Click here to switch to the map view.

The map label for this gene is pncB1 [H]

Identifier: 119715543

GI number: 119715543

Start: 1381500

End: 1382819

Strand: Reverse

Name: pncB1 [H]

Synonym: Noca_1307

Alternate gene names: 119715543

Gene position: 1382819-1381500 (Counterclockwise)

Preceding gene: 119715549

Following gene: 119715538

Centisome position: 27.73

GC content: 74.39

Gene sequence:

>1320_bases
GTGTCCCTCACCCCCGCACCGAGCACCGGCCTCGGCACCGAGTCCAGCACCGCGCTCCTCACCGACCACTACGAGCTGAC
GATGCTCCAGGCCGCGTTGGCGGCCGGGACAGCGGACCGCCGGGCGGTCTTCGAGCTGTTCCCGCGACGGCTGCCCGAGG
GCCGTCGGTACGGCGTGGTCGCCGGCGTCGGCCGGGCCCTGGACGCTGTGGAGCGGTTCCGGTTCGACGAGCAGGTGCTC
GCCGTGCTCGCGGACGTGGTGGACGCACCGACGCTGGAGTGGTTGGCGTCGTACCGCTTCTCCGGCGACGTGTGGGGCTA
CGCCGAGGGCGAGGCCTACTTCCCCTACTCGCCGATCGCGATCGTGGAGTCGACGTTCGCCGAGGCGGTGCTGCTGGAGA
CGCTGCTGCTCTCGATCTACAACCACGACTCGGCCATCGCCTCGGCCGCCTCCCGGATGACCCTGGTCGCCGGCGACCGC
CCCTGCATCGAGATGGGGTCGCGGCGCACCCACGAGGAGGCCGCGGTCGCCGCCGCGCGGGCGGCGTACGTCGCCGGCTT
CGCCACCAGCTCGAACCTCGCCGCGCGGCAGCGGTACGGCGTACCGTCGGCCGGCACCAGCGCCCACAGCTTCACGCTCC
TCCACGACAGCGAGGCGGACGCGTTCCGGGCCCAGGTGGACTCGCTGGGGACCGGCACGACGCTGCTCGTGGACACCTAC
GACGTCGCGGAGGCCGTGCGGCTGGCCGTGGAGGTCGCCGGACCCGAGCTGGGCGCGGTCCGCCTCGACTCCGGCGATCT
CGGCGCGCTGGCGCACGAGGTCCGGGCGGAGCTGGACCGGCTCGGCGCCACCCGCACCCGGATCATCGTCACCAGCGACC
TCGACGAGTTCGCGATCGCCGCGCTGGCCGCGGCACCGGTCGACGGGTACGGCGTCGGCACCGAGCTCGTCACCGGCAGT
GGGCACCCGACGAGCGGCTTCGTCTACAAGCTGGTGGCGCGTGCCGACGACGCCGGTGAGCTGGTGCCGGTCGCCAAGCG
CAGCGTGGACAAGGCCTCGATCGGCGGCCGCAAGTACGCGCTGCGGCGCCGGGACGCGTCCGGCACGGCCGAGGCCGAGG
TGGTCGGGATCGGCACGCCTCCGGTGGACGACGGCGACGACCGCCCGCTGCTGGTCCCGCTCGTGCGCGCCGGGGAGGTG
GTCGGGCGGGAGCCGCTCGACGATGCGCGGGCCCGACACCTGGCCGCGCGCGCCGAGCTCCCCGTCGCGGTGCAGCAGAT
GTCACGCGGCGAGCCGGTGATCCCGACCCTCCACGTCTGA

Upstream 100 bases:

>100_bases
TCACCCAGGGCTTCGAGGTCTGGGTGATCTCGTCGGGAGTGAGAGTCGGCTCGACCTCGACGGGGGCAGACACGGTGCCC
ATGTTGGCACACTGGGCCAC

Downstream 100 bases:

>100_bases
CACCTGCGGTAGTCCCTGACGCTTGCGGGCTCCGAGAGCGCTCCCACACCACACAAGCGTCAGGGACTACCGCACCGGAG
GAGCCGGCACCTGACCACCC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB1 [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MSLTPAPSTGLGTESSTALLTDHYELTMLQAALAAGTADRRAVFELFPRRLPEGRRYGVVAGVGRALDAVERFRFDEQVL
AVLADVVDAPTLEWLASYRFSGDVWGYAEGEAYFPYSPIAIVESTFAEAVLLETLLLSIYNHDSAIASAASRMTLVAGDR
PCIEMGSRRTHEEAAVAAARAAYVAGFATSSNLAARQRYGVPSAGTSAHSFTLLHDSEADAFRAQVDSLGTGTTLLVDTY
DVAEAVRLAVEVAGPELGAVRLDSGDLGALAHEVRAELDRLGATRTRIIVTSDLDEFAIAALAAAPVDGYGVGTELVTGS
GHPTSGFVYKLVARADDAGELVPVAKRSVDKASIGGRKYALRRRDASGTAEAEVVGIGTPPVDDGDDRPLLVPLVRAGEV
VGREPLDDARARHLAARAELPVAVQQMSRGEPVIPTLHV

Sequences:

>Translated_439_residues
MSLTPAPSTGLGTESSTALLTDHYELTMLQAALAAGTADRRAVFELFPRRLPEGRRYGVVAGVGRALDAVERFRFDEQVL
AVLADVVDAPTLEWLASYRFSGDVWGYAEGEAYFPYSPIAIVESTFAEAVLLETLLLSIYNHDSAIASAASRMTLVAGDR
PCIEMGSRRTHEEAAVAAARAAYVAGFATSSNLAARQRYGVPSAGTSAHSFTLLHDSEADAFRAQVDSLGTGTTLLVDTY
DVAEAVRLAVEVAGPELGAVRLDSGDLGALAHEVRAELDRLGATRTRIIVTSDLDEFAIAALAAAPVDGYGVGTELVTGS
GHPTSGFVYKLVARADDAGELVPVAKRSVDKASIGGRKYALRRRDASGTAEAEVVGIGTPPVDDGDDRPLLVPLVRAGEV
VGREPLDDARARHLAARAELPVAVQQMSRGEPVIPTLHV
>Mature_438_residues
SLTPAPSTGLGTESSTALLTDHYELTMLQAALAAGTADRRAVFELFPRRLPEGRRYGVVAGVGRALDAVERFRFDEQVLA
VLADVVDAPTLEWLASYRFSGDVWGYAEGEAYFPYSPIAIVESTFAEAVLLETLLLSIYNHDSAIASAASRMTLVAGDRP
CIEMGSRRTHEEAAVAAARAAYVAGFATSSNLAARQRYGVPSAGTSAHSFTLLHDSEADAFRAQVDSLGTGTTLLVDTYD
VAEAVRLAVEVAGPELGAVRLDSGDLGALAHEVRAELDRLGATRTRIIVTSDLDEFAIAALAAAPVDGYGVGTELVTGSG
HPTSGFVYKLVARADDAGELVPVAKRSVDKASIGGRKYALRRRDASGTAEAEVVGIGTPPVDDGDDRPLLVPLVRAGEVV
GREPLDDARARHLAARAELPVAVQQMSRGEPVIPTLHV

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=435, Percent_Identity=32.183908045977, Blast_Score=130, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71997952, Length=452, Percent_Identity=27.8761061946903, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71997947, Length=436, Percent_Identity=28.2110091743119, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI71997955, Length=209, Percent_Identity=32.5358851674641, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24581587, Length=433, Percent_Identity=27.9445727482679, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI161076680, Length=201, Percent_Identity=32.3383084577114, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24581595, Length=201, Percent_Identity=32.3383084577114, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28574709, Length=201, Percent_Identity=32.3383084577114, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24581593, Length=201, Percent_Identity=32.3383084577114, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24581591, Length=201, Percent_Identity=32.3383084577114, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 46292; Mature: 46161

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTPAPSTGLGTESSTALLTDHYELTMLQAALAAGTADRRAVFELFPRRLPEGRRYGVV
CCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEHH
AGVGRALDAVERFRFDEQVLAVLADVVDAPTLEWLASYRFSGDVWGYAEGEAYFPYSPIA
HHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEECCCEECCCCCHH
IVESTFAEAVLLETLLLSIYNHDSAIASAASRMTLVAGDRPCIEMGSRRTHEEAAVAAAR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCEEEEECCCCHHHHCCCCCHHHHHHHHHH
AAYVAGFATSSNLAARQRYGVPSAGTSAHSFTLLHDSEADAFRAQVDSLGTGTTLLVDTY
HHHHHEECCCCCHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCEEEEECH
DVAEAVRLAVEVAGPELGAVRLDSGDLGALAHEVRAELDRLGATRTRIIVTSDLDEFAIA
HHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHH
ALAAAPVDGYGVGTELVTGSGHPTSGFVYKLVARADDAGELVPVAKRSVDKASIGGRKYA
HHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHCCCCCCCCCHHHHHCCCHHHCCCCEEE
LRRRDASGTAEAEVVGIGTPPVDDGDDRPLLVPLVRAGEVVGREPLDDARARHLAARAEL
EEECCCCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCHHCCCCCCHHHHHHHHHHHCCC
PVAVQQMSRGEPVIPTLHV
CHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SLTPAPSTGLGTESSTALLTDHYELTMLQAALAAGTADRRAVFELFPRRLPEGRRYGVV
CCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEHH
AGVGRALDAVERFRFDEQVLAVLADVVDAPTLEWLASYRFSGDVWGYAEGEAYFPYSPIA
HHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEECCCEECCCCCHH
IVESTFAEAVLLETLLLSIYNHDSAIASAASRMTLVAGDRPCIEMGSRRTHEEAAVAAAR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCEEEEECCCCHHHHCCCCCHHHHHHHHHH
AAYVAGFATSSNLAARQRYGVPSAGTSAHSFTLLHDSEADAFRAQVDSLGTGTTLLVDTY
HHHHHEECCCCCHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCEEEEECH
DVAEAVRLAVEVAGPELGAVRLDSGDLGALAHEVRAELDRLGATRTRIIVTSDLDEFAIA
HHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHH
ALAAAPVDGYGVGTELVTGSGHPTSGFVYKLVARADDAGELVPVAKRSVDKASIGGRKYA
HHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHCCCCCCCCCHHHHHCCCHHHCCCCEEE
LRRRDASGTAEAEVVGIGTPPVDDGDDRPLLVPLVRAGEVVGREPLDDARARHLAARAEL
EEECCCCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCHHCCCCCCHHHHHHHHHHHCCC
PVAVQQMSRGEPVIPTLHV
CHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]