGCTGA

Upstream 100 bases:

>100_bases
CCGAGCAGGACCTGCGTGCCTACCTCGACCGGGCACCGTTCGGCTCGCACCGCCAGACGGTCCGGGCCGTGCTCGCCCTC
GTGCAGAAGGAGGGACGTCG

Downstream 100 bases:

>100_bases
CCGGTCTGGCGGCCGAAGCCCTCGAGGAACTCGCGGGCGTCGAAGTGCTCCCAGCCGAGGCCGTCGATGTAGGCGCGGTG
CGCCTCCAGGGAGGCGACCC

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR 2

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSRLTCLAFPGRSIPMAVLERLSVAARELPASVRALRAVPGVDQVLVLSTCERTEVYAWWTDEADPAALLRALAGQRGLG
PEPLLEHAVGLTGREAVQHLLRVTAGLDSFVRGESDIVGQVRAAVQAARAEGAVGLEVQRLVDAAVNTSRRVHRSTGAGL
AAGSVASTAVAAVAGLLPDGLAGRDLLVVGTGQVAVSVVAAAREAGARLTVCGRDPERAAAIAPAGARVLGLDDLPGALL
DADAVVFGTSSPERLLRAGDLGPGLSEHRSGRELVVVDLCVPRNVDPDVRGVPGVRLLDLTDLRGAAVPGRRPSAPAPAA
LELAEQIVAQEVDRFLHWWVDRAAAEPVRRLRADVEACVREEVARATRGLSPDLEPLVAEGIRRAVQHLAHGPTRRLLDA
AAAGEDEVVALLAGLFAPSAEEDQAVPAYSPQPIGNTSNAAASATPRR

Sequences:

>Translated_448_residues
MSRLTCLAFPGRSIPMAVLERLSVAARELPASVRALRAVPGVDQVLVLSTCERTEVYAWWTDEADPAALLRALAGQRGLG
PEPLLEHAVGLTGREAVQHLLRVTAGLDSFVRGESDIVGQVRAAVQAARAEGAVGLEVQRLVDAAVNTSRRVHRSTGAGL
AAGSVASTAVAAVAGLLPDGLAGRDLLVVGTGQVAVSVVAAAREAGARLTVCGRDPERAAAIAPAGARVLGLDDLPGALL
DADAVVFGTSSPERLLRAGDLGPGLSEHRSGRELVVVDLCVPRNVDPDVRGVPGVRLLDLTDLRGAAVPGRRPSAPAPAA
LELAEQIVAQEVDRFLHWWVDRAAAEPVRRLRADVEACVREEVARATRGLSPDLEPLVAEGIRRAVQHLAHGPTRRLLDA
AAAGEDEVVALLAGLFAPSAEEDQAVPAYSPQPIGNTSNAAASATPRR
>Mature_447_residues
SRLTCLAFPGRSIPMAVLERLSVAARELPASVRALRAVPGVDQVLVLSTCERTEVYAWWTDEADPAALLRALAGQRGLGP
EPLLEHAVGLTGREAVQHLLRVTAGLDSFVRGESDIVGQVRAAVQAARAEGAVGLEVQRLVDAAVNTSRRVHRSTGAGLA
AGSVASTAVAAVAGLLPDGLAGRDLLVVGTGQVAVSVVAAAREAGARLTVCGRDPERAAAIAPAGARVLGLDDLPGALLD
ADAVVFGTSSPERLLRAGDLGPGLSEHRSGRELVVVDLCVPRNVDPDVRGVPGVRLLDLTDLRGAAVPGRRPSAPAPAAL
ELAEQIVAQEVDRFLHWWVDRAAAEPVRRLRADVEACVREEVARATRGLSPDLEPLVAEGIRRAVQHLAHGPTRRLLDAA
AAGEDEVVALLAGLFAPSAEEDQAVPAYSPQPIGNTSNAAASATPRR

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=414, Percent_Identity=29.951690821256, Blast_Score=157, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM12_NOCSJ (A1SI37)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_923159.1
- ProteinModelPortal:   A1SI37
- SMR:   A1SI37
- STRING:   A1SI37
- GeneID:   4599868
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_1962
- eggNOG:   COG0373
- OMA:   RAVNEDI
- PhylomeDB:   A1SI37
- BioCyc:   NSP35761:NOCA_1962-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 46538; Mature: 46406

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 51-51 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLTCLAFPGRSIPMAVLERLSVAARELPASVRALRAVPGVDQVLVLSTCERTEVYAWW
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEE
TDEADPAALLRALAGQRGLGPEPLLEHAVGLTGREAVQHLLRVTAGLDSFVRGESDIVGQ
CCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VRAAVQAARAEGAVGLEVQRLVDAAVNTSRRVHRSTGAGLAAGSVASTAVAAVAGLLPDG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
LAGRDLLVVGTGQVAVSVVAAAREAGARLTVCGRDPERAAAIAPAGARVLGLDDLPGALL
CCCCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHEECCCCCEEEECCCCCCHHH
DADAVVFGTSSPERLLRAGDLGPGLSEHRSGRELVVVDLCVPRNVDPDVRGVPGVRLLDL
CCCEEEECCCCHHHHHHHCCCCCCHHHHCCCCEEEEEEEECCCCCCCCCCCCCCEEEEEE
TDLRGAAVPGRRPSAPAPAALELAEQIVAQEVDRFLHWWVDRAAAEPVRRLRADVEACVR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEVARATRGLSPDLEPLVAEGIRRAVQHLAHGPTRRLLDAAAAGEDEVVALLAGLFAPSA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCC
EEDQAVPAYSPQPIGNTSNAAASATPRR
CCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SRLTCLAFPGRSIPMAVLERLSVAARELPASVRALRAVPGVDQVLVLSTCERTEVYAWW
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEE
TDEADPAALLRALAGQRGLGPEPLLEHAVGLTGREAVQHLLRVTAGLDSFVRGESDIVGQ
CCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VRAAVQAARAEGAVGLEVQRLVDAAVNTSRRVHRSTGAGLAAGSVASTAVAAVAGLLPDG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
LAGRDLLVVGTGQVAVSVVAAAREAGARLTVCGRDPERAAAIAPAGARVLGLDDLPGALL
CCCCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHEECCCCCEEEECCCCCCHHH
DADAVVFGTSSPERLLRAGDLGPGLSEHRSGRELVVVDLCVPRNVDPDVRGVPGVRLLDL
CCCEEEECCCCHHHHHHHCCCCCCHHHHCCCCEEEEEEEECCCCCCCCCCCCCCEEEEEE
TDLRGAAVPGRRPSAPAPAALELAEQIVAQEVDRFLHWWVDRAAAEPVRRLRADVEACVR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEVARATRGLSPDLEPLVAEGIRRAVQHLAHGPTRRLLDAAAAGEDEVVALLAGLFAPSA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCC
EEDQAVPAYSPQPIGNTSNAAASATPRR
CCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA