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The map label for this gene is tcrA [H]

Identifier: 119715846

GI number: 119715846

Start: 1709691

End: 1710389

Strand: Direct

Name: tcrA [H]

Synonym: Noca_1610

Alternate gene names: 119715846

Gene position: 1709691-1710389 (Clockwise)

Preceding gene: 119715836

Following gene: 119715847

Centisome position: 34.29

GC content: 66.38

Gene sequence:

>699_bases
GTGCGGATCTTGGTGGTCGAGGACGACAAGCAGCTGGCGGCTGCGCTGCGGCGTGGGCTGGAGTCCGAGGGCCACGCCGT
GGATGTCGCTCTGACCGGTACCGACGGTGAGTGGTATGCCAGCGAGAACACCTACGACGCGATGGTGGTGGACGTGATGC
TGCCTGGCCTCACAGGTGACGCCCTGTGTGCCCGGCGTCGGGAGTCAGGTGACTGGACTCCCATCCTGATGCTCACCGCA
CGCAGCGGGCCCGAGCAGGAGGCACGTGCGCTTGACGCAGGGGCGGACGACTTCTTGTCCAAGCCGTTCTCGTTCATGGT
CCTGACCGCCCGGCTGCGGGCGCTGCTGCGGCGAGACAGTCGCGAGCGGCCCACCGTGCTGGAGGTCGGAGACCTGCGCC
TGGATCCGGCGCTCCACCGGGTGTGGCGAGGGGACACGTCAATCGACCTGACTCCCAAGCAGTTCTCCCTGCTGGAGTTC
ATGATGCGCCACGCCGACCACATCCTCTCCAAGTCGATGATCTTGGAGCACGTCTGGGACTTCTCCTACGACGGACATCC
CAACATCGTCGAGGTCTACGTACGCCAGCTGCGGCAGCGCATCGACGAGCCGTTCCAGCGATCCTCCTTGCAGACTGTCC
GCCTGGTCGGCTACCGGGTCGTCGACGACCTGGCGCAGCCGGGAACGGCCGCGAAGTGA

Upstream 100 bases:

>100_bases
GTCGAAACCAGCCTGCACGAGCCTTGCTGAAGCCACCCTGAAGCATCTGAATTTGTTGTGACTTCAGGGAGCGTTCAGCG
GCGGCTGAGATGCTGGCCAC

Downstream 100 bases:

>100_bases
TGGGCAGGCTGAGCTTGCGAGCTCGAGCCACACTGCTCGGCACCGTGGTGTTCGCCGTGCTCCTTGCTGTCGGCTCTGTG
TTGTTGGTCTCGACGCTGGA

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MRILVVEDDKQLAAALRRGLESEGHAVDVALTGTDGEWYASENTYDAMVVDVMLPGLTGDALCARRRESGDWTPILMLTA
RSGPEQEARALDAGADDFLSKPFSFMVLTARLRALLRRDSRERPTVLEVGDLRLDPALHRVWRGDTSIDLTPKQFSLLEF
MMRHADHILSKSMILEHVWDFSYDGHPNIVEVYVRQLRQRIDEPFQRSSLQTVRLVGYRVVDDLAQPGTAAK

Sequences:

>Translated_232_residues
MRILVVEDDKQLAAALRRGLESEGHAVDVALTGTDGEWYASENTYDAMVVDVMLPGLTGDALCARRRESGDWTPILMLTA
RSGPEQEARALDAGADDFLSKPFSFMVLTARLRALLRRDSRERPTVLEVGDLRLDPALHRVWRGDTSIDLTPKQFSLLEF
MMRHADHILSKSMILEHVWDFSYDGHPNIVEVYVRQLRQRIDEPFQRSSLQTVRLVGYRVVDDLAQPGTAAK
>Mature_232_residues
MRILVVEDDKQLAAALRRGLESEGHAVDVALTGTDGEWYASENTYDAMVVDVMLPGLTGDALCARRRESGDWTPILMLTA
RSGPEQEARALDAGADDFLSKPFSFMVLTARLRALLRRDSRERPTVLEVGDLRLDPALHRVWRGDTSIDLTPKQFSLLEF
MMRHADHILSKSMILEHVWDFSYDGHPNIVEVYVRQLRQRIDEPFQRSSLQTVRLVGYRVVDDLAQPGTAAK

Specific function: Member of the three-protein two-component system HK1/HK2/tcrA [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=219, Percent_Identity=40.6392694063927, Blast_Score=167, Evalue=4e-43,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=37.10407239819, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=36.2385321100917, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=34.3891402714932, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=35.6828193832599, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=31.304347826087, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=30.7339449541284, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=33.0357142857143, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790860, Length=202, Percent_Identity=32.6732673267327, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788394, Length=228, Percent_Identity=28.9473684210526, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=31.6017316017316, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=28.695652173913, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=27.5862068965517, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI48994928, Length=129, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26219; Mature: 26219

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVEDDKQLAAALRRGLESEGHAVDVALTGTDGEWYASENTYDAMVVDVMLPGLTGD
CEEEEEECCHHHHHHHHHCCCCCCCEEEEEEECCCCCEEECCCCCHHEEEEHHCCCCCCH
ALCARRRESGDWTPILMLTARSGPEQEARALDAGADDFLSKPFSFMVLTARLRALLRRDS
HHHHHHCCCCCCCEEEEEEECCCCHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCC
RERPTVLEVGDLRLDPALHRVWRGDTSIDLTPKQFSLLEFMMRHADHILSKSMILEHVWD
CCCCCEEEECCCEECHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FSYDGHPNIVEVYVRQLRQRIDEPFQRSSLQTVRLVGYRVVDDLAQPGTAAK
CCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRILVVEDDKQLAAALRRGLESEGHAVDVALTGTDGEWYASENTYDAMVVDVMLPGLTGD
CEEEEEECCHHHHHHHHHCCCCCCCEEEEEEECCCCCEEECCCCCHHEEEEHHCCCCCCH
ALCARRRESGDWTPILMLTARSGPEQEARALDAGADDFLSKPFSFMVLTARLRALLRRDS
HHHHHHCCCCCCCEEEEEEECCCCHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCC
RERPTVLEVGDLRLDPALHRVWRGDTSIDLTPKQFSLLEFMMRHADHILSKSMILEHVWD
CCCCCEEEECCCEECHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FSYDGHPNIVEVYVRQLRQRIDEPFQRSSLQTVRLVGYRVVDDLAQPGTAAK
CCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]