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The map label for this gene is irlS [H]

Identifier: 119715847

GI number: 119715847

Start: 1710386

End: 1711744

Strand: Direct

Name: irlS [H]

Synonym: Noca_1611

Alternate gene names: 119715847

Gene position: 1710386-1711744 (Clockwise)

Preceding gene: 119715846

Following gene: 119715849

Centisome position: 34.3

GC content: 69.68

Gene sequence:

>1359_bases
GTGATGGGCAGGCTGAGCTTGCGAGCTCGAGCCACACTGCTCGGCACCGTGGTGTTCGCCGTGCTCCTTGCTGTCGGCTC
TGTGTTGTTGGTCTCGACGCTGGAGAGCCGGTTGACCGCCACATCCGACCAATTGTCCCAATCGCGGGTCGATGACCTGC
TGACCCTGGCCCGCCGTGGGGCACTGCCGACGAGCCTGCGGAATGTCGACGACAACGGTGTGGCTCAGGTCGTCAGGACT
GACGGGACCGTGGTGGCCGCGTCACCCAATGTGGCAGGCCAGCCCGCGGTGGCGGCGCTGCATCCCGGTGAACGCGCCGA
GACCAGTACCTTCCGGGCGCCCGACGACACGGAGACTGAGACGTACCGGTTCTGGTACGCCTCCGGCCCAACTCCGGATG
GAACGGTCACCGTCTATGTCGGCGACAGTCTCGAGACGGTCTCGGAGGCGTCCCGGGCTCTGCGCTGGGCGCTGGGAGTC
GGCGTGCCCATGGTCGTGGTCCTGCTCGGGATAGCGATCTGGCTGCTCCTGGGCCGGGTGATCGGGCGCCTGGACCAGAT
CCGGGCCGAGGTCGACCGGATCTCGGAGGAGAACCTGGACGCCCGCGTGGCCGGCGACGGCGTCGACGACGAGGTCGGTC
GCCTTGCCGCGACGATGAACGCGATGCTCGAGCGTCTCGACGCGGCCGCGCGGCGGCAGCGCGACTTCGTGGCCGATGTG
TCCCACGATCTCCAGAGCCCGCTGGCCGCGCAGCGAGTCGCACTCGAGGTGGCCCTCACGACACCGGACACTGTCGATGC
CGTTCGTCTGCGCGACGATGTGCTGGGCGCGACCGCCGACATGGAGCGCCTCGTAGCTGACCTGCTCGTCATCGCCTCGG
TGGACGCCAGAACTGACCCCGCAGCCGAGTTGATGGACCTGGACAGCGTGGTCCTCGAGGAGGCCGCACGCGCTCGGGTC
AGTGCGGCCGTCGAGGTGGACACGTCTGCCGTCTCGGCGGCGCCGACGTACGCCGATCCGGGCGATGTCCGCCGCGTCGT
CCGCAACCTGGTGGAAAACGCTCTCGCCCACGCTGACAGCCGGGTCGGGCTGTCCGTCGACCTGGCCGAAGTCGGCCCCG
GCCCGTGGGCAGAGCTCCTGGTCATGGATGACGGGCCCGGCGTGCCGGCGGAGCACCGGGACCGGATCTTCGACCGCTTC
TACCGGGCCGACACCGCTCGGCCTCGTCACGGCAGCGGATTGGGTCTGTCGATCGCCCGCGAGCTCGCCGAGCGAAACGG
CGGAACCCTCGACCTGGTCGTCACGGAGCCGGGCGCAACATTTCGGTTGAGGCTCCCGGGGTCTCGGGAGGCCGCGTAG

Upstream 100 bases:

>100_bases
AGCGCATCGACGAGCCGTTCCAGCGATCCTCCTTGCAGACTGTCCGCCTGGTCGGCTACCGGGTCGTCGACGACCTGGCG
CAGCCGGGAACGGCCGCGAA

Downstream 100 bases:

>100_bases
GCGCGAGACCACGTCCTCGACCGTCTGGTCGGCGGCGCCGAAGCGAGTGGCCCCGCCGCTGGTCGCGGCGGGGCCACTCG
GGTTGCCGACGTCGCTCGAC

Product: ATPase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MMGRLSLRARATLLGTVVFAVLLAVGSVLLVSTLESRLTATSDQLSQSRVDDLLTLARRGALPTSLRNVDDNGVAQVVRT
DGTVVAASPNVAGQPAVAALHPGERAETSTFRAPDDTETETYRFWYASGPTPDGTVTVYVGDSLETVSEASRALRWALGV
GVPMVVVLLGIAIWLLLGRVIGRLDQIRAEVDRISEENLDARVAGDGVDDEVGRLAATMNAMLERLDAAARRQRDFVADV
SHDLQSPLAAQRVALEVALTTPDTVDAVRLRDDVLGATADMERLVADLLVIASVDARTDPAAELMDLDSVVLEEAARARV
SAAVEVDTSAVSAAPTYADPGDVRRVVRNLVENALAHADSRVGLSVDLAEVGPGPWAELLVMDDGPGVPAEHRDRIFDRF
YRADTARPRHGSGLGLSIARELAERNGGTLDLVVTEPGATFRLRLPGSREAA

Sequences:

>Translated_452_residues
MMGRLSLRARATLLGTVVFAVLLAVGSVLLVSTLESRLTATSDQLSQSRVDDLLTLARRGALPTSLRNVDDNGVAQVVRT
DGTVVAASPNVAGQPAVAALHPGERAETSTFRAPDDTETETYRFWYASGPTPDGTVTVYVGDSLETVSEASRALRWALGV
GVPMVVVLLGIAIWLLLGRVIGRLDQIRAEVDRISEENLDARVAGDGVDDEVGRLAATMNAMLERLDAAARRQRDFVADV
SHDLQSPLAAQRVALEVALTTPDTVDAVRLRDDVLGATADMERLVADLLVIASVDARTDPAAELMDLDSVVLEEAARARV
SAAVEVDTSAVSAAPTYADPGDVRRVVRNLVENALAHADSRVGLSVDLAEVGPGPWAELLVMDDGPGVPAEHRDRIFDRF
YRADTARPRHGSGLGLSIARELAERNGGTLDLVVTEPGATFRLRLPGSREAA
>Mature_452_residues
MMGRLSLRARATLLGTVVFAVLLAVGSVLLVSTLESRLTATSDQLSQSRVDDLLTLARRGALPTSLRNVDDNGVAQVVRT
DGTVVAASPNVAGQPAVAALHPGERAETSTFRAPDDTETETYRFWYASGPTPDGTVTVYVGDSLETVSEASRALRWALGV
GVPMVVVLLGIAIWLLLGRVIGRLDQIRAEVDRISEENLDARVAGDGVDDEVGRLAATMNAMLERLDAAARRQRDFVADV
SHDLQSPLAAQRVALEVALTTPDTVDAVRLRDDVLGATADMERLVADLLVIASVDARTDPAAELMDLDSVVLEEAARARV
SAAVEVDTSAVSAAPTYADPGDVRRVVRNLVENALAHADSRVGLSVDLAEVGPGPWAELLVMDDGPGVPAEHRDRIFDRF
YRADTARPRHGSGLGLSIARELAERNGGTLDLVVTEPGATFRLRLPGSREAA

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance. Probably activates irlR by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=335, Percent_Identity=26.2686567164179, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1789403, Length=474, Percent_Identity=26.1603375527426, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788393, Length=234, Percent_Identity=30.3418803418803, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=31.858407079646, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1787894, Length=279, Percent_Identity=28.3154121863799, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082128, Length=339, Percent_Identity=28.023598820059, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790861, Length=355, Percent_Identity=26.4788732394366, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790346, Length=252, Percent_Identity=27.7777777777778, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789808, Length=218, Percent_Identity=30.7339449541284, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1786912, Length=246, Percent_Identity=29.6747967479675, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788279, Length=257, Percent_Identity=24.124513618677, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789149, Length=341, Percent_Identity=24.9266862170088, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787374, Length=283, Percent_Identity=25.7950530035336, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790436, Length=216, Percent_Identity=28.7037037037037, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788713, Length=231, Percent_Identity=25.1082251082251, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=25.1012145748988, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48053; Mature: 48053

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGRLSLRARATLLGTVVFAVLLAVGSVLLVSTLESRLTATSDQLSQSRVDDLLTLARRG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ALPTSLRNVDDNGVAQVVRTDGTVVAASPNVAGQPAVAALHPGERAETSTFRAPDDTETE
CCCHHHCCCCCCCHHHEEECCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCC
TYRFWYASGPTPDGTVTVYVGDSLETVSEASRALRWALGVGVPMVVVLLGIAIWLLLGRV
EEEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
IGRLDQIRAEVDRISEENLDARVAGDGVDDEVGRLAATMNAMLERLDAAARRQRDFVADV
HHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHDLQSPLAAQRVALEVALTTPDTVDAVRLRDDVLGATADMERLVADLLVIASVDARTDP
HHHHHCHHHHHHEEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCC
AAELMDLDSVVLEEAARARVSAAVEVDTSAVSAAPTYADPGDVRRVVRNLVENALAHADS
HHHHHHHHHHHHHHHHHHHHHHHEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
RVGLSVDLAEVGPGPWAELLVMDDGPGVPAEHRDRIFDRFYRADTARPRHGSGLGLSIAR
CCCCEEEHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
ELAERNGGTLDLVVTEPGATFRLRLPGSREAA
HHHHCCCCEEEEEEECCCCEEEEECCCCCCCC
>Mature Secondary Structure
MMGRLSLRARATLLGTVVFAVLLAVGSVLLVSTLESRLTATSDQLSQSRVDDLLTLARRG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ALPTSLRNVDDNGVAQVVRTDGTVVAASPNVAGQPAVAALHPGERAETSTFRAPDDTETE
CCCHHHCCCCCCCHHHEEECCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCC
TYRFWYASGPTPDGTVTVYVGDSLETVSEASRALRWALGVGVPMVVVLLGIAIWLLLGRV
EEEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
IGRLDQIRAEVDRISEENLDARVAGDGVDDEVGRLAATMNAMLERLDAAARRQRDFVADV
HHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHDLQSPLAAQRVALEVALTTPDTVDAVRLRDDVLGATADMERLVADLLVIASVDARTDP
HHHHHCHHHHHHEEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCC
AAELMDLDSVVLEEAARARVSAAVEVDTSAVSAAPTYADPGDVRRVVRNLVENALAHADS
HHHHHHHHHHHHHHHHHHHHHHHEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
RVGLSVDLAEVGPGPWAELLVMDDGPGVPAEHRDRIFDRFYRADTARPRHGSGLGLSIAR
CCCCEEEHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
ELAERNGGTLDLVVTEPGATFRLRLPGSREAA
HHHHCCCCEEEEEEECCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]