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The map label for this gene is degP [C]

Identifier: 119715448

GI number: 119715448

Start: 1285152

End: 1286567

Strand: Direct

Name: degP [C]

Synonym: Noca_1212

Alternate gene names: 119715448

Gene position: 1285152-1286567 (Clockwise)

Preceding gene: 119715447

Following gene: 119715450

Centisome position: 25.78

GC content: 75.14

Gene sequence:

>1416_bases
GTGACGCAGGACGAGCCCCGCGACGACGAGTCGACGCAGCCGCTGGCGGCCGCGCCCCTCGGGCCGCCGCCAGCCACGCC
CCCGGCCACGCCCGCAGAACCCCCCGCCGCGCCGCCGGCGGCACCACCCGTCGCACCGCCGGCCGGACCGCCCGCGGGTC
CGCGGCCGCCGAGCTGGCTGCCGCCCACCGTGCAGTCCCCTCCGCACCGGTGGGCCGGGCTGCCGCCGGGAGCGCCGTAC
GCCGGCCAGCAGCAGCCCTTCGGGCCGTCGTTCGGTCCTCCGTCGGGCCCGCCACCGGGCCACCTGGCCCCGCGCGGCCG
GGTCCCCGGCTGGCTGTGGCCCGTGGTCTGCGTGCTCGCCCTCACCCTCGGGCTCGTGGGTGGCGCGCTCGGCGGCCTCG
CCTACGATCAGCTCAGCGAGGACGAGCCGGGCACCGTGAGCAGCGGCCTGGCCGGCGTCGACACCGTCTCCGAGGCGCCG
CTGTCGGCGGACAACGGGTCGATCGAGGCGGTCGCCGCGCGGCTGCTGCCGAGCACCGTGCAGATCTCCGCCGAGTACGA
GGGCCAGCGCGGCGGGGCCACCGGCTCCGGCTTCGTGTTGGACCGGCAGGGGCACGTGATCACCAACAACCACGTGGTGG
CCGACGCCGACGAGGCCGACGGCCCGATCCAGATCGTCGACCAGGACGGCAACCGCTACCCCGCGACCGTGGTCGGGCGC
AGCCCGGTCTACGACCTGGCGGTCCTCTACTCGCCGAAGGCGAAGGGCCTGACGCCGGCCGCCCTGGGTGCCTCCCAGGA
GCTGCGGGTCGGTGAGGGCGTGGTCGCCATCGGCTCGCCCCTCGGGCTCAGCTCGACCGTGACCGCCGGGATCGTGAGCG
CGCTGCACCGGCCGGTCACCACCGGCGACGCCGGCAACGACTCCTCCTACATCAACGCGGTCCAGACGGACGCGGCGATC
AACCCCGGCAACTCCGGGGGGCCGCTGGTGAACCTGCGCGGCCAGGTCGTCGGCGTGAACTCCGCGATCGCGACGACCGG
CGGCGGCATCGGCGGTGAGTCCGGCAACATCGGCGTCGGCTTCGCGATCCCGATCGAGCAGGTGCGGGTCACCGCGGACC
AGATCCTGCGCACCGGCGAGGCGAAGTACCCGGTCATCGGCGCGCAGGTGCAGACCGGGCAGAACGACGGCAACGGCGCC
GAGATCGACGAGGTCATGCCCGACACCCCCGCCGAGAGGGGCGGCCTGCGCAAGGGCGACGTGATCATCGAGGTCGAGGG
CGAGCGGGTCACCGACGGCATCGCCCTGATCGTCGCGATCCGCACCCACCAGCCGGGGGAGACTGTGGAGTTCACGATCC
TGCGGGACGGTCAGGAGCGCACCATCTCGCTCACCCTGGGCGCCGAGACCGGCTGA

Upstream 100 bases:

>100_bases
ACGCCGACGCCGACGGTGCCGGCCGCCCACGTCACCCGACAGGCGAAGCGGTAGCGAGCCCGCCGGTCCCGGATTTCGCG
GCGCGGGTCAAGATAGTGCC

Downstream 100 bases:

>100_bases
GCTTCGCGTCCGCGGTGGCCAGGGCTCGCGGTGATCGGTTTCCCCGGTGAACCGGGGAAACCGGAACTGTTGGGCCGAAA
CTTCGGGCCAGAAGTTCCGG

Product: peptidase S1 and S6, chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTQDEPRDDESTQPLAAAPLGPPPATPPATPAEPPAAPPAAPPVAPPAGPPAGPRPPSWLPPTVQSPPHRWAGLPPGAPY
AGQQQPFGPSFGPPSGPPPGHLAPRGRVPGWLWPVVCVLALTLGLVGGALGGLAYDQLSEDEPGTVSSGLAGVDTVSEAP
LSADNGSIEAVAARLLPSTVQISAEYEGQRGGATGSGFVLDRQGHVITNNHVVADADEADGPIQIVDQDGNRYPATVVGR
SPVYDLAVLYSPKAKGLTPAALGASQELRVGEGVVAIGSPLGLSSTVTAGIVSALHRPVTTGDAGNDSSYINAVQTDAAI
NPGNSGGPLVNLRGQVVGVNSAIATTGGGIGGESGNIGVGFAIPIEQVRVTADQILRTGEAKYPVIGAQVQTGQNDGNGA
EIDEVMPDTPAERGGLRKGDVIIEVEGERVTDGIALIVAIRTHQPGETVEFTILRDGQERTISLTLGAETG

Sequences:

>Translated_471_residues
MTQDEPRDDESTQPLAAAPLGPPPATPPATPAEPPAAPPAAPPVAPPAGPPAGPRPPSWLPPTVQSPPHRWAGLPPGAPY
AGQQQPFGPSFGPPSGPPPGHLAPRGRVPGWLWPVVCVLALTLGLVGGALGGLAYDQLSEDEPGTVSSGLAGVDTVSEAP
LSADNGSIEAVAARLLPSTVQISAEYEGQRGGATGSGFVLDRQGHVITNNHVVADADEADGPIQIVDQDGNRYPATVVGR
SPVYDLAVLYSPKAKGLTPAALGASQELRVGEGVVAIGSPLGLSSTVTAGIVSALHRPVTTGDAGNDSSYINAVQTDAAI
NPGNSGGPLVNLRGQVVGVNSAIATTGGGIGGESGNIGVGFAIPIEQVRVTADQILRTGEAKYPVIGAQVQTGQNDGNGA
EIDEVMPDTPAERGGLRKGDVIIEVEGERVTDGIALIVAIRTHQPGETVEFTILRDGQERTISLTLGAETG
>Mature_470_residues
TQDEPRDDESTQPLAAAPLGPPPATPPATPAEPPAAPPAAPPVAPPAGPPAGPRPPSWLPPTVQSPPHRWAGLPPGAPYA
GQQQPFGPSFGPPSGPPPGHLAPRGRVPGWLWPVVCVLALTLGLVGGALGGLAYDQLSEDEPGTVSSGLAGVDTVSEAPL
SADNGSIEAVAARLLPSTVQISAEYEGQRGGATGSGFVLDRQGHVITNNHVVADADEADGPIQIVDQDGNRYPATVVGRS
PVYDLAVLYSPKAKGLTPAALGASQELRVGEGVVAIGSPLGLSSTVTAGIVSALHRPVTTGDAGNDSSYINAVQTDAAIN
PGNSGGPLVNLRGQVVGVNSAIATTGGGIGGESGNIGVGFAIPIEQVRVTADQILRTGEAKYPVIGAQVQTGQNDGNGAE
IDEVMPDTPAERGGLRKGDVIIEVEGERVTDGIALIVAIRTHQPGETVEFTILRDGQERTISLTLGAETG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=302, Percent_Identity=34.1059602649007, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI24308541, Length=326, Percent_Identity=32.8220858895706, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI4506141, Length=259, Percent_Identity=36.2934362934363, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI7019477, Length=276, Percent_Identity=35.8695652173913, Blast_Score=125, Evalue=1e-28,
Organism=Escherichia coli, GI1786356, Length=284, Percent_Identity=38.0281690140845, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1789629, Length=282, Percent_Identity=36.1702127659575, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1789630, Length=282, Percent_Identity=34.3971631205674, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24646839, Length=301, Percent_Identity=33.2225913621262, Blast_Score=132, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 47502; Mature: 47371

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQDEPRDDESTQPLAAAPLGPPPATPPATPAEPPAAPPAAPPVAPPAGPPAGPRPPSWL
CCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PPTVQSPPHRWAGLPPGAPYAGQQQPFGPSFGPPSGPPPGHLAPRGRVPGWLWPVVCVLA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LTLGLVGGALGGLAYDQLSEDEPGTVSSGLAGVDTVSEAPLSADNGSIEAVAARLLPSTV
HHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEE
QISAEYEGQRGGATGSGFVLDRQGHVITNNHVVADADEADGPIQIVDQDGNRYPATVVGR
EEEEEECCCCCCCCCCCEEEECCCCEEECCEEEECCCCCCCCEEEEECCCCCCCEEEECC
SPVYDLAVLYSPKAKGLTPAALGASQELRVGEGVVAIGSPLGLSSTVTAGIVSALHRPVT
CCCEEEEEEECCCCCCCCHHHCCCCCCEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCC
TGDAGNDSSYINAVQTDAAINPGNSGGPLVNLRGQVVGVNSAIATTGGGIGGESGNIGVG
CCCCCCCCHHEEEEECCCEECCCCCCCCEEEECCEEEECCCEEEECCCCCCCCCCCEEEE
FAIPIEQVRVTADQILRTGEAKYPVIGAQVQTGQNDGNGAEIDEVMPDTPAERGGLRKGD
EECCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHCCCCCHHHCCCCCCC
VIIEVEGERVTDGIALIVAIRTHQPGETVEFTILRDGQERTISLTLGAETG
EEEEECCCEECCCEEEEEEEECCCCCCEEEEEEEECCCCEEEEEEECCCCC
>Mature Secondary Structure 
TQDEPRDDESTQPLAAAPLGPPPATPPATPAEPPAAPPAAPPVAPPAGPPAGPRPPSWL
CCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PPTVQSPPHRWAGLPPGAPYAGQQQPFGPSFGPPSGPPPGHLAPRGRVPGWLWPVVCVLA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LTLGLVGGALGGLAYDQLSEDEPGTVSSGLAGVDTVSEAPLSADNGSIEAVAARLLPSTV
HHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEE
QISAEYEGQRGGATGSGFVLDRQGHVITNNHVVADADEADGPIQIVDQDGNRYPATVVGR
EEEEEECCCCCCCCCCCEEEECCCCEEECCEEEECCCCCCCCEEEEECCCCCCCEEEECC
SPVYDLAVLYSPKAKGLTPAALGASQELRVGEGVVAIGSPLGLSSTVTAGIVSALHRPVT
CCCEEEEEEECCCCCCCCHHHCCCCCCEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCC
TGDAGNDSSYINAVQTDAAINPGNSGGPLVNLRGQVVGVNSAIATTGGGIGGESGNIGVG
CCCCCCCCHHEEEEECCCEECCCCCCCCEEEECCEEEECCCEEEECCCCCCCCCCCEEEE
FAIPIEQVRVTADQILRTGEAKYPVIGAQVQTGQNDGNGAEIDEVMPDTPAERGGLRKGD
EECCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHCCCCCHHHCCCCCCC
VIIEVEGERVTDGIALIVAIRTHQPGETVEFTILRDGQERTISLTLGAETG
EEEEECCCEECCCEEEEEEEECCCCCCEEEEEEEECCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]