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The map label for this gene is tcrA [H]

Identifier: 119715849

GI number: 119715849

Start: 1712465

End: 1713142

Strand: Direct

Name: tcrA [H]

Synonym: Noca_1613

Alternate gene names: 119715849

Gene position: 1712465-1713142 (Clockwise)

Preceding gene: 119715847

Following gene: 119715850

Centisome position: 34.35

GC content: 65.49

Gene sequence:

>678_bases
GTGCGGGTGTTGATGGTAGAAGACGAGGTGCGACTGGCCGAGACGGTCAGCCGCGGCCTGCGGGCCGAGGGCTTCGTCGT
CGACACGATCCATGACGGGGCCGAGGGCCTGGCCGAGGCGCAGCTCCGTGACTACGACGTGATCGTGCTGGACATCATGC
TGCCCTCGATGAACGGCTACGACGTGTGCCGTGAGCTGCGCAAGGCCGGGGTGTGGGTGCCGATCCTGATGTTGACGGCC
AAGGATGGGGAGTACGACGAGGCGGATGCCCTCGACCTGGGTGCCGACGACTACCTGACCAAACCGTTCTCCTTCGTCGT
CCTGGTCGCTCGGTTGCGAGCACTTGTCCGCCGAGGTGCCCCGAAGCGTCCATCGGTCCTGACTGTGGGTGACCTGACAC
TCGACCCCGCGACGCGGATGGTCGGCCGGGGTGGGACCGAGATCGCCTTGACGCCCCGGGAGTTCGCGCTGTTGCACTTC
TTGATGCGCCACCCAGGTGAGGTGCTGTCCAAGACCGCGATCGTGCAGAGTGTGTGGGACTTGAACTACGACGGGGACGA
GAACGTCGTCGAAGTCTATGTCGGCTACCTGCGTCGCAAGATCGACCAGCCCTTCGGCACCACCACGATCCAGACCATGC
GCGGGGCCGGCTACCGGCTGCTGGGTGACGGCGTATGA

Upstream 100 bases:

>100_bases
AGGGGTGCTGTGAGGACGCTGAGACCTCCTGAGAGCCGTCCTCAGCGTCCTCACAACCCTGATCGCTCAGACTGGGACCA
CGGGATCTGGAGGTACGCGC

Downstream 100 bases:

>100_bases
GACGACCGAGGCCCCGCGCGCGCAGCGTGCGGGTGCGCGCCACCGCCGCGGCCACGCTGGTTGTGGCGATCTTCCTCGCC
GCAGGGGCGATCGGCTTCGC

Product: response regulator receiver

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MRVLMVEDEVRLAETVSRGLRAEGFVVDTIHDGAEGLAEAQLRDYDVIVLDIMLPSMNGYDVCRELRKAGVWVPILMLTA
KDGEYDEADALDLGADDYLTKPFSFVVLVARLRALVRRGAPKRPSVLTVGDLTLDPATRMVGRGGTEIALTPREFALLHF
LMRHPGEVLSKTAIVQSVWDLNYDGDENVVEVYVGYLRRKIDQPFGTTTIQTMRGAGYRLLGDGV

Sequences:

>Translated_225_residues
MRVLMVEDEVRLAETVSRGLRAEGFVVDTIHDGAEGLAEAQLRDYDVIVLDIMLPSMNGYDVCRELRKAGVWVPILMLTA
KDGEYDEADALDLGADDYLTKPFSFVVLVARLRALVRRGAPKRPSVLTVGDLTLDPATRMVGRGGTEIALTPREFALLHF
LMRHPGEVLSKTAIVQSVWDLNYDGDENVVEVYVGYLRRKIDQPFGTTTIQTMRGAGYRLLGDGV
>Mature_225_residues
MRVLMVEDEVRLAETVSRGLRAEGFVVDTIHDGAEGLAEAQLRDYDVIVLDIMLPSMNGYDVCRELRKAGVWVPILMLTA
KDGEYDEADALDLGADDYLTKPFSFVVLVARLRALVRRGAPKRPSVLTVGDLTLDPATRMVGRGGTEIALTPREFALLHF
LMRHPGEVLSKTAIVQSVWDLNYDGDENVVEVYVGYLRRKIDQPFGTTTIQTMRGAGYRLLGDGV

Specific function: Member of the three-protein two-component system HK1/HK2/tcrA [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=49.3212669683258, Blast_Score=205, Evalue=2e-54,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=41.4414414414414, Blast_Score=176, Evalue=1e-45,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=40, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=35.4260089686099, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=39.1891891891892, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=36.036036036036, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=35.7758620689655, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=37.0535714285714, Blast_Score=130, Evalue=5e-32,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=33.0396475770925, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=32.2727272727273, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=33.9130434782609, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=32.7586206896552, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=32.034632034632, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=30, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24941; Mature: 24941

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLMVEDEVRLAETVSRGLRAEGFVVDTIHDGAEGLAEAQLRDYDVIVLDIMLPSMNGY
CEEEEECCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEEEECCCCCH
DVCRELRKAGVWVPILMLTAKDGEYDEADALDLGADDYLTKPFSFVVLVARLRALVRRGA
HHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHCCC
PKRPSVLTVGDLTLDPATRMVGRGGTEIALTPREFALLHFLMRHPGEVLSKTAIVQSVWD
CCCCCEEEECCCEECHHHHHHCCCCCEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHC
LNYDGDENVVEVYVGYLRRKIDQPFGTTTIQTMRGAGYRLLGDGV
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEECCCCC
>Mature Secondary Structure
MRVLMVEDEVRLAETVSRGLRAEGFVVDTIHDGAEGLAEAQLRDYDVIVLDIMLPSMNGY
CEEEEECCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEEEECCCCCH
DVCRELRKAGVWVPILMLTAKDGEYDEADALDLGADDYLTKPFSFVVLVARLRALVRRGA
HHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHCCC
PKRPSVLTVGDLTLDPATRMVGRGGTEIALTPREFALLHFLMRHPGEVLSKTAIVQSVWD
CCCCCEEEECCCEECHHHHHHCCCCCEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHC
LNYDGDENVVEVYVGYLRRKIDQPFGTTTIQTMRGAGYRLLGDGV
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]